The utilization of pressure vessels in aerospace applications is manifold.In this work,fnite element analysis（FEA）has been carried out using ANSYS software package with 2D axisymmetric model to access the failure pr...The utilization of pressure vessels in aerospace applications is manifold.In this work,fnite element analysis（FEA）has been carried out using ANSYS software package with 2D axisymmetric model to access the failure pressure of cylindrical pressure vessel made of ASTM A36 carbon steel having weld-induced residual stresses.To fnd out the effect of residual stresses on failure pressure,frst an elasto-plastic analysis is performed to fnd out the failure pressure of pressure vessel not having residual stresses.Then a thermo-mechanical fnite element analysis is performed to assess the residual stresses developed in the pressure vessel during welding.Finally one more elasto-plastic analysis is performed to assess the effect of residual stresses on failure pressure of the pressure vessel having residual stresses.This analysis indicates reduction in the failure pressure due to unfavorable residual stresses.展开更多
Atherosclerosis(AS)is a chronic inflammatory condition influenced by glucose and lipid disorders,oxidative stress,and thrombosis,reflecting the complexity of its pathological process.The development of accurate experi...Atherosclerosis(AS)is a chronic inflammatory condition influenced by glucose and lipid disorders,oxidative stress,and thrombosis,reflecting the complexity of its pathological process.The development of accurate experimental models that simulate human AS is essential for understanding its initiation and progression.This review summarizes the current AS research models and analyzes their specific application scenarios.We discuss tissue-engineered blood vessels(TEBVs)and vessels-on-a-chip(VoCs),which leverage tissue engineering and precise microenvironmental control to construct in vitro models that closely resemble the structure and function of human AS.Isolated vessel segments from live animals provide a valuable tool for investigating human AS due to their physiological similarity,controllability,and reproducibility.The review further outlines the construction of AS animal models through high-fat diets and gene-editing techniques,highlighting how immune-inflammatory responses,mechanical arterial injury,and hemodynamic changes accelerate model development.This comprehensive analysis highlights the potential of AS models to revolutionize theranostic applications in clinical translational research,paving the way for more personalized and effective treatments for AS in the near future.展开更多
文摘The utilization of pressure vessels in aerospace applications is manifold.In this work,fnite element analysis（FEA）has been carried out using ANSYS software package with 2D axisymmetric model to access the failure pressure of cylindrical pressure vessel made of ASTM A36 carbon steel having weld-induced residual stresses.To fnd out the effect of residual stresses on failure pressure,frst an elasto-plastic analysis is performed to fnd out the failure pressure of pressure vessel not having residual stresses.Then a thermo-mechanical fnite element analysis is performed to assess the residual stresses developed in the pressure vessel during welding.Finally one more elasto-plastic analysis is performed to assess the effect of residual stresses on failure pressure of the pressure vessel having residual stresses.This analysis indicates reduction in the failure pressure due to unfavorable residual stresses.
基金supported by the National Key Research&Development Program of China(grant nos.2021YFA1201000 and 2023YFC2605000)National Natural Science Foundation of China(grant no.82302364)+6 种基金NSFC International Collaboration Key Project(grant no.51861135103)the support by the China Postdoctoral Science Foundation(grant no.2023M730589)the Chongqing Municipal High-Level Medical Talents Program for Young and Middle-Aged Professionals(grant no.YXGD202401-58)Program for Youth Innovation in Future Medicine,Chongqing Medical University(grant no.W170)Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University(grant nos.KRYC-GG-2213 and KRYC-YQ-2201)the Kuanren Talents Enhancement Program(grant no.2024krpy02)the Doctoral Supervisor Cultivation Program of the Second Affiliated Hospital of Chongqing Medical University.
文摘Atherosclerosis(AS)is a chronic inflammatory condition influenced by glucose and lipid disorders,oxidative stress,and thrombosis,reflecting the complexity of its pathological process.The development of accurate experimental models that simulate human AS is essential for understanding its initiation and progression.This review summarizes the current AS research models and analyzes their specific application scenarios.We discuss tissue-engineered blood vessels(TEBVs)and vessels-on-a-chip(VoCs),which leverage tissue engineering and precise microenvironmental control to construct in vitro models that closely resemble the structure and function of human AS.Isolated vessel segments from live animals provide a valuable tool for investigating human AS due to their physiological similarity,controllability,and reproducibility.The review further outlines the construction of AS animal models through high-fat diets and gene-editing techniques,highlighting how immune-inflammatory responses,mechanical arterial injury,and hemodynamic changes accelerate model development.This comprehensive analysis highlights the potential of AS models to revolutionize theranostic applications in clinical translational research,paving the way for more personalized and effective treatments for AS in the near future.
