Engineering benefits humanity,and technology creates the future.On October 13,2025,the Global Top Ten Engineering Achievements 2025,selected by the Chinese Academy of Engineering’s flagship journal Engineering,were o...Engineering benefits humanity,and technology creates the future.On October 13,2025,the Global Top Ten Engineering Achievements 2025,selected by the Chinese Academy of Engineering’s flagship journal Engineering,were officially released at the World Federation of Engineering Organizations 2025 General Assembly,jointly organized by the World Federation of Engineering Organizations,China Association for Science and Technology,Chinese Academy of Engineering,and Shanghai Municipal People’s Government.展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by t...High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by the alloy interface structures.Despite substantial efforts,a comprehensive overview of interface engineering of high-performance alloys has not been presented so far.In this study,the interfaces in high-performance alloys,particularly grain and phase boundaries,were systematically examined,with emphasis on their crystallographic characteristics and chemical element segregations.The effects of the interfaces on the electrical conductivity,mechanical strength,toughness,hydrogen embrittlement resistance,and thermal stability of the alloys were elucidated.Moreover,correlations among various types of interfaces and advanced experimental and computational techniques were examined using big data analytics,enabling robust design strategies.Challenges currently faced in the field of interface engineering and emerging opportunities in the field are also discussed.The study results would guide the development of next-generation high-performance alloys.展开更多
Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmolo...Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmology,Capital Medical University Director,National Engineering Research Center for Ophthalmic Diagnosis and Treatment National Distinguished Physician Member,Academic Advisory Committee.展开更多
Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu...Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.展开更多
Aims and scope Being an international journal,China Ocean Engineering(COE)takes its prime function as the integration of new research concepts,equipment,technology,materials and structures and other scientific advance...Aims and scope Being an international journal,China Ocean Engineering(COE)takes its prime function as the integration of new research concepts,equipment,technology,materials and structures and other scientific advances within the field of estuarial,coastal,offshore,and deepwater engineering with particular reference to developments.The Journal is concerned with all engineering aspects involved in the exploration and utilization of ocean resources.Topics regularly covered include research,design and construction of structures(including wharfs,dikes,breakwaters,platforms,mooring systems,etc.),instrumentation/testing(physical model and numerical model),wave dynamics,sedimentation,structural/stress analysis,soil mechanics,and material research.展开更多
Journal Introduction"International Journal of Plant Engineering and Management"is in the charge of Ministry of Industry and Information Technology of the People's Republic of China,and organized by North...Journal Introduction"International Journal of Plant Engineering and Management"is in the charge of Ministry of Industry and Information Technology of the People's Republic of China,and organized by Northwestern Polytechnical University.It is a kind of English academic quarterly publication publicly issued at home and abroad.Plant engineering and management is a comprehensive interdisciplinary subject mainly reporting academic research on the application technology of equipment and industry management.展开更多
In this work,firstly the general definition of law and types of law are presented.Then general definition of justice and types of justice are explained.Constructional and/or complementary theories are defined as gener...In this work,firstly the general definition of law and types of law are presented.Then general definition of justice and types of justice are explained.Constructional and/or complementary theories are defined as general/specific,and interaction theories,relationship theories,and hybrid theories are specifically mentioned.Accordingly,the interactions between the disciplines of law and justice are explained in more detail.Then,the general definition of engineering and philosophy of engineering are explained.The interactions between engineering and law are specifically evaluated,and interactions between engineering and 52 types of law are defined and case studies found in the literature are indicated for each.Then interactions between engineering and justice briefly mentioned.Relationships/interactions between engineering and 25 different types of justice discussed and evaluated with specific examples.Emphasis was placed on the historical development of the subject of philosophy in general,and philosophy of law was defined more specifically.Some of the philosophers of law and their areas of interest are presented in a table format and compared.The new perspective of philosophy was defined and the disciplines of R-Philosophy,R-Science,R-Justice,R-Law,R-Engineering,and R-Religion were expressed with the relevant basic concepts.New Era Philosophy,new and reconstructed Basic Philosophies,and Ideal Philosophical System explained generally.New perspective for the philosophy of justice is defined by considering the related new theories.Philosophy of defense,philosophy of equity,philosophy of equivalence,philosophy of judgment,philosophy of law,philosophy of protection,philosophy of punishment,and philosophy of rights are defined due to new perspective of philosophy.Also,philosophy of engineering law,philosophy of information technology law,philosophy of telecommunication law,and philosophy of security are defined by taking into account hybrid philosophies and general theories related to them.The interaction of engineering,law,justice,and basic philosophies has been generally expressed.展开更多
