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Construction and characteristic analysis of background error covariance coupled with land surface temperature 被引量:1
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作者 Qihang Yang Yaodeng Chen +4 位作者 Luyao Qin Yuanbing Wang Deming Meng Xusheng Yan Xinyao Qian 《Atmospheric and Oceanic Science Letters》 2025年第3期7-12,共6页
Land surface temperature(LST)is the key variable in land-atmosphere interaction,having an important impact on weather and climate forecasting.However,achieving consistent analysis of LST and the atmosphere in assimila... Land surface temperature(LST)is the key variable in land-atmosphere interaction,having an important impact on weather and climate forecasting.However,achieving consistent analysis of LST and the atmosphere in assimilation is quite challenging.This is because there is limited knowledge about the cross-component background error covariance(BEC)between LST and atmospheric state variables.This study aims to clarify whether there is a relationship between the error of LST and atmospheric variables,and whether this relationship varies spatially and temporally.To this end,the BEC coupled with atmospheric variables and LST was constructed(LST-BEC),and its characteristics were analyzed based on the 2023 mei-yu season.The general characteristics of LST-BEC show that the LST is mainly correlated with the atmospheric temperature and the correlation decreases gradually with a rise in atmospheric height,and the error standard deviation of the LST is noticeably larger than that of the low-level atmospheric temperature.The spatiotemporal characteristics of LST-BEC on the heavy-rain day and light-rain day show that the error correlation and error standard deviation of LST and low-level atmospheric temperature and humidity are closely related to the weather background,and also have obvious diurnal variations.These results provide valuable information for strongly coupled land-atmosphere assimilation. 展开更多
关键词 Background error covariance Land surface temperature error correlation error standard deviation Data assimilation
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基于分子对接技术筛选大菱鲆ACE抑制肽的研究
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作者 简恒源 赵彦钦 +10 位作者 陆佳伟 李燕苹 张瑶 张斌成 孔菲 王晓彤 代姣南 卢航 田元勇 鲁雪峰 赵慧 《农产品加工》 2026年第4期19-24,共6页
选择性筛选大菱鲆ACE抑制肽,利用生物信息学方法,以大菱鲆肌肉蛋白(ID:A0A8D3A461)为研究对象,在碱性蛋白酶(Subtilisin,EC 3.4.21.62)最适条件下对大菱鲆肌肉蛋白进行虚拟酶解,筛选具有ACE抑制活性的肽,并对其水溶性、毒性、等电点、... 选择性筛选大菱鲆ACE抑制肽,利用生物信息学方法,以大菱鲆肌肉蛋白(ID:A0A8D3A461)为研究对象,在碱性蛋白酶(Subtilisin,EC 3.4.21.62)最适条件下对大菱鲆肌肉蛋白进行虚拟酶解,筛选具有ACE抑制活性的肽,并对其水溶性、毒性、等电点、分子量及三维结构进行预测分析。虚拟酶解得到的肽段与ACE分子进行半柔性对接,筛选ACE抑制肽,选取其中3条潜在高活性ACE抑制肽(Arg-Phe,Arg-Phe,Gly-Trp),通过分子对接分析发现,上述活性肽与关键氨基酸(ARG522、GLU411)之间能够形成范德华力、电荷相互作用力、Pi-Pi键、盐桥等作用力,并可通过作用于Zn2+,改变ACE分子结构,进而通过竞争性ACE抑制作用达到降低血压的效果。虚拟筛选出的Arg-Phe和Arg-Phe能够显著降低SHR的收缩压,说明ACE抑制肽Arg-Phe和Arg-Phe具有降血压活性。研究结果证明了计算机模拟技术应用于活性肽研发的可行性,为研发具有ACE抑制活性的食源性降血压活性成分提供了新思路。 展开更多
关键词 食源性ace抑制肽 大菱鲆 分子对接 活性肽 降血压
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Error Analysis of MSAV Scheme for Two Phase Magnetohydrodynamic Diffuse Interface Model
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作者 HU Kun WANG Danxia +1 位作者 ZHANG Jianwen JIA Hongen 《应用数学》 北大核心 2025年第2期348-371,共24页
In this paper,we develop a multi-scalar auxiliary variables(MSAV)scheme for the Cahn-Hilliard Magnetohydrodynamics system by introducing two scalar auxiliary variables(SAV).This scheme is linear,fully decoupled and un... In this paper,we develop a multi-scalar auxiliary variables(MSAV)scheme for the Cahn-Hilliard Magnetohydrodynamics system by introducing two scalar auxiliary variables(SAV).This scheme is linear,fully decoupled and unconditionally stable in energy.Subsequently,we provide a detailed implementation procedure for full decoupling.Thus,at each time step,only a series of linear differential equations with constant coefficients need to be solved.To validate the effectiveness of our approach,we conduct an error analysis for this first-order scheme.Finally,some numerical experiments are provided to verify the energy dissipation of the system and the convergence of the proposed approach. 展开更多
