1.The development history of enhanced recovery after surgery(ERAS)Enhanced recovery after surgery(ERAS)is a multimodal perioperative care approach that has evolved over the past 2 decades since its inception.In 1997,P...1.The development history of enhanced recovery after surgery(ERAS)Enhanced recovery after surgery(ERAS)is a multimodal perioperative care approach that has evolved over the past 2 decades since its inception.In 1997,Professor Henrik Kehlet,also known as the“father of ERAS”,from the University of Copenhagen in Denmark first proposed the ERAS concept and discovered its clinical feasibility and superiority,achieving remarkable results.ERAS was initially applied in colorectal surgery;subsequently,the concept gradually gained popularity and application worldwide.展开更多
Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials prov...Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.展开更多
Cholecystectomy is extensively employed for the treatment of various gallbladder diseases,including symptomatic cholelithiasis,asymptomatic cholelithiasis with a high risk of gallbladder cancer or complications,non-ca...Cholecystectomy is extensively employed for the treatment of various gallbladder diseases,including symptomatic cholelithiasis,asymptomatic cholelithiasis with a high risk of gallbladder cancer or complications,non-calculous cholecystitis,gallbladder polyps larger than 1.0 cm,and porcelain gallbladder,etc.Currently,laparoscopic cholecystectomy(LC)constitutes over 95%of all cholecystectomy procedures,which is the preferred approach for gallbladder surgery[1,2].展开更多
Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxyge...Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS quenching.To address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal complexes.As a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer Ir-TPE.This approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE groups.Ir-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light irradiation.Photoirradiated Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA damage.This damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer cells.The aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic effect.In vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor eradication.This study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.展开更多
Previous research utilizing Cartoon Generative Adversarial Network(CartoonGAN)has encountered limitations in managing intricate outlines and accurately representing lighting effects,particularly in complex scenes requ...Previous research utilizing Cartoon Generative Adversarial Network(CartoonGAN)has encountered limitations in managing intricate outlines and accurately representing lighting effects,particularly in complex scenes requiring detailed shading and contrast.This paper presents a novel Enhanced Pixel Integration(EPI)technique designed to improve the visual quality of images generated by CartoonGAN.Rather than modifying the core model,the EPI approach employs post-processing adjustments that enhance images without significant computational overhead.In this method,images produced by CartoonGAN are converted from Red-Green-Blue(RGB)to Hue-Saturation-Value(HSV)format,allowing for precise adjustments in hue,saturation,and brightness,thereby improving color fidelity.Specific correction values are applied to fine-tune colors,ensuring they closely match the original input while maintaining the characteristic,stylized effect of CartoonGAN.The corrected images are blended with the originals to retain aesthetic appeal and visual distinctiveness,resulting in improved color accuracy and overall coherence.Experimental results demonstrate that EPI significantly increases similarity to original input images compared to the standard CartoonGAN model,achieving a 40.14%enhancement in visual similarity in Learned Perceptual Image Patch Similarity(LPIPS),a 30.21%improvement in structural consistency in Structural Similarity Index Measure(SSIM),and an 11.81%reduction in pixel-level error in Mean Squared Error(MSE).By addressing limitations present in the traditional CartoonGAN pipeline,EPI offers practical enhancements for creative applications,particularly within media and design fields where visual fidelity and artistic style preservation are critical.These improvements align with the goals of Fog and Edge Computing,which also seek to enhance processing efficiency and application performance in sensitive industries such as healthcare,logistics,and education.This research not only resolves key deficiencies in existing CartoonGAN models but also expands its potential applications in image-based content creation,bridging gaps between technical constraints and creative demands.Future studies may explore the adaptability of EPI across various datasets and artistic styles,potentially broadening its impact on visual transformation tasks.展开更多
The use of Minimum Quantity Lubrication(MQL)with bio-lubricants has been extensively studied in aerospace sustainable manufacturing.Enhanced MQL technologies have been proposed to reduce tool wear and improve workpiec...The use of Minimum Quantity Lubrication(MQL)with bio-lubricants has been extensively studied in aerospace sustainable manufacturing.Enhanced MQL technologies have been proposed to reduce tool wear and improve workpiece surface integrity by increasing lubricant activity.However,the relationship between enhancement behavior,physicochemical properties of biolubricants,and processability remains unclear,presenting challenges for MQL technologies,particularly with difficult-to-machine materials.To address this gap,this paper provides an in-depth mechanism analysis and a comprehensive quantitative evaluation of the machinability of enhanced MQL technologies,considering chemistry,molecular dynamics,fluid dynamics,tribology,and heat transfer.Firstly,the cooling and lubrication enhancement mechanisms of nano-lubricants were systematically summarized.focusing on molecular structure.physical properties,and preparation processes.Secondly,the atomization enhancement mechanism of Electrostatic Minimum Quantity Lubrication(EMQL)was analyzed.revealing a 49%reduction in PM2.5 concentration during the atomization process compared to conventional MQL.Thirdly,the transport and infiltration enhancement mechanisms of bio-lubricants in cutting and grinding zones were summarized,incorporating electromagnetic fields and ultrasound-assisted processes.Finally,for cutting and grinding applications involving difficult-to-machine materials in aerospace,the optimized machinability of enhanced MQL technologies was concluded,showing a 50.1%increase in lubricant heat transfer coefficient and a 31.6%decrease in grinding temperature compared to standard MQL.This paper aims to help scientists understand the effective mechanisms,formulate process specifications,and identify future development trends in this technology.展开更多
Developing microwave electric field sensing based on Rydberg atoms has received significant attention due to its unique advantages. However, achieving effective coupling between Rydberg atoms and the microwave electri...Developing microwave electric field sensing based on Rydberg atoms has received significant attention due to its unique advantages. However, achieving effective coupling between Rydberg atoms and the microwave electric field in the sensing process is a challenging problem that greatly impacts the sensitivity. To address this, we propose using a microwave resonant cavity to enhance the effective coupling between the Rydberg atoms and the microwave electric field. In our experiment, Rydberg atoms are prepared via a three-photon excitation scheme, and the electric fields are measured without and with a microwave cavity in which the vapor cell is placed inside, respectively. As a result, we achieved an 18 dB enhancement of power sensitivity by adding the cavity,which is an effective enhancement in electric field pulse signal detection. This experimental testing provides a promising direction for enhancing the sensitivity of Rydberg atomic electric field sensors and paves the way for their application in precision electric field measurements.展开更多
