期刊文献+
共找到52篇文章
< 1 2 3 >
每页显示 20 50 100
Chain architecture-engineered artesunate nanoassemblies target LONP1 to induce oxidative damage for enhanced anti-tumor therapy
1
作者 Yupeng Wang Xinxin Sun +5 位作者 Jianbin Shi Zhixiao Zhang Jin Sun Cong Luo Zhonggui He Shenwu Zhang 《Chinese Chemical Letters》 2026年第1期497-502,共6页
Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the del... Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy. 展开更多
关键词 Chain architecture engineering ART LONP1 NANOASSEMBLIES Cancer therapy
原文传递
A Quarter Century of Work to Revolutionize Architecture, Engineering and Construction Enterprise Information Systems
2
作者 Alain Zarli Patrice Poyet 《Journal of Civil Engineering and Architecture》 2017年第8期715-735,共21页
More than two decades ago, object-oriented representation of AEC (architecture engineering and construction) projects started to offer the promise of seamless communication of semantic data models between computer-b... More than two decades ago, object-oriented representation of AEC (architecture engineering and construction) projects started to offer the promise of seamless communication of semantic data models between computer-based systems used from the design stage to the operation of the facilities. BIM (building information modelling) emerged and appeared as a means to store all relevant data generated during the life-cycle of the facilities. But this upstream view of the built environment, arising from the design and construction stages, extended to the downstream operations where building and industrial facilities appeared more and more as huge dynamic data producers and concentrators while being operated. This created new challenges leading to what is referred to as ISCs (intelligent and smart constructions). The current state of the art is that final constructions still contain various and increasingly versatile control and service systems, which are hardly standardised, and not interconnected among themselves. Monitoring, maintenance and services are done by specialised companies, each responsible of different systems, which are relying on customised software and techniques to meet specific user needs and are based on monolithic applications that require manual configuration for specific uses, maintenance and support. We demonstrate in this paper that the early promises of integration across the actors and along the life-time of facilities have gone a long way but will only be delivered through enhanced standardisation of computerized models, representations, services and operations still not yet fully accomplished 25 years after work started. 展开更多
关键词 architecture engineering and construction building information models semantic interoperability intelligent and smart built environment information systems and sensors for new services.
在线阅读 下载PDF
Architecture and Implementation of 3D Engine Based on WebGL
3
作者 Xinliang Wei Wei Sun Xiaolong Wan 《Applied Mathematics》 2016年第7期701-708,共8页
As the progress of 3D rendering technology and the changes of market demand, the 3D application has been widely used and reached as far as education, entertainment, medical treatment, city planning, military training ... As the progress of 3D rendering technology and the changes of market demand, the 3D application has been widely used and reached as far as education, entertainment, medical treatment, city planning, military training and so on. Its trend is gradually changed from client to web, and so many people start to research the 3D graphics engine technology on the web. WebGL and HTML5 rise in recent years and WebGL solves two problems of interactive 3D application on the web perfectly. Firstly, it implements the interactive 3D web application by JavaScript without any browser plug-in components. Secondly, it makes graphics rendering using the underlying graphics hardware, which is united, standard and cross-platform OpenGL interface. However, it is very difficult for 3D application web programmer to understand multifarious details. Therefore, a 3D engine based on WebGL comes into being. The paper consults the existing 3D engine design idea, architecture and implementation experience, and designs a 3D graphics engine based on WebGL and Typescript. 展开更多
关键词 WEBGL Design Idea architecture of 3D engine
在线阅读 下载PDF
Reform and Practice of the Core Curriculum of Civil Engineering and Architecture Based on the “1+X” System
4
作者 Yajuan Liu 《Journal of World Architecture》 2022年第1期1-4,共4页
