Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, ...Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.展开更多
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven...Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.展开更多
Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. I...Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. It is in this context that the present study was carried out to evaluate the measles epidemiological surveillance system in the Kangaba health district. Method: This was a descriptive cross-sectional study with retrospective data collection for the period from 1 January to 31 December 2022 in the Kangaba health district with 18 epidemiological surveillance officers. Data were collected using an observation grid and documentary analysis. Results: We found a simplicity of 97%, a representativeness of 95% and a reactivity of 53%. Not all notified cases were sampled (64%). Of the 17 CSCom, 8 were positive. A total of 34 confirmed cases of measles were recorded, with one death. Conclusion: Overall, the system is functional and well-established in the health centres, but it remains important to ensure that suspected cases are investigated and that the time between sampling and the availability of laboratory results is respected.展开更多
Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely availabl...Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely available. In Congo there is little published data on this entity. Objectives: To describe the epidemiological, diagnostic, and progression characteristics of peritoneal tuberculosis at the university hospital center in Brazzaville. Patients and Methods: This study is a descriptive and retrospective analysis conducted from January 1, 2015, to December 31, 2021, in the Gastroenterology and Internal Medicine department of the CHU of Brazzaville. It included all patients hospitalized during this period with a confirmed diagnosis of peritoneal tuberculosis, encompassing 54 records that met the inclusion criteria. Results: Out of the study period, 54 records that fulfilled the inclusion criteria were analyzed. The annual incidence of peritoneal tuberculosis was 7.7 patients, with a prevalence of 1.4%, showing a male predominance of 61% and an average age of 39.93 ± 14.62 years. The primary symptoms were abdominal bloating and abdominal pain, present in 100% and 74% of cases, respectively. The clinical presentation was primarily characterized by febrile ascites observed in all patients. HIV co-infection was noted in 29.6% of cases. Anemia was present in 79.6% of patients, and an elevated sedimentation rate was observed in 74% of cases. The tuberculin skin test returned positive in 50% of cases. The ascitic fluid was exudative, rich in proteins and white blood cells (exceeding 1000/mm3, predominantly lymphocytes) in the majority of cases (100%, 83.3%, 83.3%, respectively). The diagnosis was deemed highly probable based on the clinical and paraclinical signs and the favorable response to treatment in 79.6% of cases. There were instances of pleural involvement (33.3%) and lymph node involvement (pulmonary 22.2% and lymph node 16.6%). Treatment outcomes were favorable in 37% of cases, with a mortality rate of 9%. Conclusion: Peritoneal tuberculosis is prevalent in Brazzaville, predominantly affecting young males. The diagnosis relies chiefly on a combination of clinical, paraclinical, and progression indicators.展开更多
Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the...Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.展开更多
Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological m...Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and epidemiological trends of hepatitis B data in Harbin from 2010 to 2023.Results:A total of 38,604 cases of hepatitis B were reported in Harbin from 2010 to 2023,with an average annual incidence rate of 26.38 per 100,000.The majority of hepatitis B cases were chronic.There was no obvious seasonal distribution pattern of hepatitis B.The average incidence rate was lowest in the<10-year-old group(1.72 per 100,000)and highest in the 40-year-old group(34.71 per 100,000).Cases were mainly concentrated in the 30-69-year-old population,accounting for 75.35%.The male-to-female ratio was 1.35:1.The majority of cases were farmers,accounting for 57.31%.Conclusion:Except for a significant decrease from 2020 to 2022,the overall incidence of hepatitis B showed a trend of decreasing first and then increasing from 2010 to 2023.The prevention and control measures for the 0-19-year-old population were effective.It is necessary to strengthen the prevention and control of hepatitis B among adults over 20 years old,especially to develop differentiated hepatitis B prevention and control strategies targeting key areas and high-risk populations.展开更多
