In the terraced fields in Honghe Hani and Yi Autonomous Prefecture,southwest China’s Yunnan Province,the morning mist drifts up from the valleys while the tiered ridges spread like the fingerprints of the earth.
The lack of proper knowledge about investment products can have a large negative influence on the financial well being of investors. Inspire of that, there is a dearth of studies conducted, specifically to investigate...The lack of proper knowledge about investment products can have a large negative influence on the financial well being of investors. Inspire of that, there is a dearth of studies conducted, specifically to investigate the factors influencing the knowledge of investors about investment products. This paper propose a model and investigates the direct and indirect （mediated through investor＇s enduring involvement with product） influence of investor＇s product importance perception （PIP） and need for cognition （NFC） on investor＇s knowledge of investment products. The hypothesized relationship is empirically validated in the context of mutual fund schemes （MFs）. Survey conducted on the sample of 268 MF investors suggests that there is an insignificant direct influence of investor＇s PIP and NFC on investor＇s knowledge of investment product （KIP）. However, when mediated through enduring involvement with product （EIP）, the influence was found to be significant. The results suggest that EIP perfectly mediates the influence of PIP and NFC on investor＇s KIP. The relevance of the results to the policy makers is also discussed.展开更多
Zhang Liwei, an associate professor from the Party School of the Communist Party of China （CPC） Central Committee, recently penned an article on China,org.cn discussing the importance of the rule of law in modernizi...Zhang Liwei, an associate professor from the Party School of the Communist Party of China （CPC） Central Committee, recently penned an article on China,org.cn discussing the importance of the rule of law in modernizing a country＇s governance. The fol- lowing are excerpts：CHINA has gone through four phases promoting the rule of law. The first phase, lasting from 1954 to 1978, featured explorations and trials. The second stage, from 1978 to 1997, focused on renewal, The third （1997-2014） was a period of accelerated devel- opment. The next stage will target comprehensive implementation.展开更多
Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focu...Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focus on their effects on recovery metrics,particularly how they influence sleep quality,perceived wellness,and athletic performance.Despite anecdotal evidence of its efficacy,rigorous comparative studies are scarce.Objective:This study aimed to evaluates and compare the effects of WCT and DCT on endurance,perceived wellness,exertion levels,and sleep quality among young,active males,addressing the gap in the literature regarding CT's efficacy in sports performance and recovery.Methods:Thirty-two amateur runners were randomly divided into two groups:one followed WCT sessions and the other followed DCT sessions.The study assessed the interventions'impacts on endurance performance(Yo-Yo intermittent recovery test),sleep quality(Pittsburgh Sleep Quality Index),and perceived exertion(Borg CR10 Scale).Heart rate was measured using a Polar H10 sensor to gauge physiological responses during physical tests.Results:Significant improvements were observed in the WCT group for sleep latency(%change=-82.31%;interaction group×time p=0.006;Cohen's d=0.74)and sleep disturbance(%change=-68.70%;interaction group×time p<0.001;Cohen's d=1.09),suggesting enhanced sleep quality(global score;%change=-52.81;interaction group×time p=0.004;Cohen's d=0.77).However,no significant differences were found in direct performance metrics(distance,maximal heart rate,maximal oxygen uptake)between WCT and DCT groups.These findings highlight WCT's potential as a recovery aid,particularly through improved sleep,without directly influencing endurance performance outcomes.Conclusion:WCT may serve as an effective ergogenic aid for athletes by potentially improving sleep quality and reducing perceived exertion,thus contributing indirectly to performance through enhanced recovery.展开更多
Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how t...Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how the coronavirus disease 2019(COVID-19)pandemic has impacted this trend.Methods:We conducted a systematic review and meta-analyses to assess pandemic-related changes in physical fitness among children and adolescents(0-19 years)in the World Health Organization European Region.Seven databases were searched up to February 28,2025 for studies reporting validated pre-and during/post-pandemic fitness measurements.Two reviewers independently performed screening,data extraction,risk-of-bias assessment(Risk Of Bias In Non-randomized Studies-of Exposure)(ROBINS-E),and certainty grading(Grading of Recommendations,Assessment,Development and Evaluation)(GRADE).Random-effects meta-analyses yielded standardized mean differences(SMDs)with 95%confidence intervals(95%CIs).Subgroup analyses examined sex,age,year,and national restriction severity(Oxford Stringency Index).Results:Thirty-two studies comprising 270,179 participants and 1,519,386 fitness measurements from 17 European countries were included.Cardiorespiratory fitness declined significantly during the pandemic,especially in 2021,with reductions in endurance(SMD=-0.43;95%CI:-0.61 to-0.25)and speed(SMD=-0.29;95%CI:-0.61 to 0.03).While speed returned to baseline by 2023,endurance remained below pre-pandemic levels(SMD=-0.10;95%CI:-0.12 to-0.08).Girls and adolescents were disproportionately affected.In contrast to cardiorespiratory fitness,muscular fitness remained largely unchanged.Stricter national regulations were associated with greater declines in cardiorespiratory fitness.Conclusion:COVID-19 pandemic restrictions were associated with a marked decline in cardiorespiratory fitness in European children and adolescents,with levels not recovered by 2023.These findings call for urgent,targeted public health interventions to improve physical fitness and prevent long-term health consequences.展开更多
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in...Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.展开更多
Post-exercise whey protein isolate(WPI)supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids(BCAAs).This implies us that intake slow digestion rate of protein to su...Post-exercise whey protein isolate(WPI)supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids(BCAAs).This implies us that intake slow digestion rate of protein to sustain BCAAs releasing rate may facilitate muscle protein synthesis.To examine this hypothesis,we conducted a series of protein supplements including modified slow-digesting whey(SDW),whey,hydrolyzed whey and casein,orally to mice undergoing endurance running.Our results showed that the SDW gavage constant supplied BCAAs in the serum of mice within 6 h and significantly enhanced(P<0.01)endurance exercise capacity,compared to other groups.In addition,the SDW supplementation increased the crosssectional area of mice gastrocnemius fibers,as well as their muscle and liver glycogen content.It also increased the testosterone/cortisol ratio in serum and interleukin-6(IL-6)levels in muscle,while it decreased the tumor necrosis factor-alpha(TNF-α)levels and oxidative stress in muscle.Moreover,it may activate mechanistic target of rapamycin signaling by upregulating mRNA(bcat-1 and pgc-1α)expression.Thus,our findings illustrate that prolonged BCAAs supply duration promotes mice endurance running capacity and skeletal muscle growth,contributing to the advancement of sports nutrition practices.展开更多
China and the United States promote stable relations through the Strategic Economic Dialogue As Chinese and U.S.officials concluded their last Strategic Economic Dialogue(SED)dur-ing George W.Bush’s presidency,there ...China and the United States promote stable relations through the Strategic Economic Dialogue As Chinese and U.S.officials concluded their last Strategic Economic Dialogue(SED)dur-ing George W.Bush’s presidency,there were high expectations that the two countries would keep up their efforts to fos-ter sustainable economic relations.展开更多
Sino-Vietnamese relations witness their 60th anniversary amid high hopes This month commemorates the 60th anniversary of the establishment of Sino-Vietnamese relations,
Lingering inflation has become the biggest headache for ordinary Chinese people. The CPI growth,a broad measure of inflation,has been hovering around 5 percent since last November,and it even hit a 32-monthhigh of 5.4...Lingering inflation has become the biggest headache for ordinary Chinese people. The CPI growth,a broad measure of inflation,has been hovering around 5 percent since last November,and it even hit a 32-monthhigh of 5.4 percent in March.展开更多
The United States and India reaffirm their mutual commitment during Indian prime minister’s recent U.S. trip u.S. President Barack Obama welcomed Indian Prime Minister Manmohan Singh on November 24 with an em- phasis...The United States and India reaffirm their mutual commitment during Indian prime minister’s recent U.S. trip u.S. President Barack Obama welcomed Indian Prime Minister Manmohan Singh on November 24 with an em- phasis on the continuing value of a partnership carefully developed over展开更多
Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of co...Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of conventional UAVs presents a significant challenge to comprehensive and continuous monitoring,which is crucial for maintaining the integrity of pipeline infrastructure.This review paper evaluates methods for extending UAV flight endurance,focusing on their potential application in pipeline inspection.Through an extensive literature review,this study identifies the latest advancements in UAV technology,evaluates their effectiveness,and highlights the existing gaps in achieving prolonged flight operations.Advanced techniques,including artificial intelligence(AI),machine learning(ML),and deep learning(DL),are reviewed for their roles in pipeline monitoring.Notably,DL algorithms like You Only Look Once(YOLO)are explored for autonomous flight in UAV-based inspections,real-time defect detection,such as cracks,corrosion,and leaks,enhancing reliability and accuracy.A vital aspect of this research is the proposed deployment of a hybrid drone design combining lighter-than-air(LTA)and heavier-than-air(HTA)principles,achieving a balance of endurance and maneuverability.LTA vehicles utilize buoyancy to reduce energy consumption,thereby extending flight durations.The paper details the methodology for designing LTA vehicles,presenting an analysis of design parameters that align with the requirements for effective pipeline surveillance.The ongoing work is currently at Technology Readiness Level(TRL)4,where key components have been validated in laboratory conditions,with fabrication and flight testing planned for the next phase.Initial design analysis indicates that LTA configurations could offer significant advantages in flight endurance compared to traditional UAV designs.These findings lay the groundwork for future fabrication and testing phases,which will be critical in validating and assessing the proposed approach’s real-world applicability.By outlining the technical complexities and proposing specialized techniques tailored for pipeline monitoring,this paper provides a foundational framework for advancing UAV capabilities in the oil and gas sector.Researchers and industry practitioners can use this roadmap to further develop UAV-enabled surveillance solutions,aiming to improve the reliability,efficiency,and safety of pipeline monitoring.展开更多
BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematicall...BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematically review and conduct a meta-analysis on the effects of exercise rehabilitation on the physical activity of lung cancer patients and determine the best implementation methods to provide clinical guidance.METHODS Literature was searched through multiple electronic databases.A random effects model was used to combine effect sizes through standardized mean difference(SMD).The Cochrane risk of bias tool was used to assess the quality of the lite-rature,sensitivity analysis was used to ensure the robustness of the results,and Egger’s test was used to detect publication bias and asymmetry.RESULTS A total of 11 studies involving 541 patients were included in this study.The phy-sical endurance,muscle function and cardiopulmonary function of non-small cell lung cancer(NSCLC)patients were evaluated.The overall effect size of the six-minute walk test(6MWT)was not statistically significant.However,subgroup analysis found that endurance significantly improved when exercise duration exceeded 0.5 hours(P≤0.05).In terms of muscle function,the overall effect size was SMD=0.619.Subgroup analysis showed that strength training,respiratory training,and cross-training(XT)significantly improved muscle function.Exercise rehabilitation significantly enhanced cardiopulmonary endurance(SMD=0.856,P=0.002),and the effect was better when the single exercise duration was more than 1 hour,age was over 65 years,and the intervention period was more than 3 months.CONCLUSION Exercise rehabilitation effectively improved muscle function in NSCLC patients,especially strength training,respiratory training,and cross-training.Cardiopulmonary function also showed improvement,particularly when exercise duration exceeded 1 hour,age was≥65 years,and the intervention period was more than 3 months.A single exercise duration of more than 0.5 hours can enhance patients’physical endurance.Appropriately increasing exercise duration and selecting suitable exercise forms can effectively improve the physical activity of NSCLC patients.展开更多
