Novel applications of nanotechnology may lead to the release of engineered nanoparticles（ENPs）, which result in concerns over their potential environmental hazardous impact. It is essential for the research workers ...Novel applications of nanotechnology may lead to the release of engineered nanoparticles（ENPs）, which result in concerns over their potential environmental hazardous impact. It is essential for the research workers to be able to quantitatively characterise ENPs in the environment and subsequently to assist the risk assessment of the ENPs. This study hence explored the application of nanoparticle tracking system（NTA） to quantitatively describe the behaviour of the ENPs in natural sediment-water systems. The NTA allows the measurement of both particle number concentration（PNC） and particle size distribution（PSD） of the ENPs. The developed NTA method was applied to a range of gold and magnetite ENPs with a selection of surface properties. The results showed that the positively-charged ENPs interacted more strongly with the sediment than neutral and negatively-charged ENPs. It was also found that the citrate coated Au ENPs had a higher distribution percentage（53%） than 11-mercaptoundecanoic acid coated Au ENPs（20%） and citrate coated magnetite ENPs（21%）. The principles of the electrostatic interactions between hard（and soft） acids and bases（HSAB） are used to explain such behaviours; the hard base coating（i.e. citrate ions） will interact more strongly with hard acid（i.e. magnetite） than soft acid（i.e. gold）.The results indicate that NTA is a complementary method to existing approaches to characterise the fate and behaviour of ENPs in natural sediment.展开更多
Dissolved organic matter（DOM） is ubiquitous in the environment and has high reactivity.Once engineered nanoparticles（ENPs） are released into natural systems, interactions of DOM with ENPs may significantly affect ...Dissolved organic matter（DOM） is ubiquitous in the environment and has high reactivity.Once engineered nanoparticles（ENPs） are released into natural systems, interactions of DOM with ENPs may significantly affect the fate and transport of ENPs, as well as the bioavailability and toxicity of ENPs to organisms. However, because of the complexity of DOM and the shortage of useful characterization methods, large knowledge gaps exist in our understanding of the interactions between DOM and ENPs. In this article, we systematically reviewed the interactions between DOM and ENPs, discussed the effects of DOM on the environmental behavior of ENPs, and described the changes in bioavailability and toxicity of ENPs caused by DOM. Critical evaluations of published references suggest further need for assessing and predicting the influences of DOM on the transport,transformation, bioavailability, and toxicity of ENPs in the environment.展开更多
This review focuses on the occurrence and interactions of engineered nanoparticles(ENPs)and brominated flame retardants(BFRs)such as polybrominated diphenyl ethers(PBDEs)in water systems and the generation of highly c...This review focuses on the occurrence and interactions of engineered nanoparticles(ENPs)and brominated flame retardants(BFRs)such as polybrominated diphenyl ethers(PBDEs)in water systems and the generation of highly complex compounds in the environment.The release of ENPs and BFRs(e.g.PBDEs)to aquatic environments during their usage and disposal are summarised together with their key interaction mechanisms.The major interaction mechanisms including electrostatic,van derWaals,hydrophobic,molecular bridging and steric,hydrogen andπ-bonding,cation bridging and ligand exchange were identified.The presence of ENPs could influence the fate and behaviour of PBDEs through the interactions as well as induced reactions under certain conditions which increases the formation of complex compounds.The interaction leads to alteration of behaviour for PBDEs and their toxic effects to ecological receptors.The intermingled compound(ENPs-BFRs)would show different behaviour from the parental ENPs or BFRs,which are currently lack of investigation.This review provided insights on the interactions of ENPs and BFRs in artificial,environmental water systems and wastewater treatment plants(WWTPs),which are important for a comprehensive risk assessment.展开更多
Nanoparticles(NPs)play dual roles in neurodegeneration.Incidental NPs,generated unintentionally from environmental and industrial sources,are linked to oxidative stress,neuroinflammation,and disruption of the blood-br...Nanoparticles(NPs)play dual roles in neurodegeneration.Incidental NPs,generated unintentionally from environmental and industrial sources,are linked to oxidative stress,neuroinflammation,and disruption of the blood-brain barrier in Alzheimer’s disease(AD)and Parkinson’s disease(PD).Engineered NPs are designed for diagnosis and therapy using nanobodies,nanozymes,and other engineered nanoparticle(ENP)platforms that enable targeted delivery,modulation of neuroimmune pathways,and interference with pathological protein aggregation.This review aligns source-based classes(incidental versus engineered)with composition-based families(metal-based,carbon-based,and polymeric or inorganic),and summarizes routes of exposure,mechanistic toxicology,and engineered interventions relevant to AD and PD.We also evaluate current limitations,including biocompatibility,relevance to chronic exposure,and clinical benchmarking,and we outline priorities for translating nanotechnology into practical diagnostics and therapeutics for neurodegenerative disease.展开更多
The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant ...The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant cells persists.To address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface modification.This comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic effectiveness.Moreover,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic modalities.Finally,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.展开更多
Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous surroundings.Studies on the interaction and joint ...Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous surroundings.Studies on the interaction and joint toxicity of MPs on engineered nanoparticles(ENPs)are exhaustive,but limited research on the effect of MPs on the properties of ENPs in multisolute systems.Here,the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first time.The results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on ENPs.Aged polyamide prevented aggregation of ZnONPs by introducing negative charges,whereas virgin polyamide affected ZnONPs with the help of electrostatic attraction.FT-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and MPs.The results showed no chemical interaction and electrostatic interactionwas the dominant force between them.Furthermore,the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic strength.Our study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs,which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on biota.It also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.展开更多
Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increas...Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound repair.As a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy.Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair follicles.In addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix production.Additionally,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma repair.Through the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair.In conclusion,MSCderived EV-based therapies have important application prospects in wound repair.Here we provide a comprehensive overview of their current status,application potential,and associated drawbacks.展开更多
Engineered nanoparticles(ENPs)accumulate in marine sediments and exhibit adverse effects on benthic or-ganisms.However,the effect of ENPs on marine benthic food chains is largely unknown.Herein,we investigated the tro...Engineered nanoparticles(ENPs)accumulate in marine sediments and exhibit adverse effects on benthic or-ganisms.However,the effect of ENPs on marine benthic food chains is largely unknown.Herein,we investigated the trophic transfer and transformation of CeO_(2) ENPs within a simulated marine benthic food chain from clamworm(Perinereis aibuhitensis)to turbot(Scophthalmus maximus),as well as their effects on fish flesh quality.The results showed that Ce contents in turbot increased with the accumulation of CeO_(2) ENPs in clamworm,but no biomagnification of CeO_(2) ENPs occurred along this food chain.During trophic transfer,CeO_(2) ENPs in turbot experienced transformation from Ce(IV)to Ce(III).Importantly,CeO_(2) ENPs accumulated in the muscle of turbot and decreased the crude protein,total amino acid,and delicious amino acid contents,as well as the texture of the muscle.CeO_(2) ENPs induced the deterioration of flesh quality,which was mainly related to metabolism in muscle and intestinal disorders caused by oxidative stress.Specifically,CeO_(2) ENPs increased the relative abundance of Stenotrophomonas and Vibrio in the turbot intestine,while decreasing those of Lactobacillus,Bacillus,and Acine-tobacter.Significant disturbances in purine and amino acid(aspartate,glutamate,glycine,etc.)metabolism in muscle were induced by CeO_(2) ENPs.Moreover,correlation analysis showed that microbiota dysbiosis was highly correlated with muscle metabolic dysfunction.Our study provides insights into the transfer and transformation of CeO_(2) ENPs and their interference with fish flesh quality via the gut–muscle axis,providing useful information on assessing ecological risk and food safety in marine environments.展开更多
In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this na...In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this narrative,arguing that the toxicity of nanoplastics is fundamentally a subset of the well-established field of nanotoxicology.4 Through extensive data mining,machine learning,and molecular dynamics simulations,the authors demonstrate that nanoplastics and engineered nanoparticles(ENPs)share striking similarities in their physicochemical properties,environmental behaviors,biological interactions,and toxicity profiles.This revelation calls for a paradigm shift in how nanoplastics research is conducted,advocating for the integration of this field into the broader nanotoxicology framework to avoid redundant efforts and accelerate the development of sustainable solutions.展开更多
基金CEFIC LRI,Natural Science Foundation of Jiangsu Province(No.BK20130186)the Fundamental Research Funds for the Central Universities(No.2013QNA18)for funding this project
文摘Novel applications of nanotechnology may lead to the release of engineered nanoparticles（ENPs）, which result in concerns over their potential environmental hazardous impact. It is essential for the research workers to be able to quantitatively characterise ENPs in the environment and subsequently to assist the risk assessment of the ENPs. This study hence explored the application of nanoparticle tracking system（NTA） to quantitatively describe the behaviour of the ENPs in natural sediment-water systems. The NTA allows the measurement of both particle number concentration（PNC） and particle size distribution（PSD） of the ENPs. The developed NTA method was applied to a range of gold and magnetite ENPs with a selection of surface properties. The results showed that the positively-charged ENPs interacted more strongly with the sediment than neutral and negatively-charged ENPs. It was also found that the citrate coated Au ENPs had a higher distribution percentage（53%） than 11-mercaptoundecanoic acid coated Au ENPs（20%） and citrate coated magnetite ENPs（21%）. The principles of the electrostatic interactions between hard（and soft） acids and bases（HSAB） are used to explain such behaviours; the hard base coating（i.e. citrate ions） will interact more strongly with hard acid（i.e. magnetite） than soft acid（i.e. gold）.The results indicate that NTA is a complementary method to existing approaches to characterise the fate and behaviour of ENPs in natural sediment.
