Introduction The global burden of orthopedic diseases has reached unprecedented levels,with recent epidemiological data revealing that musculoskeletal conditions affect over 1.71 billion people worldwide,representing ...Introduction The global burden of orthopedic diseases has reached unprecedented levels,with recent epidemiological data revealing that musculoskeletal conditions affect over 1.71 billion people worldwide,representing a 150%increase since 1990[1].By 2050,the number of individuals aged 60 and above requiring orthopedic interventions is projected to exceed 2.1 billion,with osteoporosis alone affecting 200 million people globally.展开更多
Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide ...Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.展开更多
Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and T...Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and Treponema pallidum(TP),along with ongoing monitoring of epidemiological data on TTIs among donors,is essential to ensure blood safety.Methods:This study conducted a retrospective analysis of the seroprevalence of HBsAg,anti-HCV,anti-HIV,and anti-TP among 3,111,265 blood donation events in Guangzhou from 2014 to 2023,investigating their relationships with demographic characteristics such as gender,age,and donation status.Results:The findings indicated that the overall seroprevalence of TTIs among blood donations was 866.21 per 100,000,demonstrating a declining trend over the ten-year period.Seroprevalence rates of transfusion-transmissible infections also exhibited a downward trend across various demographic groups.Notably,male donors,first-time donors,and older donors demonstrated higher seroprevalence rates for TTIs.Conclusions:While the overall seroprevalence rate of transfusion-transmissible infections among blood donors remains relatively low,significant disparities exist among different demographic groups.It is necessary of sustained TTIs monitoring among blood donors to guide public health interventions and donor screening practices.展开更多
Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores...Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.展开更多
Introduction:Southern Xinjiang Uygur Autonomous Region,China,experiences a substantial tuberculosis burden,yet comprehensive genotypic characterization of Mycobacterium tuberculosis strains in this region remains limi...Introduction:Southern Xinjiang Uygur Autonomous Region,China,experiences a substantial tuberculosis burden,yet comprehensive genotypic characterization of Mycobacterium tuberculosis strains in this region remains limited.Methods:This study collected Mycobacterium tuberculosis strains and corresponding epidemiological data from patients between 2021 and 2023.Bacterial isolates underwent whole-genome sequencing using the Illumina next-generation sequencing platform.We constructed phylogenetic trees using iqtree and generated minimum spanning trees based on GraphSNP analysis,applying a clustering threshold of 12 single nucleotide polymorphisms(SNPs)to identify transmission clusters.Results:Lineage 2 emerged as the predominant strain type,accounting for the majority of isolates,followed by Lineages 4 and 3.Notably,Lineage 2 demonstrated significantly elevated clustering rates compared to other lineages.Genetic diversity analysis revealed that Lineage 2 strains exhibited the most limited intra-lineage variation,whereas Lineage 3 displayed the greatest genetic heterogeneity among strains.Conclusion:Our investigation demonstrates substantial genetic polymorphism among Mycobacterium tuberculosis strains circulating in southern Xinjiang.These findings highlight the critical need for enhanced transmission control strategies,with particular emphasis on intensive surveillance and prevention measures targeting Lineage 2 strains.展开更多
Malaria infection continues to be a major problem in many parts of the world including Africa.Environmental variables are known to significantly affect the population dynamics and abundance of insects,major catalysts ...Malaria infection continues to be a major problem in many parts of the world including Africa.Environmental variables are known to significantly affect the population dynamics and abundance of insects,major catalysts of vector-borne diseases,but the exact extent and consequences of this sensitivity are not yet well established.To assess the impact of the variability in temperature and rainfall on the transmission dynamics of malaria in a population,we propose a model consisting of a system of non-autonomous deterministic equations that incorporate the effect of both temperature and rainfall to the dispersion and mortality rate of adult mosquitoes.The model has been validated using epidemiological data collected from the western region of Ethiopia by considering the trends for the cases of malaria and the climate variation in the region.Further,a mathematical analysis is performed to assess the impact of temperature and rainfall change on the transmission dynamics of the model.The periodic variation of seasonal variables as well as the non-periodic variation due to the long-term climate variation have been incorporated and analyzed.In both periodic and non-periodic cases,it has been shown that the disease-free solution of the model is globally asymptotically stable when the basic reproduction ratio is less than unity in the periodic system and when the threshold function is less than unity in the non-periodic system.The disease is uniformly persistent when the basic reproduction ratio is greater than unity in the periodic system and when the threshold function is greater than unity in the non-periodic system.展开更多
基金support from Qinghai Province basic research project(2024-ZJ-760)Changzhou Sci&Tech Program(CZ20240029)+1 种基金Science and Technology Project of Changzhou Health Commission(QN202356)Top Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project(2022CZBJ059 and 2022CZBJ061).