The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to D...The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to December 31, 2023, on 225 patients seen in consultation for anxiety disorders in the department. The prevalence of anxiety disorders was 2.5% in consultation. The 20 - 29 age group was the most represented at 33.3%. Females were slightly represented at 55.1%, with a sex ratio of 1.2. The secondary level was the most affected, accounting for 36.4% of cases. Insomnia was the most frequent reason for consultation, accounting for 71.1% of cases. A larger general population study would be necessary to better assess the extent of anxiety disorders in Guinea.展开更多
Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on f...Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on farms.Disease is a serious constraint to the healthy development of small ruminant farming.Studies published on PubMed,CNKI,VIP,Wanfang and the resulting references of selected studies were included.Risk factors affecting prevalence were analyzed and stratified by geographic location and climatic variables,age,sex,feeding model,season,sample year,breeds and environment.The total prevalence of coccidia in sheep and goats reached more than 60%in most regions,in which the dominant species in sheep were mainly E.parva,E.ovinoidalis,and E.parva and E.ahsata.East China had the lowest prevalence of coccidia infection in sheep(43.24%),and the dominant species were different from those in the other regions,mainly E.bakuensis and E.gonzalezi.Southwestern China and Central China had slightly less than 40.0%goat coccidia infection,and the dominant species in goats were mainly E.arloingi,E.aligevi,E.hirci and E.ninakohlyakimovae.Sheep/goats of different ages can be infected with coccidiosis,but lambs between 1 and 3 months of age are more susceptible to the disease.When lambs become infected,the pathogen spreads rapidly throughout the herd.Spring,summer and autumn are the seasons with a high incidence of this disease.Environmental pollution may be a significant factor in the development of coccidiosis in sheep raised in large-scale housing.This study provides a comprehensive overview of the species,morphology and geographic distribution of Eimeria species in sheep and goats,summary prevalence in different regions of China,risk factors affecting prevalence,and prevention and control strategies.展开更多
Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective...Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.展开更多
BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple c...BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple chemotherapy regimens at different stages.METHODS This was a retrospective study conducted from 2005 to 2014,involving six cancer hospitals and eight general hospitals across seven geographical regions of China(East,South,North,Central,Southwest,Northwest,and Northeast).Stratified sampling was used based on the population distribution of each region.Efficacy assessments were conducted by Cox proportional hazards regression models.When assessing the effectiveness of various chemotherapy regimens,traditional drugs such as gemcitabine used as monotherapy served as the reference.RESULTS A total of 3256 patients were included.The median follow-up time was 407 days,and the median overall survival was 183 days.At diagnosis,56%of patients were already in stage IV.Chemotherapy was administered to 39.73%of patients.In the adjuvant therapy phase,gemcitabine+fluorouracil was superior to gemcitabine monotherapy[hazard ratio(HR)=0.35,95%confidence interval(CI):0.14-0.89].In fluorouracil-based regimens,other combination regimens did not show effectiveness relative to monotherapy.For first-line treatment in patients with advanced disease,tegafur alone(HR=0.20,95%CI:0.06-0.66),gemcitabine plus cisplatin(HR=0.16,95%CI:0.04-0.70),and tegafur,gemcitabine plus platinum-based agents(HR=0.32,95%CI:0.11-0.91)were associated with a lower risk of death compared to gemcitabine alone.In second-line treatment,there were no significant differences in efficacy among various drugs,but FOLFIRINOX(irinotecan+oxaliplatin+leucovorin+5-fluorouracil)had an outstanding point estimate(HR=0.10,95%CI:0.01-1.27).CONCLUSION In China,pancreatic cancer is often diagnosed at advanced stages,emphasizing the need for early diagnosis and treatment.Combined therapies in adjuvant and first-line settings may reduce the risk of death compared with monotherapy,and FOLFIRINOX might offer more significant benefits in second-line treatment.展开更多
