A physiological state of＂normoxia＂obtains when tissue oxygen tension（pO_2）is sufficient to drive mitochondrial respiration throughout a volume of cells.Between 30-40%of the available oxygen is normally extracted f...A physiological state of＂normoxia＂obtains when tissue oxygen tension（pO_2）is sufficient to drive mitochondrial respiration throughout a volume of cells.Between 30-40%of the available oxygen is normally extracted from hemoglobin as it passes through neural tissue.展开更多
Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focu...Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focus on their effects on recovery metrics,particularly how they influence sleep quality,perceived wellness,and athletic performance.Despite anecdotal evidence of its efficacy,rigorous comparative studies are scarce.Objective:This study aimed to evaluates and compare the effects of WCT and DCT on endurance,perceived wellness,exertion levels,and sleep quality among young,active males,addressing the gap in the literature regarding CT's efficacy in sports performance and recovery.Methods:Thirty-two amateur runners were randomly divided into two groups:one followed WCT sessions and the other followed DCT sessions.The study assessed the interventions'impacts on endurance performance(Yo-Yo intermittent recovery test),sleep quality(Pittsburgh Sleep Quality Index),and perceived exertion(Borg CR10 Scale).Heart rate was measured using a Polar H10 sensor to gauge physiological responses during physical tests.Results:Significant improvements were observed in the WCT group for sleep latency(%change=-82.31%;interaction group×time p=0.006;Cohen's d=0.74)and sleep disturbance(%change=-68.70%;interaction group×time p<0.001;Cohen's d=1.09),suggesting enhanced sleep quality(global score;%change=-52.81;interaction group×time p=0.004;Cohen's d=0.77).However,no significant differences were found in direct performance metrics(distance,maximal heart rate,maximal oxygen uptake)between WCT and DCT groups.These findings highlight WCT's potential as a recovery aid,particularly through improved sleep,without directly influencing endurance performance outcomes.Conclusion:WCT may serve as an effective ergogenic aid for athletes by potentially improving sleep quality and reducing perceived exertion,thus contributing indirectly to performance through enhanced recovery.展开更多
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in...Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.展开更多
BEFORE coming to China in 1986, I had spent months collecting all sorts of information on China and asking Chinese friends of mine about their everyday lives. So I felt fairly well informed before my trip. But when I ...BEFORE coming to China in 1986, I had spent months collecting all sorts of information on China and asking Chinese friends of mine about their everyday lives. So I felt fairly well informed before my trip. But when I landed in China, I was a bit disappointed. Everyihing looked so Western here. Of course, in Germany you never see a man kill a hen in the street for lunch or cabbages stacked on the sidewalk to dry in the sun. But overall, China’s streets resemble those in big cities all over the world. Looking at Western-style clothing, vehicles and modern buildings, somehow I missed the Chinese flair. I knew about China’s modernization drive, but I was展开更多
Before you can tie your shoelaces for one of the worlds most remote races,you must first navigate through wild seas,endure(忍受)freezing temperatures and go on a journey that tests more than just your physical enduran...Before you can tie your shoelaces for one of the worlds most remote races,you must first navigate through wild seas,endure(忍受)freezing temperatures and go on a journey that tests more than just your physical endurance.This is no ordinary race;it requires thorough preparation and a strong will.展开更多
Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of co...Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of conventional UAVs presents a significant challenge to comprehensive and continuous monitoring,which is crucial for maintaining the integrity of pipeline infrastructure.This review paper evaluates methods for extending UAV flight endurance,focusing on their potential application in pipeline inspection.Through an extensive literature review,this study identifies the latest advancements in UAV technology,evaluates their effectiveness,and highlights the existing gaps in achieving prolonged flight operations.Advanced techniques,including artificial intelligence(AI),machine learning(ML),and deep learning(DL),are reviewed for their roles in pipeline monitoring.Notably,DL algorithms like You Only Look Once(YOLO)are explored for autonomous flight in UAV-based inspections,real-time defect detection,such as cracks,corrosion,and leaks,enhancing