Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It i...Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.展开更多
Famous for their enigmatic smiles,Qingzhou's buried Buddhist sculptures at Longxing Temple unveil a thousand-year legacy of artistic mastery,religious devotion and cultural preservation.
From clandestine meetings to smuggling priceless artifacts,China's most exclusive and enigmatic academic society has carried on the spirit of seal art through wars and revolutions for over a certury.
基金the support from Perron Institute for Neurological and Translational Science, Department of Orthopaedics, The Second Affiliated HospitalYuying Children's Hospital of Wenzhou Medical UniversityDepartment of Orthopaedics, Shanghai Sixth People’s Hospital of Shanghai Jiaotong University
文摘Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.
文摘Famous for their enigmatic smiles,Qingzhou's buried Buddhist sculptures at Longxing Temple unveil a thousand-year legacy of artistic mastery,religious devotion and cultural preservation.
文摘From clandestine meetings to smuggling priceless artifacts,China's most exclusive and enigmatic academic society has carried on the spirit of seal art through wars and revolutions for over a certury.