[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and ex...[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.展开更多
Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are...Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are influenced by multiple factors,especially during the COVID-19 pandemic.Based on data from the National Influenza Surveillance Program in China,we analyzed the epidemiological and genomic data in Tianjin collected from 2017 to 2025.A total of 77,473 throat swabs were collected,of which 9144 were IAV-positive.The A/pdm09 H1N1 and A/H3N2 lineages exhibited distinct epidemics across different influenza seasons,with a decline in cases observed during the COVID-19 pandemic.We sequenced the genomes of 128 A/pdm09 H1N1 and 113 A/H3N2 clinical isolates and characterized their temporal evolution and genetic diversity using time-scaled phylogenetic analysis.Additionally,we conducted a genetic risk evaluation of the hemagglutinin and neuraminidase segments,identifying key amino acid residues associated with viral adaptation,transmissibility,virulence,and drug resistance.Moreover,no antigenic variants were found in clinical isolates during the recent influenza seasons,though reduced sensitivity to oseltamivir and zanamivir was observed in individual strains.Our surveillance highlights the epidemiology and evolution of IAV before and after the COVID-19 pandemic in Tianjin.展开更多
Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,...Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,064 patients were collected from 555 hospitals in 28 provinces of China.Results:Among 9,064 NHL patients,there were 5,241 males(57.8%)and 3,823 females(42.2%),with a male-to-female ratio of 1.37:1.Patients aged≥45 years accounted for 89.6%,with a mean age of 61.87±13.30 years.The predominant NHL subtypes were diffuse large B-cell lymphoma(DLBCL,45.2%),chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL,19.8%),marginal zone lymphoma(MZL,13.9%),mantle cell lymphoma(MCL,9.7%),and central nervous system lymphoma(CNSL,4.3%).Combination therapy served as the primary treatment modality across all NHL subtypes.Conclusions:NHL in China demonstrates male predominance and primarily affects middle-aged and elderly populations,with combination chemotherapy remaining the mainstay therapeutic approach.展开更多
The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential th...The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential threat to the poultry industry and public health.During the period from 2011 to 2022,we conducted an active surveillance programm.A total of 154,762 swab samples were collected across various provinces,and 427 H4 viruses were detected,resulting in a positivity rate of 0.28%.All H4 viruses were isolated from poultry,primarily from ducks in live poultry markets.We further investigated the genetic evolutionary characteristics and pathogenicity of 20 H4Nx viruses isolated in our program.Phylogenetic analysis revealed that the 20 H4Nx viruses belonged to the Eurasian lineage and exhibited significant genetic diversity,with 19 distinct genotypes identified.Molecular characterization indicated that these viruses were low-pathogenicity AIVs with limited binding affinity to human receptors,yet they contained mutations associated with enhanced viral replication and pathogenicity in mammals.Pathogenicity tests conducted in ducks demonstrated that H4 viruses were weakly pathogenic,exhibiting limited replication and transmission capabilities.However,some viruses were able to replicate effectively in mice and induce weight loss.For instance,DK/AH/AG61/11(H4N6)can replicate efficiently in MDCK cells,indicating a potential threat to mammals.These findings underscore the importance of ongoing surveillance of H4 AIVs to better understand their evolution and transmission dynamics and to prevent potential public health risks.展开更多
Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional stu...Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional study was conducted using respiratory samples from 9,696 ARI patients between 2016 and 2020 in southern China.All samples were analyzed by quantitative real-time polymerase chain reaction to determine the presence of HPIV and other common respiratory viruses.Descriptive statistics were performed to determine the temporal and population distribution of HPIV.The fulllength hemagglutinin-neuraminidase(HN)gene of HPIV3-positive samples was sequenced for phylogenetic analysis.A total of 577(6.0%)patients tested positive for HPIV,with HPIV3 being the predominant serotype,accounting for 46.8%of cases.Notably,66.0%of these HPIV-positive cases were children aged 0-2 years.The prevalence of HPIV infections showed a decreased trend and altered peak during 2016-2020.Cough,fever,sputum production,and rhinorrhea were common respiratory symptoms in HPIV-positive patients.The majority of cases had pneumonia(63.4%).Human rhinovirus(HRV)and human coronavirus(HCoV)were the most common coinfection viruses in HPIV-positive cases,with proportions of 20.1%and 14.4%,respectively.Phylogenetic analysis revealed that the predominant lineage of HPIV3 was C3f(86.0%),followed by lineage C3a(8.0%),C3d(4.0%),and C3b(2.0%).These findings help to better understand the epidemiology of HPIV,and improve public health strategies to prevent and control HPIV infections in southern China.展开更多
Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorab...Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.展开更多
Duck circovirus （DuCV）, a potential immunosuppressive virus, was investigated in Southern China from March 2006 to December 2009 by using a polymerase chain reaction （PCR） based method. In this study, a total of 1...Duck circovirus （DuCV）, a potential immunosuppressive virus, was investigated in Southern China from March 2006 to December 2009 by using a polymerase chain reaction （PCR） based method. In this study, a total of 138 sick or dead duck samples from 18 different farms were examined with an average DuCV infection rate of-35%. It was found that ducks between the ages of 40~60 days were more susceptible to DuCV. There was no evidence showing that the DuCV virus was capable of vertical transmission. Farms with positive PCR results exhibited no regularly apparent clinical abnormalities such as feathering disorders, growth retardation or lower-than-average weight. The complete genomes of 91 strains from Fujian Province and 1 from Zhejiang Province were sequenced and analyzed. The 10 DuCV genomes, comlbared with others genomes downloaded from GenBank, ranged in size from 1988 to 1996 base pairs, with sequence identities ranging from 83.2% to 99.8%. Phylogenetic analysis based on genome sequences demonstrated that DuCVs can be divided into two distinct genetic genotypes, Group I （the Euro-USA lineage） and Group II（the Taiwan lineage）, with approximately 10.0% genetic difference between the two types. Molecular epidemiological data suggest there is no obvious difference among DuCV strains isolated from different geographic locations or different species, including Duck, Muscovy duck, Mule duck, Cheery duck, Mulard duck and Pekin duck.展开更多
The epidemiologic characteristics of 631 infant pertussis cases 〈 12 months, which accounted for 57.42% of the total cases, were analyzed by descriptive epidemiology in Tianjin, between 2010 and 2015. The incidence o...The epidemiologic characteristics of 631 infant pertussis cases 〈 12 months, which accounted for 57.42% of the total cases, were analyzed by descriptive epidemiology in Tianjin, between 2010 and 2015. The incidence of infants was 104.66/100,000, which was 118 times higher than in other age groups （P 〈 0.001）. The primary type of pertussis simultaneously presented in households was adult-to-infant （70.51%）. The parents were identified as the source of infection in 80.18% of cases for infants. The positive rate of placental antibody transfer was 31.06% and 3.13% for 3-month-old infants. Infants presented the highest age-specific pertussis incidence. The most important reason was parents were the important sources of infection, and secondly the lower level of antibodies in neonates and the rapid waning of maternal antibody titer.展开更多
Ecological methodology plus negative binomial regression were used to identify dengue fever （DF） epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of...Ecological methodology plus negative binomial regression were used to identify dengue fever （DF） epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of DF in Guangzhou was 0.33, 0.11, 0.15, 0.64, 0.45, and 1.34 （per 100 000） respectively, showing an increasing trend. Each 1℃ rise of temperature corresponded to an increase of 10.23% （95% CI 7.68% to 12.83%） in the monthly number of DF cases, whereas l hPa rise of atmospheric pressure corresponded to a decrease in the number of cases by 5.14% （95% CI： 7.10%-3.14%）. Likewise, each one meter per second rise in wind velocity led to an increase by 43.80% or 107.53%, and one percent rise of relative humidity led to an increase by 2.04% or 2.19%.展开更多
文摘Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.
基金supported by Public Health Talent Training and Surport Plan(National Administration of Disease Prevention and Control)Research and application of new technology for rapid monitoring and tracing of emergent infectious diseases among entry-exit population(2024YFFK0056)Monitoring,Early warning and Response of Major Infectious Diseases(2022ZDZX0017).
