In a recent issue of Immunity,Teijeira et al.provide some crucial evidence that provides an important piece of the puzzle representing the immune-escaping strategies of cancer.1 It is well established that a complex n...In a recent issue of Immunity,Teijeira et al.provide some crucial evidence that provides an important piece of the puzzle representing the immune-escaping strategies of cancer.1 It is well established that a complex network of innate and adaptive immune effector mechanisms,including immune cells with phagocytic or cytotoxic activity and soluble factors,such as antibodies,chemokines,cytokines,antimicrobial peptides,and toxins,such as extracellular DNA and histones,protect us from infections and cancer.2 Nevertheless,pathogens and tumor cells have developed sophisticated mechanisms to escape from immunological surveillance,and the overall process is referred to as‘immuno-editing’.3 In their manuscript,Teijeira and colleagues report that neutrophil extracellular traps(NETs)have the potential to limit the immune response against cancer by coating malignant cells.NETs are composed of extracellular weblike DNA decorated with antimicrobial proteins,which are released from activated neutrophils during NETosis.While NETosis plays essential roles in the elimination of microorganisms,excessive formation of NETs can harm the host.4 By binding pathogens,NETs prevent their spread,ensuring increased local concentrations of toxic factors.展开更多
文摘In a recent issue of Immunity,Teijeira et al.provide some crucial evidence that provides an important piece of the puzzle representing the immune-escaping strategies of cancer.1 It is well established that a complex network of innate and adaptive immune effector mechanisms,including immune cells with phagocytic or cytotoxic activity and soluble factors,such as antibodies,chemokines,cytokines,antimicrobial peptides,and toxins,such as extracellular DNA and histones,protect us from infections and cancer.2 Nevertheless,pathogens and tumor cells have developed sophisticated mechanisms to escape from immunological surveillance,and the overall process is referred to as‘immuno-editing’.3 In their manuscript,Teijeira and colleagues report that neutrophil extracellular traps(NETs)have the potential to limit the immune response against cancer by coating malignant cells.NETs are composed of extracellular weblike DNA decorated with antimicrobial proteins,which are released from activated neutrophils during NETosis.While NETosis plays essential roles in the elimination of microorganisms,excessive formation of NETs can harm the host.4 By binding pathogens,NETs prevent their spread,ensuring increased local concentrations of toxic factors.
