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A Numerical Study of Fluid Velocity and Temperature Distribution in Regenerative Cooling Channels for Liquid Rocket Engines
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作者 Liang Yin Huanqi Zhang +1 位作者 Jie Ding Mehdi Khan 《Fluid Dynamics & Materials Processing》 2025年第8期1861-1873,共13页
In liquid rocket engines,regenerative cooling technology is essential for preserving structural integrity under extreme thermal loads.However,non-uniform coolant flow distribution within the cooling channels often lea... In liquid rocket engines,regenerative cooling technology is essential for preserving structural integrity under extreme thermal loads.However,non-uniform coolant flow distribution within the cooling channels often leads to localized overheating,posing serious risks to engine reliability and operational lifespan.This study employs a three-dimensional fluid–thermal coupled numerical model to systematically investigate the influence of geometric parameters-specifically the number of inlets,the number of channels,and inlet manifold configurations-on flow uniformity and thermal distribution in non-pyrolysis zones.Key findings reveal that increasing the number of inlets from one to three significantly enhances flow uniformity,reducing mass flow rate deviation from 1.2%to below 0.3%.However,further increasing the inlets to five yields only marginal improvements indicating diminishing(<0.1%),returns beyond three inlets.Additionally,temperature non-uniformity at the combustion chamber throat decreases by 37%-from 3050 K with 18 channels to 1915 K with 30 channels-highlighting the critical role of channel density in effective thermal regulation.Notably,while higher channel counts improve cooling efficiency,they also result in increased pressure losses of approximately 18%–22%,emphasizing the need to balance thermal performance against hydraulic resistance.An optimal configuration comprising 24 channels and three inlets was identified,providing minimal temperature gradients while maintaining acceptable pressure losses.The inlet manifold structure also plays a pivotal role in determining flow distribution.Configuration 3(Config-3),which features an enlarged manifold and reduced inlet velocity,achieves a 40%reduction in velocity fluctuations compared to Configuration 1(Config-1).This improvement leads to a more uniform mass flow distribution,with a relative standard deviation(RSD)of less than 0.15%.Furthermore,this design effectively mitigates localized hot spots near the nozzle-where temperature gradients are most severe-achieving a reduction of approximately 1135 K. 展开更多
关键词 regenerative cooling flow distribution thermal load geometric parameters liquid rocket engine
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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications 被引量:5
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作者 Shuai Liu Jiang-Ming Yu +11 位作者 Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou 《Military Medical Research》 SCIE CAS CSCD 2024年第1期50-79,共30页
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds bas... Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field. 展开更多
关键词 Biomimic SCAFFOLD BIOSYNTHESIS Natural biomaterial Tissue engineering
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Flow and heat transfer characteristics of regenerative cooling parallel channel
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作者 JU Yinchao LIU Xiaoyong +1 位作者 XU Guoqiang DONG Bensi 《推进技术》 北大核心 2025年第1期163-171,共9页
Due to the complex high-temperature characteristics of hydrocarbon fuel,the research on the long-term working process of parallel channel structure under variable working conditions,especially under high heat-mass rat... Due to the complex high-temperature characteristics of hydrocarbon fuel,the research on the long-term working process of parallel channel structure under variable working conditions,especially under high heat-mass ratio,has not been systematically carried out.In this paper,the heat transfer and flow characteristics of related high temperature fuels are studied by using typical engine parallel channel structure.Through numeri⁃cal simulation and systematic experimental verification,the flow and heat transfer characteristics of parallel chan⁃nels under typical working conditions are obtained,and the effectiveness of high-precision calculation method is preliminarily established.It is known that the stable time required for hot start of regenerative cooling engine is about 50 s,and the flow resistance of parallel channel structure first increases and then decreases with the in⁃crease of equivalence ratio(The following equivalence ratio is expressed byΦ),and there is a flow resistance peak in the range ofΦ=0.5~0.8.This is mainly caused by the coupling effect of high temperature physical proper⁃ties,flow rate and pressure of fuel in parallel channels.At the same time,the cooling and heat transfer character⁃istics of parallel channels under some conditions of high heat-mass ratio are obtained,and the main factors affect⁃ing the heat transfer of parallel channels such as improving surface roughness and strengthening heat transfer are mastered.In the experiment,whenΦis less than 0.9,the phenomenon of local heat transfer enhancement and deterioration can be obviously observed,and the temperature rise of local structures exceeds 200℃,which is the risk of structural damage.Therefore,the reliability of long-term parallel channel structure under the condition of high heat-mass ratio should be fully considered in structural design. 展开更多
关键词 regenerative cooling Heat transfer Flow resistance enginE Parallel channel
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Geographical Engineering and Its Role in Promoting Integrated Geography Research 被引量:1
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作者 LIU Yansui SU Sixin LI Xuhong 《Chinese Geographical Science》 2025年第1期1-23,共23页
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien... Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies. 展开更多
关键词 geographical engineering geographical science and engineering integrated geography research human-earth system Chinese geography