reliability and accuracy.A vital aspect of this research is the proposed deployment of a hybrid drone design combining lighter-than-air(LTA)and heavier-than-air(HTA)principles,achieving a balance of endurance and maneuverability.LTA vehicles utilize buoyancy to reduce energy consumption,thereby extending flight durations.The paper details the methodology for designing LTA vehicles,presenting an analysis of design parameters that align with the requirements for effective pipeline surveillance.The ongoing work is currently at Technology Readiness Level(TRL)4,where key components have been validated in laboratory conditions,with fabrication and flight testing planned for the next phase.Initial design analysis indicates that LTA configurations could offer significant advantages in flight endurance compared to traditional UAV designs.These findings lay the groundwork for future fabrication and testing phases,which will be critical in validating and assessing the proposed approach’s real-world applicability.By outlining the technical complexities and proposing specialized techniques tailored for pipeline monitoring,this paper provides a foundational framework for advancing UAV capabilities in the oil and gas sector.Researchers and industry practitioners can use this roadmap to further develop UAV-enabled surveillance solutions,aiming to improve the reliability,efficiency,and safety of pipeline monitoring.展开更多
BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematicall...BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematically review and conduct a meta-analysis on the effects of exercise rehabilitation on the physical activity of lung cancer patients and determine the best implementation methods to provide clinical guidance.METHODS Literature was searched through multiple electronic databases.A random effects model was used to combine effect sizes through standardized mean difference(SMD).The Cochrane risk of bias tool was used to assess the quality of the lite-rature,sensitivity analysis was used to ensure the robustness of the results,and Egger’s test was used to detect publication bias and asymmetry.RESULTS A total of 11 studies involving 541 patients were included in this study.The phy-sical endurance,muscle function and cardiopulmonary function of non-small cell lung cancer(NSCLC)patients were evaluated.The overall effect size of the six-minute walk test(6MWT)was not statistically significant.However,subgroup analysis found that endurance significantly improved when exercise duration exceeded 0.5 hours(P≤0.05).In terms of muscle function,the overall effect size was SMD=0.619.Subgroup analysis showed that strength training,respiratory training,and cross-training(XT)significantly improved muscle function.Exercise rehabilitation significantly enhanced cardiopulmonary endurance(SMD=0.856,P=0.002),and the effect was better when the single exercise duration was more than 1 hour,age was over 65 years,and the intervention period was more than 3 months.CONCLUSION Exercise rehabilitation effectively improved muscle function in NSCLC patients,especially strength training,respiratory training,and cross-training.Cardiopulmonary function also showed improvement,particularly when exercise duration exceeded 1 hour,age was≥65 years,and the intervention period was more than 3 months.A single exercise duration of more than 0.5 hours can enhance patients’physical endurance.Appropriately increasing exercise duration and selecting suitable exercise forms can effectively improve the physical activity of NSCLC patients.展开更多
Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity....1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity.2 The novel follows the life of Xu Fugui,a once⁃wealthy landowner who lost his fortune through gambling(赌博).As his status shifted to that of a peasant,he witnessed the rapid changes of society.Despite enduring relentless hardship,Fugui survived,finding moments of comfort in small and everyday acts of perseverance.展开更多
Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized c...Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized controlled trials(RCTs)compared the effects of compression garment wearing with those of non-compression garment wearing(controls)during running on improving running performance.Methods:A comprehensive search was conducted in the electronic databases(Web of Science,EBSCOhost,PubMed,Embase,Scopus,and Cochrane)for RCTs comparing running performance between runners wearing compression garments and controls during running,from inception to September 2024.Independent reviewers screened studies,extracted data,appraised risk of bias(RoB 2)and certainty of evidence(Grading of Recommendations Assessments,Development and Evaluation(GRADE)).Primary outcomes were race time and time to exhaustion.Secondary outcomes covered