The two-dimensional van der Waals layered semiconductor In_(2)Se_(3) has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In_(...The two-dimensional van der Waals layered semiconductor In_(2)Se_(3) has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In_(2)Se_(3) typically stabilizes in three distinct phases:α-,β′-,and β^(*)-In_(2)Se_(3),each dominant within specific temperature ranges.Although the crystal structures and ferroelectric properties of these phases have been widely studied,the unambiguous assignment of their in-plane and out-of-plane ferroelectric behaviors,as well as the mechanisms governing their phase transitions,remains a subject of active debate.In this study,we investigate the evolution of atomic and electronic structures in molecular beam epitaxy-grown ultrathin In_(2)Se_(3) films through correlated microstructural and macroscopic physical property analysis.By employing scanning tunneling microscopy/spectroscopy,temperature-dependent Raman spectroscopy,and piezoresponse force microscopy,we demonstrate a reversible temperature-induced phase transition between the in-plane ferroelectric β^(*)and antiferroelectric β′phases.Furthermore,we confirm robust out-of-plane ferroelectric polarization in the as-grown films and achieve an electric-field-driven transition from the β^(*)to β′phase.Our findings not only advance the fundamental understanding of phase transitions and polarization evolution in two-dimensional semiconductors but also open new avenues for the design of tunable,non-volatile ferroelectric memory devices.展开更多
Welcome to the 4th volume of Biomedical Engineering Communications the first issue of 2025!Biomedical engineering is a rapidly evolving field that combines engineering principles with medical and biological sciences t...Welcome to the 4th volume of Biomedical Engineering Communications the first issue of 2025!Biomedical engineering is a rapidly evolving field that combines engineering principles with medical and biological sciences to create innovative healthcare technologies.Biomedical engineering brings an interdisciplinary,problem-solving approach to bioengineering,biology and medicine.This interdisciplinary field is essential for developing advanced medical devices,diagnostic tools,and therapeutic solutions that enhance patient care and improve health outcomes.It allows them to develop technologies and systems that directly contribute to diagnosing,treating and preventing diseases.展开更多
With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a co...With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a comparative study of software engineering education in China and Europe,aiming to explore the theoretical frameworks and practical pathways employed in both regions.Initially,we introduce and contrast the engineering education accreditation systems of China and Europe,including the Chinese engineering education accreditation framework and the European EUR-ACE(European Accreditation of Engineering Programmes)standards,highlighting their core principles and evaluation methodologies.Subsequently,we provide case studies of several universities in China and Europe,such as Sun Yat-sen University,Tsinghua University,Technical University of Munich,and Imperial College London.Finally,we offer recommendations to foster mutual learning and collaboration between Chinese and European institutions,aiming to enhance the overall quality of software engineering education globally.This work provides valuable insights for educational administrators,faculty members,and policymakers,contributing to the ongoing improvement and innovative development of software engineering education in China and Europe.展开更多
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien...Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.展开更多
Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous s...Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous solutions,resulting in significant optical losses and exciton recombination.In this study,two series of six novel polymer photocatalysts(FLUSO,FLUSO-PEG10,FLUSO-PEG30;CPDTSO,CPDTSO-PEG10,CPDTSO-PEG30)are designed and synthesized by incorporating the hydrophilic,non-conjugated polyethylene glycol(PEG)chain,into both the main and side chains of polymers.By precisely optimizing the ratio of hydrophilic PEG segments,the water dispersibility is significantly improved while the light absorption capability of the polymer photocatalysts is well maintained.The experimental results confirm that the optimized FLUSO-PEG10 exhibits excellent photocatalytic hydrogen evolution rate,reaching up to 33.9 mmol/(g·h),which is nearly three times higher than that of fullyπ-conjugated counterparts.Water contact angles and particle size analyses reveal that incorporating non-conjugated segments into the main chains enhances the capacitance of the polymer/water interface and reduces particle aggregation,leading to improved photocatalyst dispersion and enhanced charge generation.展开更多
About us:The College of Chemistry and Materials Engineering(CME)in Wenzhou University(Zhejiang Province,China)is looking for postdoctoral candidates(up to 25)specialized in Chemistry,Chemical Engineering and Materials...About us:The College of Chemistry and Materials Engineering(CME)in Wenzhou University(Zhejiang Province,China)is looking for postdoctoral candidates(up to 25)specialized in Chemistry,Chemical Engineering and Materials Science.The college has its Chemistry program ranking ESI Top 6%o worldwide,and Materials Science program ranking 589th in the world since2023.The college has led publications appearing in journals such as Nat.Catal.,Nat.Commun.,Sci.Adv.,J.Am.Chem.Soc.,Angew.Chem.展开更多