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Artificial Intelligence-Enhanced Digital Twin Systems Engineering Towards the Industrial Metaverse in the Era of Industry 5.0 被引量:3
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作者 He Zhang Yilin Li +2 位作者 Shuai Zhang Lukai Song Fei Tao 《Chinese Journal of Mechanical Engineering》 2025年第2期98-119,共22页
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu... With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE. 展开更多
关键词 Digital twins Systems engineering Industrial metaverse Artificial intelligence Industry 5.0 Smart manufacturing
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New Orientation of Interdisciplinarity in Medicine:Engineering Medicine 被引量:1
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作者 Jinhui Wu Ning Gu 《Engineering》 2025年第2期252-261,共10页
The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of con... The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences,clinical medicine,and public health.Nevertheless,the present phase of medical advancement encounters significant challenges,particularly in effectively translating basic research findings into practical applications in clinical and public health settings.Scientists increasingly collaborate with clinical experts to overcome these obstacles and address specific clinical issues by delving deeper into fundamental mechanisms.This collaborative effort has created a new interdisciplinary field:engineering medicine(EngMed),which focuses on addressing clinical and public health needs by integrating various scientific disciplines.This article discusses the definition,key tasks,significance,educational implications,and future trends in EngMed. 展开更多
关键词 engineering medicine Life sciences Interdisciplinary medicine Medical theranostics
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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion
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作者 Wei Ma Jiahao Yao +6 位作者 Fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao Zhen Zhou 《Green Energy & Environment》 SCIE EI CAS 2025年第1期109-131,共23页
Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the e... Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active sites.This optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of electrocatalysts.To elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization techniques.Importantly,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse reactions.This underscores the pivotal role of point defects in enhancing catalytic performance.At last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials. 展开更多
关键词 Point defect engineering DOPING VACANCY ELECTROCATALYSIS Electronic structure
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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application
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作者 Liang Chu Haoyu Shen +3 位作者 Hudie Wei Hongyu Chen Guoqiang Ma Wensheng Yan 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期498-503,共6页
Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 eV.Solvothermal reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,si... Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 eV.Solvothermal reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy implementation.Moreover,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room temperature.In this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single crystals.Finally,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors. 展开更多
关键词 morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector
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Integrating Main-Chain and Side-Chain Engineering in Polymers for Enhanced Photocatalytic Hydrogen Production
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作者 TIAN Changhao LIU Xueyan +4 位作者 YU Miaojie WU Yongzhen CHE Yu ZHANG Weiwei ZHU Weihong 《功能高分子学报》 北大核心 2025年第3期216-227,共12页
Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous s... Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous solutions,resulting in significant optical losses and exciton recombination.In this study,two series of six novel polymer photocatalysts(FLUSO,FLUSO-PEG10,FLUSO-PEG30;CPDTSO,CPDTSO-PEG10,CPDTSO-PEG30)are designed and synthesized by incorporating the hydrophilic,non-conjugated polyethylene glycol(PEG)chain,into both the main and side chains of polymers.By precisely optimizing the ratio of hydrophilic PEG segments,the water dispersibility is significantly improved while the light absorption capability of the polymer photocatalysts is well maintained.The experimental results confirm that the optimized FLUSO-PEG10 exhibits excellent photocatalytic hydrogen evolution rate,reaching up to 33.9 mmol/(g·h),which is nearly three times higher than that of fullyπ-conjugated counterparts.Water contact angles and particle size analyses reveal that incorporating non-conjugated segments into the main chains enhances the capacitance of the polymer/water interface and reduces particle aggregation,leading to improved photocatalyst dispersion and enhanced charge generation. 展开更多
关键词 organic semiconductor polymer photocatalyst main-chain engineering side-chain engineering photocatalytic hydrogen evolution
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Defect Engineering with Rational Dopants Modulation for High‑Temperature Energy Harvesting in Lead‑Free Piezoceramics
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作者 Kaibiao Xi Jianzhe Guo +2 位作者 Mupeng Zheng Mankang Zhu Yudong Hou 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期87-101,共15页
High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors.However,simultaneously excellent performances,inclu... High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors.However,simultaneously excellent performances,including high figure of merit(FOM),insulation resistivity(ρ)and depolarization temperature(Td)are indispensable but hard to achieve in lead-free piezoceramics,especially operating at 250°C has not been reported before.Herein,well-balanced performances are achieved in BiFeO3–BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese doping.Due to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization,regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole,comprehensive excellent electrical performances(Td=340°C,ρ250°C>10^(7)Ωcm and FOM_(250°C)=4905×10^(–15)m^(2)N^(−1))are realized at the solid solubility limit of manganese ions.The HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250°C with high energy conversion efficiency(η=11.43%).These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements,paving a new way in developing selfpowered wireless sensors working in HT environments. 展开更多
