Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceram...Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceramic fillers.Here,a host–vip inversion engineering strategy is proposed to develop superionic CSEs using cost-effective SiO_(2) nanoparticles as passive ceramic hosts and poly(vinylidene fluoride-hexafluoropropylene)(PVH)microspheres as polymer vips,forming an unprecedented“polymer vip-in-ceramic host”(i.e.,PVH-in-SiO_(2))architecture differing from the traditional“ceramic vip-in-polymer host”.The PVH-in-SiO_(2) exhibits excellent Li-salt dissociation,achieving high-concentration free Li+.Owing to the low diffusion energy barriers and high diffusion coefficient,the free Li+is thermodynamically and kinetically favorable to migrate to and transport at the SiO_(2)/PVH interfaces.Consequently,the PVH-in-SiO_(2) delivers an exceptional ionic conductivity of 1.32.10−3 S cm−1 at 25℃(vs.typically 10−5–10−4 S cm−1 using high-cost active ceramics),achieved under an ultralow residual solvent content of 2.9 wt%(vs.8–15 wt%in other CSEs).Additionally,PVH-in-SiO_(2) is electrochemically stable with Li anode and various cathodes.Therefore,the PVH-in-SiO_(2) demonstrates excellent high-rate cyclability in LiFePO4|Li full cells(92.9%capacity-retention at 3C after 300 cycles under 25℃)and outstanding stability with high-mass-loading LiFePO4(9.2 mg cm−1)and high-voltage NCM622(147.1 mAh g−1).Furthermore,we verify the versatility of the host–vip inversion engineering strategy by fabricating Na-ion and K-ion-based PVH-in-SiO_(2) CSEs with similarly excellent promotions in ionic conductivity.Our strategy offers a simple,low-cost approach to fabricating superionic CSEs for large-scale application of solid-state Li metal batteries and beyond.展开更多
Based on the theory and the practical experiences of linearity design of feasible design area and inverse solution of non linear outer characteristic of suspension shock absorber, in accordance with non linearity ou...Based on the theory and the practical experiences of linearity design of feasible design area and inverse solution of non linear outer characteristic of suspension shock absorber, in accordance with non linearity outer characteristic formed by open up damping coefficient, full open damping coefficient and smoothness to safety ratio of suspension shock absorber, a method and a research conclusion of the feasible design and inverse solution for the basic problems of designing and inverse solution of non linear outer characteristic of suspension damping components are provided.展开更多
This article primarily establishes a two-soliton system and employs the Lewis-Riesenfeld invariant inverse control method to achieve shortcuts to adiabaticity(STA)technology.We study an atomic soliton Josephson juncti...This article primarily establishes a two-soliton system and employs the Lewis-Riesenfeld invariant inverse control method to achieve shortcuts to adiabaticity(STA)technology.We study an atomic soliton Josephson junctions(SJJs)device and subsequently compare and analyze it with atomic bosonic Josephson junctions.Moreover,we use higher-order expressions of the auxiliary equations to optimize the results and weaken the detrimental effect of the sloshing amplitude.We find that in the adiabatic shortcut evolution of two systems with time-containing tunnelling rates,the SJJs system is more robust over a rather short time evolution.In comparison with linear ramping,the STA technique is easier to achieve with the precise modulation of the quantum state in the SJJs system.展开更多
Cardiovascular disease associated with hyperphosphatemia is a leading cause of mortality in patients with chronic kidney disease(CKD).Although treatments such as dialysis,phosphorus-restricted diets,and phosphate bind...Cardiovascular disease associated with hyperphosphatemia is a leading cause of mortality in patients with chronic kidney disease(CKD).Although treatments such as dialysis,phosphorus-restricted diets,and phosphate binders are available,these therapies can reduce the quality of life for CKD patients and are associated with side effects.Probiotics,particularly those that accumulate polyphosphate,have emerged as a promising alternative without harmful side effects.This study aimed to enhance the polyphosphate-accumulating ability of Lactiplantibacillus paraplantarum KCCM 11826P using inverse metabolic engineering.Random mutagenesis was performed,and fluorescence-activated cell sorting(FACS)was used to select strains with enhanced phosphate accumulation capacity.After resequencing,we identified that the selected L.paraplantarum SNUP7 strain,derived from KCCM 11826P,exhibited mutations in the tuf,dnaK,and groL genes,and it absorbed 76.01% more phosphorus in a phosphate-rich medium compared to the wild-type strain.In a CKD rat model administered L.paraplantarum SNUP7 probiotics(Nx+P),blood phosphorus levels decreased by 30.5% relative to the vehicle group(Nx+V).Additionally,kidney injury was significantly suppressed by 53.1%in the Nx+P group,whereas no such effect was observed in the Nx+V group.These findings indicate that L.paraplantarum SNUP7 functions as a biophosphate binder with therapeutic potential for alleviating CKD symptoms,improving patients’quality of life.As a novel probiotic strain with enhanced phosphate-binding capacity,L.paraplantarum SNUP7 offers a promising therapeutic approach for CKD-related complications.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.52250010 and 52201242)the 261 Project of MIIT,Natural Science Foundation of Jiangsu Province(No.BK20240179)the Young Elite Scientists Sponsorship Program by CAST(No.2021QNRC001).