running speed and race pace,submaximal oxygen uptake,tissue oxygenation,and soft tissue vibration.Randomeffects meta-analyses were conducted to generate pooled estimates,expressed in standardized mean difference(SMD).Subgroup differences of garment,race type,and contact surface were tested in moderator analyses.Results:The search yielded 51 eligible studies comprising 899 participants,of which 33 studies were available for meta-analysis of primary outcomes.Runners wearing compression garments during running showed no significant improvement in race time(SMD=-0.07,95%CI:-0.22 to 0.09;p=0.40)or time to exhaustion(SMD=0.04,95%CI:-0.20 to 0.29;p=0.72).Moderator analyses indicated no effects from garment type,race type,or surface.Secondary outcomes also showed no performance benefits,although compression garments significantly reduced soft tissue vibration(SMD=-0.43,95%CI:-0.70 to-0.15;p<0.01).Certainty of evidence was rated low to very low.Conclusion:Data synthesis of current RCTs offers no updated evidence favoring the support of wearing compression garments during running as a viable strategy for improving running and endurance performance among runners of varying performance levels and types of running races.展开更多
Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic r...Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic review was aimed at analyzing determinants of sport climbing performance and evaluation methods by comparing climbers of different levels.Methods:PubMed,Scopus,and Web of Science were searched up to December 20,2022.Studies providing the self-reported climbing ability associated with different functional outcomes in groups of climbers of contiguous performance levels were eligible.Results:74 studies were finally included.Various methods have been proposed to evaluate determinants of sport climbing performance.Climbing-specific assessments were able to discriminate climbers of different levels when compared to general functional tests.Test validity resulted high for climbing-specific cardiorespiratory endurance as well as muscular-strength,-endurance,and-power;similarly,reliability was good except for cardiorespiratory endurance.Climbing-specific flexibility assessment resulted in high reliability but moderate validity,whereas balance showed low validity.Considerable conflicting evidence was found regarding anthropometric characteristics.Conclusion:The present analysis identified cardiorespiratory endurance as well as muscular-strength,-endurance,and-power as determinants of sport climbing performance.In contrast,balance,flexibility,and anthropometric characteristics seem to count less.This review also proposes an evidence-based Functional Sport Climbing test battery for asses sing performance determinants,which includes tests that have been identified to be valid,reliable,and feasible.While athletes and coaches should rely on evidence-based and standardized evaluation methods,researchers may design specific large-scale trials as a resource for providing additional,homogenous,and comparable data to improve scientific evidence and professionalism in this popular sport discipline.展开更多
Rainbows-symbolizing peace,hope,promise and endurance(忍耐力)in hard times-are springing up in neighborhoods throughout Long Island in an effort to color the future road with optimism.The campaign,Rainbows over Nassau...Rainbows-symbolizing peace,hope,promise and endurance(忍耐力)in hard times-are springing up in neighborhoods throughout Long Island in an effort to color the future road with optimism.The campaign,Rainbows over Nassau and Suffolk Counties and Beyond,started on March 21 and spread through a group.It's a campaign that encourages participants to make rainbows to display outside their homes,anywhere from their front windows and doors to lawns and sidewalks.It follows another similar project,Chalk Your Walk,which promotes writing hopeful messages in chalk on driveways and sidewalks.展开更多
Background:Surf skateboards have grown in popularity among young people in recent years.However,no research studies have analyzed the effect of surf skateboarding on physical fitness.Objective:The purpose of this stud...Background:Surf skateboards have grown in popularity among young people in recent years.However,no research studies have analyzed the effect of surf skateboarding on physical fitness.Objective:The purpose of this study was to determine the effects of 8-week surf skateboard training on physical fitness in young adults.Methods:Twenty-two young people,ages 18–24 years were randomly assigned into two groups:a control(CON;n=11)and surf skateboarding(SSK;n=11)group.The surf skateboard training group received an eight-week intervention consisting of three 60-minute(min)sessions per week,while the control group continued with their normal daily lives.Physical fitness