关键词 Lead-free piezoceramic Defect engineering Dopants modulation High-temperature Piezoelectric energy harvester
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Research progress of intelligent testing technology and evaluation methods for subgrade engineering 被引量:1
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作者 Guojun Cai Hongliang Tian +2 位作者 Lulu Liu Xiaoyan Liu Songyu Liu 《Journal of Road Engineering》 2025年第2期164-183,共20页
Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the su... Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the substantial pressures exerted by vehicles,trains,and other forms of transportation,but also efficiently transfer these loads to the underlying foundation,ensuring the stability and longevity of the roadway.In recent years,advancements in subgrade engineering technology have propelled the industry towards smarter,greener,and more sustainable practices,particularly in the areas of intelligent monitoring,disaster management,and innovative construction methods.This paper reviews the application and methodologies of intelligent testing equipment,including cone penetration testing(CPT)devices,soil resistivity testers,and intelligent rebound testers,in subgrade engineering.It examines the operating principles,advantages,limitations,and application ranges of these tools in subgrade testing.Additionally,the paper evaluates the practical use of advanced equipment from both domestic and international perspectives,addressing the challenges encountered by various instruments in realworld applications.These devices enable precise,comprehensive testing and evaluation of subgrade conditions at different stages,providing real-time data analysis and intelligent early warnings.This supports effective subgrade health management and maintenance.As intelligent technologies continue to evolve and integrate,these tools will increasingly enhance the accuracy,efficiency,and sustainability of subgrade monitoring. 展开更多
关键词 Subgrade engineering Intelligent testing technology Technology evaluation Health management and maintenance
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Smart Techniques Promoting Sustainability in Construction Engineering and Management 被引量:1
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作者 Song-Shun Lin Shui-Long Shen +1 位作者 Annan Zhou Xiang-Sheng Chen 《Engineering》 2025年第2期262-282,共21页
Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.T... Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted. 展开更多
关键词 Construction engineering and management Multi-criteria decision-making techniques Intelligent techniques Digital transformation SUSTAINABILITY
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Tissue Engineering and Spinal Cord Injury Repair
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作者 Lai Xu Songlin Zhou +2 位作者 Xiu Dai Xiaosong Gu Zhaolian Ouyang 《Engineering》 2025年第3期60-72,共13页
Tissue engineering and regenerative medicine is a new interdisciplinary subject integrating life science,material science,engineering technology,and clinical medicine.Over the last ten years,significant advancements h... Tissue engineering and regenerative medicine is a new interdisciplinary subject integrating life science,material science,engineering technology,and clinical medicine.Over the last ten years,significant advancements have been achieved in the study of biomaterials and tissue engineering.Progress in the field of tissue engineering and regenerative medicine can result in optimal tissue regeneration and effective functional reconstruction.Spinal cord injury(SCI)is the most severe complication of spinal trauma and frequently results in significant functional impairments in the lower extremities of the affected segment.Repair of SCI is a medical challenge worldwide.Advancements in tissue engineering theory and technology offer fresh opportunities for addressing SCI,as well as providing new strategies and methodologies to tackle the challenges associated with repairing and reconstructing spinal cord function.This article provides an overview of the latest developments in tissue engineering and SCI repair,focusing on biomaterials,cells,and active factors.It also introduces nine key components related to SCI and proposes innovative approaches for repairing and functionally reconstructing the injured spinal cord. 展开更多
关键词 Tissue engineering Spinal cord injury regenerative microenvironment
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Recent advances in interfacial engineering for high-efficiency perovskite photovoltaics 被引量:1
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作者 Zhijie Wang Cheng Gong +4 位作者 Cong Zhang Chenxu Zhao Tzu-Sen Su Haiyun Li Hong Zhang 《DeCarbon》 2025年第2期10-23,共14页
Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 2... Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 25%power conversion efficiency(PCE).However,as PCE continues to improve,interfacial issues within the devices have emerged as critical bottlenecks,hindering further performance enhancements.Recently,interfacial engineering has driven transformative progress,pushing PCEs to nearly 27%.Building upon these developments,this review first summarizes the pivotal role of interfacial modifications in elevating device performance and then,as a starting point,provides a comprehensive overview of recent advancements in normal,inverted,and tandem structure devices.Finally,based on the current progress of PSCs,preliminary perspectives on future directions are presented. 展开更多
关键词 Perovskite solar cells Interfacial engineering Defect passivation Energy level alignment Ion migration Device stability
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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?
