Artificial intelligence(AI)is transforming protein engineering,offering powerful solutions for crop improvement and plant biotechnology.A notable example is AlphaFold3,which delivers highly accurate predictions of pla...Artificial intelligence(AI)is transforming protein engineering,offering powerful solutions for crop improvement and plant biotechnology.A notable example is AlphaFold3,which delivers highly accurate predictions of plant protein structures,making structural information broadly accessible to researchers who previously lacked experimental data(Li et al.,2025).By integrating structural insights into design strategies,AI-assisted protein engineering exploits protein plasticity—the ability of a protein’s structure and function to be reshaped through amino acid substitutions—accelerating molecular evolution and generating optimized variants(Li et al.,2025).展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Category B,XDB1090o00).
文摘Artificial intelligence(AI)is transforming protein engineering,offering powerful solutions for crop improvement and plant biotechnology.A notable example is AlphaFold3,which delivers highly accurate predictions of plant protein structures,making structural information broadly accessible to researchers who previously lacked experimental data(Li et al.,2025).By integrating structural insights into design strategies,AI-assisted protein engineering exploits protein plasticity—the ability of a protein’s structure and function to be reshaped through amino acid substitutions—accelerating molecular evolution and generating optimized variants(Li et al.,2025).