文摘Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceramic fillers.Here,a host–vip inversion engineering strategy is proposed to develop superionic CSEs using cost-effective SiO_(2) nanoparticles as passive ceramic hosts and poly(vinylidene fluoride-hexafluoropropylene)(PVH)microspheres as polymer vips,forming an unprecedented“polymer vip-in-ceramic host”(i.e.,PVH-in-SiO_(2))architecture differing from the traditional“ceramic vip-in-polymer host”.The PVH-in-SiO_(2) exhibits excellent Li-salt dissociation,achieving high-concentration free Li+.Owing to the low diffusion energy barriers and high diffusion coefficient,the free Li+is thermodynamically and kinetically favorable to migrate to and transport at the SiO_(2)/PVH interfaces.Consequently,the PVH-in-SiO_(2) delivers an exceptional ionic conductivity of 1.32.10−3 S cm−1 at 25℃(vs.typically 10−5–10−4 S cm−1 using high-cost active ceramics),achieved under an ultralow residual solvent content of 2.9 wt%(vs.8–15 wt%in other CSEs).Additionally,PVH-in-SiO_(2) is electrochemically stable with Li anode and various cathodes.Therefore,the PVH-in-SiO_(2) demonstrates excellent high-rate cyclability in LiFePO4|Li full cells(92.9%capacity-retention at 3C after 300 cycles under 25℃)and outstanding stability with high-mass-loading LiFePO4(9.2 mg cm−1)and high-voltage NCM622(147.1 mAh g−1).Furthermore,we verify the versatility of the host–vip inversion engineering strategy by fabricating Na-ion and K-ion-based PVH-in-SiO_(2) CSEs with similarly excellent promotions in ionic conductivity.Our strategy offers a simple,low-cost approach to fabricating superionic CSEs for large-scale application of solid-state Li metal batteries and beyond.
文摘Based on the theory and the practical experiences of linearity design of feasible design area and inverse solution of non linear outer characteristic of suspension shock absorber, in accordance with non linearity outer characteristic formed by open up damping coefficient, full open damping coefficient and smoothness to safety ratio of suspension shock absorber, a method and a research conclusion of the feasible design and inverse solution for the basic problems of designing and inverse solution of non linear outer characteristic of suspension damping components are provided.
基金supported by the National Natural Science Foundation of China(Grant nos.12075145 and 12211540002)the Science and Technology Commission of Shanghai Municipal(Grant no.2019SHZDZX01-ZX04)。
文摘This article primarily establishes a two-soliton system and employs the Lewis-Riesenfeld invariant inverse control method to achieve shortcuts to adiabaticity(STA)technology.We study an atomic soliton Josephson junctions(SJJs)device and subsequently compare and analyze it with atomic bosonic Josephson junctions.Moreover,we use higher-order expressions of the auxiliary equations to optimize the results and weaken the detrimental effect of the sloshing amplitude.We find that in the adiabatic shortcut evolution of two systems with time-containing tunnelling rates,the SJJs system is more robust over a rather short time evolution.In comparison with linear ramping,the STA technique is easier to achieve with the precise modulation of the quantum state in the SJJs system.
基金supported by a National Research Foundation of Korea grant from the Korean Government(Ministry of Science and ICTMSIT)(NRF-2021R1F1A1058927)the Technology Innovation Program(or Industrial Strategic Technology Development Program)(20018683,Development of technology for manufacturing biomass-based cellulose fibers and commercializing edible coating)funded By the Ministry of Trade,Industry and Energy(MOTIE,Korea).
文摘Cardiovascular disease associated with hyperphosphatemia is a leading cause of mortality in patients with chronic kidney disease(CKD).Although treatments such as dialysis,phosphorus-restricted diets,and phosphate binders are available,these therapies can reduce the quality of life for CKD patients and are associated with side effects.Probiotics,particularly those that accumulate polyphosphate,have emerged as a promising alternative without harmful side effects.This study aimed to enhance the polyphosphate-accumulating ability of Lactiplantibacillus paraplantarum KCCM 11826P using inverse metabolic engineering.Random mutagenesis was performed,and fluorescence-activated cell sorting(FACS)was used to select strains with enhanced phosphate accumulation capacity.After resequencing,we identified that the selected L.paraplantarum SNUP7 strain,derived from KCCM 11826P,exhibited mutations in the tuf,dnaK,and groL genes,and it absorbed 76.01% more phosphorus in a phosphate-rich medium compared to the wild-type strain.In a CKD rat model administered L.paraplantarum SNUP7 probiotics(Nx+P),blood phosphorus levels decreased by 30.5% relative to the vehicle group(Nx+V).Additionally,kidney injury was significantly suppressed by 53.1%in the Nx+P group,whereas no such effect was observed in the Nx+V group.These findings indicate that L.paraplantarum SNUP7 functions as a biophosphate binder with therapeutic potential for alleviating CKD symptoms,improving patients’quality of life.As a novel probiotic strain with enhanced phosphate-binding capacity,L.paraplantarum SNUP7 offers a promising therapeutic approach for CKD-related complications.