文摘Introduction The global burden of orthopedic diseases has reached unprecedented levels,with recent epidemiological data revealing that musculoskeletal conditions affect over 1.71 billion people worldwide,representing a 150%increase since 1990[1].By 2050,the number of individuals aged 60 and above requiring orthopedic interventions is projected to exceed 2.1 billion,with osteoporosis alone affecting 200 million people globally.
文摘Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.
基金supported by the Medical Scientific Research Foundation of Guangdong Province(A2024391)Science and Technology Projects in Guangzhou(2023A03J0544,2023A03J0550,2024A03J0447,2023A03J0552,2024A03J0150)The Key Medical Disciplines and Specialties Program of Guangzhou(2025-2027).
文摘Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and Treponema pallidum(TP),along with ongoing monitoring of epidemiological data on TTIs among donors,is essential to ensure blood safety.Methods:This study conducted a retrospective analysis of the seroprevalence of HBsAg,anti-HCV,anti-HIV,and anti-TP among 3,111,265 blood donation events in Guangzhou from 2014 to 2023,investigating their relationships with demographic characteristics such as gender,age,and donation status.Results:The findings indicated that the overall seroprevalence of TTIs among blood donations was 866.21 per 100,000,demonstrating a declining trend over the ten-year period.Seroprevalence rates of transfusion-transmissible infections also exhibited a downward trend across various demographic groups.Notably,male donors,first-time donors,and older donors demonstrated higher seroprevalence rates for TTIs.Conclusions:While the overall seroprevalence rate of transfusion-transmissible infections among blood donors remains relatively low,significant disparities exist among different demographic groups.It is necessary of sustained TTIs monitoring among blood donors to guide public health interventions and donor screening practices.
基金Supported by the Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai(2023-2025)Key Discipline Project(GWVI-11.1-12)the National Parasite Resource Center(NPRC-2019-194-30).
文摘Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.
基金Supported by the“Tianshan Talents”Medical and Health High-level Talent Training Program(TSYC202301B166)the Natural Science Foundation of Xinjiang Uygur Autonomous Region Project(2023D01C57),and grant WJW2024-087.
文摘Introduction:Southern Xinjiang Uygur Autonomous Region,China,experiences a substantial tuberculosis burden,yet comprehensive genotypic characterization of Mycobacterium tuberculosis strains in this region remains limited.Methods:This study collected Mycobacterium tuberculosis strains and corresponding epidemiological data from patients between 2021 and 2023.Bacterial isolates underwent whole-genome sequencing using the Illumina next-generation sequencing platform.We constructed phylogenetic trees using iqtree and generated minimum spanning trees based on GraphSNP analysis,applying a clustering threshold of 12 single nucleotide polymorphisms(SNPs)to identify transmission clusters.Results:Lineage 2 emerged as the predominant strain type,accounting for the majority of isolates,followed by Lineages 4 and 3.Notably,Lineage 2 demonstrated significantly elevated clustering rates compared to other lineages.Genetic diversity analysis revealed that Lineage 2 strains exhibited the most limited intra-lineage variation,whereas Lineage 3 displayed the greatest genetic heterogeneity among strains.Conclusion:Our investigation demonstrates substantial genetic polymorphism among Mycobacterium tuberculosis strains circulating in southern Xinjiang.These findings highlight the critical need for enhanced transmission control strategies,with particular emphasis on intensive surveillance and prevention measures targeting Lineage 2 strains.
文摘Malaria infection continues to be a major problem in many parts of the world including Africa.Environmental variables are known to significantly affect the population dynamics and abundance of insects,major catalysts of vector-borne diseases,but the exact extent and consequences of this sensitivity are not yet well established.To assess the impact of the variability in temperature and rainfall on the transmission dynamics of malaria in a population,we propose a model consisting of a system of non-autonomous deterministic equations that incorporate the effect of both temperature and rainfall to the dispersion and mortality rate of adult mosquitoes.The model has been validated using epidemiological data collected from the western region of Ethiopia by considering the trends for the cases of malaria and the climate variation in the region.Further,a mathematical analysis is performed to assess the impact of temperature and rainfall change on the transmission dynamics of the model.The periodic variation of seasonal variables as well as the non-periodic variation due to the long-term climate variation have been incorporated and analyzed.In both periodic and non-periodic cases,it has been shown that the disease-free solution of the model is globally asymptotically stable when the basic reproduction ratio is less than unity in the periodic system and when the threshold function is less than unity in the non-periodic system.The disease is uniformly persistent when the basic reproduction ratio is greater than unity in the periodic system and when the threshold function is greater than unity in the non-periodic system.
