BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential fo...BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential for developing strategies to prevent MDE relapse.Despite its clinical importance,the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.AIM To investigate the brain network mechanism underlying rumination in patients with remitted MDEs using functional magnetic resonance imaging(fMRI).METHODS We conducted an fMRI-based rumination-distraction task to induce rumination and distraction states in 51 patients with remitted MDEs.Functional connectivity(FC)was analyzed using the network-based statistic(NBS)approach,and eight topological metrics were calculated to compare the network topological properties between the two states.Correlation analyses were further performed to identify the relationships between individual rumination levels and the significantly altered brain network metrics.RESULTS The NBS analysis revealed that the altered FCs between the rumination and distraction states were located primarily in the frontoparietal,default mode,and cerebellar networks.No significant correlation was detected between these altered FCs and individual rumination levels.Among the eight topological metrics,the clustering coefficient,shortest path length,and local efficiency were significantly lower during rumination and positively correlated with individual rumination levels.In contrast,global efficiency was greater in the rumination state than in the distraction state and was negatively correlated with individual rumination levels.CONCLUSION Our work revealed the altered FC and topological properties during rumination in remitted MDE patients,offering valuable insights into the neural mechanisms of rumination from a brain network perspective.展开更多
BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,eff...BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,effective treatment options,particularly for cognitive dysfunction,remain limited.AIM To evaluate the efficacy of computerized cognitive behavioral therapy(CCBT)with sertraline vs sertraline monotherapy in improving depressive symptoms,cognitive function,and quality of life in schizophrenia and depressive episodes.METHODS In this single-center,randomized controlled trial,68 adults[mean age(SD)=36.5(10.0),57.4%male]with schizophrenia and depressive symptoms were randomly assigned to receive either CCBT with sertraline or sertraline monotherapy during a 4-week hospitalization.The CCBT intervention involved 45-60-minute sessions twice weekly for four weeks.Outcomes included comparisons of depressive symptoms(Calgary depression scale for schizophrenia),cognitive function[MATRICS consensus cognitive battery(MCCB)],and quality of life(36-item short form survey)between the groups.RESULTS The experimental group showed greater improvements in depressive symptoms at 4,8,and 12 weeks compared to the controls,with the most notable difference at 12 weeks[mean difference(MD)=-1.7;P<0.001;Cohen’s d=0.9].Cognitive function improved across all MCCB domains in the experimental group,with higher processing speed scores(MD=4.1;P=0.043;Cohen’s d=0.5)and social cognition scores(MD=4.9;P=0.006;Cohen’s d=0.7)than in the control group.Quality of life,particularly in mental health,was significantly better in the experimental group.CONCLUSION CCBT with sertraline was more effective than sertraline monotherapy for patients with schizophrenia and depressive episodes,supporting its use as an adjunctive therapy.展开更多
Previous studies have obtained some petrogenetic and metallogenic chronological data with SHRIMP （sensitive high-resolution ion microprobe） zircon U-Pb, zircon LA-ICPMS （laser-ablation-inductively coupled plasma ma...Previous studies have obtained some petrogenetic and metallogenic chronological data with SHRIMP （sensitive high-resolution ion microprobe） zircon U-Pb, zircon LA-ICPMS （laser-ablation-inductively coupled plasma mass spectroscopy） U-Pb, molybdenite Re-Os isochron and muscovite Ar-Ar methods in southern Jiangxi Province and its adjacent areas. Based on these, the purpose of this paper is to study the petrogenetic and metallogenic ages and their time gap for different genetic types of W-Sn deposits, and thus to research their numerous episodes, zonal arrangement and their geodynamic background. The result shows that the large-scale W-Sn mineralization in southern Jiangxi Province occurred in the middle to late Jurassic （170-150 Ma）, the skarn W-Sn-polymetallic deposits formed much earlier （170-161 Ma）, and all of the wolframite-quartz vein type, greisen type, altered granite type and fractured zone type tungsten deposits formed in the late Jurassic （160-150 Ma）. In one ore field or ore district, greisen type tungsten deposits formed earlier than quartz vein type ones hosted in the endoor exo-contact zone; and quartz vein type hosted in the endocontact zone formed earlier than that of exocontact zone. There is no significant time difference between tungstentin mineralization and its intimately associated parent granite emplacement （1-6 Ma）. They all formed in the same rock-forming and ore-forming system and under the same geodynamic setting. Regionally, rock-forming and ore-forming processes of the W-Sn deposits in the Nanling region （include southern Jiangxi Province, southern Hunan Province, northern Guangdong Province and eastern Guangxi Zhuang Autonomous Region） exhibit numerous episodes. The mineralization in the Nanling region mainly occurred at （240-210） Ma, （170-150） Ma and （130-90） Ma. The tungsten-tin deposits in this region are centered by the largest scale in southern Jiangxi Province and southern Hunan Province, and become small in the east, west, south and north directions. This displays a zonal arrangement and temporal and spatial distribution regularity. Integrated with the latest research results, it is concluded that the W-Sn mineralization in southern Jiangxi Province and its adjacent areas corresponds to the second large-scale mineralization in South China. The Indosinian W-Sn mineralization formed under the extensional tectonic regime between collisional compressional stages, while the Yanshanian large-scale petrogenetic and metallogenic processes occurred in the Jurassic intraplate extensional geodynamic setting of lithosphere extension.展开更多