文摘Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
文摘Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. It is in this context that the present study was carried out to evaluate the measles epidemiological surveillance system in the Kangaba health district. Method: This was a descriptive cross-sectional study with retrospective data collection for the period from 1 January to 31 December 2022 in the Kangaba health district with 18 epidemiological surveillance officers. Data were collected using an observation grid and documentary analysis. Results: We found a simplicity of 97%, a representativeness of 95% and a reactivity of 53%. Not all notified cases were sampled (64%). Of the 17 CSCom, 8 were positive. A total of 34 confirmed cases of measles were recorded, with one death. Conclusion: Overall, the system is functional and well-established in the health centres, but it remains important to ensure that suspected cases are investigated and that the time between sampling and the availability of laboratory results is respected.
文摘Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely available. In Congo there is little published data on this entity. Objectives: To describe the epidemiological, diagnostic, and progression characteristics of peritoneal tuberculosis at the university hospital center in Brazzaville. Patients and Methods: This study is a descriptive and retrospective analysis conducted from January 1, 2015, to December 31, 2021, in the Gastroenterology and Internal Medicine department of the CHU of Brazzaville. It included all patients hospitalized during this period with a confirmed diagnosis of peritoneal tuberculosis, encompassing 54 records that met the inclusion criteria. Results: Out of the study period, 54 records that fulfilled the inclusion criteria were analyzed. The annual incidence of peritoneal tuberculosis was 7.7 patients, with a prevalence of 1.4%, showing a male predominance of 61% and an average age of 39.93 ± 14.62 years. The primary symptoms were abdominal bloating and abdominal pain, present in 100% and 74% of cases, respectively. The clinical presentation was primarily characterized by febrile ascites observed in all patients. HIV co-infection was noted in 29.6% of cases. Anemia was present in 79.6% of patients, and an elevated sedimentation rate was observed in 74% of cases. The tuberculin skin test returned positive in 50% of cases. The ascitic fluid was exudative, rich in proteins and white blood cells (exceeding 1000/mm3, predominantly lymphocytes) in the majority of cases (100%, 83.3%, 83.3%, respectively). The diagnosis was deemed highly probable based on the clinical and paraclinical signs and the favorable response to treatment in 79.6% of cases. There were instances of pleural involvement (33.3%) and lymph node involvement (pulmonary 22.2% and lymph node 16.6%). Treatment outcomes were favorable in 37% of cases, with a mortality rate of 9%. Conclusion: Peritoneal tuberculosis is prevalent in Brazzaville, predominantly affecting young males. The diagnosis relies chiefly on a combination of clinical, paraclinical, and progression indicators.
文摘Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.
基金Heilongjiang Provincial Health Commission(Project No.:20231212050085)。
文摘Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and epidemiological trends of hepatitis B data in Harbin from 2010 to 2023.Results:A total of 38,604 cases of hepatitis B were reported in Harbin from 2010 to 2023,with an average annual incidence rate of 26.38 per 100,000.The majority of hepatitis B cases were chronic.There was no obvious seasonal distribution pattern of hepatitis B.The average incidence rate was lowest in the<10-year-old group(1.72 per 100,000)and highest in the 40-year-old group(34.71 per 100,000).Cases were mainly concentrated in the 30-69-year-old population,accounting for 75.35%.The male-to-female ratio was 1.35:1.The majority of cases were farmers,accounting for 57.31%.Conclusion:Except for a significant decrease from 2020 to 2022,the overall incidence of hepatitis B showed a trend of decreasing first and then increasing from 2010 to 2023.The prevention and control measures for the 0-19-year-old population were effective.It is necessary to strengthen the prevention and control of hepatitis B among adults over 20 years old,especially to develop differentiated hepatitis B prevention and control strategies targeting key areas and high-risk populations.
文摘The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to December 31, 2023, on 225 patients seen in consultation for anxiety disorders in the department. The prevalence of anxiety disorders was 2.5% in consultation. The 20 - 29 age group was the most represented at 33.3%. Females were slightly represented at 55.1%, with a sex ratio of 1.2. The secondary level was the most affected, accounting for 36.4% of cases. Insomnia was the most frequent reason for consultation, accounting for 71.1% of cases. A larger general population study would be necessary to better assess the extent of anxiety disorders in Guinea.