The potential of the vertical-horizontal well hybrid SAGD technique for developing shallow heavy oil reservoirs is gradually being realized.However,challenges remain in terms of low thermal efficiency and high carbon ...The potential of the vertical-horizontal well hybrid SAGD technique for developing shallow heavy oil reservoirs is gradually being realized.However,challenges remain in terms of low thermal efficiency and high carbon emissions in reservoirs with interlayers.Currently,there is limited research on the low-carbon strategy of coupling exhaust gas from steam boilers with the VH-SAGD technique.Herein,considering heterogeneity,a series of flue gas-assisted VH-SAGD experiments were conducted employing a high-performance 2D visualization model.The mechanism of enhanced recovery of flue gas in VH-SAGD and the effect of its injection methods were studied,with a focus on steam chamber development and oil saturation distribution.Crucially,the interlayer length was optimized to enhance oil recovery,providing a new perspective for well location design in heavy oil reservoirs with interlayers.The results showed that flue gas,as an additive,could fully exploit the well-type advantage of VH-SAGD.By supplementing energy at the reservoir top,flue gas effectively promoted steam chamber development,expanded the oil drainage area of VH-SAGD,and increased the oil recovery from 58.9%to 71.7%.The flow channels formed by pre-injection flue gas accelerated the early-stage expansion of the steam chamber while also inducing lateral migration of steam,slowing steam rise,and consequently increasing the heating range within the low-permeability layer.When the distance between the vertical and horizontal wells was set to twice the interlayer length,the negative effects of the interlayer were more effectively turned into advantages.Because when the lateral development distance of the steam chamber in the low-permeability layer slightly exceeds the interlayer,enhanced heating of the lower part of the reservoir occurred through vertical convection of rising steam and returning condensate.The research results contribute to reducing carbon emissions from steam-based heavy oil extraction while advancing the maturity of VH-SAGD.展开更多
The electrokinetic(EK)process has been proposed for soil decontamination from heavy metals and organic matter.The advantages of the EK process include the low operating energy,suitability for fine-grained soil deconta...The electrokinetic(EK)process has been proposed for soil decontamination from heavy metals and organic matter.The advantages of the EK process include the low operating energy,suitability for fine-grained soil decontamination,and no need for excavation.During the last three decades,enhanced and hybrid EK systems were developed and tested for improving the efficiency of contaminants removal from soils.Chemically enhanced-EK processes exhibited excellent efficiency in removing contaminants by controlling the soil pH or the chemical reaction of contaminants.EK hybrid systems were tested to overcome environmental hurdles or technical drawbacks of decontamination technologies.Hybridization of the EK process with phytoremediation,bioremediation,or reactive filtermedia(RFM)improved the remediation process performance by capturing contaminants or facilitating biological agents’movement in the soil.Also,EK process coupling with solar energy was proposed to treat off-grid contaminated soils or reduce the EK energy requirements.This study reviews recent advancements in the enhancement and hybrid EK systems for soil remediation and the type of contaminants targeted by the process.The study also covered the impact of operating parameters,imperfect pollution separation,and differences in the physicochemical characteristics and microstructure of soil/sediment on the EK performance.Finally,a comparison between various remediation processes was presented to highlight the pros and cons of these technologies.展开更多
Rare-earth supramolecular compounds,such as lanthanide organic polyhedrons(LOPs),are of particular interest due to their many possible applications in various fields.Here we report the first syntheses of Ln_(4)(L^(...Rare-earth supramolecular compounds,such as lanthanide organic polyhedrons(LOPs),are of particular interest due to their many possible applications in various fields.Here we report the first syntheses of Ln_(4)(L^(·+))_(4)-type(Ln,lanthanides;L^(·+),radical ligand)radical-bridged lanthanide organic tetrahedrons by self-assembly of face-capping triphenylamine(TPA)-cored radical ligand with different lanthanide ions.Remarkable coordination enhanced radical stability has been observed,with half-life times(t_(1/2))for L_(1)^(·+),La_(4)(L_(1)^(·+))_(4),Eu_(4)(L_(1)^(·+))_(4),Gd_(4)(L_(1)^(·+))_(4),Tb_(4)(L_(1)^(·+))_(4)and Lu_(4)(L_(1)^(·+))_(4)estimated to be 53 min,482 min,624 min,1248 min,822 min and 347 min,respectively.The TPA radical in Ln_(4)(L_(1)^(·+))_(4)containing paramagnetic Ln ions(Ln=Eu^(Ⅲ),Gd^(Ⅲ)and Tb^(Ⅲ))is observed to be more stable than that in Ln_(4)(L_(1)^(·+))_(4)(Ln=La^(Ⅲ)and Lu^(Ⅲ))constructed by diamagnetic Ln ions.This difference in radical stability is possibly due to the magnetic interactions between paramagnetic Ln^(Ⅲ)ions and L_(1)^(·+)ligands,as confirmed by electron paramagnetic resonance(EPR)in La_(4)(L)_(4)(L=L_(1)and L_(1)^(·+))and Tb_(4)(L)_(4)(L=L_(1)and L_(1)^(·+)),and magnetic susceptibility measurements in Tb·_(4)(L)_(4)(L=L_(1)and L_(1)^(·+)).Our study reveals the coordination of radical ligands with lanthanide ions can improve the radical stability,which is crucial for their applications.展开更多
Ferroptosis is a newly proposed type of programmed cell death,which has been associated with a variety of diseases including tumors.Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-canc...Ferroptosis is a newly proposed type of programmed cell death,which has been associated with a variety of diseases including tumors.Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy.However,the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors,poor active pharmaceutical ingredient(API)loading content and the systemic toxicity.Herein,self-propelled ferroptosis nanoinducers composed of two endogenous proteins,glucose oxidase and ferritin,are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility.The accumulation of our proteomotors at tumor regions is facilitated by the active tumor-targeting effect of ferritin.The enhanced diffusion of proteomotors is then actuated by efficiently decomposing glucose into gluconic acid and H_(2)O_(2),leading to deeper penetration and enhanced uptake into tumors.Under the synergistic effect of glucose oxidase and ferritin,the equilibrium between reactive oxygen species and GSH is damaged,leading to lipid peroxidation.As a result,by inducing ferroptosis,our self-propelled ferroptosis nanoinducers exhibit enhanced tumor inhibitory effects.This work paves a way for the construction of a biocompatible anticancer platform with enhanced diffusion utilizing only two endogenous proteins,centered around the concept of ferroptosis.展开更多
