Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is...Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation efficiency.Fortunately,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its reactivity.Herein,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other support.The activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical pathways.The effects of pH,inorganic ions,and natural organic matter on degradation reactions are also discussed.Finally,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.展开更多
It is known that many physical phenomenons can be described by the KdV-Burgers equation. By the enhanced modifed simple equation method, we obtain the exact solutions with variable coefcients involving parameters to K...It is known that many physical phenomenons can be described by the KdV-Burgers equation. By the enhanced modifed simple equation method, we obtain the exact solutions with variable coefcients involving parameters to KdV-Burgers equation, and some new exact solutions are gained. When these parameters are taken special values, the solitary wave solutions are derived from the exact solutions. It is shown that the proposed method provides a more powerful mathematical tool for solving nonlinear evolution equations in mathematical physics.展开更多
Immunotherapy has transformed cancer treatment,but its effectiveness in breast cancer remains suboptimal.Tumor-associated macrophages(TAMs),a key component of the tumor microenvironment(TME),contribute significantly t...Immunotherapy has transformed cancer treatment,but its effectiveness in breast cancer remains suboptimal.Tumor-associated macrophages(TAMs),a key component of the tumor microenvironment(TME),contribute significantly to immune evasion.In this study,we identified gamma-interferon-inducible lysosomal thiol reductase(IFI30)as a critical regulator of TAM function in breast cancer.IFI30 expression is upregulated in breast cancer via enhanced Histone 3 lysine 27 acetylation(H3K27ac)modification and promotes tumor progression and metastasis in an immune-dependent manner.Mechanistically,IFI30 in breast cancer cells recruits TAMs by activating the ATF3-CCL5 axis.Within macrophages,it promotes M2-like polarization and PD-L1 upregulation,fostering an immunosuppressive TME.Our findings established IFI30 as a promising therapeutic target for disrupting TAM-mediated immune suppression and enhancing breast cancer immunotherapy.展开更多
基金the National Natural Science Foundation of China(Nos.52170088 and 52070133)for financial support。
文摘Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation efficiency.Fortunately,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its reactivity.Herein,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other support.The activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical pathways.The effects of pH,inorganic ions,and natural organic matter on degradation reactions are also discussed.Finally,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.
基金supported by the National Natural Science Fund of China (30970231)the Genetically Modified Organisms Breeding Major Project of China (2014ZX08003001)
文摘supported by the National Natural Science Fund of China （30970231）;the Genetically Modified Organisms Breeding Major Project of China （2014ZX08003001）
文摘It is known that many physical phenomenons can be described by the KdV-Burgers equation. By the enhanced modifed simple equation method, we obtain the exact solutions with variable coefcients involving parameters to KdV-Burgers equation, and some new exact solutions are gained. When these parameters are taken special values, the solitary wave solutions are derived from the exact solutions. It is shown that the proposed method provides a more powerful mathematical tool for solving nonlinear evolution equations in mathematical physics.
基金supported by the Beijing Natural Science Foundation(7252202 and 25JL008)the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-029 and 2023-I2M-2-006,China)the National Natural Science Foundation of China(82304523).
文摘Immunotherapy has transformed cancer treatment,but its effectiveness in breast cancer remains suboptimal.Tumor-associated macrophages(TAMs),a key component of the tumor microenvironment(TME),contribute significantly to immune evasion.In this study,we identified gamma-interferon-inducible lysosomal thiol reductase(IFI30)as a critical regulator of TAM function in breast cancer.IFI30 expression is upregulated in breast cancer via enhanced Histone 3 lysine 27 acetylation(H3K27ac)modification and promotes tumor progression and metastasis in an immune-dependent manner.Mechanistically,IFI30 in breast cancer cells recruits TAMs by activating the ATF3-CCL5 axis.Within macrophages,it promotes M2-like polarization and PD-L1 upregulation,fostering an immunosuppressive TME.Our findings established IFI30 as a promising therapeutic target for disrupting TAM-mediated immune suppression and enhancing breast cancer immunotherapy.