1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity....1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity.2 The novel follows the life of Xu Fugui,a once⁃wealthy landowner who lost his fortune through gambling(赌博).As his status shifted to that of a peasant,he witnessed the rapid changes of society.Despite enduring relentless hardship,Fugui survived,finding moments of comfort in small and everyday acts of perseverance.展开更多
Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized c...Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized controlled trials(RCTs)compared the effects of compression garment wearing with those of non-compression garment wearing(controls)during running on improving running performance.Methods:A comprehensive search was conducted in the electronic databases(Web of Science,EBSCOhost,PubMed,Embase,Scopus,and Cochrane)for RCTs comparing running performance between runners wearing compression garments and controls during running,from inception to September 2024.Independent reviewers screened studies,extracted data,appraised risk of bias(RoB 2)and certainty of evidence(Grading of Recommendations Assessments,Development and Evaluation(GRADE)).Primary outcomes were race time and time to exhaustion.Secondary outcomes covered running speed and race pace,submaximal oxygen uptake,tissue oxygenation,and soft tissue vibration.Randomeffects meta-analyses were conducted to generate pooled estimates,expressed in standardized mean difference(SMD).Subgroup differences of garment,race type,and contact surface were tested in moderator analyses.Results:The search yielded 51 eligible studies comprising 899 participants,of which 33 studies were available for meta-analysis of primary outcomes.Runners wearing compression garments during running showed no significant improvement in race time(SMD=-0.07,95%CI:-0.22 to 0.09;p=0.40)or time to exhaustion(SMD=0.04,95%CI:-0.20 to 0.29;p=0.72).Moderator analyses indicated no effects from garment type,race type,or surface.Secondary outcomes also showed no performance benefits,although compression garments significantly reduced soft tissue vibration(SMD=-0.43,95%CI:-0.70 to-0.15;p<0.01).Certainty of evidence was rated low to very low.Conclusion:Data synthesis of current RCTs offers no updated evidence favoring the support of wearing compression garments during running as a viable strategy for improving running and endurance performance among runners of varying performance levels and types of running races.展开更多
Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic r...Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic review was aimed at analyzing determinants of sport climbing performance and evaluation methods by comparing climbers of different levels.Methods:PubMed,Scopus,and Web of Science were searched up to December 20,2022.Studies providing the self-reported climbing ability associated with different functional outcomes in groups of climbers of contiguous performance levels were eligible.Results:74 studies were finally included.Various methods have been proposed to evaluate determinants of sport climbing performance.Climbing-specific assessments were able to discriminate climbers of different levels when compared to general functional tests.Test validity resulted high for climbing-specific cardiorespiratory endurance as well as muscular-strength,-endurance,and-power;similarly,reliability was good except for cardiorespiratory endurance.Climbing-specific flexibility assessment resulted in high reliability but moderate validity,whereas balance showed low validity.Considerable conflicting evidence was found regarding anthropometric characteristics.Conclusion:The present analysis identified cardiorespiratory endurance as well as muscular-strength,-endurance,and-power as determinants of sport climbing performance.In contrast,balance,flexibility,and anthropometric characteristics seem to count less.This review also proposes an evidence-based Functional Sport Climbing test battery for asses sing performance determinants,which includes tests that have been identified to be valid,reliable,and feasible.While athletes and coaches should rely on evidence-based and standardized evaluation methods,researchers may design specific large-scale trials as a resource for providing additional,homogenous,and comparable data to improve scientific evidence and professionalism in this popular sport discipline.展开更多
文摘In the terraced fields in Honghe Hani and Yi Autonomous Prefecture,southwest China’s Yunnan Province,the morning mist drifts up from the valleys while the tiered ridges spread like the fingerprints of the earth.