关键词 Cahn-Hilliard Magnetohydrodynamics system Fully decoupled Stability in energy error analysis
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Global receptive field transformer decoder method on quantum surface code data and syndrome error correction
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作者 Ao-Qing Li Ce-Wen Tian +2 位作者 Xiao-Xuan Xu Hong-Yang Ma Jun-Qing Liang 《Chinese Physics B》 2025年第3期267-276,共10页
Quantum computing has the potential to solve complex problems that are inefficiently handled by classical computation.However,the high sensitivity of qubits to environmental interference and the high error rates in cu... Quantum computing has the potential to solve complex problems that are inefficiently handled by classical computation.However,the high sensitivity of qubits to environmental interference and the high error rates in current quantum devices exceed the error correction thresholds required for effective algorithm execution.Therefore,quantum error correction technology is crucial to achieving reliable quantum computing.In this work,we study a topological surface code with a two-dimensional lattice structure that protects quantum information by introducing redundancy across multiple qubits and using syndrome qubits to detect and correct errors.However,errors can occur not only in data qubits but also in syndrome qubits,and different types of errors may generate the same syndromes,complicating the decoding task and creating a need for more efficient decoding methods.To address this challenge,we used a transformer decoder based on an attention mechanism.By mapping the surface code lattice,the decoder performs a self-attention process on all input syndromes,thereby obtaining a global receptive field.The performance of the decoder was evaluated under a phenomenological error model.Numerical results demonstrate that the decoder achieved a decoding accuracy of 93.8%.Additionally,we obtained decoding thresholds of 5%and 6.05%at maximum code distances of 7 and 9,respectively.These results indicate that the decoder used demonstrates a certain capability in correcting noise errors in surface codes. 展开更多
关键词 quantum error correction surface code transformer decoder
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M-Estimation-Based Minimum Error Entropy with Affine Projection Algorithm for Outlier Suppression in Spaceborne SAR System
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作者 WANG Weixin CHANG Xuelian OU Shifeng 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第5期615-628,共14页
Conventional adaptive filtering algorithms often exhibit performance degradation when processing multipath interference in raw echoes of spaceborne synthetic aperture radar(SAR)systems due to anomalous outliers,manife... Conventional adaptive filtering algorithms often exhibit performance degradation when processing multipath interference in raw echoes of spaceborne synthetic aperture radar(SAR)systems due to anomalous outliers,manifesting as insufficient convergence and low estimation accuracy.To address this issue,this study proposes a novel robust adaptive filtering algorithm,namely the M-estimation-based minimum error entropy with affine projection(APMMEE)algorithm.This algorithm inherits the joint multi-data-block update mechanism of the affine projection algorithm,enabling rapid adaptation to the dynamic characteristics of raw echoes and achieving fast convergence.Meanwhile,it incorporates the M-estimation-based minimum error entropy(MMEE)criterion,which weights error samples in raw echoes through M-estimation functions,effectively suppressing outlier interference during the algorithm update.Both the system identification simulations and practical multipath interference suppression experiments using raw echoes demonstrate that the proposed APMMEE algorithm exhibits superior filtering performance. 展开更多