The“1+X”system has a great impact on the development of vocational education.Based on this system,it is imperative to carry out the reform and practice of the core curriculum of Civil Engineering and Architecture.Se... The“1+X”system has a great impact on the development of vocational education.Based on this system,it is imperative to carry out the reform and practice of the core curriculum of Civil Engineering and Architecture.Several vocational colleges have made attempts in the reform and practice of the curriculum,but the effect is not ideal.Under the influence of various factors,such as the lack of experience,there are also several problems in the reform and practice of the curriculum.Among them,the most apparent problems are as follows:the curriculum reform is not synchronized with the development of teaching materials,the pertinence of practical teaching is lacking,and the guidance provided for professional certificate examinations is not well-established.This paper specifically analyzes the problems existing in the reform and practice of the core curriculum of Civil Engineering and Architecture under the“1+X”system,and then puts forward effective strategies for these problems. 展开更多
关键词 “1+X”system Civil engineering and architecture Curriculum reform
在线阅读 下载PDF
Bringing Tibetan Painting Art into Modern Classroom
5
作者 Kelsang Lhundrup(Text/Photos) 《China's Tibet》 2026年第1期42-45,共4页
In the training studio of the School of Architecture and Engineering at Xizang Vocational Technical College,Lhasa,Gyatso,a senior artist specializing in Tibetan-style architectural decorative painting,bent over to dem... In the training studio of the School of Architecture and Engineering at Xizang Vocational Technical College,Lhasa,Gyatso,a senior artist specializing in Tibetan-style architectural decorative painting,bent over to demonstrate a student how to paint.His left hand steadied the painting board,while his right hand held a brush pen to present the Tibetan-style painting technique of"blurring"-dipping the brush lightly into the pigment,spreading it from dark to light on the paper.The eight-petaled lotus,a symbol of auspiciousness,gradually took shape,blossoming with layers of vitality. 展开更多
关键词 school architecture engineering Tibetan painting modern classroom Xizang Vocational Technical College Gyatso LHASA brush pen training studio
在线阅读 下载PDF
Application Research and Case Analysis of Green Technology in Building Engineering under the Direction of Energy Conservation Demands
6
作者 SONG Rui TIAN Juanjuan +1 位作者 YANG Xin LI Xingyi 《Journal of Landscape Research》 2023年第2期1-5,共5页
With the rapid development of the economy,the scale of construction projects in China is gradually expanding.In terms of construction technology,continuous innovation is being made to meet the needs of sustainable dev... With the rapid development of the economy,the scale of construction projects in China is gradually expanding.In terms of construction technology,continuous innovation is being made to meet the needs of sustainable development strategies,and green energy conservation technologies have emerged.It has a brand new design concept,and advocates for maximum energy conservation and environmental protection,fundamentally promoting the rational use of resources and space,and preventing the expansion of air and land pollution.First of all,a brief explanation is given on the current development status of green energy conservation technology in this paper.Secondly,through the introduction and analysis of energy conservation technologies and related building cases,the in-depth research on energy conservation measures of buildings is conducted.Finally,the prospects of green energy conservation technologies are proposed based on the current development status in China.This paper has certain reference value for its related engineering and theoretical research. 展开更多
关键词 Green technology Energy conservation Architectural engineering PEDF
在线阅读 下载PDF
Research on Teaching Reform of Architectural Engineering Drawing Based on BIM Technology
7
作者 Yuan Lu 《Journal of Architectural Research and Development》 2020年第5期5-9,共5页
The course of architectural engineering drawing is the basic course before the students of civil engineering related majors study the professional courses.It aims to cultivate the students’ability of configuration,ex... The course of architectural engineering drawing is the basic course before the students of civil engineering related majors study the professional courses.It aims to cultivate the students’ability of configuration,expression,reading and drawing.BIM Technology simulates the real component information of a building through digital information simulation,and flexibly transforms between two-dimensional and threedimensional,providing a new tool for the teaching of architectural engineering drawing.This paper analyzes the characteristics of BIM Technology and teaching advantages,combined with the current teaching situation of architectural engineering drawing course,puts forward reform suggestions and implementation process,and provides reform ideas for the teaching of engineering basic courses. 展开更多
关键词 BIM Technology Architectural engineering drawing Reform in education
在线阅读 下载PDF
Present situation and improving measures of Chinese Construction Engineering Management informatization
8
作者 ZHOU Chuan 《International English Education Research》 2017年第4期73-74,共2页