Enhanced oil recovery(EOR)refers to themanymethodologies used to augment the volume of crude oil extracted froman oil reservoir.These approaches are used subsequent to the exhaustion of basic and secondary recovery me...Enhanced oil recovery(EOR)refers to themanymethodologies used to augment the volume of crude oil extracted froman oil reservoir.These approaches are used subsequent to the exhaustion of basic and secondary recovery methods.There are three primary categories of Enhanced Oil Recovery(EOR):thermal,gas injection,and chemical.Enhanced oil recovery methods may be costly and intricate;yet,they facilitate the extraction of supplementary oil that would otherwise remain in the reservoir.Enhanced Oil Recovery(EOR)may prolong the lifespan of an oil field and augment the total output from a specific field.The parameters influencing oil recovery are a significant problem in Enhanced Oil Recovery(EOR)systems,necessitating further examination of the components that impact them.This research examined the impact of permeability fluctuations on fluid dynamics inside a sandstone reservoir and presented a contemporary overview of the three phases of Enhanced Oil Recovery(EOR),including detailed explanations of the methodologies used and the processes facilitating oil recovery.The challenges faced with several common EOR mechanisms were identified,and solutions were suggested.Additionally,the modern trend of incorporating nanotechnology and its synergistic impacts on the stability and efficacy of conventional chemicals for enhanced oil recovery(EOR)was scrutinised and evaluated.Ultimately,laboratory results and field activities were examined.The study looked closely at hownanoparticlesmove through reservoirs and evaluated enhanced oil recovery(EOR),mobility ratio,and fluid displacement efficiency.This study offers comprehensive insights into the use of enhanced oil recovery techniques for sustainable energy generation.展开更多
BACKGROUND Enhanced recovery after surgery(ERAS)represents an innovative,protocoldriven perioperative care program designed to optimize patient outcomes.However,its application and efficacy in infants and children wit...BACKGROUND Enhanced recovery after surgery(ERAS)represents an innovative,protocoldriven perioperative care program designed to optimize patient outcomes.However,its application and efficacy in infants and children with Hirschsprung disease(HD)remain underexplored.AIM To delve into the impact of ERAS on perioperative recovery and the overall medical experience in HD infants and children.METHODS Thirty-eight infants and children with HD who received the Soave surgical procedure were enrolled in this case-control study.According to age-and sexstratified single-blind randomized tables,20 cases received ERAS treatment(ERAS group)and 18 cases received conventional treatment(control group).The two treatments were then compared in terms of perioperative recovery and medical experience.RESULTS Significant differences were observed in pain scores at awakening(4.2±1.3 vs 5.2±1.2,t=2.516,P=0.017)and pain duration(85.69±7.46 hours vs 67.00±8.56 hours,t=7.139,P<0.001)between the ERAS and control group.The recovery of bowel movement was earlier in the ERAS group than in the control group(borborygmus time:33.63±9.83 hours vs 44.69±16.85 hours,t=2.501,P=0.017;feeding time:36.63±9.55 hours vs 49.36±16.99 hours,t=2.884,P=0.007;anal catheter indwelling time:75.83±13.80 hours vs 93.36±20.65 hours,t=3.104,P=0.004),and fever duration(40.73±14.42 hours vs 52.63±18.69 hours,t=2.211,P=0.034).In the ERAS group,hospital stay was shorter(7.5±0.9 days vs 8.3±1.2 days)and the cost was lower(14203±2381 yuan vs 16847±3558 yuan).During the 1-month follow-up period,of the multiple postoperative complications observed,the occurrence of perianal dermatitis(PFisher=0.016)and defecation dysfunction(PFisher=0.027)were lower in the ERAS group than in the control group.CONCLUSION The ERAS protocol has the potential to profoundly enhance postoperative recovery and significantly elevate the overall comfort and quality of the medical experience,making it an indispensable approach that warrants widespread adoption.Continuous refinement through evidence-based practices is anticipated to further optimize its efficacy.展开更多
BACKGROUND Enhanced recovery after surgery(ERAS)programs provide recommendations for an optimized management of patients undergoing surgery.An ERAS program tailored on surgery for retroperitoneal sarcomas(RPS)may impr...BACKGROUND Enhanced recovery after surgery(ERAS)programs provide recommendations for an optimized management of patients undergoing surgery.An ERAS program tailored on surgery for retroperitoneal sarcomas(RPS)may improve patient outcomes and it has still not been established.AIM To determine how an ERAS program tailored to RPS surgery can be agreed upon,structured,and implemented.METHODS Twenty-five candidate items from existing ERAS programs,potentially relevant for RPS surgery,were identified via literature review and expert input.These were included in a questionnaire refined through cognitive interviews and pilot testing.Expert sarcoma surgeons rated each item’s relevance and feasibility on a 6-point scale.The survey was recirculated after one year.Intra-observer reproducibility,inter-observer concordance,and agreement with the modal value of the most experienced participants were analyzed.RESULTS Thirteen sarcoma surgeons from 6 centers participated in the survey.Although surgeons agreed on several items,their overall concordance was low.After recirculating the survey,the intraobserver reproducibility was low.Interestingly,the median concordance with the reference increased for relevance and decreased for feasibility.CONCLUSION Despite interest in ERAS for RPS,surgeon concordance on item relevance and feasibility remains low,underscoring the need for collaborative efforts toward a standardized,consensus-based protocol.展开更多
BACKGROUND Enhanced recovery after surgery(ERAS)protocols have emerged as a promising approach in perioperative care.This study evaluated ERAS's impact on gastrointestinal recovery and microbiota composition follo...BACKGROUND Enhanced recovery after surgery(ERAS)protocols have emerged as a promising approach in perioperative care.This study evaluated ERAS's impact on gastrointestinal recovery and microbiota composition following laparoscopic gastric cancer surgery.AIM To evaluate the impact of ERAS protocols on postoperative gastrointestinal function recovery and intestinal microbiota composition in patients undergoing laparoscopic gastric cancer surgery,and to identify factors associated with improved clinical outcomes and microbial diversity preservation.METHODS We conducted a retrospective analysis of 80 patients who underwent laparoscopic D2 gastrectomy,comparing ERAS(n=40)vs traditional care(n=40).Primary outcomes included postoperative gastrointestinal function recovery and complications.Intestinal microbiota was analyzed using 16S rRNA sequencing at multiple timepoints perioperatively.RESULTS ERAS patients demonstrated faster recovery of bowel function,with earlier return of bowel sounds(16.25±6.41 hours vs 22.3±6.49 hours),first flatus(23.95±6.02 hours vs 28.45±7.12 hours),and defecation(34.95±9.34 hours vs 48.1±15.64 hours),all P<0.05.Complication rates,including antibiotic-associated diarrhea and surgical site infections,were comparable between groups.Microbial diversity indices and probiotic populations showed better preservation in the ERAS group postoperatively(P<0.05),though neither group achieved complete restoration to preoperative levels at one month.CONCLUSION These results support tailoring ERAS protocols to prioritize gut microbiome resilience through early feeding and shortened antibiotic courses,with particular benefits for younger patients.展开更多
