Replacing urethral tissue with functional scaffolds has been one of the challenging problems in the field of urethra reconstruction or repair over the last several decades. Various scaffold materials have been used in...Replacing urethral tissue with functional scaffolds has been one of the challenging problems in the field of urethra reconstruction or repair over the last several decades. Various scaffold materials have been used in animal studies, but clinical studies on use of scaffolds for urethral repair are scarce. The aim of this study was to review recent animal and clinical studies on the use of different scaffolds for urethral repair, and to evaluate these scaffolds based on the evidence from these studies. Pub Med and OVID databases were searched to identify relevant studies, in conjunction with further manual search. Studies that met the inclusion criteria were systematically evaluated. Of 555 identified studies, 38 were included for analysis. It was found that in both animal and clinical studies, scaffolds seeded with cells were used for repair of large segmental defects of the urethra, such as in tubular urethroplasty. When the defect area was small, cell-free scaffolds were more likely to be applied. A lot of pre-clinical and limited clinical evidence showed that natural or artificial materials could be used as scaffolds for urethral repair. Urinary tissue engineering is still in the immature stage, and the safety, efficacy, cost-effectiveness of the scaffolds are needed for further study.展开更多
In the stability study of the regional structures in the area of the Longyang Gorge Hydroelectrical Power Station, a model of the current stress-deformation field of the area was constructed based on analyses of avail...In the stability study of the regional structures in the area of the Longyang Gorge Hydroelectrical Power Station, a model of the current stress-deformation field of the area was constructed based on analyses of available data of regional surveys and historical earthquakes and field investigations of active faults and ancient earthquakes. This model was examined and verified by physical and mathematical simulation experiments, and quantitative relations and data were obtained.展开更多
The compression stroke characteristics of free-piston engine generator were studied. The numerical model of the compression stroke was established based on thermodynamics and dynamics equation,and the leak loss,heat l...The compression stroke characteristics of free-piston engine generator were studied. The numerical model of the compression stroke was established based on thermodynamics and dynamics equation,and the leak loss,heat loss and friction loss were considered. Through solving numerical equations,the in-cylinder pressure of compression stroke under different compression ratios was calculated,energy transfer and conversion process was analyzed,and the calculated results were experimentally verified. The results showed that the actual effective output of electronic energy and the compression energy stored in the com-pressed gas accounted for about 70%. The compression energy gradually increased with the increasing com-pression ratio. When the compression ratio was more than 7. 5,the actual compression energy increased slowly and the energy error between simulation and test decreased.展开更多
Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and...Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and environmental sciences,modern life sciences have entered the information-rich era,the era of the 4th paradigm.The creation of Chinese information engineering infrastructure for pan-omics studies(CIEIPOS) has been long overdue as part of national scientific infrastructure,in accelerating the further development of Chinese life sciences,and translating rich data into knowledge and medical applications.By gathering facts of current status of international and Chinese bioinformatics communities in collecting,managing and utilizing biological data,the essay stresses the significance and urgency to create a 'data hub' in CIEIPOS,discusses challenges and possible solutions to integrate,query and visualize these data.Another important component of CIEIPOS,which is not part of traditional biological data centers such as NCBI and EBI,is omics informatics.Mass spectroscopy platform was taken as an example to illustrate the complexity of omics informatics.Its heavy dependency on computational power is highlighted.The demand for such power in omics studies is argued as the fundamental function to meet for CIEIPOS.Implementation outlook of CIEIPOS in hardware and network is discussed.展开更多
Throughout the world, infrastructure to support cities is critical to support sustainable and responsible economic development. This can include new infrastructure projects in the case of growing areas. It can also in...Throughout the world, infrastructure to support cities is critical to support sustainable and responsible economic development. This can include new infrastructure projects in the case of growing areas. It can also include the renewal and upgrading of existing infrastructure in areas that have been inhabited and already developed. Infrastructure includes roads, bridges and transportation systems; power grids and energy service;internet and telecommunications; and water and sewer services. This development can be part of a system of systems, in which government, industries, and universities can contribute knowledge, skills, and abilities. This paper will investigate the strategic project management taken by one university to provide an academic experience that will prepare engineering students to address several of the Grand Engineering Challenges of the 21 st Century, as identified by the US National Academy of Engineering.The challenges relating to energy, water, information, and urban infrastructure can be approached using the functions of teaching, research, and service. By approaching the challenges strategically, resources of faculty time, student effort and laboratory facilities can be leveraged to achieve greater results. This case study will describe the efforts and results to date and identify opportunities for future growth.展开更多
Since the disastrous aftermath of the 2004 Sumatra Tsunami(Indonesia)and the 2011 Tohoku Tsunami(Japan),China has made much effort to mitigate tsunami hazards.We briefly reviewed the progress of cataloguing,modeling,e...Since the disastrous aftermath of the 2004 Sumatra Tsunami(Indonesia)and the 2011 Tohoku Tsunami(Japan),China has made much effort to mitigate tsunami hazards.We briefly reviewed the progress of cataloguing,modeling,early warning and hazard analysis for tsunamis in China.Compiling a Chinese tsunami catalogue is a challenge at present due to a large number of inconsistent research results.In China,the numerical models widely used in engineering and related studies are developed by other countries,and the development of a domestic model is being funded by the Chinese government.The tsunami early warning system has been set up and used during the recent tsunami events,such as the Chile earthquake on February 27,2010.展开更多
文摘Replacing urethral tissue with functional scaffolds has been one of the challenging problems in the field of urethra reconstruction or repair over the last several decades. Various scaffold materials have been used in animal studies, but clinical studies on use of scaffolds for urethral repair are scarce. The aim of this study was to review recent animal and clinical studies on the use of different scaffolds for urethral repair, and to evaluate these scaffolds based on the evidence from these studies. Pub Med and OVID databases were searched to identify relevant studies, in conjunction with further manual search. Studies that met the inclusion criteria were systematically evaluated. Of 555 identified studies, 38 were included for analysis. It was found that in both animal and clinical studies, scaffolds seeded with cells were used for repair of large segmental defects of the urethra, such as in tubular urethroplasty. When the defect area was small, cell-free scaffolds were more likely to be applied. A lot of pre-clinical and limited clinical evidence showed that natural or artificial materials could be used as scaffolds for urethral repair. Urinary tissue engineering is still in the immature stage, and the safety, efficacy, cost-effectiveness of the scaffolds are needed for further study.