Building engineering management is a huge and complex work, which the key to ensure the quality ofconstruction projects. With the rapid development of the domestic construction industry, the traditional engineering ma... Building engineering management is a huge and complex work, which the key to ensure the quality ofconstruction projects. With the rapid development of the domestic construction industry, the traditional engineering management model can not meet the needs of a large number of construction project information exchanges. Only realizing informationization of construction engineering management, can reduce the cost of construction projects, improve the efficiency of project management and construction progress. This paper analyzes the current situation of construction management informatization, and puts forward some suggestions to strengthen the construction management information construction. 展开更多
关键词 engineering management~ Information system~ Architectural engineering
在线阅读 下载PDF
On Site Implementation and Dynamic Management of Green Construction Technology in Construction Engineering
9
作者 MIAO Fei CHEN Lei 《外文科技期刊数据库(文摘版)工程技术》 2021年第6期374-377,共6页
With the development of China's economy, the scale of construction projects is expanding, and the disadvantages of construction are gradually exposed, which seriously affects the quality of construction. In order ... With the development of China's economy, the scale of construction projects is expanding, and the disadvantages of construction are gradually exposed, which seriously affects the quality of construction. In order to realize the sustainable development of the construction industry, the construction technology must be innovated. This paper analyzes the implementation and management of green construction technology, and puts forward some suggestions for reference. 展开更多
关键词 architectural engineering green construction technology ADMINISTRATION
原文传递
Application of New Building Materials in Structural Design of Building Engineering
10
作者 CHEN Huibiao 《外文科技期刊数据库(文摘版)工程技术》 2021年第6期023-026,共6页
In the process of continuous development of the current construction industry, in order to meet people's requirements for living, the construction industry began to try a variety of new building materials, and use... In the process of continuous development of the current construction industry, in order to meet people's requirements for living, the construction industry began to try a variety of new building materials, and used new building materials in wall structure, waterproof measures and thermal insulation, which can not only improve the overall architectural structure design, which also contributes to the construction of green environmental protection project to a certain extent. Under the promotion of the current concept of sustainable development, the construction industry only adheres to the concept of green, research and application of new building materials can leave a place in the future industry competition. In this paper, the importance of new building materials for building engineering structure and the specific application are described in detail. 展开更多
关键词 new type building material architectural engineering structural design APPLICATION
原文传递
Discussion on the Construction Technology of Concrete Structure in Civil Engineering Construction
11
作者 LIJianjun 《外文科技期刊数据库(文摘版)工程技术》 2022年第6期117-120,共4页
Reinforced concrete structure can ensure the stability and safety of buildings, so it has been widely used in contemporary civil construction. However, judging from the current situation, there are still many problems... Reinforced concrete structure can ensure the stability and safety of buildings, so it has been widely used in contemporary civil construction. However, judging from the current situation, there are still many problems in the construction of concrete structures, the root of which lies in the fact that the constructors have not adopted practical construction techniques or improper use of techniques. Therefore, the article analyzes the current construction situation of concrete structures in our country and puts forward corresponding countermeasures in order to achieve the goal of improving the construction quality in our country. 展开更多
关键词 civil engineering architectural engineering CONCRETE construction technology
原文传递
Cost Analysis of Construction Engineering in Construction Stage
12
作者 JIANGWenjue 《外文科技期刊数据库(文摘版)工程技术》 2022年第4期111-115,共5页
The rapid development of contemporary social economy promotes the increasing number of construction projects. However, with the rapid development of China's construction industry, there will be some problems, one ... The rapid development of contemporary social economy promotes the increasing number of construction projects. However, with the rapid development of China's construction industry, there will be some problems, one of which is the cost management in the construction stage. At present, in order to improve the profit of the construction project, the cost of the project cost needs to be reduced as much as possible, but the quality assurance of the construction project is the premise, and the project cost fluctuates greatly in the construction stage of the construction project, which also has a great impact on the construction. This paper studies the cost control in the construction stage for reference. 展开更多
