Skin protection and wound healing in harsh environments such as seawater,cold,and dryness face great challenges.However,traditional hydrogels tend to lose adhesion underwater,freeze at low temperatures,and dehydrate i...Skin protection and wound healing in harsh environments such as seawater,cold,and dryness face great challenges.However,traditional hydrogels tend to lose adhesion underwater,freeze at low temperatures,and dehydrate in dry environments,severely limiting their applications.Inspired by marine barnacles,a chitosan(CTS)–butyl acrylate(BA)-glycerol gel(CB-G-Gel)is fabricated,which mimic the electrostatic and hydrophobic interactions of barnacle cement proteins using CTS and BA respectively to enhance adhesion underwater,and employ a glycerol/water solvent exchange strategy to endow the gel with anti-freezing and water-retaining properties.CB-G-Gel exhibits strong underwater adhesion and good antibacterial activity,and promotes seawater-immersed wound healing.CB-G-Gel protects the skin from frostbite and scald(-196~120°C),and has excellent water retention under dry conditions of 20%relative humidity and 60°C.This strategy of combining barnacle biomimicry with glycerol/water solvent exchange provides a guidance for skin protection and wound healing in harsh environments.展开更多
基金supported by the Natural Science Foundation of Qingdao Municipality(No.24-4-4-zrjj-156-jch)the National Natural Science Foundation of China(No.U21A20297)。
文摘Skin protection and wound healing in harsh environments such as seawater,cold,and dryness face great challenges.However,traditional hydrogels tend to lose adhesion underwater,freeze at low temperatures,and dehydrate in dry environments,severely limiting their applications.Inspired by marine barnacles,a chitosan(CTS)–butyl acrylate(BA)-glycerol gel(CB-G-Gel)is fabricated,which mimic the electrostatic and hydrophobic interactions of barnacle cement proteins using CTS and BA respectively to enhance adhesion underwater,and employ a glycerol/water solvent exchange strategy to endow the gel with anti-freezing and water-retaining properties.CB-G-Gel exhibits strong underwater adhesion and good antibacterial activity,and promotes seawater-immersed wound healing.CB-G-Gel protects the skin from frostbite and scald(-196~120°C),and has excellent water retention under dry conditions of 20%relative humidity and 60°C.This strategy of combining barnacle biomimicry with glycerol/water solvent exchange provides a guidance for skin protection and wound healing in harsh environments.