In the summers of 2003 and 2007, eastern China suffered similar climate disasters with severe flooding in the Huaihe River valley and heat waves in the southern Yangtze River delta and South China. Using SST data and ...In the summers of 2003 and 2007, eastern China suffered similar climate disasters with severe flooding in the Huaihe River valley and heat waves in the southern Yangtze River delta and South China. Using SST data and outgoing longwave radiation （OLR） data from NOAA along with reanalysis data from NCEP/NCAR, the 2002/03 and 2006/07 E1 Nifio episodes in the central Pacific and their delayed impacts on the following early summertime climate anomalies of eastern China were analyzed. The possible physical progresses behaved as follows： Both of the moderate E1 Ninio episodes matured in the central equatorial Pacific during the early winter. The zonal wind anomalies near the sea surface of the west-central equatorial Pacific excited equatorial Kelvin waves propagating eastward and affected the evolution of the E1 Nifio episodes. From spring to early summer, the concurring anomalous easterly winds in the central equatorial Pacific and the end of upwelling Kelvin waves propagating eastward in the western equatorial Pacific, favored the equatorial warm water both of the SST and the subsurface temperature in the western Pacific. These conditions favored the warm state of the western equatorial Pacific in the early summer for both cases of 2003 and 2007. Due to the active convection in the western equatorial Pacific in the early summer and the weak warm SST anomalies in the tropical western Pacific from spring to early summer, the convective activities in the western Pacific warm pool showed the pattern in which the anomalous strong convection only appeared over the southern regions of the tropical western Pacific warm pool, which effects the meridional shift of the western Pacific subtropical high in the summer. The physical progress of the delayed impacts of the E1 Nino episodes in the central equatorial Pacific and their decaying evolution on the climate anomalies in eastern China were interpreted through the key role of special pattern for the heat convection in the tropical western Pacific warm pool and the response of the western North Pacific anomalous anticyclone.展开更多
A lot of new gold deposits have been found on the eastern margin of the Qinghai-Tibet Plateau during the past two decades. Among them, three main types of gold deposits have been recognized, including quartz-vein-type...A lot of new gold deposits have been found on the eastern margin of the Qinghai-Tibet Plateau during the past two decades. Among them, three main types of gold deposits have been recognized, including quartz-vein-type, shear- zone-type and porphyry-type. The former two types of gold deposits are mainly hosted within metamorphic rocks, while the latter is related to Cenozoic magmatism. Although all of these gold deposits are believed to have been formed during the uplift process of the Qinghai-Tibet Plateau in the Cenozoic era (Wang et al., 2002b), precise isotopic age constraints have still been lacking until quite recently. This paper presents new 40Ar/39Ar data of some gold deposits on the eastern margin of the Qinghai-Tibet Plateau, which indicate that gold mineralization in the region occurred in response to the episodic stages of the orogenies. Recently obtained 40Ar/39Ar data on quartz and feldspars from several gold deposits, such as the Sandiao deposit, the Baijintaizi deposit, the Pusagang deposits, provide new constraints on gold mineralization on the eastern margin of the Qinghai-Tibet Plateau. Geochronological studies of gold deposits along the Daduhe River indicate that there are three stages of gold mineralization. The early two stages occurred as early as 65.1 Ma in the Shuibaiyang deposit and 58.95 Ma in the Ruoji deposit, while the latter stage occurred as late as 25.35 Ma in Baijintaizi and 24.70 Ma in Sandiao. Isotopic dating of three plagioclases from the Beiya deposit, Zhifanggou deposit and Luobodi deposit and a K-feldspar from the Jinchangqing deposit in Yunnan Province indicates that these deposits were formed at two stages. The Zhifanggou and Jinchangqing deposits have early stage records as old as 58.82 Ma in Zhifanggou and 55.49 Ma in Jinchangqing, but all of the above four deposits in Yunnan have late stage records of 23.18 Ma in Jinchangqing, 24.54 Ma in Zhifanggou, 24.60 Ma in Luobodi and 24.56 Ma in Hongnitang. The above results suggest that the gold deposits on the eastern margin of the Qinghai-Tibet Plateau were formed concentratedly at two main episodes, i.e. the end of the Paleocene (about 58 Ma) and the boundary between the Paleogene and the Neogene (about 25 Ma). The later episode appears to be looks like more important and was coupled with the Sichuan movement, which was extensively activated at that period. The beginning of the Cenozoic Era (about 65 Ma) might be another episode of gold mineralization, but only one deposit (Shuibaiyang) in this study has been proved to have been be formed at this stage and might be earlier than the initial collision between the Indian Plate and the Eurasia Plate. In view of geology, the above three episodes of gold mineralization are associated with three events of tectonic- magmatism and/or fluid events. Even though the gold deposits (for example, the Shuibaiyang deposit, Ruoji deposit and Pusagang deposit) were formed at different episodes, all of them are genetically related to tectonic movements in large- scale shear zones. It looks like theat tectonic events (including large-scale strike-slip) between Paleogene and Neogene had a wide influence upon gold mineralization, with new deposits formed and old deposits enriched or superimposed to be a higher grade by new stage of mineralization. The above data suggest that gold deposits were not only concentrated in some areas, but also formed mainly at different boundaries of geological times, indicating that there existed some peak stages of gold mineralization (metallogenic episodes), and that the gold deposits were formed mainly by episodic mineralization.展开更多
On the basis of NOAA/CPC data of sea surface temperature anomaly in the Nifio regions during Jan. 1950 - Dec. 2003, the wavelet power spectrum of SST were studied with significance and confidence testing at different ...On the basis of NOAA/CPC data of sea surface temperature anomaly in the Nifio regions during Jan. 1950 - Dec. 2003, the wavelet power spectrum of SST were studied with significance and confidence testing at different scales in this paper. It shows that the SST are provided with multi-time scales structure nested one another, and vary on scales of 2 - 7 years, 8 - 20 years and 〉30 years. The most significant variation of the warm and cold episodes is in the 4-year band of period. The power, frequency structure and confidence of the same episode are different in different Nino regions. The intensity of oscillations is increasing at low frequency bands and decreasing at high frequency bands from east to west in the Nino regions, especially after 1970.展开更多
Objective To study the characteristics of spectra on proton magnetic resonance spectroscopy （^1H-MRS） and its value in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes （ME...Objective To study the characteristics of spectra on proton magnetic resonance spectroscopy （^1H-MRS） and its value in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes （MELAS）. Methods Seven clinically diagnosed patients with MELAS underwent magnetic resonance imaging （MRI） and ^1H-MRS examinations. The ^1H-MRS techniques, characteristics of the spectra, and its correlation with the laboratory tests were analyzed. Reaults Cerebral abnormalities were revealed in all 7 patients on conventional MR images, and most abnormal signals were observed in bilateral occipital, parietal, and temporal lobes. We found 4 cases with basal ganglia involvement, 2 cases with mild frontal lobe lesions, and 1 case with involvement of lateral cerebral peduncles and thalami. Additionally, 1 patient was involved with left insular lobe. Spectra from prominent lesions in brain parenchyma showed lactate doublet peak in 6 patients, 3 of whom were also noted lactate peak in ventricular cerehrospinal fluid （CSF）. Conclusion ^1H-MRS may provide more direct information about the metabolism changes, which aids to affirm the diagnosis, and may replace the conventional invasive method of quantifying lactate in CSF.展开更多