文摘The lack of proper knowledge about investment products can have a large negative influence on the financial well being of investors. Inspire of that, there is a dearth of studies conducted, specifically to investigate the factors influencing the knowledge of investors about investment products. This paper propose a model and investigates the direct and indirect （mediated through investor＇s enduring involvement with product） influence of investor＇s product importance perception （PIP） and need for cognition （NFC） on investor＇s knowledge of investment products. The hypothesized relationship is empirically validated in the context of mutual fund schemes （MFs）. Survey conducted on the sample of 268 MF investors suggests that there is an insignificant direct influence of investor＇s PIP and NFC on investor＇s knowledge of investment product （KIP）. However, when mediated through enduring involvement with product （EIP）, the influence was found to be significant. The results suggest that EIP perfectly mediates the influence of PIP and NFC on investor＇s KIP. The relevance of the results to the policy makers is also discussed.
文摘Zhang Liwei, an associate professor from the Party School of the Communist Party of China （CPC） Central Committee, recently penned an article on China,org.cn discussing the importance of the rule of law in modernizing a country＇s governance. The fol- lowing are excerpts：CHINA has gone through four phases promoting the rule of law. The first phase, lasting from 1954 to 1978, featured explorations and trials. The second stage, from 1978 to 1997, focused on renewal, The third （1997-2014） was a period of accelerated devel- opment. The next stage will target comprehensive implementation.
文摘Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focus on their effects on recovery metrics,particularly how they influence sleep quality,perceived wellness,and athletic performance.Despite anecdotal evidence of its efficacy,rigorous comparative studies are scarce.Objective:This study aimed to evaluates and compare the effects of WCT and DCT on endurance,perceived wellness,exertion levels,and sleep quality among young,active males,addressing the gap in the literature regarding CT's efficacy in sports performance and recovery.Methods:Thirty-two amateur runners were randomly divided into two groups:one followed WCT sessions and the other followed DCT sessions.The study assessed the interventions'impacts on endurance performance(Yo-Yo intermittent recovery test),sleep quality(Pittsburgh Sleep Quality Index),and perceived exertion(Borg CR10 Scale).Heart rate was measured using a Polar H10 sensor to gauge physiological responses during physical tests.Results:Significant improvements were observed in the WCT group for sleep latency(%change=-82.31%;interaction group×time p=0.006;Cohen's d=0.74)and sleep disturbance(%change=-68.70%;interaction group×time p<0.001;Cohen's d=1.09),suggesting enhanced sleep quality(global score;%change=-52.81;interaction group×time p=0.004;Cohen's d=0.77).However,no significant differences were found in direct performance metrics(distance,maximal heart rate,maximal oxygen uptake)between WCT and DCT groups.These findings highlight WCT's potential as a recovery aid,particularly through improved sleep,without directly influencing endurance performance outcomes.Conclusion:WCT may serve as an effective ergogenic aid for athletes by potentially improving sleep quality and reducing perceived exertion,thus contributing indirectly to performance through enhanced recovery.
文摘Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how the coronavirus disease 2019(COVID-19)pandemic has impacted this trend.Methods:We conducted a systematic review and meta-analyses to assess pandemic-related changes in physical fitness among children and adolescents(0-19 years)in the World Health Organization European Region.Seven databases were searched up to February 28,2025 for studies reporting validated pre-and during/post-pandemic fitness measurements.Two reviewers independently performed screening,data extraction,risk-of-bias assessment(Risk Of Bias In Non-randomized Studies-of Exposure)(ROBINS-E),and certainty grading(Grading of Recommendations,Assessment,Development and Evaluation)(GRADE).Random-effects meta-analyses yielded standardized mean differences(SMDs)with 95%confidence intervals(95%CIs).Subgroup analyses examined sex,age,year,and national restriction severity(Oxford Stringency Index).Results:Thirty-two studies comprising 270,179 participants and 1,519,386 fitness measurements from 17 European countries were included.Cardiorespiratory fitness declined significantly during the pandemic,especially in 2021,with reductions in endurance(SMD=-0.43;95%CI:-0.61 to-0.25)and speed(SMD=-0.29;95%CI:-0.61 to 0.03).While speed returned to baseline by 2023,endurance remained below pre-pandemic levels(SMD=-0.10;95%CI:-0.12 to-0.08).Girls and adolescents were disproportionately affected.In contrast to cardiorespiratory fitness,muscular fitness remained largely unchanged.Stricter national regulations were associated with greater declines in cardiorespiratory fitness.Conclusion:COVID-19 pandemic restrictions were associated with a marked decline in cardiorespiratory fitness in European children and adolescents,with levels not recovered by 2023.These findings call for urgent,targeted public health interventions to improve physical fitness and prevent long-term health consequences.