基金supported by the National Key Research and Development Program of China (2016YFA0203102)the National Natural Science Foundation of China (Nos. 21227012, 21337004, 21507147)
文摘Dissolved organic matter（DOM） is ubiquitous in the environment and has high reactivity.Once engineered nanoparticles（ENPs） are released into natural systems, interactions of DOM with ENPs may significantly affect the fate and transport of ENPs, as well as the bioavailability and toxicity of ENPs to organisms. However, because of the complexity of DOM and the shortage of useful characterization methods, large knowledge gaps exist in our understanding of the interactions between DOM and ENPs. In this article, we systematically reviewed the interactions between DOM and ENPs, discussed the effects of DOM on the environmental behavior of ENPs, and described the changes in bioavailability and toxicity of ENPs caused by DOM. Critical evaluations of published references suggest further need for assessing and predicting the influences of DOM on the transport,transformation, bioavailability, and toxicity of ENPs in the environment.
文摘This review focuses on the occurrence and interactions of engineered nanoparticles(ENPs)and brominated flame retardants(BFRs)such as polybrominated diphenyl ethers(PBDEs)in water systems and the generation of highly complex compounds in the environment.The release of ENPs and BFRs(e.g.PBDEs)to aquatic environments during their usage and disposal are summarised together with their key interaction mechanisms.The major interaction mechanisms including electrostatic,van derWaals,hydrophobic,molecular bridging and steric,hydrogen andπ-bonding,cation bridging and ligand exchange were identified.The presence of ENPs could influence the fate and behaviour of PBDEs through the interactions as well as induced reactions under certain conditions which increases the formation of complex compounds.The interaction leads to alteration of behaviour for PBDEs and their toxic effects to ecological receptors.The intermingled compound(ENPs-BFRs)would show different behaviour from the parental ENPs or BFRs,which are currently lack of investigation.This review provided insights on the interactions of ENPs and BFRs in artificial,environmental water systems and wastewater treatment plants(WWTPs),which are important for a comprehensive risk assessment.
基金the joint participation by the Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with The Johns Hopkins Hospital and the Johns Hopkins University School of Medicine and the Foundation’s Parkinson’s Disease Program M-2023.This work was supported by the NIH AG079487(X.B.M.)the Adrienne Helis Malvin Medical Research Foundation(X.B.M.)+2 种基金the Parkinson’s Foundation(No.PF-JFA-1933)the Maryland Stem Cell Research Foundation(Nos.2019-MSCRFD-4292 and 2024-MSCRFD-6394)the American Parkinson’s Disease Association(X.B.M.).
文摘Nanoparticles(NPs)play dual roles in neurodegeneration.Incidental NPs,generated unintentionally from environmental and industrial sources,are linked to oxidative stress,neuroinflammation,and disruption of the blood-brain barrier in Alzheimer’s disease(AD)and Parkinson’s disease(PD).Engineered NPs are designed for diagnosis and therapy using nanobodies,nanozymes,and other engineered nanoparticle(ENP)platforms that enable targeted delivery,modulation of neuroimmune pathways,and interference with pathological protein aggregation.This review aligns source-based classes(incidental versus engineered)with composition-based families(metal-based,carbon-based,and polymeric or inorganic),and summarizes routes of exposure,mechanistic toxicology,and engineered interventions relevant to AD and PD.We also evaluate current limitations,including biocompatibility,relevance to chronic exposure,and clinical benchmarking,and we outline priorities for translating nanotechnology into practical diagnostics and therapeutics for neurodegenerative disease.