关键词 radar signal adaptive filtering minimum error entropy M-ESTIMATION affine projection
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Detection of co-phasing error in segmented mirror based on extended Young’s interferometry combined with Vision Transformer
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作者 LIU Yin-ling YAO Chi +3 位作者 OUYANG Shang-tao WAN Yi-rong CHEN Mo LI Bin 《中国光学(中英文)》 北大核心 2026年第1期205-218,共14页
Due to the inability of manufacturing a single monolithic mirror at the 10-meter scales,segmented mirrors have become indispensable tools in modern astronomical research.However,to match the imaging performance of the... Due to the inability of manufacturing a single monolithic mirror at the 10-meter scales,segmented mirrors have become indispensable tools in modern astronomical research.However,to match the imaging performance of the monolithic counterpart,the sub-mirrors must maintain precise co-phasing.Piston error critically degrades segmented mirror imaging quality,necessitating efficient and precise detection.To ad-dress the limitations that the conventional circular-aperture diffraction with two-wavelength algorithm is sus-ceptible to decentration errors,and the traditional convolutional neural networks(CNNs)struggle to capture global features under large-range piston errors due to their restricted local receptive fields,this paper pro-poses a method that integrates extended Young’s interference principles with a Vision Transformer(ViT)to detect piston error.By suppressing decentration error interference through two symmetrically arranged aper-tures and extending the measurement range to±7.95μm via a two-wavelength(589 nm/600 nm)algorithm.This approach exploits ViT’s self-attention mechanism to model global characteristics of interference fringes.Unlike CNNs constrained by local convolutional kernels,the ViT significantly improves sensitivity to inter-ferogram periodicity.The simulation results demonstrate that the proposed method achieves a measurement accuracy of 5 nm(0.0083λ0)across the range of±7.95μm,while maintaining an accuracy exceeding 95%in the presence of Gaussian noise(SNR≥15 dB),Poisson noise(λ≥9 photons/pixel),and sub-mirror gap er-ror(Egap≤0.2)interference.Moreover,the detection speed shows significant improvement compared to the cross-correlation algorithm.This study establishes an accurate,robust framework for segmented mirror error detection,advancing high-precision astronomical observation. 展开更多
关键词 segmented mirror co-phasing piston errors ViT Young’s interference principles
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黑曲霉转录因子ACE1的功能分析及其对β-葡萄糖苷酶表达合成的影响
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作者 王硕 王昕 +3 位作者 叶伟 吕育财 马东旭 龚大春 《微生物学通报》 北大核心 2026年第1期238-253,共16页
【背景】ACE1转录因子广泛存在于产纤维素酶的丝状真菌中,然而其在黑曲霉(Aspergillus niger)中的调控功能有待明确。【目的】在A.niger中敲除和过表达转录因子ACE1,探究其对β-葡萄糖苷酶(β-glucosidase,BGL)表达、菌丝发育和色素合... 【背景】ACE1转录因子广泛存在于产纤维素酶的丝状真菌中,然而其在黑曲霉(Aspergillus niger)中的调控功能有待明确。【目的】在A.niger中敲除和过表达转录因子ACE1,探究其对β-葡萄糖苷酶(β-glucosidase,BGL)表达、菌丝发育和色素合成的调控作用。【方法】以A.niger An-1为出发菌株,利用CRISPR-Cas9基因编辑技术,获得敲除菌株∆ace1、过表达菌株Oace1。于不同诱导环境下,检测各菌株中的BGL酶活变化、菌丝生长、产孢情况及黄色素合成差异。【结果】系统发育树分析发现,A.niger与里氏木霉(Trichoderma reesei)、粗糙脉孢菌(Neurospora crassa)中ACE1的同源性较低。经原生质体转化法将操作质粒和供体片段同时导入,获得缺失突变菌株∆ace1。以微晶纤维素、玉米芯粉为诱导物,纤维二糖为检测底物时,菌株∆ace1的BGL酶活分别下降了86.1%、54.9%;以p-硝基苯酚-α-D-吡喃葡萄糖苷为检测底物时,菌株∆ace1的BGL酶活分别下降了23.7%、63.98%。组装过表达框Pgpd-ace1-Tgla,在kus A位点进行精准插入,成功获得过表达菌株Oace1。以微晶纤维素诱导时,过表达菌株Oace1的BGL酶活是野生菌株An-1的1.37-2.16倍。在以甜菊糖苷和微晶纤维素为碳源的培养基上,缺失菌株∆ace1的菌丝延伸迟缓、分生孢子梗分化延迟,而过表达菌株Oace1与菌株An-1的菌丝形态无差异。在以甜菊糖苷为碳源,进行固、液体培养时,敲除菌株∆ace1生物合成黄色素的能力显著加强。【结论】转录因子ACE1正向调控A.niger的BGL表达和产孢能力,负调控黄色素的合成,增强ACE1表达水平能够有效提升A.niger产BGL能力,本研究为优化A.niger的产酶性能提供新思路。 展开更多
关键词 黑曲霉 ace1转录因子 Β-葡萄糖苷酶 孢子分化 黄色素
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Forecast errors of tropical cyclone track and intensity by the China Meteorological Administration from 2013 to 2022
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作者 Huanmujin Yuan Hong Wang +2 位作者 Yubin Li Kevin K.W.Cheung Zhiqiu Gao 《Atmospheric and Oceanic Science Letters》 2026年第1期72-77,共6页