关键词 architectural engineering construction stage manufacturing cost CONTROL
原文传递
Construction Quality Management Methods and Control Measures of Construction Engineering
13
作者 LOU Yulei 《外文科技期刊数据库(文摘版)工程技术》 2021年第5期348-350,共5页
The construction industry plays an important role in the economic development. In the process of construction, we should realize the importance of quality management. The gradual increase in the number of construction... The construction industry plays an important role in the economic development. In the process of construction, we should realize the importance of quality management. The gradual increase in the number of construction projects, in the process of continuous development has also increased the incidence of construction quality problems, so we should strengthen the construction quality management, maximize the quality of engineering construction and better promote the development of the construction industry. 展开更多
关键词 architectural engineering construction quality MANAGEMENT control measures
原文传递
The Control of Engineering Cost in the Whole Process of Construction Project Management
14
作者 HU Mingming 《外文科技期刊数据库(文摘版)工程技术》 2021年第5期271-273,共5页
With the continuous development of economy and society, China's construction industry has also seen unprecedented progress in recent years. In the process of cost management of current construction projects, whole... With the continuous development of economy and society, China's construction industry has also seen unprecedented progress in recent years. In the process of cost management of current construction projects, whole-process project cost management is a major development trend. In the field of construction engineering, to ensure the all-round implementation of the work, we must pay attention to the management effect, change the concept of cost control, and effectively implement the work concept. In view of the shortcomings of the whole process cost control in the construction project management, this paper puts forward relevant countermeasures and explorations. In order to ensure the safety of construction project funds and improve the overall quality of the project. 展开更多
关键词 architectural engineering whole process manufacturing cost ADMINISTRATION
原文传递
Problems and Countermeasures of Supervision and Management of Architectural Engineering Quality and Safety
15
作者 JIANGGangchu 《外文科技期刊数据库(文摘版)工程技术》 2020年第2期135-138,共7页
With the rapid development of China's economy, the construction industry has gained great benefits. While promoting the progress of the industry, it also further expands the competition among industries. Moreover,... With the rapid development of China's economy, the construction industry has gained great benefits. While promoting the progress of the industry, it also further expands the competition among industries. Moreover, in this competition, the success or failure of the building does not depend on how high the technical content of the building is and how expensive the materials are, but on the overall quality and safety of the building. Good building quality safety is the most direct manifestation of the extension of building use value. So now the major construction industries have also shifted their focus to how to improve the quality and safety of buildings, and also strengthened the supervision and management of their quality and safety. However, according to the current development situation, the scope of supervision is still not comprehensive. 展开更多
关键词 architectural engineering quality and safety supervision and management PROBLEMS COUNTERMEASURES
原文传递
Analysis on Construction Technology of Construction Engineering and Countermeasures of Site Construction Management
16
作者 ZHANG Xiankai 《外文科技期刊数据库(文摘版)工程技术》 2021年第7期035-038,共6页
For the development of construction work, construction personnel are an important factor in the overall development of the work. Therefore, strengthening the management of construction personnel plays a vital role in ... For the development of construction work, construction personnel are an important factor in the overall development of the work. Therefore, strengthening the management of construction personnel plays a vital role in improving the quality of construction work. The higher the management level of construction work, the more guaranteed the quality of construction work. Therefore, in the actual construction process of construction work, the construction unit should raise the awareness of construction management work and give full play to the subjective initiative of construction personnel. Improve the coordination degree of each construction department, strengthen the efficiency of information communication and exchange, and strengthen the management of the construction site, so as to realize the optimization of the overall construction management while combining the needs of the owners and the market demand, and further improve the overall construction quality of the construction project. 展开更多