基金supported,in part,by Key Research and Development Projects of Henan,China(231111111600)the National Key R&D Program(2023YFD1801200)the China Agriculture(sheep and goats)Research System(CARS-38).
文摘Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on farms.Disease is a serious constraint to the healthy development of small ruminant farming.Studies published on PubMed,CNKI,VIP,Wanfang and the resulting references of selected studies were included.Risk factors affecting prevalence were analyzed and stratified by geographic location and climatic variables,age,sex,feeding model,season,sample year,breeds and environment.The total prevalence of coccidia in sheep and goats reached more than 60%in most regions,in which the dominant species in sheep were mainly E.parva,E.ovinoidalis,and E.parva and E.ahsata.East China had the lowest prevalence of coccidia infection in sheep(43.24%),and the dominant species were different from those in the other regions,mainly E.bakuensis and E.gonzalezi.Southwestern China and Central China had slightly less than 40.0%goat coccidia infection,and the dominant species in goats were mainly E.arloingi,E.aligevi,E.hirci and E.ninakohlyakimovae.Sheep/goats of different ages can be infected with coccidiosis,but lambs between 1 and 3 months of age are more susceptible to the disease.When lambs become infected,the pathogen spreads rapidly throughout the herd.Spring,summer and autumn are the seasons with a high incidence of this disease.Environmental pollution may be a significant factor in the development of coccidiosis in sheep raised in large-scale housing.This study provides a comprehensive overview of the species,morphology and geographic distribution of Eimeria species in sheep and goats,summary prevalence in different regions of China,risk factors affecting prevalence,and prevention and control strategies.
文摘Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.
文摘BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple chemotherapy regimens at different stages.METHODS This was a retrospective study conducted from 2005 to 2014,involving six cancer hospitals and eight general hospitals across seven geographical regions of China(East,South,North,Central,Southwest,Northwest,and Northeast).Stratified sampling was used based on the population distribution of each region.Efficacy assessments were conducted by Cox proportional hazards regression models.When assessing the effectiveness of various chemotherapy regimens,traditional drugs such as gemcitabine used as monotherapy served as the reference.RESULTS A total of 3256 patients were included.The median follow-up time was 407 days,and the median overall survival was 183 days.At diagnosis,56%of patients were already in stage IV.Chemotherapy was administered to 39.73%of patients.In the adjuvant therapy phase,gemcitabine+fluorouracil was superior to gemcitabine monotherapy[hazard ratio(HR)=0.35,95%confidence interval(CI):0.14-0.89].In fluorouracil-based regimens,other combination regimens did not show effectiveness relative to monotherapy.For first-line treatment in patients with advanced disease,tegafur alone(HR=0.20,95%CI:0.06-0.66),gemcitabine plus cisplatin(HR=0.16,95%CI:0.04-0.70),and tegafur,gemcitabine plus platinum-based agents(HR=0.32,95%CI:0.11-0.91)were associated with a lower risk of death compared to gemcitabine alone.In second-line treatment,there were no significant differences in efficacy among various drugs,but FOLFIRINOX(irinotecan+oxaliplatin+leucovorin+5-fluorouracil)had an outstanding point estimate(HR=0.10,95%CI:0.01-1.27).CONCLUSION In China,pancreatic cancer is often diagnosed at advanced stages,emphasizing the need for early diagnosis and treatment.Combined therapies in adjuvant and first-line settings may reduce the risk of death compared with monotherapy,and FOLFIRINOX might offer more significant benefits in second-line treatment.
基金Supported by TCM Scientific Research Guidance Program of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F074).
文摘[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.
基金supported by Tianjin Municipal Health Commission(TJWJ2022ZD010)Tianjin Key Medical Discipline(Specialty)Construction Project.
