Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of gly...Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of glycosylation,whereas xylosylation is relatively rare.Despite their unique chemical structures and beneficial activities,xylosylated natural products from microorganisms have received little attention.This review provides,for the first time,a comprehensive summary of 126 microbial-derived xylosylated natural products,including xylosyl-cyathane diterpenes,xylosylated triterpenes,xylosyl aromatic compounds,and others.Among these compounds,xylosyl-cyathane diterpenes represent the highest number of derivatives,followed by xylosylated triterpenes.Xylosyl compounds from bacterial sources have less defined structural profiles compared to those from fungi.The characterization of xylosyltransferase EriJ from Basidiomycota extended the structural diversity of xylosyl cyathane diterpenes.This work provides a valuable reference for the research and use of xylosyltransferase for drug discovery and synthetic chemistry.Further work is needed to explore the potential applications of microbial derived xylosyl compounds and to develop novel xylosyl transferases.With the deepening of genomic sequencing of medicinal fungi,more biosynthesis of bioactive xylosyl compounds is expected to be elucidated in the future.展开更多
The characteristics of a hybrid hydraulic vehicle driven by the hydraulic common rail propulsion system with a hydraulic free-piston engine and a hydraulic transformer were studied.A mathematical model of the propulsi...The characteristics of a hybrid hydraulic vehicle driven by the hydraulic common rail propulsion system with a hydraulic free-piston engine and a hydraulic transformer were studied.A mathematical model of the propulsion system was established and a control method of the propulsion system was proposed.Extensive simulation results of hybrid hydraulic vehicles with the hydraulic common rail propulsion system were presented.The hydraulic common rail propulsion system achieved the switch power control and the constant power propulsion.The control method based on the propulsion,break and speed limit requirement was verified.Our results showed that the hydraulic common rail propulsion system gained an ideal acceleration process.展开更多
We are thrilled to launch Med-X,a new international and high-quality open-access journal that publishes groundbreaking papers across the areas of biomedical engineering for the purpose of transforming modern medicine....We are thrilled to launch Med-X,a new international and high-quality open-access journal that publishes groundbreaking papers across the areas of biomedical engineering for the purpose of transforming modern medicine.Biomedical engineering applies principles of engineering to develop solutions for various health-related issues.It is the fastest-growing engineering discipline with unlimited potential and opportunities.Our journal aims to provide an interdisciplinary platform for communicating the latest important discoveries and innovations in basic and applied biomedical science and technology.We will accomplish this goal by publishing state-of-the-art research articles,rapid communications,case reports,reviews,perspectives,and commentaries.展开更多
While the global waste crisis is intensifying,we are missing a crucial opportunity to address this challenge by embracing a transformative approach:engineered microbial consortia have the potential to revolutionize in...While the global waste crisis is intensifying,we are missing a crucial opportunity to address this challenge by embracing a transformative approach:engineered microbial consortia have the potential to revolutionize industrial waste management,reduce greenhouse gas emissions for climate mitigation,and promote a sustainable bioeconomy.Greenhouse gas emissions(GHG)from industrial processes pose a notable threat to planetary health[1].The need for biotechnological solutions specifically targeting CO_(2) capture and recycling for bio-based compounds and energy production is clear but far from achieved[2].There are one trillion microorganisms with a pangenome covering an unspeakable potential of processes.Microbes could provide a solution to many of the challenges our planet is currently facing,such as restoring environmental health,substituting fossil fuels-originating chemicals and products with biomassoriginating ones,enabling regenerative agriculture,restoring eutrophic water recipients,reducing biodiversity losses,and mitigating pollution.展开更多
基金supported by the Key R&D Projects in Shaanxi Province of China(No.2023-YBSF-164)the National Natural Science Foundation of China(No.31800031 and No.32370069)+1 种基金the Fundamental Research Funds for the Central Universities(2572023AW40)the Natural Science Foundation of Heilongjiang Province of China(No.LH2023C035).
文摘Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of glycosylation,whereas xylosylation is relatively rare.Despite their unique chemical structures and beneficial activities,xylosylated natural products from microorganisms have received little attention.This review provides,for the first time,a comprehensive summary of 126 microbial-derived xylosylated natural products,including xylosyl-cyathane diterpenes,xylosylated triterpenes,xylosyl aromatic compounds,and others.Among these compounds,xylosyl-cyathane diterpenes represent the highest number of derivatives,followed by xylosylated triterpenes.Xylosyl compounds from bacterial sources have less defined structural profiles compared to those from fungi.The characterization of xylosyltransferase EriJ from Basidiomycota extended the structural diversity of xylosyl cyathane diterpenes.This work provides a valuable reference for the research and use of xylosyltransferase for drug discovery and synthetic chemistry.Further work is needed to explore the potential applications of microbial derived xylosyl compounds and to develop novel xylosyl transferases.With the deepening of genomic sequencing of medicinal fungi,more biosynthesis of bioactive xylosyl compounds is expected to be elucidated in the future.
基金Supported by the National Ministry Fundamental Research Foundation of China(A2220060053)
文摘The characteristics of a hybrid hydraulic vehicle driven by the hydraulic common rail propulsion system with a hydraulic free-piston engine and a hydraulic transformer were studied.A mathematical model of the propulsion system was established and a control method of the propulsion system was proposed.Extensive simulation results of hybrid hydraulic vehicles with the hydraulic common rail propulsion system were presented.The hydraulic common rail propulsion system achieved the switch power control and the constant power propulsion.The control method based on the propulsion,break and speed limit requirement was verified.Our results showed that the hydraulic common rail propulsion system gained an ideal acceleration process.
文摘We are thrilled to launch Med-X,a new international and high-quality open-access journal that publishes groundbreaking papers across the areas of biomedical engineering for the purpose of transforming modern medicine.Biomedical engineering applies principles of engineering to develop solutions for various health-related issues.It is the fastest-growing engineering discipline with unlimited potential and opportunities.Our journal aims to provide an interdisciplinary platform for communicating the latest important discoveries and innovations in basic and applied biomedical science and technology.We will accomplish this goal by publishing state-of-the-art research articles,rapid communications,case reports,reviews,perspectives,and commentaries.
基金I.A.was supported by the ERC-advanced grant 101098064 e ANAEROB。
文摘While the global waste crisis is intensifying,we are missing a crucial opportunity to address this challenge by embracing a transformative approach:engineered microbial consortia have the potential to revolutionize industrial waste management,reduce greenhouse gas emissions for climate mitigation,and promote a sustainable bioeconomy.Greenhouse gas emissions(GHG)from industrial processes pose a notable threat to planetary health[1].The need for biotechnological solutions specifically targeting CO_(2) capture and recycling for bio-based compounds and energy production is clear but far from achieved[2].There are one trillion microorganisms with a pangenome covering an unspeakable potential of processes.Microbes could provide a solution to many of the challenges our planet is currently facing,such as restoring environmental health,substituting fossil fuels-originating chemicals and products with biomassoriginating ones,enabling regenerative agriculture,restoring eutrophic water recipients,reducing biodiversity losses,and mitigating pollution.