This study presents a comprehensive evaluation of tropical cyclone(TC)forecast performance in the western North Pacific from 2013 to 2022,based on operational forecasts issued by the China Meteorological Administratio... This study presents a comprehensive evaluation of tropical cyclone(TC)forecast performance in the western North Pacific from 2013 to 2022,based on operational forecasts issued by the China Meteorological Administration.The analysis reveals systematic improvements in both track and intensity forecasts over the decade,with distinct error characteristics observed across various forecast parameters.Track forecast errors have steadily decreased,particularly for longer lead times,while error magnitudes have increased with longer forecast lead times.Intensity forecasts show similar progressive enhancements,with maximum sustained wind speed errors decreasing by 0.26 m/s per year for 120 h forecasts.The study also identifies several key patterns in forecast performance:typhoon-grade or stronger TCs exhibit smaller track errors than week or weaker systems;intensity forecasts systematically overestimate weaker TCs while underestimating stronger systems;and spatial error distributions show greater track inaccuracies near landmasses and regional intensity biases.These findings highlight both the significant advances in TC forecasting capability achieved through improved modeling and observational systems,and the remaining challenges in predicting TC changes and landfall behavior,providing valuable benchmarks for future forecast system development. 展开更多
关键词 Forecast error Tropical cyclone TRACK INTENSITY
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杜尔推出新一代EcoGun ACE pro低压喷枪
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《化工装备技术》 2026年第1期22-22,共1页
全新升级的EcoGun ACE pro喷枪质量更轻、握持更舒适,且所需零件数量进一步减少。杜尔创新的低压喷枪结构使操作更简便,同时显著提升运行可靠性。在延续前代产品成熟优势的基础上,EcoGun ACE pro喷枪实现了高达23%的减重。喷枪配备的油... 全新升级的EcoGun ACE pro喷枪质量更轻、握持更舒适,且所需零件数量进一步减少。杜尔创新的低压喷枪结构使操作更简便,同时显著提升运行可靠性。在延续前代产品成熟优势的基础上,EcoGun ACE pro喷枪实现了高达23%的减重。喷枪配备的油漆通道快速更换系统,支持数秒内完成颜色切换,全程无需冲洗,几乎不消耗溶剂。同时,其专为快速换色设计的替换式喷嘴,能保障清晰的喷雾形态、高上漆率与稳定的涂装效果。 展开更多
关键词 低压喷枪 EcoGun ace pro
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Total score of the computer vision syndrome questionnaire predicts refractive errors and binocular vision anomalies
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作者 Mosaad Alhassan Tasneem Samman +5 位作者 Hatoun Badukhen Muhamad Alrashed Balsam Alabdulkader Essam Almutleb Tahani Alqahtani Ali Almustanyir 《International Journal of Ophthalmology(English edition)》 2026年第1期90-96,共7页
AIM:To evaluate the efficacy of the total computer vision syndrome questionnaire(CVS-Q)score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors.METHODS:A... AIM:To evaluate the efficacy of the total computer vision syndrome questionnaire(CVS-Q)score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors.METHODS:A total of 141 healthy computer users underwent comprehensive clinical visual function assessments,including evaluations of refractive errors,accommodation(amplitude of accommodation,positive relative accommodation,negative relative accommodation,accommodative accuracy,and accommodative facility),and vergence(phoria,positive and negative fusional vergence,near point of convergence,and vergence facility).Total CVS-Q scores were recorded to explore potential associations between symptom scores and the aforementioned clinical visual function parameters.RESULTS:The cohort included 54 males(38.3%)with a mean age of 23.9±0.58y and 87 age-matched females(61.7%)with a mean age of 23.9±0.53y.The multiple regression model was statistically significant[R²=0.60,F=13.28,degrees of freedom(DF=17122,P<0.001].This indicates that 60%of the variance in total CVS-Q scores(reflecting reported symptoms)could be explained by four clinical measurements:amplitude of accommodation,positive relative accommodation,exophoria at distance and near,and positive fusional vergence at near.CONCLUSION:The total CVS-Q score is a valid and reliable tool for predicting the presence of various nonstrabismic binocular vision anomalies and refractive errors in symptomatic computer users. 展开更多