文摘Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are influenced by multiple factors,especially during the COVID-19 pandemic.Based on data from the National Influenza Surveillance Program in China,we analyzed the epidemiological and genomic data in Tianjin collected from 2017 to 2025.A total of 77,473 throat swabs were collected,of which 9144 were IAV-positive.The A/pdm09 H1N1 and A/H3N2 lineages exhibited distinct epidemics across different influenza seasons,with a decline in cases observed during the COVID-19 pandemic.We sequenced the genomes of 128 A/pdm09 H1N1 and 113 A/H3N2 clinical isolates and characterized their temporal evolution and genetic diversity using time-scaled phylogenetic analysis.Additionally,we conducted a genetic risk evaluation of the hemagglutinin and neuraminidase segments,identifying key amino acid residues associated with viral adaptation,transmissibility,virulence,and drug resistance.Moreover,no antigenic variants were found in clinical isolates during the recent influenza seasons,though reduced sensitivity to oseltamivir and zanamivir was observed in individual strains.Our surveillance highlights the epidemiology and evolution of IAV before and after the COVID-19 pandemic in Tianjin.
文摘Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,064 patients were collected from 555 hospitals in 28 provinces of China.Results:Among 9,064 NHL patients,there were 5,241 males(57.8%)and 3,823 females(42.2%),with a male-to-female ratio of 1.37:1.Patients aged≥45 years accounted for 89.6%,with a mean age of 61.87±13.30 years.The predominant NHL subtypes were diffuse large B-cell lymphoma(DLBCL,45.2%),chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL,19.8%),marginal zone lymphoma(MZL,13.9%),mantle cell lymphoma(MCL,9.7%),and central nervous system lymphoma(CNSL,4.3%).Combination therapy served as the primary treatment modality across all NHL subtypes.Conclusions:NHL in China demonstrates male predominance and primarily affects middle-aged and elderly populations,with combination chemotherapy remaining the mainstay therapeutic approach.
基金funded by the National Key Research and Development Program of China(Grant No.2021YFD1800201).
文摘The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential threat to the poultry industry and public health.During the period from 2011 to 2022,we conducted an active surveillance programm.A total of 154,762 swab samples were collected across various provinces,and 427 H4 viruses were detected,resulting in a positivity rate of 0.28%.All H4 viruses were isolated from poultry,primarily from ducks in live poultry markets.We further investigated the genetic evolutionary characteristics and pathogenicity of 20 H4Nx viruses isolated in our program.Phylogenetic analysis revealed that the 20 H4Nx viruses belonged to the Eurasian lineage and exhibited significant genetic diversity,with 19 distinct genotypes identified.Molecular characterization indicated that these viruses were low-pathogenicity AIVs with limited binding affinity to human receptors,yet they contained mutations associated with enhanced viral replication and pathogenicity in mammals.Pathogenicity tests conducted in ducks demonstrated that H4 viruses were weakly pathogenic,exhibiting limited replication and transmission capabilities.However,some viruses were able to replicate effectively in mice and induce weight loss.For instance,DK/AH/AG61/11(H4N6)can replicate efficiently in MDCK cells,indicating a potential threat to mammals.These findings underscore the importance of ongoing surveillance of H4 AIVs to better understand their evolution and transmission dynamics and to prevent potential public health risks.
基金supported by grants from the National Mega Project on Major Infectious Disease Prevention of China(2017ZX10103011)Guangdong Marine Economy Development Special Project of China(NO.GDNRC[2022]35)+1 种基金the National Natural Science Foundation of China(82171675,82101775,82071352,82341094)Guangdong Basic and Applied Basic Research Foundation of China(2022A1515011156).
文摘Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional study was conducted using respiratory samples from 9,696 ARI patients between 2016 and 2020 in southern China.All samples were analyzed by quantitative real-time polymerase chain reaction to determine the presence of HPIV and other common respiratory viruses.Descriptive statistics were performed to determine the temporal and population distribution of HPIV.The fulllength hemagglutinin-neuraminidase(HN)gene of HPIV3-positive samples was sequenced for phylogenetic analysis.A total of 577(6.0%)patients tested positive for HPIV,with HPIV3 being the predominant serotype,accounting for 46.8%of cases.Notably,66.0%of these HPIV-positive cases were children aged 0-2 years.The prevalence of HPIV infections showed a decreased trend and altered peak during 2016-2020.Cough,fever,sputum production,and rhinorrhea were common respiratory symptoms in HPIV-positive patients.The majority of cases had pneumonia(63.4%).Human rhinovirus(HRV)and human coronavirus(HCoV)were the most common coinfection viruses in HPIV-positive cases,with proportions of 20.1%and 14.4%,respectively.Phylogenetic analysis revealed that the predominant lineage of HPIV3 was C3f(86.0%),followed by lineage C3a(8.0%),C3d(4.0%),and C3b(2.0%).These findings help to better understand the epidemiology of HPIV,and improve public health strategies to prevent and control HPIV infections in southern China.