was assessed before and after the intervention through a battery of tests that included body composition,cardiorespiratory fitness,muscular strength and endurance,flexibility,and balance.Results:The results showed that the SSK group demonstrated significant(p<0.05)improvements in maximum voluntary ventilation,back and leg strength,lower body muscular endurance by the sit-to-stand tests,and balance in all direction compared with the pre-test and the CON group.In addition,the SSK group showed significantly(p<0.05)decreased body weight,body mass index,percent body fat,and resting heart rate,while increased maximum oxygen consumption,pulmonary function,respiratory muscle strength,upper body muscular endurance by the sit-up test and flexibility compared with the pre-test.Conclusion:The findings suggest that surf skateboard training have an effective physical activity intervention to improve body composition,cardiorespiratory fitness,muscular strength and endurance,flexibility,and balance in young people.展开更多
BACKGROUND In pediatric and adolescent athletes,there is a lack of understanding about the impact of factors such as race on the structural or cardiovascular adaptations in response to exercise which may unnecessarily...BACKGROUND In pediatric and adolescent athletes,there is a lack of understanding about the impact of factors such as race on the structural or cardiovascular adaptations in response to exercise which may unnecessarily disqualify athletes from the competitive sport.We hypothesized that race has an impact on cardiac adaptions in non-adult athletes.AIM To explore the racial disparity in electrocardiographic(ECG)and echocardiographic(ECHO)parameters in healthy adolescent athletes.METHODS A comprehensive electronic systematic literature search using MEDLINE database was performed from inception to September 20,2024.Inclusion criteria included randomized or observational cohort studies that recruited adolescent competitive athletes in any sport discipline and compared between the Black and White races with an age range of 12-18 years.RESULTS Of 723 records that were identified by the literature search,seven studies(n=5036)were included.The mean age was 13.0-18.0 years old with male predominance.Black athletes had significantly longer PR interval[mean difference(MD)=17.49 millisecond,95% CI:11.70-23.29]and shorter QRS complex duration(MD=-7.35 millisecond,95% CI:-9.17 to-5.53)and corrected QT interval(MD=-4.95 millisecond,95% CI:-7.69 to-2.22)than the White athletes.Black athletes were approximately four times more likely to have first-degree atrioventricular(AV)block,inverted T wave,ST-segment elevation,and left atrium(LA)enlargement than their White counterparts.In terms of ECHO parameters,Black athletes had significantly greater septal wall thickness(MD=0.85 mm,95% CI:0.62-1.07),posterior wall thickness(MD=1.07 mm,95% CI:0.36-1.78),relative wall thickness(MD=0.03,95%CI:0.001-0.06),maximal wall thickness(MD=1.05 mm,95%CI:0.28-1.83),and LA diameter(MD=1.64 mm,95%CI:0.16-3.12).CONCLUSION Race has an impact on the ECG and ECHO parameters that reflect cardiac adaptations in adolescent athletes.Black athletes tend to have an increased prevalence of distinct ECG changes such as first-degree AV block and T-wave inversions compared with their White counterparts.Despite having thicker septal and posterior walls,the overall prevalence of left ventricular hypertrophy did not differ between the races.展开更多
Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exerc...Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide(TMAO)levels,a metabolite related to major adverse cardiovascular events.Methods:Blood samples from 28 marathon runners were collected two weeks before the marathon run(baseline),after finishing the race(post-marathon),and two weeks after the race(2 weeks post-marathon).Serum cardiac troponin I(c Tn I),endothelin-1(ET-1),galectin-3,pentraxin-3,human growth differentiation factor 15,and neopterin were determined by the enzyme immunoassay method.Plasma trimethylamine(TMA)and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.Results:Running a marathon increased levels of circulating biomarkers.A greater post-marathon elevation of cTn I and ET-1 was associated with baseline plasma TMAO levels(R=0.400,p=0.035 and R=0.476,p=0.012,respectively).Moreover,we observed an increase in post-marathon TMA levels.Conclusion:Greater post-marathon elevation of cTn I and ET-1 was associated with higher baseline plasma TMAO levels.Therefore,TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.展开更多
文摘A physiological state of＂normoxia＂obtains when tissue oxygen tension（pO_2）is sufficient to drive mitochondrial respiration throughout a volume of cells.Between 30-40%of the available oxygen is normally extracted from hemoglobin as it passes through neural tissue.