关键词 computer vision syndrome refractive errors ACCOMMODATION VERGENCE binocular vision SYMPTOMS
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Rateless Polar Codes with Unequal Error Protection Property
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作者 Cui Chen Xiang Wei +1 位作者 Ma Siwei Guo Qing 《China Communications》 2026年第1期10-23,共14页
Mobile communications are reaching out to every aspect of our daily life,necessitating highefficiency data transmission and support for diverse data types and communication scenarios.Polar codes have emerged as a prom... Mobile communications are reaching out to every aspect of our daily life,necessitating highefficiency data transmission and support for diverse data types and communication scenarios.Polar codes have emerged as a promising solution due to their outstanding error-correction performance and low complexity.Unequal error protection(UEP)involves nonuniform error safeguarding for distinct data segments,achieving a fine balance between error resilience and resource allocation,which ultimately enhancing system performance and efficiency.In this paper,we propose a novel class of UEP rateless polar codes.The codes are designed based on matrix extension of polar codes,and elegant mapping and duplication operations are designed to achieve UEP property while preserving the overall performance of conventional polar codes.Superior UEP performance is attained without significant modifications to conventional polar codes,making it straightforward for compatibility with existing polar codes.A theoretical analysis is conducted on the block error rate and throughput efficiency performance.To the best of our knowledge,this work provides the first theoretical performance analysis of UEP rateless polar codes.Simulation results show that the proposed codes significantly outperform existing polar coding schemes in both block error rate and throughput efficiency. 展开更多
关键词 matrix extension polar codes rateless coding unequal error protection
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Design of the support structure for a space-based concave thin mirror
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作者 Ming Bu Kejun Wang 《Astronomical Techniques and Instruments》 2026年第1期55-63,共9页
The neutral surface of a concave thin mirror is too close to the mirror surface,which makes it difficult to effectively mount the flexible structure and increases the mirror surface shape error.To address this problem... The neutral surface of a concave thin mirror is too close to the mirror surface,which makes it difficult to effectively mount the flexible structure and increases the mirror surface shape error.To address this problem,we design a flexible support structure including connectors,a support plate,and flexible structures,and construct an equivalent mirror by installing connectors and a support plate on the back of the mirror.While ensuring that the neutral surface of the equivalent mirror is moved away from the mirror surface,we optimize the support structure so that the rotary center of the flexible structure is located on the neutral surface of the equivalent mirror,avoiding the tilting moment.Following design and modeling of the structure,we analyze the static and dynamic characteristics using a finite element simulation,finding a root-mean-square(RMS)value for the surface shape error of 9.28 nm under the coupled effects of 1g gravity load,4℃ temperature rise,and 0.005 mm unevenness assembly error,with a fundamental frequency of 170.75 Hz,which all meet the design requirements.Finally,we carry out a surface shape error test of the mirror assembly,confirming it to meet the design index requirement of the mirror assembly.Simulation and test results verify the reliability and effectiveness of our proposed support structure. 展开更多