In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain sta...In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.展开更多
An efficient determination of the geological characteristics and soil-rock type ahead of a tunnel face is critical for adjusting construction parameters during shield tunnelling.In general,operational engineers rely o...An efficient determination of the geological characteristics and soil-rock type ahead of a tunnel face is critical for adjusting construction parameters during shield tunnelling.In general,operational engineers rely on visual observations of mucky soil types from belt conveyors.This results in shield halting and involves both time and cost implications.This paper proposes a deep learning approach designed to identify mucky soil by monitoring a video installed on the strut of a belt conveyer.The proposed approach comprises four steps:(1)image acquisition,(2)enhanced you-only-look-once(YOLO)modelling,(3)model performance evaluation,and(4)soil identification based on an optimal analysis.The enhanced YOLO model is a deep image detection algorithm.It was introduced by integrating two innovative strategies:data augmentation and imbalance learning.This enhancement accelerates the speed of image identification and improves the overall classification performance.A case study of shield tunnelling in the soil-rock mixed strata of the GuangzhoueFoshan intercity railway line was conducted to validate the proposed approach.The results indicate that the enhanced YOLO model achieves a classification performance comparable to that of the highly optimised AlexNet and GoogleNet.Additionally,the proposed approach more effectively detects the muck soil content than manual observation.This demonstrates its potential for real-time applications in shield tunnelling operations.展开更多
Bionic microfluidics is garnering increasing attention due to the superior fluidic performance enabled by biomimetic microstructures.Inspired by the unique structures of young pumpkin stems,we fabricate helicoidally p...Bionic microfluidics is garnering increasing attention due to the superior fluidic performance enabled by biomimetic microstructures.Inspired by the unique structures of young pumpkin stems,we fabricate helicoidally patterned microchannels with precisely controlled morphologies using the projection micro-stereolithography(PμSL)-based 3D printing technique.Our helicoidally patterned microchannels achieve approximately twice the liquid lifting height compared to similarly sized smooth microchannels.This improvement is attributed to the enhanced capillary force.The additional meniscus formed between the helicoidally patterned microstructures significantly contributes to the increased capillary effects.Furthermore,the underlying mechanisms of fluidic performance in helicoidally patterned microchannels are theorized using a newly developed equation,which is also employed to optimize the geometric parameters and fluidic performance of the biomimetic helicoidal microchannels.Additionally,our biomimetic helicoidally patterned microchannels facilitate a significant step-lifting phenomenon,mimicking tall trees'transpiration.The fluidic performance of our biomimetic helicoidally patterned microchannels show promise for applications in enhanced liquid lifting,step-lifting,clean-water production,and others.展开更多
Hydraulic fracturing then fluid circulation in enhanced geothermal system(EGS)reservoirs have been shown to induce seismicity remote from the stimulation-potentially generated by the distal projection of thermoporoela...Hydraulic fracturing then fluid circulation in enhanced geothermal system(EGS)reservoirs have been shown to induce seismicity remote from the stimulation-potentially generated by the distal projection of thermoporoelastic stresses.We explore this phenomenon by evaluating stress perturbations resulting from stimulation of a single stage of hydraulic fracturing that is followed by thermal depletion of a prismatic zone adjacent to the hydraulic fracture.We use Coulomb failure stress to assess the effect of resulting stress perturbations on instability on adjacent critically-stressed faults.Results show that hydraulic fracturing in a single stage is capable of creating stress perturbations at distances to 1000 m that reach 10^(-5)-10^(-4)MPa.At a closer distance,the magnitude of stress perturbations increases even further.The stress perturbation induced by temperature depletion could also reach 10^(-3)-10^(-2)MPa within 1000 m-much higher than that by hydraulic fracturing.Considering that a critical change in Coulomb failure stress for fault instability is 10^(-2)MPa,a single stage of hydraulic fracturing and thermal drawdown are capable of reactivating critically-stressed faults at distances within 200 m and 1000 m,respectively.These results have important implications for understanding the distribution and magnitudes of stress perturbations driven by thermoporoelastic effects and the associated seismicity during the simulation and early production of EGS reservoirs.展开更多
BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptom...BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptoms in such patients.AIM To evaluate the enhanced recovery after surgery(ERAS)-based evidence-based care(EBC)plus ice stimulation therapy for thirst management of convalescent patients following digestive surgery performed under general anesthesia.METHODS A total of 191 patients convalescing after digestive surgery performed under general anesthesia between March 2020 and February 2023 and experiencing thirst were selected.In total,89 patients and 102 patients in the control and research groups received routine care and ERAS-based EBC plus ice stimulation therapy,respectively.The following data were comparatively analyzed:(1)Thirst degree(thirst intensity numerical rating scale)and thirst distress(TD)degree(TD scale);(2)Oral mucosal wetness;(3)Unstimulated whole salivary flow rate(UWSFR);(4)Adverse reactions(palpitation,fatigue,chapped lips,and nausea and vomiting);and(5)Nursing satisfaction.RESULTS After nursing,thirst degree and distress were statistically lower in the research group than in the control group.Additionally,compared with the control group,the research group exhibited a lower degree of oral mucosal wetness,higher UWSFR,fewer adverse reactions,and more total nursing satisfaction.CONCLUSION ERAS-based EBC plus ice stimulation therapy can effectively alleviate thirst in convalescent patients recovering from a digestive surgery performed under general anesthesia.It can alleviate xerostomia symptoms,reduce adverse reactions,and improve patient comfort.展开更多
文摘1.The development history of enhanced recovery after surgery(ERAS)Enhanced recovery after surgery(ERAS)is a multimodal perioperative care approach that has evolved over the past 2 decades since its inception.In 1997,Professor Henrik Kehlet,also known as the“father of ERAS”,from the University of Copenhagen in Denmark first proposed the ERAS concept and discovered its clinical feasibility and superiority,achieving remarkable results.ERAS was initially applied in colorectal surgery;subsequently,the concept gradually gained popularity and application worldwide.
