Growing health awareness triggers the public's concern about health problems. People want a timely and comprehensive picture of their condition without frequent trips to the hospital for costly and cumbersome gene...Growing health awareness triggers the public's concern about health problems. People want a timely and comprehensive picture of their condition without frequent trips to the hospital for costly and cumbersome general check-ups. The wearable technique provides a continuous measurement method for health monitoring by tracking a person's physiological data and analyzing it locally or remotely.During the health monitoring process,different kinds of sensors convert physiological signals into electrical or optical signals that can be recorded and transmitted, consequently playing a crucial role in wearable techniques. Wearable application scenarios usually require sensors to possess excellent flexibility and stretchability. Thus, designing flexible and stretchable sensors with reliable performance is the key to wearable technology. Smart composite hydrogels, which have tunable electrical properties, mechanical properties, biocompatibility, and multi-stimulus sensitivity, are one of the best sensitive materials for wearable health monitoring. This review summarizes the common synthetic and performance optimization strategies of smart composite hydrogels and focuses on the current application of smart composite hydrogels in the field of wearable health monitoring.展开更多
Spinal cord injury（SCI）frequently results in the permanent loss of function below the level of injury due to the failure of axonal regeneration in the adult mammalian central nervous system（CNS）.The limited intrin...Spinal cord injury（SCI）frequently results in the permanent loss of function below the level of injury due to the failure of axonal regeneration in the adult mammalian central nervous system（CNS）.The limited intrinsic growth capacity of adult neurons,a lack of growth-promoting factors and the multifactorial inhibitory microenvironment around the lesion site contribute to the lack of axonalregeneration. Strategies such as transplantation of cells,展开更多
Chronic osteomyelitis caused by implant infections is a common complication following orthopedic surgery.Preventing bacterial infection and simultaneously improving bone regeneration are the key for osteomyelitis.Curr...Chronic osteomyelitis caused by implant infections is a common complication following orthopedic surgery.Preventing bacterial infection and simultaneously improving bone regeneration are the key for osteomyelitis.Current treatments include systemic antibiotics and multiple surgical interventions,but the strategies available for treatment are limited.In this study,a multifunctional engineered Bacillus subtilis(B.sub)hydrogel with sulfasalazine(SSZ)is developed to treat methicillin-resistant Staphylococcus aureus(MRSA)infection and antiinflammatory and promote bone regeneration.B.sub in alginate hydrogels protects B.sub from being cleared by the host immune system while allowing the release of its bioactive substances,including antibacterial peptides and anti-inflammatory agents such as SSZ.The results show that the engineered probiotic hydrogels exhibit excellent antibacterial efficacy against MRSA(97%)and prevent the development of bacterial resistance.The antibacterial effect is primarily mediated through the secretion of bioactive peptides by B.sub,which not only inhibit MRSA growth but also reduce the likelihood of resistance development.Meanwhile,the probiotic hydrogel has a greater ability to induce M2 polarization of macrophages and promote angiogenesis,resulting in enhanced osteogenic differentiation in bone marrow mesenchymal stem cells(BMSCs)and thus enhancing bone regeneration.This engineered probiotic hydrogel offers a promising strategy by simultaneously combating bacterial infection and enhancing osteogenic differentiation for chronic osteomyelitis.展开更多
Background Olfactory ensheathing cell （OEC） transplantation is a promising or potential therapy for spinal cord injury （SCI）. However, the effects of injecting OECs directly into SCI site have been limited and uns...Background Olfactory ensheathing cell （OEC） transplantation is a promising or potential therapy for spinal cord injury （SCI）. However, the effects of injecting OECs directly into SCI site have been limited and unsatisfied due to the complexity of SCI. To improve the outcome, proper biomaterials are thought to be helpful since these materials would allow the cells to grow three-dimensionally and guide cell miqration.展开更多