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作者 Zhengqing Fan Ruimin Li +3 位作者 Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期135-159,共25页
Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage market.However,th... Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage market.However,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical applications.Defect engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for RMBs.In this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further presented.Then,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are discussed.The applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also summarized.Finally,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described. 展开更多
关键词 Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration
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The Interface of Gene Editing with Regenerative Medicine
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作者 Veronica E.Farag Elsie A.Devey Kam W.Leong 《Engineering》 2025年第3期73-100,共28页
The potential of regenerative medicine in the clinical space is vast,given its ability to repair and replace damaged tissues,restore lost functions due to age or disease,and transform personalized therapy.Traditional ... The potential of regenerative medicine in the clinical space is vast,given its ability to repair and replace damaged tissues,restore lost functions due to age or disease,and transform personalized therapy.Traditional regenerative medicine and tissue engineering strategies have created specialized tissues using progenitor cells and various biological stimuli.To date,there are many US Food and Drug Administration(FDA)-approved regenerative medicine therapies,such as those for wound healing and orthopedic injuries.Nonetheless,these therapies face challenges,including off-target effects,a lack of precision,and failure to target the disease or injury at its origin.In search of novel,precise,and efficient alternatives,the regenerative medicine landscape is shifting towards genome engineering technologies,particularly gene editing.Clustered regularly interspaced short palindromic repeats(CRISPR)-based gene editing systems enable precise knock-ins,knockouts,transcriptional activation and repression,as well as specific base conversions.This advancement has allowed researchers to treat genetic and degenerative diseases,control cell fate for highly regulated tissue repair,and enhance tissue functions.In this review,we explore the progress and future prospects of CRISPR technologies in regenerative medicine,focusing on how gene editing has led to advanced therapeutic applications and served as a versatile research tool for understanding tissue development and disease progression. 展开更多
关键词 CRISPR/Cas9 Tissue engineering regenerative medicine Gene editing Stem cell transplantation Disease models
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Variation of Membrane Electrode Assembly Catalyst Layer in Unitized Regenerative Fuel Cell
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作者 Yollanda Nurcholifah Dedi Rohendi +4 位作者 Edy Herianto Majlan Nirwan Syarif Addy Rachmat Dwi Hawa Yulianti Nyimas Febrika S 《电化学(中英文)》 北大核心 2025年第4期32-43,共12页
A unitized regenerative fuel cell(URFC)is a device that may function reversibly as either a fuel cell(FC)or water elec-trolysis(WE).An important component of this device is the Membrane electrode assembly(MEA).Therefo... A unitized regenerative fuel cell(URFC)is a device that may function reversibly as either a fuel cell(FC)or water elec-trolysis(WE).An important component of this device is the Membrane electrode assembly(MEA).Therefore,this study aimed to compare the performance outcomes of MEA using electrodes with single and three catalyst layers.This study measured Electrochemical Surface Area(ECSA),Electrochemical Impedance Spectroscopy(EIS),X-ray Diffraction analysis(XRD),and X-ray Fluorescence(XRF).Furthermore,the round-trip efficiency(RTE)of the MEA,as w ell as the performance in FC and WE mode,was measured.In comparison,The ECSA values of Pt-Ru/C and Pt/C with three catalyst layers were higher than the single catalyst layer.This result was supported by electrode characterization data for XRD and XRF.The respective electrical conductivity values of Pt-Ru/C and Pt/C with three catalyst layers are also higher than the single cata-lyst layer,and the performance of URFC using MEA with three catalyst layers has the highest value of RTE among the MEA performances of URFC,which is 100%at a current density of 4 mA·cm-2. 展开更多
关键词 Unitized regenerative fuel cell Round trip efficiency Pt-Ru/C Membrane electrode assembly Electrochemical surface area
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Innovations and Progress in Tissue Engineering Theory and Technology