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY)+2 种基金The Science and Technology Development Program of Jilin Province(No.2020122256JC)Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079)Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。
文摘Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
文摘Cholecystectomy is extensively employed for the treatment of various gallbladder diseases,including symptomatic cholelithiasis,asymptomatic cholelithiasis with a high risk of gallbladder cancer or complications,non-calculous cholecystitis,gallbladder polyps larger than 1.0 cm,and porcelain gallbladder,etc.Currently,laparoscopic cholecystectomy(LC)constitutes over 95%of all cholecystectomy procedures,which is the preferred approach for gallbladder surgery[1,2].
基金support from the National Natural Science Foundation of China(Nos.22277056,21977052)the Distinguished Young Scholars of Jiangsu Province(No.BK20230006)+2 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20230977,BK20231090)the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.23KJB150020)the Jiangsu Excellent Postdoctoral Program(No.2022ZB758)。
文摘Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS quenching.To address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal complexes.As a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer Ir-TPE.This approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE groups.Ir-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light irradiation.Photoirradiated Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA damage.This damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer cells.The aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic effect.In vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor eradication.This study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.
基金supported by the National Research Foundation of Korea(NRF)under Grant RS-2022-NR-069955(2022R1A2C1092178).
文摘Previous research utilizing Cartoon Generative Adversarial Network(CartoonGAN)has encountered limitations in managing intricate outlines and accurately representing lighting effects,particularly in complex scenes requiring detailed shading and contrast.This paper presents a novel Enhanced Pixel Integration(EPI)technique designed to improve the visual quality of images generated by CartoonGAN.Rather than modifying the core model,the EPI approach employs post-processing adjustments that enhance images without significant computational overhead.In this method,images produced by CartoonGAN are converted from Red-Green-Blue(RGB)to Hue-Saturation-Value(HSV)format,allowing for precise adjustments in hue,saturation,and brightness,thereby improving color fidelity.Specific correction values are applied to fine-tune colors,ensuring they closely match the original input while maintaining the characteristic,stylized effect of CartoonGAN.The corrected images are blended with the originals to retain aesthetic appeal and visual distinctiveness,resulting in improved color accuracy and overall coherence.Experimental results demonstrate that EPI significantly increases similarity to original input images compared to the standard CartoonGAN model,achieving a 40.14%enhancement in visual similarity in Learned Perceptual Image Patch Similarity(LPIPS),a 30.21%improvement in structural consistency in Structural Similarity Index Measure(SSIM),and an 11.81%reduction in pixel-level error in Mean Squared Error(MSE).By addressing limitations present in the traditional CartoonGAN pipeline,EPI offers practical enhancements for creative applications,particularly within media and design fields where visual fidelity and artistic style preservation are critical.These improvements align with the goals of Fog and Edge Computing,which also seek to enhance processing efficiency and application performance in sensitive industries such as healthcare,logistics,and education.This research not only resolves key deficiencies in existing CartoonGAN models but also expands its potential applications in image-based content creation,bridging gaps between technical constraints and creative demands.Future studies may explore the adaptability of EPI across various datasets and artistic styles,potentially broadening its impact on visual transformation tasks.
基金supported by the following organizations:the Special Fund of Taishan Scholars Project(No.tsqn202211179)the National Natural Science Foundation of China(No.52105457)+2 种基金Young Talent of Lifting engineering for Science and Technology in Shandong,China(No.SDAST2021qt12)the National Natural Science Foundation of China(No.52375447)China Postdoctoral Science Foundation Funded Project(No.2023M732826).
文摘The use of Minimum Quantity Lubrication(MQL)with bio-lubricants has been extensively studied in aerospace sustainable manufacturing.Enhanced MQL technologies have been proposed to reduce tool wear and improve workpiece surface integrity by increasing lubricant activity.However,the relationship between enhancement behavior,physicochemical properties of biolubricants,and processability remains unclear,presenting challenges for MQL technologies,particularly with difficult-to-machine materials.To address this gap,this paper provides an in-depth mechanism analysis and a comprehensive quantitative evaluation of the machinability of enhanced MQL technologies,considering chemistry,molecular dynamics,fluid dynamics,tribology,and heat transfer.Firstly,the cooling and lubrication enhancement mechanisms of nano-lubricants were systematically summarized.focusing on molecular structure.physical properties,and preparation processes.Secondly,the atomization enhancement mechanism of Electrostatic Minimum Quantity Lubrication(EMQL)was analyzed.revealing a 49%reduction in PM2.5 concentration during the atomization process compared to conventional MQL.Thirdly,the transport and infiltration enhancement mechanisms of bio-lubricants in cutting and grinding zones were summarized,incorporating electromagnetic fields and ultrasound-assisted processes.Finally,for cutting and grinding applications involving difficult-to-machine materials in aerospace,the optimized machinability of enhanced MQL technologies was concluded,showing a 50.1%increase in lubricant heat transfer coefficient and a 31.6%decrease in grinding temperature compared to standard MQL.This paper aims to help scientists understand the effective mechanisms,formulate process specifications,and identify future development trends in this technology.
基金the fundings from National Key R&D Program of China (Grant No. 2022YFA1404002)National Natural Science Foundation of China (Grant Nos. T2495253, U20A20218, 61525504, and 61435011)+4 种基金Anhui Initiative in Quantum Information Technologies (Grant No. AHY020200)Major Science and Technology Projects in Anhui Province (Grant No. 202203a13010001)Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2018490)the fundings from Anhui Provincial Department of Education (Grant No. YQZD2024061)Research Program of Higher Education Institutions in Anhui Province (Grant No. 2024AH050645)。
文摘Developing microwave electric field sensing based on Rydberg atoms has received significant attention due to its unique advantages. However, achieving effective coupling between Rydberg atoms and the microwave electric field in the sensing process is a challenging problem that greatly impacts the sensitivity. To address this, we propose using a microwave resonant cavity to enhance the effective coupling between the Rydberg atoms and the microwave electric field. In our experiment, Rydberg atoms are prepared via a three-photon excitation scheme, and the electric fields are measured without and with a microwave cavity in which the vapor cell is placed inside, respectively. As a result, we achieved an 18 dB enhancement of power sensitivity by adding the cavity,which is an effective enhancement in electric field pulse signal detection. This experimental testing provides a promising direction for enhancing the sensitivity of Rydberg atomic electric field sensors and paves the way for their application in precision electric field measurements.