基金supported by grants from Karolinska Institute Network Medicine Global Alliance Collaborative Grant(C24401073,Sweden)China Postdoctoral Science Foundation(2021M703602)Natural Science Foundation of Liaoning Province(2022-BS-137,China).
文摘The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant cells persists.To address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface modification.This comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic effectiveness.Moreover,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic modalities.Finally,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.
基金supported by the National Youth Foundation of China(No.52000064)the National Natural Science Foundation of China(No.U20A20323)+5 种基金the Natural Science Foundation of Hunan Province(No.2023JJ0013)the Special Funding for the Construction of Hunan’s Innovative Province(No.2021SK2040)the Science and Technology Innovation Program of Hunan Province(No.2021RC3133)the National Youth Foundation of China(No.52300227)the HunanMunicipal Natural Science Foundation(No.2023JJ41048)the Changsha Municipal Natural Science Foundation(No.kq2208423).
文摘Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous surroundings.Studies on the interaction and joint toxicity of MPs on engineered nanoparticles(ENPs)are exhaustive,but limited research on the effect of MPs on the properties of ENPs in multisolute systems.Here,the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first time.The results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on ENPs.Aged polyamide prevented aggregation of ZnONPs by introducing negative charges,whereas virgin polyamide affected ZnONPs with the help of electrostatic attraction.FT-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and MPs.The results showed no chemical interaction and electrostatic interactionwas the dominant force between them.Furthermore,the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic strength.Our study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs,which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on biota.It also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.
基金supported by the National Key Research and Development Project Intergovernmental Cooperation in Science and Technology of China(2018YFE0126900)the Key R&D Program of Lishui City(2021ZDYF12)the National Natural Science Foundation of China(82271629)。
文摘Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound repair.As a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy.Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair follicles.In addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix production.Additionally,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma repair.Through the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair.In conclusion,MSCderived EV-based therapies have important application prospects in wound repair.Here we provide a comprehensive overview of their current status,application potential,and associated drawbacks.
基金supported by National Natural Science Foundation of China(42192572,42525705,32101245)the Postdoctoral Research Foundation of China(2020M680902).
文摘Engineered nanoparticles(ENPs)accumulate in marine sediments and exhibit adverse effects on benthic or-ganisms.However,the effect of ENPs on marine benthic food chains is largely unknown.Herein,we investigated the trophic transfer and transformation of CeO_(2) ENPs within a simulated marine benthic food chain from clamworm(Perinereis aibuhitensis)to turbot(Scophthalmus maximus),as well as their effects on fish flesh quality.The results showed that Ce contents in turbot increased with the accumulation of CeO_(2) ENPs in clamworm,but no biomagnification of CeO_(2) ENPs occurred along this food chain.During trophic transfer,CeO_(2) ENPs in turbot experienced transformation from Ce(IV)to Ce(III).Importantly,CeO_(2) ENPs accumulated in the muscle of turbot and decreased the crude protein,total amino acid,and delicious amino acid contents,as well as the texture of the muscle.CeO_(2) ENPs induced the deterioration of flesh quality,which was mainly related to metabolism in muscle and intestinal disorders caused by oxidative stress.Specifically,CeO_(2) ENPs increased the relative abundance of Stenotrophomonas and Vibrio in the turbot intestine,while decreasing those of Lactobacillus,Bacillus,and Acine-tobacter.Significant disturbances in purine and amino acid(aspartate,glutamate,glycine,etc.)metabolism in muscle were induced by CeO_(2) ENPs.Moreover,correlation analysis showed that microbiota dysbiosis was highly correlated with muscle metabolic dysfunction.Our study provides insights into the transfer and transformation of CeO_(2) ENPs and their interference with fish flesh quality via the gut–muscle axis,providing useful information on assessing ecological risk and food safety in marine environments.
基金supported by the National Natural Science Foundation of China(Grants 22241604 and 22125606).
文摘In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this narrative,arguing that the toxicity of nanoplastics is fundamentally a subset of the well-established field of nanotoxicology.4 Through extensive data mining,machine learning,and molecular dynamics simulations,the authors demonstrate that nanoplastics and engineered nanoparticles(ENPs)share striking similarities in their physicochemical properties,environmental behaviors,biological interactions,and toxicity profiles.This revelation calls for a paradigm shift in how nanoplastics research is conducted,advocating for the integration of this field into the broader nanotoxicology framework to avoid redundant efforts and accelerate the development of sustainable solutions.