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作者 Xiaosong Gu 《Engineering》 2025年第3期1-2,共2页
Tissue engineering and regenera-tive medicine have shown signifi-cant potential for repairing and regenerating damaged tissues and can be used to provide personalized treatment plans,with broad applica-tion prospects.... Tissue engineering and regenera-tive medicine have shown signifi-cant potential for repairing and regenerating damaged tissues and can be used to provide personalized treatment plans,with broad applica-tion prospects.In this special issue,Bin Li’s team outlines the latest advances in minimally invasive implantable biomaterials for bone regeneration and different methods of achieving osteogenesis,with a focus on bioceramics and polymer materials and their applications in bone healing,vertebral augmenta-tion,implant fixation,tumor treatment of bone,and treatment of infections related to bone defects.Xinquan Jiang’s team constructs a novel photo-responsive multifunctional polyetheretherketone(PEEK)-based implant material(sPEEK/BP/E7)through the self-assembly of black phosphorus(BP)nanoplatelets,bioinspired poly-dopamine(PDA),and the biologically active short peptide E7 on sPEEK.The material exhibits effective osteogenic effects and good sterilization performance,providing a new idea for clinical application. 展开更多
关键词 bone regeneration polymer materials repairing regenerating damaged tissues BIOCERAMICS minimally invasive implantable biomaterials regenerative medicine tissue engineering
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Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration 被引量:2
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作者 Shihong Zhu Xiaoyin Liu +7 位作者 Xiyue Lu Qiang Liao Huiyang Luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu Jing Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第10期2157-2174,共18页
Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. ... Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential. 展开更多
关键词 bioactive materials BIOMATERIALS EXOSOMES neural regeneration scaffolds stem cells tissue engineering traumatic brain injury
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Enhanced Piezoelectric Properties of (1-x)(0.8PZT-0.2PZN)-xBZT Ceramics via Phase Boundary and Domain Engineering
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作者 CHEN Xiangjie LI Ling +2 位作者 LEI Tianfu WANG Jiajia WANG Yaojin 《无机材料学报》 北大核心 2025年第6期729-734,共6页
Pb(Zr,Ti)O_(3)-Pb(Zn_(1/3)Nb_(2/3))O_(3) (PZT-PZN) based ceramics, as important piezoelectric materials, have a wide range of applications in fields such as sensors and actuators, thus the optimization of their piezoe... Pb(Zr,Ti)O_(3)-Pb(Zn_(1/3)Nb_(2/3))O_(3) (PZT-PZN) based ceramics, as important piezoelectric materials, have a wide range of applications in fields such as sensors and actuators, thus the optimization of their piezoelectric properties has been a hot research topic. This study investigated the effects of phase boundary engineering and domain engineering on (1-x)[0.8Pb(Zr_(0.5)Ti_(0.5))O_(3)-0.2Pb(Zn_(1/3)Nb_(2/3))O_(3)]-xBi(Zn_(0.5)Ti_(0.5))O_(3) ((1-x)(0.8PZT-0.2PZN)- xBZT) ceramic to obtain excellent piezoelectric properties. The crystal phase structure and microstructure of ceramic samples were characterized. The results showed that all samples had a pure perovskite structure, and the addition of BZT gradually increased the grain size. The addition of BZT caused a phase transition in ceramic samples from the morphotropic phase boundary (MPB) towards the tetragonal phase region, which is crucial for optimizing piezoelectric properties. By adjusting content of BZT and precisely controlling position of the phase boundary, the piezoelectric performance can be optimized. Domain structure is one of the key factors affecting piezoelectric performance. By using domain engineering techniques to optimize grain size and domain size, piezoelectric properties of ceramic samples have been significantly improved. Specifically, excellent piezoelectric properties (piezoelectric constant d_(33)=320 pC/N, electromechanical coupling factor kp=0.44) were obtained simultaneously for x=0.08. Based on experimental results and theoretical analysis, influence mechanisms of phase boundary engineering and domain engineering on piezoelectric properties were explored. The study shows that addition of BZT not only promotes grain growth, but also optimizes the domain structure, enabling the polarization reversal process easier, thereby improving piezoelectric properties. These research results not only provide new ideas for the design of high-performance piezoelectric ceramics, but also lay a theoretical foundation for development of related electronic devices. 展开更多
关键词 phase boundary 0.8PZT-0.2PZN domain engineering piezoelectric property
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