基金support for this work is received from the National Natural Science Foundation of China(Grant No.U22B20144).
文摘The potential of the vertical-horizontal well hybrid SAGD technique for developing shallow heavy oil reservoirs is gradually being realized.However,challenges remain in terms of low thermal efficiency and high carbon emissions in reservoirs with interlayers.Currently,there is limited research on the low-carbon strategy of coupling exhaust gas from steam boilers with the VH-SAGD technique.Herein,considering heterogeneity,a series of flue gas-assisted VH-SAGD experiments were conducted employing a high-performance 2D visualization model.The mechanism of enhanced recovery of flue gas in VH-SAGD and the effect of its injection methods were studied,with a focus on steam chamber development and oil saturation distribution.Crucially,the interlayer length was optimized to enhance oil recovery,providing a new perspective for well location design in heavy oil reservoirs with interlayers.The results showed that flue gas,as an additive,could fully exploit the well-type advantage of VH-SAGD.By supplementing energy at the reservoir top,flue gas effectively promoted steam chamber development,expanded the oil drainage area of VH-SAGD,and increased the oil recovery from 58.9%to 71.7%.The flow channels formed by pre-injection flue gas accelerated the early-stage expansion of the steam chamber while also inducing lateral migration of steam,slowing steam rise,and consequently increasing the heating range within the low-permeability layer.When the distance between the vertical and horizontal wells was set to twice the interlayer length,the negative effects of the interlayer were more effectively turned into advantages.Because when the lateral development distance of the steam chamber in the low-permeability layer slightly exceeds the interlayer,enhanced heating of the lower part of the reservoir occurred through vertical convection of rising steam and returning condensate.The research results contribute to reducing carbon emissions from steam-based heavy oil extraction while advancing the maturity of VH-SAGD.
文摘The electrokinetic(EK)process has been proposed for soil decontamination from heavy metals and organic matter.The advantages of the EK process include the low operating energy,suitability for fine-grained soil decontamination,and no need for excavation.During the last three decades,enhanced and hybrid EK systems were developed and tested for improving the efficiency of contaminants removal from soils.Chemically enhanced-EK processes exhibited excellent efficiency in removing contaminants by controlling the soil pH or the chemical reaction of contaminants.EK hybrid systems were tested to overcome environmental hurdles or technical drawbacks of decontamination technologies.Hybridization of the EK process with phytoremediation,bioremediation,or reactive filtermedia(RFM)improved the remediation process performance by capturing contaminants or facilitating biological agents’movement in the soil.Also,EK process coupling with solar energy was proposed to treat off-grid contaminated soils or reduce the EK energy requirements.This study reviews recent advancements in the enhancement and hybrid EK systems for soil remediation and the type of contaminants targeted by the process.The study also covered the impact of operating parameters,imperfect pollution separation,and differences in the physicochemical characteristics and microstructure of soil/sediment on the EK performance.Finally,a comparison between various remediation processes was presented to highlight the pros and cons of these technologies.
基金supported by National Key Research and Development Program of China(Nos.2021YFA1500400 and 2022YFA1503300)the National Natural Science Foundation of China(Nos.21825107,21971237,22171264 and 22301301)the Science Foundation of the Fujian Province(No.2021J02016)。
文摘Rare-earth supramolecular compounds,such as lanthanide organic polyhedrons(LOPs),are of particular interest due to their many possible applications in various fields.Here we report the first syntheses of Ln_(4)(L^(·+))_(4)-type(Ln,lanthanides;L^(·+),radical ligand)radical-bridged lanthanide organic tetrahedrons by self-assembly of face-capping triphenylamine(TPA)-cored radical ligand with different lanthanide ions.Remarkable coordination enhanced radical stability has been observed,with half-life times(t_(1/2))for L_(1)^(·+),La_(4)(L_(1)^(·+))_(4),Eu_(4)(L_(1)^(·+))_(4),Gd_(4)(L_(1)^(·+))_(4),Tb_(4)(L_(1)^(·+))_(4)and Lu_(4)(L_(1)^(·+))_(4)estimated to be 53 min,482 min,624 min,1248 min,822 min and 347 min,respectively.The TPA radical in Ln_(4)(L_(1)^(·+))_(4)containing paramagnetic Ln ions(Ln=Eu^(Ⅲ),Gd^(Ⅲ)and Tb^(Ⅲ))is observed to be more stable than that in Ln_(4)(L_(1)^(·+))_(4)(Ln=La^(Ⅲ)and Lu^(Ⅲ))constructed by diamagnetic Ln ions.This difference in radical stability is possibly due to the magnetic interactions between paramagnetic Ln^(Ⅲ)ions and L_(1)^(·+)ligands,as confirmed by electron paramagnetic resonance(EPR)in La_(4)(L)_(4)(L=L_(1)and L_(1)^(·+))and Tb_(4)(L)_(4)(L=L_(1)and L_(1)^(·+)),and magnetic susceptibility measurements in Tb·_(4)(L)_(4)(L=L_(1)and L_(1)^(·+)).Our study reveals the coordination of radical ligands with lanthanide ions can improve the radical stability,which is crucial for their applications.
基金supported by National Key Research and Development Program of China(No.2022YFA1206900)National Natural Science Foundation of China(Nos.22175083,82204415,51973241,22375224)GuangDong Basic and Applied Basic Research Foundation(No.2021A1515220187)。
文摘Ferroptosis is a newly proposed type of programmed cell death,which has been associated with a variety of diseases including tumors.Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy.However,the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors,poor active pharmaceutical ingredient(API)loading content and the systemic toxicity.Herein,self-propelled ferroptosis nanoinducers composed of two endogenous proteins,glucose oxidase and ferritin,are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility.The accumulation of our proteomotors at tumor regions is facilitated by the active tumor-targeting effect of ferritin.The enhanced diffusion of proteomotors is then actuated by efficiently decomposing glucose into gluconic acid and H_(2)O_(2),leading to deeper penetration and enhanced uptake into tumors.Under the synergistic effect of glucose oxidase and ferritin,the equilibrium between reactive oxygen species and GSH is damaged,leading to lipid peroxidation.As a result,by inducing ferroptosis,our self-propelled ferroptosis nanoinducers exhibit enhanced tumor inhibitory effects.This work paves a way for the construction of a biocompatible anticancer platform with enhanced diffusion utilizing only two endogenous proteins,centered around the concept of ferroptosis.