文摘Background:Cupping therapy(CT),an ancient practice revived in modern sports medicine,offers potential benefits for athlete recovery and performance.Distinctions between wet CT(WCT)and dry CT(DCT)in sports science focus on their effects on recovery metrics,particularly how they influence sleep quality,perceived wellness,and athletic performance.Despite anecdotal evidence of its efficacy,rigorous comparative studies are scarce.Objective:This study aimed to evaluates and compare the effects of WCT and DCT on endurance,perceived wellness,exertion levels,and sleep quality among young,active males,addressing the gap in the literature regarding CT's efficacy in sports performance and recovery.Methods:Thirty-two amateur runners were randomly divided into two groups:one followed WCT sessions and the other followed DCT sessions.The study assessed the interventions'impacts on endurance performance(Yo-Yo intermittent recovery test),sleep quality(Pittsburgh Sleep Quality Index),and perceived exertion(Borg CR10 Scale).Heart rate was measured using a Polar H10 sensor to gauge physiological responses during physical tests.Results:Significant improvements were observed in the WCT group for sleep latency(%change=-82.31%;interaction group×time p=0.006;Cohen's d=0.74)and sleep disturbance(%change=-68.70%;interaction group×time p<0.001;Cohen's d=1.09),suggesting enhanced sleep quality(global score;%change=-52.81;interaction group×time p=0.004;Cohen's d=0.77).However,no significant differences were found in direct performance metrics(distance,maximal heart rate,maximal oxygen uptake)between WCT and DCT groups.These findings highlight WCT's potential as a recovery aid,particularly through improved sleep,without directly influencing endurance performance outcomes.Conclusion:WCT may serve as an effective ergogenic aid for athletes by potentially improving sleep quality and reducing perceived exertion,thus contributing indirectly to performance through enhanced recovery.
基金supported by grants from the Knut and Alice Wallenberg foundation(P-OB,JRZ,and AK)the Swedish Research Council(JRZ and AK),Centrum för idrottsforskning(AK and JRZ)+7 种基金the NovoNordisk Foundation Metabolic Stress Associated Molecules(MSAM)consortium NNF15SA0018346 and Metabolite-related Inflammation and Disease(MeRIAD)consortium Grant number 0064142(AK)the Swedish Diabetes Foundation(AK and JRZ)the European Foundation for the Study of Diabetes(JRZ and AK)the Region Stockholm(ALF project)(JRZ and KC)the Strategic Research Program in Diabetes at Karolinska Institutet(JRZ and AK)supported by the Strategic Research Programme in Diabetes(SRP Diabetes)for use of the Seahorse flux analyzer.Human islets were made possible through the Juvenile Diabetes Research Foundation(JDRF)award 31-2008-416(European Coordinating Infrastructure for Islet Transplantation(ECIT),Islet for Basic Research program)AK holds a Distinguished Investigator Grant within Endocrinology and Metabolism from the Novo Nordisk Foundation(NNF24OC0088739)JRZ received the 2024 European Association for the Study of Diabetes(ESAD)-Novo Nordisk Foundation Diabetes Prize for Excellence(NNF24SA0092609).
文摘Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.
文摘BEFORE coming to China in 1986, I had spent months collecting all sorts of information on China and asking Chinese friends of mine about their everyday lives. So I felt fairly well informed before my trip. But when I landed in China, I was a bit disappointed. Everyihing looked so Western here. Of course, in Germany you never see a man kill a hen in the street for lunch or cabbages stacked on the sidewalk to dry in the sun. But overall, China’s streets resemble those in big cities all over the world. Looking at Western-style clothing, vehicles and modern buildings, somehow I missed the Chinese flair. I knew about China’s modernization drive, but I was
文摘Before you can tie your shoelaces for one of the worlds most remote races,you must first navigate through wild seas,endure(忍受)freezing temperatures and go on a journey that tests more than just your physical endurance.This is no ordinary race;it requires thorough preparation and a strong will.
基金supported by the Yayasan Universiti Teknologi PETRONAS(YUTP)under Cost Center 015LC0-485.