The global mortality rate due to liver diseases,particularly liver fibrosis,is increasing.Among various treatment methods,stem cell therapy using placenta-derived mesenchymal stem cells(PDMSCs)offers distinct benefits...The global mortality rate due to liver diseases,particularly liver fibrosis,is increasing.Among various treatment methods,stem cell therapy using placenta-derived mesenchymal stem cells(PDMSCs)offers distinct benefits,including ease of isolation and superior proliferative potential.To enhance the therapeutic efficacy of PDMSCs,the WKYMVm peptide was selected for cell engineering.Immobilization of WKYMVm on PDMSC membranes facilitates effective peptide binding to the formyl peptide receptor 2 on adjacent PDMSCs and hepatocytes,thereby enhancing cell activation and achieving more efficient peptide utilization compared to bolus peptide treatment.Increased cell activation enhances the secretion of paracrine factors including growth factors and cytokines,which in turn improves liver function and vascular repair in both in vitro and in vivo models.This approach not only enhances the angiogenic and therapeutic capacities of stem cells,but also enables efficient peptide utilization,minimizing potential side effects and costs associated with high peptide dosages.Overall,our study demonstrates significant promise of stem cell therapy for treating liver fibrosis.Thus,stem cell therapy offers considerable prospects for clinical applications.展开更多
Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantiall...Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.展开更多
Journal Introduction″International Journal of Plant Engineering and Management″is in the charge of Ministry of Industry and Information Technology of the People′s Republic of China,and organized by Northwestern Pol...Journal Introduction″International Journal of Plant Engineering and Management″is in the charge of Ministry of Industry and Information Technology of the People′s Republic of China,and organized by Northwestern Polytechnical University.It is a kind of English academic quarterly publication publicly issued at home and abroad.Plant engineering and management is a comprehensive interdisciplinary sub⁃ject mainly reporting academic research on the application technology of equipment and industry management.It is of the characteristics of reporting both engineering and management while giving more priority to engineering as well as mechanics and electrics while giving priority to mechanics.Its contents involves technology,economy,management etc.展开更多
Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These roc...Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These rock masses are predominantly composed of sedimentary,para-metamorphic,and volcanic rock types,characterized by a set of prominent,primary bedding structural planes(layers)exhibiting relatively consistent orientations and significant spatial continuity.展开更多
The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative...The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative engineering talents with both scientific and technological literacy and humanistic feelings for the great rejuvenation of the Chinese nation through a historical narrative and a deep understanding of engineering talent cultivation in China.By tracing back to the formation of educator Mei Yiqi’s engineering intentions,the integration of engineering knowledge,and the history of engineering education governance,this paper proposes the key to the collaborative development of future learning centers in engineering university in the era of artificial intelligence.Firstly,it is necessary to update educational concepts and view learners as dynamically self-empowered individuals with plural existences.Secondly,attention should be paid to dynamic knowledge of possibilities,and cross-subject and interdisciplinary cognition and reflection should be carried out based on the types of engineering knowledge.Thirdly,it is essential to establish an engineering talent cultivation model with problem-guided knowledge learning as the core.With the support of digital network platforms and artificial intelligence technology,an infinite link of ideas and knowledge can be established through comprehensive textual methods,constructing learners’own“infinite library”and a spiritual world that is proactive,creative,and cultural.展开更多
The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education....The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.To do so,there is a need to understand the impact of LLMs on software engineering education.In this paper,we conducted a preliminary case study on three software requirements engineering classes where students are allowed to use LLMs to assist in their projects.Based on the students’experience,performance,and feedback from a survey conducted at the end of the courses,we characterized the challenges and benefits of applying LLMs in software engineering education.This research contributes to the ongoing discourse on the integration of LLMs in education,emphasizing both their prominent potential and the need for balanced,mindful usage.展开更多
文摘Engineering benefits humanity,and technology creates the future.On October 13,2025,the Global Top Ten Engineering Achievements 2025,selected by the Chinese Academy of Engineering’s flagship journal Engineering,were officially released at the World Federation of Engineering Organizations 2025 General Assembly,jointly organized by the World Federation of Engineering Organizations,China Association for Science and Technology,Chinese Academy of Engineering,and Shanghai Municipal People’s Government.