文摘Enhanced oil recovery(EOR)refers to themanymethodologies used to augment the volume of crude oil extracted froman oil reservoir.These approaches are used subsequent to the exhaustion of basic and secondary recovery methods.There are three primary categories of Enhanced Oil Recovery(EOR):thermal,gas injection,and chemical.Enhanced oil recovery methods may be costly and intricate;yet,they facilitate the extraction of supplementary oil that would otherwise remain in the reservoir.Enhanced Oil Recovery(EOR)may prolong the lifespan of an oil field and augment the total output from a specific field.The parameters influencing oil recovery are a significant problem in Enhanced Oil Recovery(EOR)systems,necessitating further examination of the components that impact them.This research examined the impact of permeability fluctuations on fluid dynamics inside a sandstone reservoir and presented a contemporary overview of the three phases of Enhanced Oil Recovery(EOR),including detailed explanations of the methodologies used and the processes facilitating oil recovery.The challenges faced with several common EOR mechanisms were identified,and solutions were suggested.Additionally,the modern trend of incorporating nanotechnology and its synergistic impacts on the stability and efficacy of conventional chemicals for enhanced oil recovery(EOR)was scrutinised and evaluated.Ultimately,laboratory results and field activities were examined.The study looked closely at hownanoparticlesmove through reservoirs and evaluated enhanced oil recovery(EOR),mobility ratio,and fluid displacement efficiency.This study offers comprehensive insights into the use of enhanced oil recovery techniques for sustainable energy generation.
基金Supported by the Project of Mianyang Central Hospital,School of Medicine,University of Electronic Science and Technology of China,No.2021YJ005the Science&Technology Department of Sichuan Province,China,No.2019YJ0701。
文摘BACKGROUND Enhanced recovery after surgery(ERAS)represents an innovative,protocoldriven perioperative care program designed to optimize patient outcomes.However,its application and efficacy in infants and children with Hirschsprung disease(HD)remain underexplored.AIM To delve into the impact of ERAS on perioperative recovery and the overall medical experience in HD infants and children.METHODS Thirty-eight infants and children with HD who received the Soave surgical procedure were enrolled in this case-control study.According to age-and sexstratified single-blind randomized tables,20 cases received ERAS treatment(ERAS group)and 18 cases received conventional treatment(control group).The two treatments were then compared in terms of perioperative recovery and medical experience.RESULTS Significant differences were observed in pain scores at awakening(4.2±1.3 vs 5.2±1.2,t=2.516,P=0.017)and pain duration(85.69±7.46 hours vs 67.00±8.56 hours,t=7.139,P<0.001)between the ERAS and control group.The recovery of bowel movement was earlier in the ERAS group than in the control group(borborygmus time:33.63±9.83 hours vs 44.69±16.85 hours,t=2.501,P=0.017;feeding time:36.63±9.55 hours vs 49.36±16.99 hours,t=2.884,P=0.007;anal catheter indwelling time:75.83±13.80 hours vs 93.36±20.65 hours,t=3.104,P=0.004),and fever duration(40.73±14.42 hours vs 52.63±18.69 hours,t=2.211,P=0.034).In the ERAS group,hospital stay was shorter(7.5±0.9 days vs 8.3±1.2 days)and the cost was lower(14203±2381 yuan vs 16847±3558 yuan).During the 1-month follow-up period,of the multiple postoperative complications observed,the occurrence of perianal dermatitis(PFisher=0.016)and defecation dysfunction(PFisher=0.027)were lower in the ERAS group than in the control group.CONCLUSION The ERAS protocol has the potential to profoundly enhance postoperative recovery and significantly elevate the overall comfort and quality of the medical experience,making it an indispensable approach that warrants widespread adoption.Continuous refinement through evidence-based practices is anticipated to further optimize its efficacy.
文摘BACKGROUND Enhanced recovery after surgery(ERAS)programs provide recommendations for an optimized management of patients undergoing surgery.An ERAS program tailored on surgery for retroperitoneal sarcomas(RPS)may improve patient outcomes and it has still not been established.AIM To determine how an ERAS program tailored to RPS surgery can be agreed upon,structured,and implemented.METHODS Twenty-five candidate items from existing ERAS programs,potentially relevant for RPS surgery,were identified via literature review and expert input.These were included in a questionnaire refined through cognitive interviews and pilot testing.Expert sarcoma surgeons rated each item’s relevance and feasibility on a 6-point scale.The survey was recirculated after one year.Intra-observer reproducibility,inter-observer concordance,and agreement with the modal value of the most experienced participants were analyzed.RESULTS Thirteen sarcoma surgeons from 6 centers participated in the survey.Although surgeons agreed on several items,their overall concordance was low.After recirculating the survey,the intraobserver reproducibility was low.Interestingly,the median concordance with the reference increased for relevance and decreased for feasibility.CONCLUSION Despite interest in ERAS for RPS,surgeon concordance on item relevance and feasibility remains low,underscoring the need for collaborative efforts toward a standardized,consensus-based protocol.
基金Supported by the Zhejiang Provincial Science and Technology Project for Traditional Chinese Medicine,No.2024ZL345.
文摘BACKGROUND Enhanced recovery after surgery(ERAS)protocols have emerged as a promising approach in perioperative care.This study evaluated ERAS's impact on gastrointestinal recovery and microbiota composition following laparoscopic gastric cancer surgery.AIM To evaluate the impact of ERAS protocols on postoperative gastrointestinal function recovery and intestinal microbiota composition in patients undergoing laparoscopic gastric cancer surgery,and to identify factors associated with improved clinical outcomes and microbial diversity preservation.METHODS We conducted a retrospective analysis of 80 patients who underwent laparoscopic D2 gastrectomy,comparing ERAS(n=40)vs traditional care(n=40).Primary outcomes included postoperative gastrointestinal function recovery and complications.Intestinal microbiota was analyzed using 16S rRNA sequencing at multiple timepoints perioperatively.RESULTS ERAS patients demonstrated faster recovery of bowel function,with earlier return of bowel sounds(16.25±6.41 hours vs 22.3±6.49 hours),first flatus(23.95±6.02 hours vs 28.45±7.12 hours),and defecation(34.95±9.34 hours vs 48.1±15.64 hours),all P<0.05.Complication rates,including antibiotic-associated diarrhea and surgical site infections,were comparable between groups.Microbial diversity indices and probiotic populations showed better preservation in the ERAS group postoperatively(P<0.05),though neither group achieved complete restoration to preoperative levels at one month.CONCLUSION These results support tailoring ERAS protocols to prioritize gut microbiome resilience through early feeding and shortened antibiotic courses,with particular benefits for younger patients.