文摘In the stability study of the regional structures in the area of the Longyang Gorge Hydroelectrical Power Station, a model of the current stress-deformation field of the area was constructed based on analyses of available data of regional surveys and historical earthquakes and field investigations of active faults and ancient earthquakes. This model was examined and verified by physical and mathematical simulation experiments, and quantitative relations and data were obtained.
基金Supported by the National Natural Science Foundation of China(51006010)the Program of Introducing Talents of Discipline to Universities(B12022)
文摘The compression stroke characteristics of free-piston engine generator were studied. The numerical model of the compression stroke was established based on thermodynamics and dynamics equation,and the leak loss,heat loss and friction loss were considered. Through solving numerical equations,the in-cylinder pressure of compression stroke under different compression ratios was calculated,energy transfer and conversion process was analyzed,and the calculated results were experimentally verified. The results showed that the actual effective output of electronic energy and the compression energy stored in the com-pressed gas accounted for about 70%. The compression energy gradually increased with the increasing com-pression ratio. When the compression ratio was more than 7. 5,the actual compression energy increased slowly and the energy error between simulation and test decreased.
基金financial support of Taicang government,Suzhou,China
文摘Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and environmental sciences,modern life sciences have entered the information-rich era,the era of the 4th paradigm.The creation of Chinese information engineering infrastructure for pan-omics studies(CIEIPOS) has been long overdue as part of national scientific infrastructure,in accelerating the further development of Chinese life sciences,and translating rich data into knowledge and medical applications.By gathering facts of current status of international and Chinese bioinformatics communities in collecting,managing and utilizing biological data,the essay stresses the significance and urgency to create a 'data hub' in CIEIPOS,discusses challenges and possible solutions to integrate,query and visualize these data.Another important component of CIEIPOS,which is not part of traditional biological data centers such as NCBI and EBI,is omics informatics.Mass spectroscopy platform was taken as an example to illustrate the complexity of omics informatics.Its heavy dependency on computational power is highlighted.The demand for such power in omics studies is argued as the fundamental function to meet for CIEIPOS.Implementation outlook of CIEIPOS in hardware and network is discussed.
文摘Throughout the world, infrastructure to support cities is critical to support sustainable and responsible economic development. This can include new infrastructure projects in the case of growing areas. It can also include the renewal and upgrading of existing infrastructure in areas that have been inhabited and already developed. Infrastructure includes roads, bridges and transportation systems; power grids and energy service;internet and telecommunications; and water and sewer services. This development can be part of a system of systems, in which government, industries, and universities can contribute knowledge, skills, and abilities. This paper will investigate the strategic project management taken by one university to provide an academic experience that will prepare engineering students to address several of the Grand Engineering Challenges of the 21 st Century, as identified by the US National Academy of Engineering.The challenges relating to energy, water, information, and urban infrastructure can be approached using the functions of teaching, research, and service. By approaching the challenges strategically, resources of faculty time, student effort and laboratory facilities can be leveraged to achieve greater results. This case study will describe the efforts and results to date and identify opportunities for future growth.
基金supported by the National Natural Science Fund No.51278473the Environmental Protection Research Fund for Public Interest No.201209040the northeast Asia(China-Japan-Korea)cooperative research project of earthquake,tsunami and volcano No.ZRH2014-11.
文摘Since the disastrous aftermath of the 2004 Sumatra Tsunami(Indonesia)and the 2011 Tohoku Tsunami(Japan),China has made much effort to mitigate tsunami hazards.We briefly reviewed the progress of cataloguing,modeling,early warning and hazard analysis for tsunamis in China.Compiling a Chinese tsunami catalogue is a challenge at present due to a large number of inconsistent research results.In China,the numerical models widely used in engineering and related studies are developed by other countries,and the development of a domestic model is being funded by the Chinese government.The tsunami early warning system has been set up and used during the recent tsunami events,such as the Chile earthquake on February 27,2010.