关键词 architectural engineering construction technology site construction management measure
原文传递
Application of BIM Technology in HVAC Design Optimization of Construction Engineering
17
作者 LIUJingjing 《外文科技期刊数据库(文摘版)工程技术》 2022年第4期079-083,共5页
In recent years, with the improvement of the living standard of the Chinese people, we have put forward higher requirements for all aspects of residential construction. HVAC engineering, as an important component of a... In recent years, with the improvement of the living standard of the Chinese people, we have put forward higher requirements for all aspects of residential construction. HVAC engineering, as an important component of architecture, affects not only the comfort of houses but also the quality of our lives. Therefore, people must pay more attention to the design of HVAC engineering and give full consideration to heating, indoor air circulation and service life. As BIM technology plays a key role in HVAC engineering design and can greatly improve the scientific engineering design, BIM technology needs to be applied to heating and cooling resistance thermal engineering design, drawing, scheme aided design, computer aided design and other activities. 展开更多
关键词 BIM technology architectural engineering HVAC design optimization APPLICATION
原文传递
Exploration of the Application of Deep Foundation Pit Supporting Construction Technology in Construction Engineering
18
作者 ZHAOBin HEYun 《外文科技期刊数据库(文摘版)工程技术》 2022年第3期120-123,共4页
In the construction process, the overall quality level of the building is mainly determined by the deep pit supporting construction. In order to further optimize the construction process and further improve the qualit... In the construction process, the overall quality level of the building is mainly determined by the deep pit supporting construction. In order to further optimize the construction process and further improve the quality level and ensure the safety, it is necessary to analyze the key points of the construction in detail. Strengthening the support construction of deep foundation pit can improve the overall quality level of the project and ensure the stability and prolong the service life of the building. Therefore, the construction industry must pay more attention to the construction technology of deep foundation pit support, and use more scientific methods to improve this technology more effectively, so that this technology can be widely popularized and used in the construction industry. In addition, although the deep foundation pit support technology has developed well, there will inevitably be some problems in the development process. The construction party should analyze and study these situations, and adjust the construction scheme according to some influencing factors to make it more reasonable, so as to ensure its accuracy and technical effectiveness. 展开更多
关键词 deep foundation pit support construction technology architectural engineering APPLICATION
原文传递
Application of BIM in the Structural Design of Architectural Engineering
19
作者 Fei Sun 《Journal of World Architecture》 2022年第3期13-18,共6页
Structural design is an important component of architectural engineering.BIM is integrated into structural design to form a complete,linked,and information-based data platform.Therefore,in line with the features of BI... Structural design is an important component of architectural engineering.BIM is integrated into structural design to form a complete,linked,and information-based data platform.Therefore,in line with the features of BIM,such as interaction and coordination,information integration,as well as data simulation,this study analyzes the advantages of BIM in architectural structural design,proposes several optimization measures using BIM for architectural structural design,and promotes the rationality of architectural structural design. 展开更多
关键词 BIM Architectural engineering Structural design
在线阅读 下载PDF
Analysis on Quality Control Countermeasures of Construction Engineering Supervision
20
作者 MENG Lili 《外文科技期刊数据库(文摘版)工程技术》 2021年第6期097-099,共5页
There are still some problems in the construction management, such as weak management consciousness, which affect the management efficiency. The quality control of construction supervision is the key point of construc... There are still some problems in the construction management, such as weak management consciousness, which affect the management efficiency. The quality control of construction supervision is the key point of construction management, which needs to be paid more attention to. It is necessary to grasp the control points of each stage of construction and to improve the construction quality and to meet people's needs, so as to make the building more in line with modern standards. 展开更多
关键词 architectural engineering SUPERVISOR quality control
原文传递
上一页 1 2 3 下一页 到第
使用帮助 返回顶部