基金financial support from the National Natural Science Foundation of China (No. 61801525)the Guangdong Basic and Applied Basic Research Foundation (Nos. 2020A1515010693, 2021A1515110269)+1 种基金the Fundamental Research Funds for the Central Universities, Sun Yatsen University (No. 22lgqb17)the Independent Fund of the State Key Laboratory of Optoelectronic Materials and Technologies (Sun Yat-sen University) under grant No. OEMT-2022-ZRC-05。
文摘Growing health awareness triggers the public's concern about health problems. People want a timely and comprehensive picture of their condition without frequent trips to the hospital for costly and cumbersome general check-ups. The wearable technique provides a continuous measurement method for health monitoring by tracking a person's physiological data and analyzing it locally or remotely.During the health monitoring process,different kinds of sensors convert physiological signals into electrical or optical signals that can be recorded and transmitted, consequently playing a crucial role in wearable techniques. Wearable application scenarios usually require sensors to possess excellent flexibility and stretchability. Thus, designing flexible and stretchable sensors with reliable performance is the key to wearable technology. Smart composite hydrogels, which have tunable electrical properties, mechanical properties, biocompatibility, and multi-stimulus sensitivity, are one of the best sensitive materials for wearable health monitoring. This review summarizes the common synthetic and performance optimization strategies of smart composite hydrogels and focuses on the current application of smart composite hydrogels in the field of wearable health monitoring.
基金Supported by grants from the Deutsche Forschungsgemeinschaft(BL414/3-1)International Foundation for Research in Paraplegia+2 种基金the Indiana University Health-Indiana University School of Medicine Strategic Research InitiativeIndiana Spinal Cord and Brain Injury Research FundMorton Cure Paralysis Fund to AB and a Heinz Gotze Memorial Fellowship to SL
文摘Spinal cord injury（SCI）frequently results in the permanent loss of function below the level of injury due to the failure of axonal regeneration in the adult mammalian central nervous system（CNS）.The limited intrinsic growth capacity of adult neurons,a lack of growth-promoting factors and the multifactorial inhibitory microenvironment around the lesion site contribute to the lack of axonalregeneration. Strategies such as transplantation of cells,
文摘Chronic osteomyelitis caused by implant infections is a common complication following orthopedic surgery.Preventing bacterial infection and simultaneously improving bone regeneration are the key for osteomyelitis.Current treatments include systemic antibiotics and multiple surgical interventions,but the strategies available for treatment are limited.In this study,a multifunctional engineered Bacillus subtilis(B.sub)hydrogel with sulfasalazine(SSZ)is developed to treat methicillin-resistant Staphylococcus aureus(MRSA)infection and antiinflammatory and promote bone regeneration.B.sub in alginate hydrogels protects B.sub from being cleared by the host immune system while allowing the release of its bioactive substances,including antibacterial peptides and anti-inflammatory agents such as SSZ.The results show that the engineered probiotic hydrogels exhibit excellent antibacterial efficacy against MRSA(97%)and prevent the development of bacterial resistance.The antibacterial effect is primarily mediated through the secretion of bioactive peptides by B.sub,which not only inhibit MRSA growth but also reduce the likelihood of resistance development.Meanwhile,the probiotic hydrogel has a greater ability to induce M2 polarization of macrophages and promote angiogenesis,resulting in enhanced osteogenic differentiation in bone marrow mesenchymal stem cells(BMSCs)and thus enhancing bone regeneration.This engineered probiotic hydrogel offers a promising strategy by simultaneously combating bacterial infection and enhancing osteogenic differentiation for chronic osteomyelitis.
文摘Background Olfactory ensheathing cell （OEC） transplantation is a promising or potential therapy for spinal cord injury （SCI）. However, the effects of injecting OECs directly into SCI site have been limited and unsatisfied due to the complexity of SCI. To improve the outcome, proper biomaterials are thought to be helpful since these materials would allow the cells to grow three-dimensionally and guide cell miqration.