文摘Unmanned aerial vehicles(UAVs)technology is rapidly advancing,offering innovative solutions for various industries,including the critical task of oil and gas pipeline surveillance.However,the limited flight time of conventional UAVs presents a significant challenge to comprehensive and continuous monitoring,which is crucial for maintaining the integrity of pipeline infrastructure.This review paper evaluates methods for extending UAV flight endurance,focusing on their potential application in pipeline inspection.Through an extensive literature review,this study identifies the latest advancements in UAV technology,evaluates their effectiveness,and highlights the existing gaps in achieving prolonged flight operations.Advanced techniques,including artificial intelligence(AI),machine learning(ML),and deep learning(DL),are reviewed for their roles in pipeline monitoring.Notably,DL algorithms like You Only Look Once(YOLO)are explored for autonomous flight in UAV-based inspections,real-time defect detection,such as cracks,corrosion,and leaks,enhancing reliability and accuracy.A vital aspect of this research is the proposed deployment of a hybrid drone design combining lighter-than-air(LTA)and heavier-than-air(HTA)principles,achieving a balance of endurance and maneuverability.LTA vehicles utilize buoyancy to reduce energy consumption,thereby extending flight durations.The paper details the methodology for designing LTA vehicles,presenting an analysis of design parameters that align with the requirements for effective pipeline surveillance.The ongoing work is currently at Technology Readiness Level(TRL)4,where key components have been validated in laboratory conditions,with fabrication and flight testing planned for the next phase.Initial design analysis indicates that LTA configurations could offer significant advantages in flight endurance compared to traditional UAV designs.These findings lay the groundwork for future fabrication and testing phases,which will be critical in validating and assessing the proposed approach’s real-world applicability.By outlining the technical complexities and proposing specialized techniques tailored for pipeline monitoring,this paper provides a foundational framework for advancing UAV capabilities in the oil and gas sector.Researchers and industry practitioners can use this roadmap to further develop UAV-enabled surveillance solutions,aiming to improve the reliability,efficiency,and safety of pipeline monitoring.
基金Supported by the Youth Doctor Support Project of the Education Department of Gansu Province,No.2024QB-100.
文摘BACKGROUND Lung cancer is one of the most common and deadly cancers worldwide.As the disease progresses and due to the side effects of treatment,patients’physical activity significantly decreases.AIM To systematically review and conduct a meta-analysis on the effects of exercise rehabilitation on the physical activity of lung cancer patients and determine the best implementation methods to provide clinical guidance.METHODS Literature was searched through multiple electronic databases.A random effects model was used to combine effect sizes through standardized mean difference(SMD).The Cochrane risk of bias tool was used to assess the quality of the lite-rature,sensitivity analysis was used to ensure the robustness of the results,and Egger’s test was used to detect publication bias and asymmetry.RESULTS A total of 11 studies involving 541 patients were included in this study.The phy-sical endurance,muscle function and cardiopulmonary function of non-small cell lung cancer(NSCLC)patients were evaluated.The overall effect size of the six-minute walk test(6MWT)was not statistically significant.However,subgroup analysis found that endurance significantly improved when exercise duration exceeded 0.5 hours(P≤0.05).In terms of muscle function,the overall effect size was SMD=0.619.Subgroup analysis showed that strength training,respiratory training,and cross-training(XT)significantly improved muscle function.Exercise rehabilitation significantly enhanced cardiopulmonary endurance(SMD=0.856,P=0.002),and the effect was better when the single exercise duration was more than 1 hour,age was over 65 years,and the intervention period was more than 3 months.CONCLUSION Exercise rehabilitation effectively improved muscle function in NSCLC patients,especially strength training,respiratory training,and cross-training.Cardiopulmonary function also showed improvement,particularly when exercise duration exceeded 1 hour,age was≥65 years,and the intervention period was more than 3 months.A single exercise duration of more than 0.5 hours can enhance patients’physical endurance.Appropriately increasing exercise duration and selecting suitable exercise forms can effectively improve the physical activity of NSCLC patients.
文摘Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
文摘1 Originally published in 1993,To Live,a novel by Chinese author Yu Hua has since gained international recognition for its raw emotional depth and exploration of themes like fate,endurance and the essence of humanity.2 The novel follows the life of Xu Fugui,a once⁃wealthy landowner who lost his fortune through gambling(赌博).As his status shifted to that of a peasant,he witnessed the rapid changes of society.Despite enduring relentless hardship,Fugui survived,finding moments of comfort in small and everyday acts of perseverance.
基金supported by the National Natural Science Foundation of China(Grant No.NSFC11932013)National Key Research and Development Program of China(Grant No.2022YFB3805800).