基金supported by the National Natural Science Foundation of China (82002130)supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-026)
文摘Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.
基金Modern Agri-industry Technology Research System(CARS-43)Science and Technology Innovation Fund of Fujian Academy of Agriculture Science(STIF-02)Science and Technology Innovation Foundation for Young Scientists of Fujian Academy of Agriculture Science(2008QB-6)
文摘Duck circovirus （DuCV）, a potential immunosuppressive virus, was investigated in Southern China from March 2006 to December 2009 by using a polymerase chain reaction （PCR） based method. In this study, a total of 138 sick or dead duck samples from 18 different farms were examined with an average DuCV infection rate of-35%. It was found that ducks between the ages of 40~60 days were more susceptible to DuCV. There was no evidence showing that the DuCV virus was capable of vertical transmission. Farms with positive PCR results exhibited no regularly apparent clinical abnormalities such as feathering disorders, growth retardation or lower-than-average weight. The complete genomes of 91 strains from Fujian Province and 1 from Zhejiang Province were sequenced and analyzed. The 10 DuCV genomes, comlbared with others genomes downloaded from GenBank, ranged in size from 1988 to 1996 base pairs, with sequence identities ranging from 83.2% to 99.8%. Phylogenetic analysis based on genome sequences demonstrated that DuCVs can be divided into two distinct genetic genotypes, Group I （the Euro-USA lineage） and Group II（the Taiwan lineage）, with approximately 10.0% genetic difference between the two types. Molecular epidemiological data suggest there is no obvious difference among DuCV strains isolated from different geographic locations or different species, including Duck, Muscovy duck, Mule duck, Cheery duck, Mulard duck and Pekin duck.
基金supported by the Research Fund of Tianjin Health and Family Planning Commission 2015KY18Science and Technology Major Project of Chinese Preventive Medicine Association Q2017A1225
文摘The epidemiologic characteristics of 631 infant pertussis cases 〈 12 months, which accounted for 57.42% of the total cases, were analyzed by descriptive epidemiology in Tianjin, between 2010 and 2015. The incidence of infants was 104.66/100,000, which was 118 times higher than in other age groups （P 〈 0.001）. The primary type of pertussis simultaneously presented in households was adult-to-infant （70.51%）. The parents were identified as the source of infection in 80.18% of cases for infants. The positive rate of placental antibody transfer was 31.06% and 3.13% for 3-month-old infants. Infants presented the highest age-specific pertussis incidence. The most important reason was parents were the important sources of infection, and secondly the lower level of antibodies in neonates and the rapid waning of maternal antibody titer.
基金supported by the Research Fund from Health Bureau of Guangzhou(201102A212006)Science and Technology Bureau of Guangzhou(2012Y2-00020)Medical Sciences Program of Guangdong(A2011507)
文摘Ecological methodology plus negative binomial regression were used to identify dengue fever （DF） epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of DF in Guangzhou was 0.33, 0.11, 0.15, 0.64, 0.45, and 1.34 （per 100 000） respectively, showing an increasing trend. Each 1℃ rise of temperature corresponded to an increase of 10.23% （95% CI 7.68% to 12.83%） in the monthly number of DF cases, whereas l hPa rise of atmospheric pressure corresponded to a decrease in the number of cases by 5.14% （95% CI： 7.10%-3.14%）. Likewise, each one meter per second rise in wind velocity led to an increase by 43.80% or 107.53%, and one percent rise of relative humidity led to an increase by 2.04% or 2.19%.