基金supported by grants from the Knut and Alice Wallenberg foundation(P-OB,JRZ,and AK)the Swedish Research Council(JRZ and AK),Centrum för idrottsforskning(AK and JRZ)+7 种基金the NovoNordisk Foundation Metabolic Stress Associated Molecules(MSAM)consortium NNF15SA0018346 and Metabolite-related Inflammation and Disease(MeRIAD)consortium Grant number 0064142(AK)the Swedish Diabetes Foundation(AK and JRZ)the European Foundation for the Study of Diabetes(JRZ and AK)the Region Stockholm(ALF project)(JRZ and KC)the Strategic Research Program in Diabetes at Karolinska Institutet(JRZ and AK)supported by the Strategic Research Programme in Diabetes(SRP Diabetes)for use of the Seahorse flux analyzer.Human islets were made possible through the Juvenile Diabetes Research Foundation(JDRF)award 31-2008-416(European Coordinating Infrastructure for Islet Transplantation(ECIT),Islet for Basic Research program)AK holds a Distinguished Investigator Grant within Endocrinology and Metabolism from the Novo Nordisk Foundation(NNF24OC0088739)JRZ received the 2024 European Association for the Study of Diabetes(ESAD)-Novo Nordisk Foundation Diabetes Prize for Excellence(NNF24SA0092609).
文摘Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.
基金financially supported by the Fundamental Research Funds for the Central Universities(JUSRP622014)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,Jiangnan University(2022-3-2)National Key Research and Development Program of China(2022YFF1100300).
文摘Post-exercise whey protein isolate(WPI)supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids(BCAAs).This implies us that intake slow digestion rate of protein to sustain BCAAs releasing rate may facilitate muscle protein synthesis.To examine this hypothesis,we conducted a series of protein supplements including modified slow-digesting whey(SDW),whey,hydrolyzed whey and casein,orally to mice undergoing endurance running.Our results showed that the SDW gavage constant supplied BCAAs in the serum of mice within 6 h and significantly enhanced(P<0.01)endurance exercise capacity,compared to other groups.In addition,the SDW supplementation increased the crosssectional area of mice gastrocnemius fibers,as well as their muscle and liver glycogen content.It also increased the testosterone/cortisol ratio in serum and interleukin-6(IL-6)levels in muscle,while it decreased the tumor necrosis factor-alpha(TNF-α)levels and oxidative stress in muscle.Moreover,it may activate mechanistic target of rapamycin signaling by upregulating mRNA(bcat-1 and pgc-1α)expression.Thus,our findings illustrate that prolonged BCAAs supply duration promotes mice endurance running capacity and skeletal muscle growth,contributing to the advancement of sports nutrition practices.
文摘China and the United States promote stable relations through the Strategic Economic Dialogue As Chinese and U.S.officials concluded their last Strategic Economic Dialogue(SED)dur-ing George W.Bush’s presidency,there were high expectations that the two countries would keep up their efforts to fos-ter sustainable economic relations.
文摘Sino-Vietnamese relations witness their 60th anniversary amid high hopes This month commemorates the 60th anniversary of the establishment of Sino-Vietnamese relations,
文摘Lingering inflation has become the biggest headache for ordinary Chinese people. The CPI growth,a broad measure of inflation,has been hovering around 5 percent since last November,and it even hit a 32-monthhigh of 5.4 percent in March.