基金supported by the General Program of the National Natural Science Foundation of China(52074335)the National Key Research and Development Program of China(2022YFE0129900 and 2019YFA0708700)+1 种基金the Fundamental Research Funds for the Central Universities(23CX07003A)the Special Funding Program for the Operational Expenses of National Research Institutions(SKLDOG2024-ZYRC-01).
文摘In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.
基金funded by Guangdong Province Scientific Research Project for Young Innovation Talent(Grant No.2022KQNCX239)The Pearl River Talent Recruitment Program(Grant No.2019CX01G338),Guangdong Province.
文摘An efficient determination of the geological characteristics and soil-rock type ahead of a tunnel face is critical for adjusting construction parameters during shield tunnelling.In general,operational engineers rely on visual observations of mucky soil types from belt conveyors.This results in shield halting and involves both time and cost implications.This paper proposes a deep learning approach designed to identify mucky soil by monitoring a video installed on the strut of a belt conveyer.The proposed approach comprises four steps:(1)image acquisition,(2)enhanced you-only-look-once(YOLO)modelling,(3)model performance evaluation,and(4)soil identification based on an optimal analysis.The enhanced YOLO model is a deep image detection algorithm.It was introduced by integrating two innovative strategies:data augmentation and imbalance learning.This enhancement accelerates the speed of image identification and improves the overall classification performance.A case study of shield tunnelling in the soil-rock mixed strata of the GuangzhoueFoshan intercity railway line was conducted to validate the proposed approach.The results indicate that the enhanced YOLO model achieves a classification performance comparable to that of the highly optimised AlexNet and GoogleNet.Additionally,the proposed approach more effectively detects the muck soil content than manual observation.This demonstrates its potential for real-time applications in shield tunnelling operations.
基金supported by National Natural Science Foundation of China through Grant Nos.52495000,52332012 and 52176093partially supported by Beijing Huiyangdao Health Technology Co.,Ltd。
文摘Bionic microfluidics is garnering increasing attention due to the superior fluidic performance enabled by biomimetic microstructures.Inspired by the unique structures of young pumpkin stems,we fabricate helicoidally patterned microchannels with precisely controlled morphologies using the projection micro-stereolithography(PμSL)-based 3D printing technique.Our helicoidally patterned microchannels achieve approximately twice the liquid lifting height compared to similarly sized smooth microchannels.This improvement is attributed to the enhanced capillary force.The additional meniscus formed between the helicoidally patterned microstructures significantly contributes to the increased capillary effects.Furthermore,the underlying mechanisms of fluidic performance in helicoidally patterned microchannels are theorized using a newly developed equation,which is also employed to optimize the geometric parameters and fluidic performance of the biomimetic helicoidal microchannels.Additionally,our biomimetic helicoidally patterned microchannels facilitate a significant step-lifting phenomenon,mimicking tall trees'transpiration.The fluidic performance of our biomimetic helicoidally patterned microchannels show promise for applications in enhanced liquid lifting,step-lifting,clean-water production,and others.
基金funded by the National Natural Science Foundation of China(Grant Nos.42107163 and 42320104003)support from the G.Albert Shoemaker endowment.
文摘Hydraulic fracturing then fluid circulation in enhanced geothermal system(EGS)reservoirs have been shown to induce seismicity remote from the stimulation-potentially generated by the distal projection of thermoporoelastic stresses.We explore this phenomenon by evaluating stress perturbations resulting from stimulation of a single stage of hydraulic fracturing that is followed by thermal depletion of a prismatic zone adjacent to the hydraulic fracture.We use Coulomb failure stress to assess the effect of resulting stress perturbations on instability on adjacent critically-stressed faults.Results show that hydraulic fracturing in a single stage is capable of creating stress perturbations at distances to 1000 m that reach 10^(-5)-10^(-4)MPa.At a closer distance,the magnitude of stress perturbations increases even further.The stress perturbation induced by temperature depletion could also reach 10^(-3)-10^(-2)MPa within 1000 m-much higher than that by hydraulic fracturing.Considering that a critical change in Coulomb failure stress for fault instability is 10^(-2)MPa,a single stage of hydraulic fracturing and thermal drawdown are capable of reactivating critically-stressed faults at distances within 200 m and 1000 m,respectively.These results have important implications for understanding the distribution and magnitudes of stress perturbations driven by thermoporoelastic effects and the associated seismicity during the simulation and early production of EGS reservoirs.
文摘BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptoms in such patients.AIM To evaluate the enhanced recovery after surgery(ERAS)-based evidence-based care(EBC)plus ice stimulation therapy for thirst management of convalescent patients following digestive surgery performed under general anesthesia.METHODS A total of 191 patients convalescing after digestive surgery performed under general anesthesia between March 2020 and February 2023 and experiencing thirst were selected.In total,89 patients and 102 patients in the control and research groups received routine care and ERAS-based EBC plus ice stimulation therapy,respectively.The following data were comparatively analyzed:(1)Thirst degree(thirst intensity numerical rating scale)and thirst distress(TD)degree(TD scale);(2)Oral mucosal wetness;(3)Unstimulated whole salivary flow rate(UWSFR);(4)Adverse reactions(palpitation,fatigue,chapped lips,and nausea and vomiting);and(5)Nursing satisfaction.RESULTS After nursing,thirst degree and distress were statistically lower in the research group than in the control group.Additionally,compared with the control group,the research group exhibited a lower degree of oral mucosal wetness,higher UWSFR,fewer adverse reactions,and more total nursing satisfaction.CONCLUSION ERAS-based EBC plus ice stimulation therapy can effectively alleviate thirst in convalescent patients recovering from a digestive surgery performed under general anesthesia.It can alleviate xerostomia symptoms,reduce adverse reactions,and improve patient comfort.