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金supported by the National Natural Science Foundation of China(Nos.52122408 and 52474397)the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences(No.242017127)+1 种基金the financial support from the Fundamental Research Funds for the Central Universities(University of Science and Technology Beijing(USTB),Nos.FRF-TP-2021-04C1 and 06500135)supported by USTB MatCom of Beijing Advanced Innovation Center for Materials Genome Engineering。
文摘High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by the alloy interface structures.Despite substantial efforts,a comprehensive overview of interface engineering of high-performance alloys has not been presented so far.In this study,the interfaces in high-performance alloys,particularly grain and phase boundaries,were systematically examined,with emphasis on their crystallographic characteristics and chemical element segregations.The effects of the interfaces on the electrical conductivity,mechanical strength,toughness,hydrogen embrittlement resistance,and thermal stability of the alloys were elucidated.Moreover,correlations among various types of interfaces and advanced experimental and computational techniques were examined using big data analytics,enabling robust design strategies.Challenges currently faced in the field of interface engineering and emerging opportunities in the field are also discussed.The study results would guide the development of next-generation high-performance alloys.
文摘Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmology,Capital Medical University Director,National Engineering Research Center for Ophthalmic Diagnosis and Treatment National Distinguished Physician Member,Academic Advisory Committee.
基金supported by grants from the Jiangxi Provincial Natural Science Foundation,No.20242BAB26134(to XF)the National Natural Science Foundation of China,Nos.82060638(to TC),82060222(to XF),82460237(to XF)+1 种基金the Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,Nos.20194BCJ22032(to TC),20213BCJL22049(to XF)Science and Technology Plan of Jiangxi Health Planning Committee,No.202210390(to XF).
文摘Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.
文摘Aims and scope Being an international journal,China Ocean Engineering(COE)takes its prime function as the integration of new research concepts,equipment,technology,materials and structures and other scientific advances within the field of estuarial,coastal,offshore,and deepwater engineering with particular reference to developments.The Journal is concerned with all engineering aspects involved in the exploration and utilization of ocean resources.Topics regularly covered include research,design and construction of structures(including wharfs,dikes,breakwaters,platforms,mooring systems,etc.),instrumentation/testing(physical model and numerical model),wave dynamics,sedimentation,structural/stress analysis,soil mechanics,and material research.
文摘Journal Introduction"International Journal of Plant Engineering and Management"is in the charge of Ministry of Industry and Information Technology of the People's Republic of China,and organized by Northwestern Polytechnical University.It is a kind of English academic quarterly publication publicly issued at home and abroad.Plant engineering and management is a comprehensive interdisciplinary subject mainly reporting academic research on the application technology of equipment and industry management.
文摘In this work,firstly the general definition of law and types of law are presented.Then general definition of justice and types of justice are explained.Constructional and/or complementary theories are defined as general/specific,and interaction theories,relationship theories,and hybrid theories are specifically mentioned.Accordingly,the interactions between the disciplines of law and justice are explained in more detail.Then,the general definition of engineering and philosophy of engineering are explained.The interactions between engineering and law are specifically evaluated,and interactions between engineering and 52 types of law are defined and case studies found in the literature are indicated for each.Then interactions between engineering and justice briefly mentioned.Relationships/interactions between engineering and 25 different types of justice discussed and evaluated with specific examples.Emphasis was placed on the historical development of the subject of philosophy in general,and philosophy of law was defined more specifically.Some of the philosophers of law and their areas of interest are presented in a table format and compared.The new perspective of philosophy was defined and the disciplines of R-Philosophy,R-Science,R-Justice,R-Law,R-Engineering,and R-Religion were expressed with the relevant basic concepts.New Era Philosophy,new and reconstructed Basic Philosophies,and Ideal Philosophical System explained generally.New perspective for the philosophy of justice is defined by considering the related new theories.Philosophy of defense,philosophy of equity,philosophy of equivalence,philosophy of judgment,philosophy of law,philosophy of protection,philosophy of punishment,and philosophy of rights are defined due to new perspective of philosophy.Also,philosophy of engineering law,philosophy of information technology law,philosophy of telecommunication law,and philosophy of security are defined by taking into account hybrid philosophies and general theories related to them.The interaction of engineering,law,justice,and basic philosophies has been generally expressed.