文摘The United States and India reaffirm their mutual commitment during Indian prime minister’s recent U.S. trip u.S. President Barack Obama welcomed Indian Prime Minister Manmohan Singh on November 24 with an em- phasis on the continuing value of a partnership carefully developed over
文摘Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
基金supported by the Yayasan Universiti Teknologi PETRONAS(YUTP)under Cost Center 015LC0-485.
文摘Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of conventional UAVs presents a significant challenge to comprehensive and continuous monitoring,which is crucial for maintaining the integrity of pipeline infrastructure.This review paper evaluates methods for extending UAV flight endurance,focusing on their potential application in pipeline inspection.Through an extensive literature review,this study identifies the latest advancements in UAV technology,evaluates their effectiveness,and highlights the existing gaps in achieving prolonged flight operations.Advanced techniques,including artificial intelligence(AI),machine learning(ML),and deep learning(DL),are reviewed for their roles in pipeline monitoring.Notably,DL algorithms like You Only Look Once(YOLO)are explored for autonomous flight in UAV-based inspections,real-time defect detection,such as cracks,corrosion,and leaks,enhancing reliability and accuracy.A vital aspect of this research is the proposed deployment of a hybrid drone design combining lighter-than-air(LTA)and heavier-than-air(HTA)principles,achieving a balance of endurance and maneuverability.LTA vehicles utilize buoyancy to reduce energy consumption,thereby extending flight durations.The paper details the methodology for designing LTA vehicles,presenting an analysis of design parameters that align with the requirements for effective pipeline surveillance.The ongoing work is currently at Technology Readiness Level(TRL)4,where key components have been validated in laboratory conditions,with fabrication and flight testing planned for the next phase.Initial design analysis indicates that LTA configurations could offer significant advantages in flight endurance compared to traditional UAV designs.These findings lay the groundwork for future fabrication and testing phases,which will be critical in validating and assessing the proposed approach’s real-world applicability.By outlining the technical complexities and proposing specialized techniques tailored for pipeline monitoring,this paper provides a foundational framework for advancing UAV capabilities in the oil and gas sector.Researchers and industry practitioners can use this roadmap to further develop UAV-enabled surveillance solutions,aiming to improve the reliability,efficiency,and safety of pipeline monitoring.
基金Supported by the Youth Doctor Support Project of the Education Department of Gansu Province,No.2024QB-100.
文摘BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematically review and conduct a meta-analysis on the effects of exercise rehabilitation on the physical activity of lung cancer patients and determine the best implementation methods to provide clinical guidance.METHODS Literature was searched through multiple electronic databases.A random effects model was used to combine effect sizes through standardized mean difference(SMD).The Cochrane risk of bias tool was used to assess the quality of the lite-rature,sensitivity analysis was used to ensure the robustness of the results,and Egger’s test was used to detect publication bias and asymmetry.RESULTS A total of 11 studies involving 541 patients were included in this study.The phy-sical endurance,muscle function and cardiopulmonary function of non-small cell lung cancer(NSCLC)patients were evaluated.The overall effect size of the six-minute walk test(6MWT)was not statistically significant.However,subgroup analysis found that endurance significantly improved when exercise duration exceeded 0.5 hours(P≤0.05).In terms of muscle function,the overall effect size was SMD=0.619.Subgroup analysis showed that strength training,respiratory training,and cross-training(XT)significantly improved muscle function.Exercise rehabilitation significantly enhanced cardiopulmonary endurance(SMD=0.856,P=0.002),and the effect was better when the single exercise duration was more than 1 hour,age was over 65 years,and the intervention period was more than 3 months.CONCLUSION Exercise rehabilitation effectively improved muscle function in NSCLC patients,especially strength training,respiratory training,and cross-training.Cardiopulmonary function also showed improvement,particularly when exercise duration exceeded 1 hour,age was≥65 years,and the intervention period was more than 3 months.A single exercise duration of more than 0.5 hours can enhance patients’physical endurance.Appropriately increasing exercise duration and selecting suitable exercise forms can effectively improve the physical activity of NSCLC patients.