关键词 Space optics Thin mirror Flexible support Neutral surface Surface shape error
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Retaining local chemical effects:An error cancellation strategy for calculating standard gas-phase enthalpy of formation
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作者 Rui Liu Chaoyang Zhang +2 位作者 Linyuan Wang Zhiyu Huang Jian Liu 《Defence Technology(防务技术)》 2026年第1期172-179,共8页
Conventional error cancellation approaches separate molecules into smaller fragments and sum the errors of all fragments to counteract the overall computational error of the parent molecules.However,these approaches m... Conventional error cancellation approaches separate molecules into smaller fragments and sum the errors of all fragments to counteract the overall computational error of the parent molecules.However,these approaches may be ineffective for systems with strong localized chemical effects,as fragmenting specific substructures into simpler chemical bonds can introduce additional errors instead of mitigating them.To address this issue,we propose the Substructure-Preserved Connection-Based Hierarchy(SCBH),a method that automatically identifies and freezes substructures with significant local chemical effects prior to molecular fragmentation.The SCBH is validated by the gas-phase enthalpy of formation calculation of CHNO molecules.Therein,based on the atomization scheme,the reference and test values are derived at the levels of Gaussian-4(G4)and M062X/6-31+G(2df,p),respectively.Compared to commonly used approaches,SCBH reduces the average computational error by half and requires only15%of the computational cost of G4 to achieve comparable accuracy.Since different types of local effect structures have differentiated influences on gas-phase enthalpy of formation,substituents with strong electronic effects should be retained preferentially.SCBH can be readily extended to diverse classes of organic compounds.Its workflow and source code allow flexible customization of molecular moieties,including azide,carboxyl,trinitromethyl,phenyl,and others.This strategy facilitates accurate,rapid,and automated computations and corrections,making it well-suited for high-throughput molecular screening and dataset construction for gas-phase enthalpy of formation. 展开更多
关键词 Gas-phase enthalpy of formation error cancellation Quantum chemical High throughput
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顾及星敏感器安装矩阵校正的GRACE-FO姿态数据处理研究
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作者 梁磊 王长青 +5 位作者 黄令勇 黄志勇 于瑶瑶 钟敏 闫易浩 穆庆禄 《测绘学报》 北大核心 2026年第2期287-300,共14页
如何获取高精度的姿态数据是重力卫星载荷数据处理的重要研究内容。GRACE-FO的每颗卫星均搭载了3颗星敏感器和1个陀螺仪,融合这两类载荷的测量数据是获得高精度姿态数据的重要途径。本文首先根据星敏感器测量噪声具有各向异性的特点,建... 如何获取高精度的姿态数据是重力卫星载荷数据处理的重要研究内容。GRACE-FO的每颗卫星均搭载了3颗星敏感器和1个陀螺仪,融合这两类载荷的测量数据是获得高精度姿态数据的重要途径。本文首先根据星敏感器测量噪声具有各向异性的特点,建立了星敏感器安装矩阵标定算法;其次,建立了星敏感器低频误差处理方法,使用滑动平均方法抑制低频误差;然后,基于Gibbs矢量建立了四元数改正量和陀螺仪偏差改正量为状态向量的间接Kalman滤波算法;最后,使用GRACE-FO Level-1A数据进行验证,并分析其对时变重力场的影响。结果表明,以其中1个星敏感器为基准,校正另外两颗星敏感器安装矩阵时,解算的卫星姿态差异较小,经过星敏感器安装矩阵校正后,可以降低姿态数据在1个轨道周期(CPR)处的低频误差。根据建立的星敏感器低频误差处理策略,可以较好地压制30 CPR频段内的星敏感器低频误差。对于星敏感器和陀螺仪融合,相较于JPL结果,本文解算的姿态数据为0.0005~0.1 Hz,具有更低的噪声,充分发挥了载荷最大性能。对时变重力场模型反演的影响,从反演的时变重力场的阶方差和等效水高差异上看,基于不同姿态数据解算的时变重力场模型精度基本一致,目前姿态数据精度的提升对时变重力场模型精度影响较小。 展开更多
关键词 GRace-FO 卫星姿态 星敏感器低频误差 安装矩阵校正 间接Kalman滤波
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植物乳杆菌-枯草芽孢杆菌混菌发酵芝麻粕制备ACE抑制肽
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作者 陈心蕊 祁慧 周志文 《中国食品添加剂》 2026年第1期49-58,共10页
本研究以芝麻粕为原料,采用植物乳杆菌NZ-116(Lactiplantibacillus plantarum)与枯草芽孢杆菌ZW-24(Bacillus subtilis)混菌发酵体系制备ACE抑制肽,通过单因素实验结合响应面法优化发酵工艺,并系统评价产物的活性及稳定性。结果表明:在3... 本研究以芝麻粕为原料,采用植物乳杆菌NZ-116(Lactiplantibacillus plantarum)与枯草芽孢杆菌ZW-24(Bacillus subtilis)混菌发酵体系制备ACE抑制肽,通过单因素实验结合响应面法优化发酵工艺,并系统评价产物的活性及稳定性。结果表明:在36℃、接种量6%、发酵54 h、转速146 r/min的优化条件下,ACE抑制率达(97.16±0.85)%,较单菌发酵分别提升了(58.65±0.63)%和(129.86±2.17)%。混菌发酵显著增强蛋白水解度(0.82±0.04)mg/mL,SDS-PAGE显示其蛋白条带消减率较单菌组提高45%〜60%,并生成分子量<20 kDa的活性片段。凝胶色谱分离获得4个洗脱峰组分,其中1号峰抑制活性最高(96.37±1.2)%。体外模拟胃肠消化后,该组分IC_(50)值从(6.52±0.24)mg/mL降至(2.28±0.12)mg/mL(P<0.01),表明消化过程可显著增强其ACE抑制效能。研究证实,混菌发酵通过菌种协同效应有效降解芝麻粕抗营养因子,释放高活性肽段,为芝麻副产物的高值化利用及新型ACE抑制肽开发提供了理论依据与技术支撑。 展开更多