Characteristics of two serious air pollution episodes（9–15 January, as the winter case; and30 June to 1 July, as the summer case）, which occurred in Beijing in 2013 were investigated and compared using multi-method...Characteristics of two serious air pollution episodes（9–15 January, as the winter case; and30 June to 1 July, as the summer case）, which occurred in Beijing in 2013 were investigated and compared using multi-method observations and numerical simulations. During these two air pollution episodes, PM2.5 concentrations varied significantly within Beijing, with PM2.5 concentrations in southern parts of Beijing being significantly higher than in northern areas. Typically, heavy air pollution episodes begin in the southern parts and disperse towards the northern parts of Beijing. Clearly, synoptic patterns and the stability of atmospheric circulation patterns were the main factors controlling air pollution in Beijing.During the winter case, a warm center above 900 h Pa occurred over Beijing. Meanwhile, in the summer case, although there was only a weak inversion, the convective inhibition energy was strong（over 200 J/k G）. This clearly influenced the duration of the air pollution event. Except for the local accumulation and secondary atmospheric reactions in both cases, regional straw burnings contributed a lot to the PM2.5 concentrations in summer case.Using the CAMxmodel, we established that regional transport contributed almost 59% to the PM2.5 averaged concentration in Beijing in the winter case, but only 31% in the summer case. Thus, the winter case was a typical regional air pollution episode, while the summer case resulted from local accumulation straw burnings transportation and strong secondary atmospheric reactions. Given that air pollution is a regional problem in China, consistent and simultaneous implementation of regional prevention and control strategies is necessary to improve regional air quality.展开更多
Air pollution in China is complex,and the formation mechanism of chemical components in particulate matter is still unclear.This study selected three consecutive heavy haze pollution episodes(HPEs)during winter in Bei...Air pollution in China is complex,and the formation mechanism of chemical components in particulate matter is still unclear.This study selected three consecutive heavy haze pollution episodes(HPEs)during winter in Beijing for continuous field observation,including an episode with heavy air pollution under red alert.Clean days during the observation period were selected for comparison.The HPE characteristics of Beijing in winter were:under the influence of adverse meteorological conditions such as high relative humidity,temperature inversion and low wind speed;and strengthening of secondary transformation reactions,which further intensified the accumulation of secondary aerosols and other pollutants,promoting the explosive growth of PM_(2.5).PM_(2.5)/CO values,as indicators of the contribution of secondary transformation in PM_(2.5),were approximately 2 times higher in the HPEs than the average PM_(2.5)/CO during the clean period.The secondary inorganic aerosols(sulfate nitrate and ammonium salt)were significantly enhanced during the HPEs,and the conversion coefficients were remarkably improved.In addition,it is interesting to observe that the production of sulfate tended to exceed that of nitrate in the late stage of all three HPEs.The existence of aqueous phase reactions led to the explosive growth sulfur oxidation ratio(SOR)and rapid generation of sulfate under high relative humidity(RH>70%).展开更多
There are a number of structures and structural styles found in extensional tectonic settings of the world,and it is a big challenge to study the evolution of these structures. Evolution of structures formed in extens...There are a number of structures and structural styles found in extensional tectonic settings of the world,and it is a big challenge to study the evolution of these structures. Evolution of structures formed in extensional tectonic settings have been studied by researchers on different extensional basins of the world. Southern Sindh Monocline lies on the western corner of Indian Plate and the tectonic history of Indian plate has also experienced different extensional episodes, and its journey rifted from Gondwanaland to its final welding to Asia. The aim of this study is to figure out the evolution of structures in the subsurface of Southern Sindh Monocline, Pakistan using the seismic data interpretation and flattening of horizons approach. Structures within the subsurface of Southern Sindh Monocline have been characterized by different tectonic episodes of Indian plate while rifting from Gondwanaland, rifting from other plates at different geological times and to its collision with the Asia. Basic structures within study area are classified into nine types while the structural styles have been classified into six types as horst and grabens, dominos, crotch, synthetic and antithetic, negative and flashlight structural style. The structures within the study area revealed evidence for three major structural episodes which can be characterized as Episode 1: Structures associated with rifting of Indian plate from Gondwanaland during Late Jurassic to Early Cretaceous, Episode 2: Modification and reactivation of previous structures while Madagascar rifted from Indian Plate during the Middle Cretaceous and during Episode 3: Inversion and reactivation of structures occurred when Indian Plate collided with Asia during Early Eocene.展开更多
To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Hesh...To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta（PRD）region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^（2-）, which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^（2-）was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na＋and K＋during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer（PBL） height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols.展开更多
Meckel's diverticulum(MD) is the most frequent congenital abnormality of the small bowel and it is often diff icult to diagnose.It is usually asymptomatic but approximately 4% are symptomatic with complications su...Meckel's diverticulum(MD) is the most frequent congenital abnormality of the small bowel and it is often diff icult to diagnose.It is usually asymptomatic but approximately 4% are symptomatic with complications such as bleeding,intestinal obstruction,and inflammation.The authors report a case of a 7-year-old boy with a one-year history of recurrent periumbilical colicky pain with associated alimentary vomiting,symptoms erroneously related to a cyclic vomiting syndrome but not to MD.The clinical features and the differential diagnostic methods employed for diagnosis of MD are discussed.展开更多
This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the bra...This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine.展开更多