文摘Background:Despite the wide use of compression garments to enhance athletic running performance,evidence supporting improvements has not been conclusive.This updated systematic review and meta-analysis of randomized controlled trials(RCTs)compared the effects of compression garment wearing with those of non-compression garment wearing(controls)during running on improving running performance.Methods:A comprehensive search was conducted in the electronic databases(Web of Science,EBSCOhost,PubMed,Embase,Scopus,and Cochrane)for RCTs comparing running performance between runners wearing compression garments and controls during running,from inception to September 2024.Independent reviewers screened studies,extracted data,appraised risk of bias(RoB 2)and certainty of evidence(Grading of Recommendations Assessments,Development and Evaluation(GRADE)).Primary outcomes were race time and time to exhaustion.Secondary outcomes covered running speed and race pace,submaximal oxygen uptake,tissue oxygenation,and soft tissue vibration.Randomeffects meta-analyses were conducted to generate pooled estimates,expressed in standardized mean difference(SMD).Subgroup differences of garment,race type,and contact surface were tested in moderator analyses.Results:The search yielded 51 eligible studies comprising 899 participants,of which 33 studies were available for meta-analysis of primary outcomes.Runners wearing compression garments during running showed no significant improvement in race time(SMD=-0.07,95%CI:-0.22 to 0.09;p=0.40)or time to exhaustion(SMD=0.04,95%CI:-0.20 to 0.29;p=0.72).Moderator analyses indicated no effects from garment type,race type,or surface.Secondary outcomes also showed no performance benefits,although compression garments significantly reduced soft tissue vibration(SMD=-0.43,95%CI:-0.70 to-0.15;p<0.01).Certainty of evidence was rated low to very low.Conclusion:Data synthesis of current RCTs offers no updated evidence favoring the support of wearing compression garments during running as a viable strategy for improving running and endurance performance among runners of varying performance levels and types of running races.
文摘Background:Sport climbing is becoming incredibly popular both in the general population and among athletes.No consensus exists regarding evidence-based sport-specific performance evaluation;therefore,this systematic review was aimed at analyzing determinants of sport climbing performance and evaluation methods by comparing climbers of different levels.Methods:PubMed,Scopus,and Web of Science were searched up to December 20,2022.Studies providing the self-reported climbing ability associated with different functional outcomes in groups of climbers of contiguous performance levels were eligible.Results:74 studies were finally included.Various methods have been proposed to evaluate determinants of sport climbing performance.Climbing-specific assessments were able to discriminate climbers of different levels when compared to general functional tests.Test validity resulted high for climbing-specific cardiorespiratory endurance as well as muscular-strength,-endurance,and-power;similarly,reliability was good except for cardiorespiratory endurance.Climbing-specific flexibility assessment resulted in high reliability but moderate validity,whereas balance showed low validity.Considerable conflicting evidence was found regarding anthropometric characteristics.Conclusion:The present analysis identified cardiorespiratory endurance as well as muscular-strength,-endurance,and-power as determinants of sport climbing performance.In contrast,balance,flexibility,and anthropometric characteristics seem to count less.This review also proposes an evidence-based Functional Sport Climbing test battery for asses sing performance determinants,which includes tests that have been identified to be valid,reliable,and feasible.While athletes and coaches should rely on evidence-based and standardized evaluation methods,researchers may design specific large-scale trials as a resource for providing additional,homogenous,and comparable data to improve scientific evidence and professionalism in this popular sport discipline.
文摘Rainbows-symbolizing peace,hope,promise and endurance(忍耐力)in hard times-are springing up in neighborhoods throughout Long Island in an effort to color the future road with optimism.The campaign,Rainbows over Nassau and Suffolk Counties and Beyond,started on March 21 and spread through a group.It's a campaign that encourages participants to make rainbows to display outside their homes,anywhere from their front windows and doors to lawns and sidewalks.It follows another similar project,Chalk Your Walk,which promotes writing hopeful messages in chalk on driveways and sidewalks.