文摘1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity.2 The novel follows the life of Xu Fugui,a once⁃wealthy landowner who lost his fortune through gambling(赌博).As his status shifted to that of a peasant,he witnessed the rapid changes of society.Despite enduring relentless hardship,Fugui survived,finding moments of comfort in small and everyday acts of perseverance.
基金supported by the National Natural Science Foundation of China(Grant No.NSFC11932013)National Key Research and Development Program of China(Grant No.2022YFB3805800).
文摘Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized controlled trials(RCTs)compared the effects of compression garment wearing with those of non-compression garment wearing(controls)during running on improving running performance.Methods:A comprehensive search was conducted in the electronic databases(Web of Science,EBSCOhost,PubMed,Embase,Scopus,and Cochrane)for RCTs comparing running performance between runners wearing compression garments and controls during running,from inception to September 2024.Independent reviewers screened studies,extracted data,appraised risk of bias(RoB 2)and certainty of evidence(Grading of Recommendations Assessments,Development and Evaluation(GRADE)).Primary outcomes were race time and time to exhaustion.Secondary outcomes covered running speed and race pace,submaximal oxygen uptake,tissue oxygenation,and soft tissue vibration.Randomeffects meta-analyses were conducted to generate pooled estimates,expressed in standardized mean difference(SMD).Subgroup differences of garment,race type,and contact surface were tested in moderator analyses.Results:The search yielded 51 eligible studies comprising 899 participants,of which 33 studies were available for meta-analysis of primary outcomes.Runners wearing compression garments during running showed no significant improvement in race time(SMD=-0.07,95%CI:-0.22 to 0.09;p=0.40)or time to exhaustion(SMD=0.04,95%CI:-0.20 to 0.29;p=0.72).Moderator analyses indicated no effects from garment type,race type,or surface.Secondary outcomes also showed no performance benefits,although compression garments significantly reduced soft tissue vibration(SMD=-0.43,95%CI:-0.70 to-0.15;p<0.01).Certainty of evidence was rated low to very low.Conclusion:Data synthesis of current RCTs offers no updated evidence favoring the support of wearing compression garments during running as a viable strategy for improving running and endurance performance among runners of varying performance levels and types of running races.
文摘Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic review was aimed at analyzing determinants of sport climbing performance and evaluation methods by comparing climbers of different levels.Methods:PubMed,Scopus,and Web of Science were searched up to December 20,2022.Studies providing the self-reported climbing ability associated with different functional outcomes in groups of climbers of contiguous performance levels were eligible.Results:74 studies were finally included.Various methods have been proposed to evaluate determinants of sport climbing performance.Climbing-specific assessments were able to discriminate climbers of different levels when compared to general functional tests.Test validity resulted high for climbing-specific cardiorespiratory endurance as well as muscular-strength,-endurance,and-power;similarly,reliability was good except for cardiorespiratory endurance.Climbing-specific flexibility assessment resulted in high reliability but moderate validity,whereas balance showed low validity.Considerable conflicting evidence was found regarding anthropometric characteristics.Conclusion:The present analysis identified cardiorespiratory endurance as well as muscular-strength,-endurance,and-power as determinants of sport climbing performance.In contrast,balance,flexibility,and anthropometric characteristics seem to count less.This review also proposes an evidence-based Functional Sport Climbing test battery for asses sing performance determinants,which includes tests that have been identified to be valid,reliable,and feasible.While athletes and coaches should rely on evidence-based and standardized evaluation methods,researchers may design specific large-scale trials as a resource for providing additional,homogenous,and comparable data to improve scientific evidence and professionalism in this popular sport discipline.