Beijing suffered from serious air pollution in October, 2011 with the occurrence of three continuous episodes. Here we analyze the pollution status of particulate matter, the relationship between the gaseous pollutant...Beijing suffered from serious air pollution in October, 2011 with the occurrence of three continuous episodes. Here we analyze the pollution status of particulate matter, the relationship between the gaseous pollutants, physical and chemical properties of single particles, and the profile of water-soluble ions in PM2.5 during the three episodes. Regional and photochemically aged air masses, which were characterized as having high values of O3 and SO2, were hypothesized to have played a dominant role in the first episode. After mixing local air masses with freshly-emitted primary pollutants, the concentration of NOx continued to increase and the size of SO42-, NO3- and NH4＋ in the particle population continued to become smaller. The amount of elemental carbon-rich and organic carbonrich particles in the scaled single particles （0.2-2 μm） and water-soluble K＋ in PM2.s also increased in the episodes. All the available information suggests that the biomass or fuel burning sources in or around Beijing may have had a huge impact on the last two episodes.展开更多
This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations. The model, with no flux adjustment, reproduces well ...This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations. The model, with no flux adjustment, reproduces well the Atlantic Water core temperature （AWCT） in the Arctic Ocean and shows that four largest decadalscale warming episodes occurred in the 1930s, 70s, 80s, and 90s, in agreement with the hydrographic observational data. The difference is that there was no pre-warming prior to the 1930s episode, while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s, leading the 1990s into the largest and prolonged warming in the 20th century. Over the last century, the simulated heat transport via Fram Strait and the Barents Sea was estimated to be, on average, 31.32 TW and 14.82 TW, respectively, while the Bering Strait also provides 15.94 TW heat into the west- ern Arctic Ocean. Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT （ C = 0.75 ） at 0- lag. The modeled North Atlantic Oscillation （NAO） index has a significant correlation with the heat transport （ C = 0.37 ）. The observed AWCT has a significant correlation with both the modeled AWCT （ C =0.49） and the heat transport （ C =0.41 ）. However, the modeled NAO index does not significantly correlate with either the observed AWCT （ C = 0.03 ） or modeled AWCT （ C = 0.16 ） at a zero-lag, indicating that the Arctic climate system is far more complex than expected.展开更多
BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux mo...BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux monitoring techno-server reliability.We hypothesized that PAR episodes alone might also predict PPI responsiveness.AIM To investigate whether PAR episodes alone predict a positive response to PPI therapy.METHODS Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwan residents tertiary centers.They underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopha-ryngeal MII-pH catheters while off medication,followed by a 12-week esomeprazole course(40 mg twice daily).Participants were categorized into four groups based on pH results:PAR alone,EAR alone,both pH(+),and both pH(-).The primary outcome was a≥50%reduction in primary laryngeal symptoms,with observers blinded to group assignments.RESULTS A total of 522 patients(mean age 52.3±12.8 years,54%male)were recruited.Of these,190(mean age 51.5±12.4 years,61%male)completed the treatment,and 89(47%)responded to PPI therapy.Response rates were highest in the PAR alone group(73%,n=11),followed by EAR alone(59%,n=68),both pH(+)(56%,n=18),and both pH(-)(33%,n=93).Multivariate analysis adjusting for age,sex,body mass index,and endoscopic esophagitis showed that participants with PAR alone,EAR alone,and both pH(+)were 7.4-fold(P=0.008),4.2-fold(P=0.0002),and 3.4-fold(P=0.03)more likely to respond to PPI therapy,respectively,compared to the both pH(-)group.Secondary analyses using the definition of≥1 PAR episode were less robust.CONCLUSION In the absence of proven hypopharyngeal predictors,this post-hoc analysis found that baseline≥2 PAR episodes alone are linked to PPI responsiveness,suggesting the importance of hypopharyngeal reflux monitoring.展开更多
Objective To check whether health risk impacts of exposure to airborne metals and Benzo（a） Pyrene during episodes of high PM10 concentrations lead to an increased number of lung cancer cases in Poland. Methods In th...Objective To check whether health risk impacts of exposure to airborne metals and Benzo（a） Pyrene during episodes of high PM10 concentrations lead to an increased number of lung cancer cases in Poland. Methods In this work, we gathered data from 2002 to 2014 concerning the ambient concentrations of PM10 and PM10-bound carcinogenic Benzo（a）pyrene [B（a）P] and As, Cd, Pb, and Ni. With the use of the criterion of the exceedance in the daily PM10 mass concentration on at least 50% of all the analyzed stations, the PM10 maxima’s were selected. Lung cancer occurrences in periods with and without the episodes were further compared. Results During a 12-year period, 348 large-scale smog episodes occurred in Poland. A total of 307 of these episodes occurred in the winter season, which is characterized by increased emissions from residential heating. The occurrence of episodes significantly （P 〈 0.05） increased the concentrations of PM10-bound carcinogenic As, Cd, Pb, Ni, and B（a）P. During these events, a significant increase in the overall health risk from those PM10-related compounds was also observed. The highest probability of lung cancer occurrences was found in cities, and the smallest probability was found in the remaining areas outside the cities and agglomerations. Conclusion The link between PM pollution and cancer risk in Poland is a serious public health threat that needs further investigation.展开更多
To define a tectonic environment switching from rifting to subduction and their respective duration time are usually largely debated.Such case occurs for the Liaohe rift:whether it went through a long subduction from ...To define a tectonic environment switching from rifting to subduction and their respective duration time are usually largely debated.Such case occurs for the Liaohe rift:whether it went through a long subduction from 2100to 1850 Ma or there were two different events in different展开更多
Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new ...Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new climate references and new index standards, ENSO episodes and their intensities for the period 1951 -2003 have been classified. Finally, an analysis has been performed comparing the new characteristics with the old ones for ENSO period, peak values and intensities.展开更多
BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vacci...BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with Xlinked Charcot-Marie-Tooth disease type 1(CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging(MRI), although this is rare.CASE SUMMARY A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no recurrence.CONCLUSION SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.展开更多
基金the National Key Research and Development Program of China,No.2021ZD0202000the National Natural Science Foundation of China,No.82101612 and No.82471570+1 种基金the Natural Science Foundation of Hunan Province,China,No.2022JJ40692the Science and Technology Innovation Program of Hunan Province,No.2021RC2040 and No.2024RC3056.