基金supported by Exercise Physiologyin Special Population Research Unit,and Faculty of Sports Science Fund,Chulalongkorn University。
文摘Background:Surf skateboards have grown in popularity among young people in recent years.However,no research studies have analyzed the effect of surf skateboarding on physical fitness.Objective:The purpose of this study was to determine the effects of 8-week surf skateboard training on physical fitness in young adults.Methods:Twenty-two young people,ages 18–24 years were randomly assigned into two groups:a control(CON;n=11)and surf skateboarding(SSK;n=11)group.The surf skateboard training group received an eight-week intervention consisting of three 60-minute(min)sessions per week,while the control group continued with their normal daily lives.Physical fitness was assessed before and after the intervention through a battery of tests that included body composition,cardiorespiratory fitness,muscular strength and endurance,flexibility,and balance.Results:The results showed that the SSK group demonstrated significant(p<0.05)improvements in maximum voluntary ventilation,back and leg strength,lower body muscular endurance by the sit-to-stand tests,and balance in all direction compared with the pre-test and the CON group.In addition,the SSK group showed significantly(p<0.05)decreased body weight,body mass index,percent body fat,and resting heart rate,while increased maximum oxygen consumption,pulmonary function,respiratory muscle strength,upper body muscular endurance by the sit-up test and flexibility compared with the pre-test.Conclusion:The findings suggest that surf skateboard training have an effective physical activity intervention to improve body composition,cardiorespiratory fitness,muscular strength and endurance,flexibility,and balance in young people.
文摘BACKGROUND In pediatric and adolescent athletes,there is a lack of understanding about the impact of factors such as race on the structural or cardiovascular adaptations in response to exercise which may unnecessarily disqualify athletes from the competitive sport.We hypothesized that race has an impact on cardiac adaptions in non-adult athletes.AIM To explore the racial disparity in electrocardiographic(ECG)and echocardiographic(ECHO)parameters in healthy adolescent athletes.METHODS A comprehensive electronic systematic literature search using MEDLINE database was performed from inception to September 20,2024.Inclusion criteria included randomized or observational cohort studies that recruited adolescent competitive athletes in any sport discipline and compared between the Black and White races with an age range of 12-18 years.RESULTS Of 723 records that were identified by the literature search,seven studies(n=5036)were included.The mean age was 13.0-18.0 years old with male predominance.Black athletes had significantly longer PR interval[mean difference(MD)=17.49 millisecond,95% CI:11.70-23.29]and shorter QRS complex duration(MD=-7.35 millisecond,95% CI:-9.17 to-5.53)and corrected QT interval(MD=-4.95 millisecond,95% CI:-7.69 to-2.22)than the White athletes.Black athletes were approximately four times more likely to have first-degree atrioventricular(AV)block,inverted T wave,ST-segment elevation,and left atrium(LA)enlargement than their White counterparts.In terms of ECHO parameters,Black athletes had significantly greater septal wall thickness(MD=0.85 mm,95% CI:0.62-1.07),posterior wall thickness(MD=1.07 mm,95% CI:0.36-1.78),relative wall thickness(MD=0.03,95%CI:0.001-0.06),maximal wall thickness(MD=1.05 mm,95%CI:0.28-1.83),and LA diameter(MD=1.64 mm,95%CI:0.16-3.12).CONCLUSION Race has an impact on the ECG and ECHO parameters that reflect cardiac adaptations in adolescent athletes.Black athletes tend to have an increased prevalence of distinct ECG changes such as first-degree AV block and T-wave inversions compared with their White counterparts.Despite having thicker septal and posterior walls,the overall prevalence of left ventricular hypertrophy did not differ between the races.
基金supported by the Polish Ministry of Science and Higher Education,grant no.2/566516/SPUB/SP/2023。
文摘Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide(TMAO)levels,a metabolite related to major adverse cardiovascular events.Methods:Blood samples from 28 marathon runners were collected two weeks before the marathon run(baseline),after finishing the race(post-marathon),and two weeks after the race(2 weeks post-marathon).Serum cardiac troponin I(c Tn I),endothelin-1(ET-1),galectin-3,pentraxin-3,human growth differentiation factor 15,and neopterin were determined by the enzyme immunoassay method.Plasma trimethylamine(TMA)and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.Results:Running a marathon increased levels of circulating biomarkers.A greater post-marathon elevation of cTn I and ET-1 was associated with baseline plasma TMAO levels(R=0.400,p=0.035 and R=0.476,p=0.012,respectively).Moreover,we observed an increase in post-marathon TMA levels.Conclusion:Greater post-marathon elevation of cTn I and ET-1 was associated with higher baseline plasma TMAO levels.Therefore,TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.