关键词 芝麻粕 混菌发酵 ace抑制肽 响应面优化 体外消化 凝胶色谱
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OPTIMAL POINT-WISE ERROR ESTIMATE OF TWO SECOND-ORDER ACCURATE FINITE DIFFERENCE SCHEMES FOR THE HEAT EQUATION WITH CONCENTRATED CAPACITY
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作者 Leilei Shi Tingchun Wang Xuanxuan Zhou 《Journal of Computational Mathematics》 2026年第1期61-83,共23页
In this paper,we propose and analyze two second-order accurate finite difference schemes for the one-dimensional heat equation with concentrated capacity on a computa-tional domain=[a,b].We first transform the target ... In this paper,we propose and analyze two second-order accurate finite difference schemes for the one-dimensional heat equation with concentrated capacity on a computa-tional domain=[a,b].We first transform the target equation into the standard heat equation on the domain excluding the singular point equipped with an inner interface matching(IIM)condition on the singular point x=ξ∈(a,b),then adopt Taylor’s ex-pansion to approximate the IIM condition at the singular point and apply second-order finite difference method to approximate the standard heat equation at the nonsingular points.This discrete procedure allows us to choose different grid sizes to partition the two sub-domains[a,ξ]and[ξ,b],which ensures that x=ξ is a grid point,and hence the pro-posed schemes can be generalized to the heat equation with more than one concentrated capacities.We prove that the two proposed schemes are uniquely solvable.And through in-depth analysis of the local truncation errors,we rigorously prove that the two schemes are second-order accurate both in temporal and spatial directions in the maximum norm without any constraint on the grid ratio.Numerical experiments are carried out to verify our theoretical conclusions. 展开更多
关键词 Heat equation with concentrated capacity Finite difference scheme Inner interface matching condition Unconditional convergence Optimal error estimate
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Acute liver failure caused by amino acid or organic acid related inborn errors of metabolism
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作者 Ying Zhou Chi Chen Xin Yang 《Hepatobiliary & Pancreatic Diseases International》 2026年第1期112-114,共3页
Inborn errors of metabolism(IEMs)are a large group of disorders resulting from deficient activities in several metabolic pathways due to the dysfunction of a distinct enzyme associated with a biochemical pathway[1,2].... Inborn errors of metabolism(IEMs)are a large group of disorders resulting from deficient activities in several metabolic pathways due to the dysfunction of a distinct enzyme associated with a biochemical pathway[1,2].Toxic intermediates will be produced due to the dysfunction of biochemical pathways.The liver is responsible for many essential metabolic processes,therefore it becomes one of the most severely affected organ by metabolic diseases[3].Early onset of liver disorders in IEMs includes jaundice,hepatomegaly,splenomegaly,ascites,hepatic encephalopathy,and liver failure[4].In infants and young children under 3 years old with acute liver failure(ALF),IEMs account for 18.9%-43%[5]. 展开更多
关键词 biochemical pathway toxic intermediates metabolic diseases early acute liver failure inborn errors metabolism iems organic acid dysfunction distinct enzyme metabolic processestherefore metabolic pathways
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Perioperative management of pediatric patients with inborn errors of metabolism during liver transplantation
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作者 Susan Paulin Akila Rajakumar +2 位作者 Jagadeesh Menon Naresh Shanmugam Mohamed Rela 《World Journal of Transplantation》 2026年第1期91-102,共12页