文摘BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential for developing strategies to prevent MDE relapse.Despite its clinical importance,the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.AIM To investigate the brain network mechanism underlying rumination in patients with remitted MDEs using functional magnetic resonance imaging(fMRI).METHODS We conducted an fMRI-based rumination-distraction task to induce rumination and distraction states in 51 patients with remitted MDEs.Functional connectivity(FC)was analyzed using the network-based statistic(NBS)approach,and eight topological metrics were calculated to compare the network topological properties between the two states.Correlation analyses were further performed to identify the relationships between individual rumination levels and the significantly altered brain network metrics.RESULTS The NBS analysis revealed that the altered FCs between the rumination and distraction states were located primarily in the frontoparietal,default mode,and cerebellar networks.No significant correlation was detected between these altered FCs and individual rumination levels.Among the eight topological metrics,the clustering coefficient,shortest path length,and local efficiency were significantly lower during rumination and positively correlated with individual rumination levels.In contrast,global efficiency was greater in the rumination state than in the distraction state and was negatively correlated with individual rumination levels.CONCLUSION Our work revealed the altered FC and topological properties during rumination in remitted MDE patients,offering valuable insights into the neural mechanisms of rumination from a brain network perspective.
基金Supported by Fuzhou Science and Technology Plan Project,No.2023-S-028.
文摘BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,effective treatment options,particularly for cognitive dysfunction,remain limited.AIM To evaluate the efficacy of computerized cognitive behavioral therapy(CCBT)with sertraline vs sertraline monotherapy in improving depressive symptoms,cognitive function,and quality of life in schizophrenia and depressive episodes.METHODS In this single-center,randomized controlled trial,68 adults[mean age(SD)=36.5(10.0),57.4%male]with schizophrenia and depressive symptoms were randomly assigned to receive either CCBT with sertraline or sertraline monotherapy during a 4-week hospitalization.The CCBT intervention involved 45-60-minute sessions twice weekly for four weeks.Outcomes included comparisons of depressive symptoms(Calgary depression scale for schizophrenia),cognitive function[MATRICS consensus cognitive battery(MCCB)],and quality of life(36-item short form survey)between the groups.RESULTS The experimental group showed greater improvements in depressive symptoms at 4,8,and 12 weeks compared to the controls,with the most notable difference at 12 weeks[mean difference(MD)=-1.7;P<0.001;Cohen’s d=0.9].Cognitive function improved across all MCCB domains in the experimental group,with higher processing speed scores(MD=4.1;P=0.043;Cohen’s d=0.5)and social cognition scores(MD=4.9;P=0.006;Cohen’s d=0.7)than in the control group.Quality of life,particularly in mental health,was significantly better in the experimental group.CONCLUSION CCBT with sertraline was more effective than sertraline monotherapy for patients with schizophrenia and depressive episodes,supporting its use as an adjunctive therapy.
基金financially supported by the National Key Basic Research Program (Grant2012CB416704) from the Ministry of Science and Technology, Chinagrant No. 40772063 from the National Natural Science Foundation of China+1 种基金the Program of Excellent Young Scientists from the Ministry of Land and Resources (200809)Geological Survey Program Grant 1212010561603-2 from the China Geological Survey
文摘Previous studies have obtained some petrogenetic and metallogenic chronological data with SHRIMP （sensitive high-resolution ion microprobe） zircon U-Pb, zircon LA-ICPMS （laser-ablation-inductively coupled plasma mass spectroscopy） U-Pb, molybdenite Re-Os isochron and muscovite Ar-Ar methods in southern Jiangxi Province and its adjacent areas. Based on these, the purpose of this paper is to study the petrogenetic and metallogenic ages and their time gap for different genetic types of W-Sn deposits, and thus to research their numerous episodes, zonal arrangement and their geodynamic background. The result shows that the large-scale W-Sn mineralization in southern Jiangxi Province occurred in the middle to late Jurassic （170-150 Ma）, the skarn W-Sn-polymetallic deposits formed much earlier （170-161 Ma）, and all of the wolframite-quartz vein type, greisen type, altered granite type and fractured zone type tungsten deposits formed in the late Jurassic （160-150 Ma）. In one ore field or ore district, greisen type tungsten deposits formed earlier than quartz vein type ones hosted in the endoor exo-contact zone; and quartz vein type hosted in the endocontact zone formed earlier than that of exocontact zone. There is no significant time difference between tungstentin mineralization and its intimately associated parent granite emplacement （1-6 Ma）. They all formed in the same rock-forming and ore-forming system and under the same geodynamic setting. Regionally, rock-forming and ore-forming processes of the W-Sn deposits in the Nanling region （include southern Jiangxi Province, southern Hunan Province, northern Guangdong Province and eastern Guangxi Zhuang Autonomous Region） exhibit numerous episodes. The mineralization in the Nanling region mainly occurred at （240-210） Ma, （170-150） Ma and （130-90） Ma. The tungsten-tin deposits in this region are centered by the largest scale in southern Jiangxi Province and southern Hunan Province, and become small in the east, west, south and north directions. This displays a zonal arrangement and temporal and spatial distribution regularity. Integrated with the latest research results, it is concluded that the W-Sn mineralization in southern Jiangxi Province and its adjacent areas corresponds to the second large-scale mineralization in South China. The Indosinian W-Sn mineralization formed under the extensional tectonic regime between collisional compressional stages, while the Yanshanian large-scale petrogenetic and metallogenic processes occurred in the Jurassic intraplate extensional geodynamic setting of lithosphere extension.