基金supported by the National Natural Science Foundation of China(Grant Nos.92365203,12534013,12174096,and 12474167)the Hunan Provincial Science Fund for Distinguished Young Scholars(Grant No.2022JJ10060)+1 种基金the Science and Technology Innovation Program of Hunan Province(Grant Nos.2025ZYJ001 and 2021RC4026)the Science Fund for Self-initiated Innovation of NUDT。
文摘The two-dimensional van der Waals layered semiconductor In_(2)Se_(3) has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In_(2)Se_(3) typically stabilizes in three distinct phases:α-,β′-,and β^(*)-In_(2)Se_(3),each dominant within specific temperature ranges.Although the crystal structures and ferroelectric properties of these phases have been widely studied,the unambiguous assignment of their in-plane and out-of-plane ferroelectric behaviors,as well as the mechanisms governing their phase transitions,remains a subject of active debate.In this study,we investigate the evolution of atomic and electronic structures in molecular beam epitaxy-grown ultrathin In_(2)Se_(3) films through correlated microstructural and macroscopic physical property analysis.By employing scanning tunneling microscopy/spectroscopy,temperature-dependent Raman spectroscopy,and piezoresponse force microscopy,we demonstrate a reversible temperature-induced phase transition between the in-plane ferroelectric β^(*)and antiferroelectric β′phases.Furthermore,we confirm robust out-of-plane ferroelectric polarization in the as-grown films and achieve an electric-field-driven transition from the β^(*)to β′phase.Our findings not only advance the fundamental understanding of phase transitions and polarization evolution in two-dimensional semiconductors but also open new avenues for the design of tunable,non-volatile ferroelectric memory devices.
文摘Welcome to the 4th volume of Biomedical Engineering Communications the first issue of 2025!Biomedical engineering is a rapidly evolving field that combines engineering principles with medical and biological sciences to create innovative healthcare technologies.Biomedical engineering brings an interdisciplinary,problem-solving approach to bioengineering,biology and medicine.This interdisciplinary field is essential for developing advanced medical devices,diagnostic tools,and therapeutic solutions that enhance patient care and improve health outcomes.It allows them to develop technologies and systems that directly contribute to diagnosing,treating and preventing diseases.
基金supported by the Guangdong Higher Education Association’s“14th Five Year Plan”2024 Higher Education Research Project(24GYB03)the Natural Science Foundation of Guangdong Province(2024A1515010255)。
文摘With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a comparative study of software engineering education in China and Europe,aiming to explore the theoretical frameworks and practical pathways employed in both regions.Initially,we introduce and contrast the engineering education accreditation systems of China and Europe,including the Chinese engineering education accreditation framework and the European EUR-ACE(European Accreditation of Engineering Programmes)standards,highlighting their core principles and evaluation methodologies.Subsequently,we provide case studies of several universities in China and Europe,such as Sun Yat-sen University,Tsinghua University,Technical University of Munich,and Imperial College London.Finally,we offer recommendations to foster mutual learning and collaboration between Chinese and European institutions,aiming to enhance the overall quality of software engineering education globally.This work provides valuable insights for educational administrators,faculty members,and policymakers,contributing to the ongoing improvement and innovative development of software engineering education in China and Europe.
基金Under the auspices of National Natural Science Foundation of China(No.42293270)。
文摘Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.
文摘Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous solutions,resulting in significant optical losses and exciton recombination.In this study,two series of six novel polymer photocatalysts(FLUSO,FLUSO-PEG10,FLUSO-PEG30;CPDTSO,CPDTSO-PEG10,CPDTSO-PEG30)are designed and synthesized by incorporating the hydrophilic,non-conjugated polyethylene glycol(PEG)chain,into both the main and side chains of polymers.By precisely optimizing the ratio of hydrophilic PEG segments,the water dispersibility is significantly improved while the light absorption capability of the polymer photocatalysts is well maintained.The experimental results confirm that the optimized FLUSO-PEG10 exhibits excellent photocatalytic hydrogen evolution rate,reaching up to 33.9 mmol/(g·h),which is nearly three times higher than that of fullyπ-conjugated counterparts.Water contact angles and particle size analyses reveal that incorporating non-conjugated segments into the main chains enhances the capacitance of the polymer/water interface and reduces particle aggregation,leading to improved photocatalyst dispersion and enhanced charge generation.
文摘About us:The College of Chemistry and Materials Engineering(CME)in Wenzhou University(Zhejiang Province,China)is looking for postdoctoral candidates(up to 25)specialized in Chemistry,Chemical Engineering and Materials Science.The college has its Chemistry program ranking ESI Top 6%o worldwide,and Materials Science program ranking 589th in the world since2023.The college has led publications appearing in journals such as Nat.Catal.,Nat.Commun.,Sci.Adv.,J.Am.Chem.Soc.,Angew.Chem.