Inborn errors of metabolism(IEM)are rare disorders,most are liver-based with liver transplantation(LT)emerging as an effective cure in the pediatric population.LT has been shown to offer a cure or deter disease progre... Inborn errors of metabolism(IEM)are rare disorders,most are liver-based with liver transplantation(LT)emerging as an effective cure in the pediatric population.LT has been shown to offer a cure or deter disease progression and provide symptomatic improvement in patients with IEM.Each metabolic disorder is unique,with the missing enzyme or transporter protein causing substrate deficiency or toxic byproduct production.Knowledge about the distribution of deficient enzymes,the percentage of enzymes replaced by LT,and the extent of extrahepatic involvement helps anticipate and manage complications in the perioperative period.Most patients have multisystem involvement and can be on complex dietary regimens.Metabolic decompensation can be triggered due to the stress response to surgery,fasting and other unanticipated complications perioperatively.Thus,a multidisciplinary team’s input including those from metabolic specialists is essential to develop disease and patient-specific strategies for the perioperative management of these patients during LT.In this review,we outline the classification of IEM,indications for LT along with potential benefits,basic metabolic defects and their implications,details of extrahepatic involvement and perioperative management strategies for LT in children with some of the commonly presenting IEM,to assist anesthesiologists handling this cohort of patients. 展开更多
关键词 Inborn errors of metabolism Anaesthesia for paediatric liver transplantation Metabolic crisis Hyperammonemia in paediatric liver transplantation Perioperative care in metabolic liver diseases
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Enhanced kernel minimum squared error algorithm and its application in face recognition
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作者 赵英男 何祥健 +1 位作者 陈北京 赵晓平 《Journal of Southeast University(English Edition)》 EI CAS 2016年第1期35-38,共4页
To improve the classification performance of the kernel minimum squared error( KMSE), an enhanced KMSE algorithm( EKMSE) is proposed. It redefines the regular objective function by introducing a novel class label ... To improve the classification performance of the kernel minimum squared error( KMSE), an enhanced KMSE algorithm( EKMSE) is proposed. It redefines the regular objective function by introducing a novel class label definition, and the relative class label matrix can be adaptively adjusted to the kernel matrix.Compared with the common methods, the newobjective function can enlarge the distance between different classes, which therefore yields better recognition rates. In addition, an iteration parameter searching technique is adopted to improve the computational efficiency. The extensive experiments on FERET and GT face databases illustrate the feasibility and efficiency of the proposed EKMSE. It outperforms the original MSE, KMSE,some KMSE improvement methods, and even the sparse representation-based techniques in face recognition, such as collaborate representation classification( CRC). 展开更多
关键词 minimum squared error kernel minimum squared error pattern recognition face recognition
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食源性ACE抑制肽的制备方法及作用机制研究进展 被引量:2
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作者 王静 王立霞 +3 位作者 任彩霞 邓雅之 方丹 冯莉萍 《中国食物与营养》 2025年第4期21-28,共8页
目的:综述血管紧张素转化酶(ACE)抑制肽调节高血压的作用机制、食源性ACE抑制肽的制备方法、分离纯化、活性评价、构效关系及分子模拟作用机制,以期为ACE抑制肽的深入研究和进一步开发提供参考。方法:文章采用文献法。结果:从食品原料... 目的:综述血管紧张素转化酶(ACE)抑制肽调节高血压的作用机制、食源性ACE抑制肽的制备方法、分离纯化、活性评价、构效关系及分子模拟作用机制,以期为ACE抑制肽的深入研究和进一步开发提供参考。方法:文章采用文献法。结果:从食品原料中提取制备ACE抑制肽的方法主要包括酶解法、发酵法、模拟消化法、合成法等四大类。目前,ACE抑制肽的分离纯化技术已较为成熟。ACE抑制肽的活性研究主要从体外和体内两个方面进行。ACE抑制肽构效关系的研究主要集中在表面疏水性、分子量大小、分子构象等多个方面。结构-活性关系已被用作分析ACE抑制肽的分子作用机制。结论:食源性ACE抑制肽在体内降血压活性及降血压机制方面的研究还不够系统深入,它的构效关系还需深入研究。ACE抑制肽分离纯化过程需要进一步改进,同时还需加强食源性ACE抑制肽安全性研究、生产过程中的质量管理,保障消费者的安全与健康。 展开更多
关键词 ace抑制肽 制备方法 活性评价 构效关系 分子机制
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