基金supported by the National Natural Science Foundation of China (No. 40705022)the "National Key Programme for Developing Basic Science" Project 2004CB418303the Frontier Project of the Knowledge Innovation Engineering of the Chinese Academy of Sciences(IAP07217)
文摘In the summers of 2003 and 2007, eastern China suffered similar climate disasters with severe flooding in the Huaihe River valley and heat waves in the southern Yangtze River delta and South China. Using SST data and outgoing longwave radiation （OLR） data from NOAA along with reanalysis data from NCEP/NCAR, the 2002/03 and 2006/07 E1 Nifio episodes in the central Pacific and their delayed impacts on the following early summertime climate anomalies of eastern China were analyzed. The possible physical progresses behaved as follows： Both of the moderate E1 Ninio episodes matured in the central equatorial Pacific during the early winter. The zonal wind anomalies near the sea surface of the west-central equatorial Pacific excited equatorial Kelvin waves propagating eastward and affected the evolution of the E1 Nifio episodes. From spring to early summer, the concurring anomalous easterly winds in the central equatorial Pacific and the end of upwelling Kelvin waves propagating eastward in the western equatorial Pacific, favored the equatorial warm water both of the SST and the subsurface temperature in the western Pacific. These conditions favored the warm state of the western equatorial Pacific in the early summer for both cases of 2003 and 2007. Due to the active convection in the western equatorial Pacific in the early summer and the weak warm SST anomalies in the tropical western Pacific from spring to early summer, the convective activities in the western Pacific warm pool showed the pattern in which the anomalous strong convection only appeared over the southern regions of the tropical western Pacific warm pool, which effects the meridional shift of the western Pacific subtropical high in the summer. The physical progress of the delayed impacts of the E1 Nino episodes in the central equatorial Pacific and their decaying evolution on the climate anomalies in eastern China were interpreted through the key role of special pattern for the heat convection in the tropical western Pacific warm pool and the response of the western North Pacific anomalous anticyclone.
基金the Major State BasicResearch Program of China(G19992043203)underthe State Science and Technology Commission,the National Natural Science Foundation of China(No.40202012)+1 种基金the State Planning Commission(Special Program 98-1) the Ministry of Land and Resources(K1.4-3-4).
文摘A lot of new gold deposits have been found on the eastern margin of the Qinghai-Tibet Plateau during the past two decades. Among them, three main types of gold deposits have been recognized, including quartz-vein-type, shear- zone-type and porphyry-type. The former two types of gold deposits are mainly hosted within metamorphic rocks, while the latter is related to Cenozoic magmatism. Although all of these gold deposits are believed to have been formed during the uplift process of the Qinghai-Tibet Plateau in the Cenozoic era (Wang et al., 2002b), precise isotopic age constraints have still been lacking until quite recently. This paper presents new 40Ar/39Ar data of some gold deposits on the eastern margin of the Qinghai-Tibet Plateau, which indicate that gold mineralization in the region occurred in response to the episodic stages of the orogenies. Recently obtained 40Ar/39Ar data on quartz and feldspars from several gold deposits, such as the Sandiao deposit, the Baijintaizi deposit, the Pusagang deposits, provide new constraints on gold mineralization on the eastern margin of the Qinghai-Tibet Plateau. Geochronological studies of gold deposits along the Daduhe River indicate that there are three stages of gold mineralization. The early two stages occurred as early as 65.1 Ma in the Shuibaiyang deposit and 58.95 Ma in the Ruoji deposit, while the latter stage occurred as late as 25.35 Ma in Baijintaizi and 24.70 Ma in Sandiao. Isotopic dating of three plagioclases from the Beiya deposit, Zhifanggou deposit and Luobodi deposit and a K-feldspar from the Jinchangqing deposit in Yunnan Province indicates that these deposits were formed at two stages. The Zhifanggou and Jinchangqing deposits have early stage records as old as 58.82 Ma in Zhifanggou and 55.49 Ma in Jinchangqing, but all of the above four deposits in Yunnan have late stage records of 23.18 Ma in Jinchangqing, 24.54 Ma in Zhifanggou, 24.60 Ma in Luobodi and 24.56 Ma in Hongnitang. The above results suggest that the gold deposits on the eastern margin of the Qinghai-Tibet Plateau were formed concentratedly at two main episodes, i.e. the end of the Paleocene (about 58 Ma) and the boundary between the Paleogene and the Neogene (about 25 Ma). The later episode appears to be looks like more important and was coupled with the Sichuan movement, which was extensively activated at that period. The beginning of the Cenozoic Era (about 65 Ma) might be another episode of gold mineralization, but only one deposit (Shuibaiyang) in this study has been proved to have been be formed at this stage and might be earlier than the initial collision between the Indian Plate and the Eurasia Plate. In view of geology, the above three episodes of gold mineralization are associated with three events of tectonic- magmatism and/or fluid events. Even though the gold deposits (for example, the Shuibaiyang deposit, Ruoji deposit and Pusagang deposit) were formed at different episodes, all of them are genetically related to tectonic movements in large- scale shear zones. It looks like theat tectonic events (including large-scale strike-slip) between Paleogene and Neogene had a wide influence upon gold mineralization, with new deposits formed and old deposits enriched or superimposed to be a higher grade by new stage of mineralization. The above data suggest that gold deposits were not only concentrated in some areas, but also formed mainly at different boundaries of geological times, indicating that there existed some peak stages of gold mineralization (metallogenic episodes), and that the gold deposits were formed mainly by episodic mineralization.
文摘On the basis of NOAA/CPC data of sea surface temperature anomaly in the Nifio regions during Jan. 1950 - Dec. 2003, the wavelet power spectrum of SST were studied with significance and confidence testing at different scales in this paper. It shows that the SST are provided with multi-time scales structure nested one another, and vary on scales of 2 - 7 years, 8 - 20 years and 〉30 years. The most significant variation of the warm and cold episodes is in the 4-year band of period. The power, frequency structure and confidence of the same episode are different in different Nino regions. The intensity of oscillations is increasing at low frequency bands and decreasing at high frequency bands from east to west in the Nino regions, especially after 1970.
文摘Objective To study the characteristics of spectra on proton magnetic resonance spectroscopy （^1H-MRS） and its value in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes （MELAS）. Methods Seven clinically diagnosed patients with MELAS underwent magnetic resonance imaging （MRI） and ^1H-MRS examinations. The ^1H-MRS techniques, characteristics of the spectra, and its correlation with the laboratory tests were analyzed. Reaults Cerebral abnormalities were revealed in all 7 patients on conventional MR images, and most abnormal signals were observed in bilateral occipital, parietal, and temporal lobes. We found 4 cases with basal ganglia involvement, 2 cases with mild frontal lobe lesions, and 1 case with involvement of lateral cerebral peduncles and thalami. Additionally, 1 patient was involved with left insular lobe. Spectra from prominent lesions in brain parenchyma showed lactate doublet peak in 6 patients, 3 of whom were also noted lactate peak in ventricular cerehrospinal fluid （CSF）. Conclusion ^1H-MRS may provide more direct information about the metabolism changes, which aids to affirm the diagnosis, and may replace the conventional invasive method of quantifying lactate in CSF.