基金supported by grants from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korean government(the Ministry of Science and ICT,the Ministry of Health and Welfare)(RS-2022-00070304)the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2024-00398030).
文摘The global mortality rate due to liver diseases,particularly liver fibrosis,is increasing.Among various treatment methods,stem cell therapy using placenta-derived mesenchymal stem cells(PDMSCs)offers distinct benefits,including ease of isolation and superior proliferative potential.To enhance the therapeutic efficacy of PDMSCs,the WKYMVm peptide was selected for cell engineering.Immobilization of WKYMVm on PDMSC membranes facilitates effective peptide binding to the formyl peptide receptor 2 on adjacent PDMSCs and hepatocytes,thereby enhancing cell activation and achieving more efficient peptide utilization compared to bolus peptide treatment.Increased cell activation enhances the secretion of paracrine factors including growth factors and cytokines,which in turn improves liver function and vascular repair in both in vitro and in vivo models.This approach not only enhances the angiogenic and therapeutic capacities of stem cells,but also enables efficient peptide utilization,minimizing potential side effects and costs associated with high peptide dosages.Overall,our study demonstrates significant promise of stem cell therapy for treating liver fibrosis.Thus,stem cell therapy offers considerable prospects for clinical applications.
基金funded by Science and Technology Project of Hebei Education Department[QN2023085].
文摘Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.
文摘Journal Introduction″International Journal of Plant Engineering and Management″is in the charge of Ministry of Industry and Information Technology of the People′s Republic of China,and organized by Northwestern Polytechnical University.It is a kind of English academic quarterly publication publicly issued at home and abroad.Plant engineering and management is a comprehensive interdisciplinary sub⁃ject mainly reporting academic research on the application technology of equipment and industry management.It is of the characteristics of reporting both engineering and management while giving more priority to engineering as well as mechanics and electrics while giving priority to mechanics.Its contents involves technology,economy,management etc.
基金supported by the National Natural Science Foundation of China(Nos.42107211 and U23A20651)the Natural Science Foundation of Sichuan Province(No.2025ZNSFSC0097)。
文摘Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These rock masses are predominantly composed of sedimentary,para-metamorphic,and volcanic rock types,characterized by a set of prominent,primary bedding structural planes(layers)exhibiting relatively consistent orientations and significant spatial continuity.
基金2024 General Research Topic of the Chinese Society of Educational Development Strategy,“Research on the Collaborative Development of‘Future Learning Centers’in Engineering University under New Strategic Needs”(Project No.:ZLB20240820)。
文摘The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative engineering talents with both scientific and technological literacy and humanistic feelings for the great rejuvenation of the Chinese nation through a historical narrative and a deep understanding of engineering talent cultivation in China.By tracing back to the formation of educator Mei Yiqi’s engineering intentions,the integration of engineering knowledge,and the history of engineering education governance,this paper proposes the key to the collaborative development of future learning centers in engineering university in the era of artificial intelligence.Firstly,it is necessary to update educational concepts and view learners as dynamically self-empowered individuals with plural existences.Secondly,attention should be paid to dynamic knowledge of possibilities,and cross-subject and interdisciplinary cognition and reflection should be carried out based on the types of engineering knowledge.Thirdly,it is essential to establish an engineering talent cultivation model with problem-guided knowledge learning as the core.With the support of digital network platforms and artificial intelligence technology,an infinite link of ideas and knowledge can be established through comprehensive textual methods,constructing learners’own“infinite library”and a spiritual world that is proactive,creative,and cultural.
基金supported in part by the Teaching Reform Project of Chongqing University of Posts and Telecommunications,China under Grant No.XJG23234Chongqing Municipal Higher Education Teaching Reform Research Project under Grant No.203399the Doctoral Direct Train Project of Chongqing Science and Technology Bureau under Grant No.CSTB2022BSXM-JSX0007。
文摘The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.To do so,there is a need to understand the impact of LLMs on software engineering education.In this paper,we conducted a preliminary case study on three software requirements engineering classes where students are allowed to use LLMs to assist in their projects.Based on the students’experience,performance,and feedback from a survey conducted at the end of the courses,we characterized the challenges and benefits of applying LLMs in software engineering education.This research contributes to the ongoing discourse on the integration of LLMs in education,emphasizing both their prominent potential and the need for balanced,mindful usage.