基金supported by the Commonwealth Project of the Ministry of Environmental Protection (No. 201409005)the National Key Technology R&D Program (Nos. 2014BAC23B03, 2016YFC0208902 and D17110900150002)the excellent talents training project of the Organization Department of Beijing municipal Party Committee (2016000021733G166)
文摘Characteristics of two serious air pollution episodes（9–15 January, as the winter case; and30 June to 1 July, as the summer case）, which occurred in Beijing in 2013 were investigated and compared using multi-method observations and numerical simulations. During these two air pollution episodes, PM2.5 concentrations varied significantly within Beijing, with PM2.5 concentrations in southern parts of Beijing being significantly higher than in northern areas. Typically, heavy air pollution episodes begin in the southern parts and disperse towards the northern parts of Beijing. Clearly, synoptic patterns and the stability of atmospheric circulation patterns were the main factors controlling air pollution in Beijing.During the winter case, a warm center above 900 h Pa occurred over Beijing. Meanwhile, in the summer case, although there was only a weak inversion, the convective inhibition energy was strong（over 200 J/k G）. This clearly influenced the duration of the air pollution event. Except for the local accumulation and secondary atmospheric reactions in both cases, regional straw burnings contributed a lot to the PM2.5 concentrations in summer case.Using the CAMxmodel, we established that regional transport contributed almost 59% to the PM2.5 averaged concentration in Beijing in the winter case, but only 31% in the summer case. Thus, the winter case was a typical regional air pollution episode, while the summer case resulted from local accumulation straw burnings transportation and strong secondary atmospheric reactions. Given that air pollution is a regional problem in China, consistent and simultaneous implementation of regional prevention and control strategies is necessary to improve regional air quality.
基金supported by the Natural Science Foundation of Beijing Municipal(No.8202052)the National Natural Science Foundation of China(Nos.21777191,42075082 and 41875147)+2 种基金S&T Development Fund of Chinese Academy of Meteorological Sciences(No.2020KJ001)Basic Research Fund of Chinese Academy of Meteorological Sciences(No.2020Z002)supported by the Innovation Team for Haze-fog Observation and Forecasts of Ministry of Science and Technology of the People’s Republic of China and China Meteorological Administration
文摘Air pollution in China is complex,and the formation mechanism of chemical components in particulate matter is still unclear.This study selected three consecutive heavy haze pollution episodes(HPEs)during winter in Beijing for continuous field observation,including an episode with heavy air pollution under red alert.Clean days during the observation period were selected for comparison.The HPE characteristics of Beijing in winter were:under the influence of adverse meteorological conditions such as high relative humidity,temperature inversion and low wind speed;and strengthening of secondary transformation reactions,which further intensified the accumulation of secondary aerosols and other pollutants,promoting the explosive growth of PM_(2.5).PM_(2.5)/CO values,as indicators of the contribution of secondary transformation in PM_(2.5),were approximately 2 times higher in the HPEs than the average PM_(2.5)/CO during the clean period.The secondary inorganic aerosols(sulfate nitrate and ammonium salt)were significantly enhanced during the HPEs,and the conversion coefficients were remarkably improved.In addition,it is interesting to observe that the production of sulfate tended to exceed that of nitrate in the late stage of all three HPEs.The existence of aqueous phase reactions led to the explosive growth sulfur oxidation ratio(SOR)and rapid generation of sulfate under high relative humidity(RH>70%).
文摘There are a number of structures and structural styles found in extensional tectonic settings of the world,and it is a big challenge to study the evolution of these structures. Evolution of structures formed in extensional tectonic settings have been studied by researchers on different extensional basins of the world. Southern Sindh Monocline lies on the western corner of Indian Plate and the tectonic history of Indian plate has also experienced different extensional episodes, and its journey rifted from Gondwanaland to its final welding to Asia. The aim of this study is to figure out the evolution of structures in the subsurface of Southern Sindh Monocline, Pakistan using the seismic data interpretation and flattening of horizons approach. Structures within the subsurface of Southern Sindh Monocline have been characterized by different tectonic episodes of Indian plate while rifting from Gondwanaland, rifting from other plates at different geological times and to its collision with the Asia. Basic structures within study area are classified into nine types while the structural styles have been classified into six types as horst and grabens, dominos, crotch, synthetic and antithetic, negative and flashlight structural style. The structures within the study area revealed evidence for three major structural episodes which can be characterized as Episode 1: Structures associated with rifting of Indian plate from Gondwanaland during Late Jurassic to Early Cretaceous, Episode 2: Modification and reactivation of previous structures while Madagascar rifted from Indian Plate during the Middle Cretaceous and during Episode 3: Inversion and reactivation of structures occurred when Indian Plate collided with Asia during Early Eocene.
基金supported by the National Natural Science Foundation of China(No.91544221)the Ministry of Environmental Protection of the People's Republic of China(No.201509001)the Ministry of Science and Technology of the People's Republic of China(No.XDB05010500)
文摘To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta（PRD）region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^（2-）, which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^（2-）was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na＋and K＋during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer（PBL） height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols.
文摘Meckel's diverticulum(MD) is the most frequent congenital abnormality of the small bowel and it is often diff icult to diagnose.It is usually asymptomatic but approximately 4% are symptomatic with complications such as bleeding,intestinal obstruction,and inflammation.The authors report a case of a 7-year-old boy with a one-year history of recurrent periumbilical colicky pain with associated alimentary vomiting,symptoms erroneously related to a cyclic vomiting syndrome but not to MD.The clinical features and the differential diagnostic methods employed for diagnosis of MD are discussed.
文摘This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine.
基金supported by the National Natural Scientific Foundation of China(No.41005065,41375132)the National Department Public Benefit Research Foundation(No.201409003,201009001,201309011)Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB05030400)
文摘Beijing suffered from serious air pollution in October, 2011 with the occurrence of three continuous episodes. Here we analyze the pollution status of particulate matter, the relationship between the gaseous pollutants, physical and chemical properties of single particles, and the profile of water-soluble ions in PM2.5 during the three episodes. Regional and photochemically aged air masses, which were characterized as having high values of O3 and SO2, were hypothesized to have played a dominant role in the first episode. After mixing local air masses with freshly-emitted primary pollutants, the concentration of NOx continued to increase and the size of SO42-, NO3- and NH4＋ in the particle population continued to become smaller. The amount of elemental carbon-rich and organic carbonrich particles in the scaled single particles （0.2-2 μm） and water-soluble K＋ in PM2.s also increased in the episodes. All the available information suggests that the biomass or fuel burning sources in or around Beijing may have had a huge impact on the last two episodes.
基金supported by the Frontier Research Center for Global Change and International Arctic Research Center,through JAMSTEC,JapanThe climate model was run on the Earth Simulator of JAMSTEC,Yokohama,Japan+1 种基金Constructive discussions with Drs.T.Matsuno,T.Tokioka and N.Suginohara of FRCGC/JAMSTEC andDr.A.Sumi of CCSR/UT are very much appreciatedJW also thanks NOAA Office of Arctic Research for partial support.This is GLERL Contribution No.1496.
文摘This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations. The model, with no flux adjustment, reproduces well the Atlantic Water core temperature （AWCT） in the Arctic Ocean and shows that four largest decadalscale warming episodes occurred in the 1930s, 70s, 80s, and 90s, in agreement with the hydrographic observational data. The difference is that there was no pre-warming prior to the 1930s episode, while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s, leading the 1990s into the largest and prolonged warming in the 20th century. Over the last century, the simulated heat transport via Fram Strait and the Barents Sea was estimated to be, on average, 31.32 TW and 14.82 TW, respectively, while the Bering Strait also provides 15.94 TW heat into the west- ern Arctic Ocean. Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT （ C = 0.75 ） at 0- lag. The modeled North Atlantic Oscillation （NAO） index has a significant correlation with the heat transport （ C = 0.37 ）. The observed AWCT has a significant correlation with both the modeled AWCT （ C =0.49） and the heat transport （ C =0.41 ）. However, the modeled NAO index does not significantly correlate with either the observed AWCT （ C = 0.03 ） or modeled AWCT （ C = 0.16 ） at a zero-lag, indicating that the Arctic climate system is far more complex than expected.
文摘BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux monitoring techno-server reliability.We hypothesized that PAR episodes alone might also predict PPI responsiveness.AIM To investigate whether PAR episodes alone predict a positive response to PPI therapy.METHODS Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwan residents tertiary centers.They underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopha-ryngeal MII-pH catheters while off medication,followed by a 12-week esomeprazole course(40 mg twice daily).Participants were categorized into four groups based on pH results:PAR alone,EAR alone,both pH(+),and both pH(-).The primary outcome was a≥50%reduction in primary laryngeal symptoms,with observers blinded to group assignments.RESULTS A total of 522 patients(mean age 52.3±12.8 years,54%male)were recruited.Of these,190(mean age 51.5±12.4 years,61%male)completed the treatment,and 89(47%)responded to PPI therapy.Response rates were highest in the PAR alone group(73%,n=11),followed by EAR alone(59%,n=68),both pH(+)(56%,n=18),and both pH(-)(33%,n=93).Multivariate analysis adjusting for age,sex,body mass index,and endoscopic esophagitis showed that participants with PAR alone,EAR alone,and both pH(+)were 7.4-fold(P=0.008),4.2-fold(P=0.0002),and 3.4-fold(P=0.03)more likely to respond to PPI therapy,respectively,compared to the both pH(-)group.Secondary analyses using the definition of≥1 PAR episode were less robust.CONCLUSION In the absence of proven hypopharyngeal predictors,this post-hoc analysis found that baseline≥2 PAR episodes alone are linked to PPI responsiveness,suggesting the importance of hypopharyngeal reflux monitoring.
文摘Objective To check whether health risk impacts of exposure to airborne metals and Benzo（a） Pyrene during episodes of high PM10 concentrations lead to an increased number of lung cancer cases in Poland. Methods In this work, we gathered data from 2002 to 2014 concerning the ambient concentrations of PM10 and PM10-bound carcinogenic Benzo（a）pyrene [B（a）P] and As, Cd, Pb, and Ni. With the use of the criterion of the exceedance in the daily PM10 mass concentration on at least 50% of all the analyzed stations, the PM10 maxima’s were selected. Lung cancer occurrences in periods with and without the episodes were further compared. Results During a 12-year period, 348 large-scale smog episodes occurred in Poland. A total of 307 of these episodes occurred in the winter season, which is characterized by increased emissions from residential heating. The occurrence of episodes significantly （P 〈 0.05） increased the concentrations of PM10-bound carcinogenic As, Cd, Pb, Ni, and B（a）P. During these events, a significant increase in the overall health risk from those PM10-related compounds was also observed. The highest probability of lung cancer occurrences was found in cities, and the smallest probability was found in the remaining areas outside the cities and agglomerations. Conclusion The link between PM pollution and cancer risk in Poland is a serious public health threat that needs further investigation.
基金supported by 973 (2012CB416601) and NFSC (41322018) projects
文摘To define a tectonic environment switching from rifting to subduction and their respective duration time are usually largely debated.Such case occurs for the Liaohe rift:whether it went through a long subduction from 2100to 1850 Ma or there were two different events in different
基金Core project in the key research of the 9th five-year economic development plan of China - "Study on Prediction System for Short-term Climate in China"(96-908-06-1-2-2)
文摘Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new climate references and new index standards, ENSO episodes and their intensities for the period 1951 -2003 have been classified. Finally, an analysis has been performed comparing the new characteristics with the old ones for ENSO period, peak values and intensities.
基金Supported by Shenzhen Science and Technology Project,No. SGLH20180628161804465The Clinical Research Project of The First Affiliated Hospital of Shenzhen University,No. 20203357035 and No. 20223357021。
文摘BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with Xlinked Charcot-Marie-Tooth disease type 1(CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging(MRI), although this is rare.CASE SUMMARY A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no recurrence.CONCLUSION SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.
