Blue phosphorescent OLEDs(Ph-OLEDs)have long faced critical challenges in efficiency,stability and brightness,which are crucial for advanced display.Herein,we introduce two novel Ir(III)emitters featuring a 3,6-di(ter...Blue phosphorescent OLEDs(Ph-OLEDs)have long faced critical challenges in efficiency,stability and brightness,which are crucial for advanced display.Herein,we introduce two novel Ir(III)emitters featuring a 3,6-di(tert-butyl)-9Hcarbazolyl(tBuCz)substituted tridentate carbene pincer ligand,significantly improving efficiency and stability.The tBuCz-m-CF3 and tBuCz-p-CF3 complexes are designed to enhance steric encumbrance and minimize exciton accumulation.These innovations lead to exceptional photoluminescence quantum yields(PLQY)of 98%and an impressive decay rate constant of 7.97×10^(5)s^(−1)in doped thin films.The Ph-OLEDs emit blue light with a peak wavelength of 485 nm and CIE coordinates of(0.175,0.446),exhibiting a peak external quantum efficiencies(EQE)of 31.62%and brightness up to 214,255 cdm^(−2).Notably,they shown minimal efficiency roll-off,retaining an EQE of 27.76%at 10,000 cdm^(−2),and 20.58%at 100,000 cdm^(−2).These consistent performances across various brightness levels represent a significant milestone for blue Ph-OLED technology.The devices also exhibit impressive stability,with an operational lifetime(LT50,the time taken for luminance to decrease by 50%)reaching 1237 h at 1000 cdm^(−2),setting new benchmarks for blue Ph-OLEDs.To enhance the color purity,hyper-OLEDs were developed with a full width at half maximum(FWHM)of 20 nm and the CIEy of 0.233,achieving an EQEm of 29.78%and LT50 of 318 h at 1000 cdm^(−2).We also fabricated the active-matrix(AM)blue Hyper-OLEDs with 400 pixels per inch to demonstrate their application in AM displays.展开更多
Objective: To investigate the clinical efficacy of Fuzheng Jiedu formula combined with interferon in the treatment of human papillomavirus (HPV) infection in patients with infertility.Methods: A total of 750 infertile...Objective: To investigate the clinical efficacy of Fuzheng Jiedu formula combined with interferon in the treatment of human papillomavirus (HPV) infection in patients with infertility.Methods: A total of 750 infertile patients with persistent HPV infection were randomly divided into Group A (n = 240, interferon), Group B (n = 260, Fuzheng Jiedu formula), and Group C (n = 250, interferon + Fuzheng Jiedu formula). The traditional Chinese medicine (TCM) symptoms, efficacy, immune function, and HPV conversion were compared among the three groups, and statistical analysis was conducted on the data before and after treatment among the three groups, including TCM symptom score, total efficacy, CD3^(+), CD4^(+), CD8^(+), CD4^(+)/CD8^(+) levels, and HPV-DNA conversion rate.Results: The total efficacies of Group A, Group B, and Group C were 89.58%, 62.50%, and 98.00%, respectively;the conversion rates of HPV-DNA in Group A, Group B, and Group C were 62.50%, 67.31%, and 90.00%, respectively. The TCM symptom score of the three groups was most significantly reduced in Group C, followed by Group B, and there was a statistical difference between the groups (P <0.05). The efficacy of the three groups was highest in Group C, followed by Group A, and Group B, with statistical differences (P <0.05). A pairwise comparison of the HPV conversion rates of the three groups showed that Group C had the highest HPV conversion rate (P <0.05);HPV16 and HPV18 subtypes displayed high conversion rates among the different HPV subtypes (P <0.05), whereas the comparisons between the remaining subtypes showed no statistically significant differences (P >0.05). CD3^(+), CD4^(+), and CD4^(+)/CD8^(+) levels showed an increasing trend in the three groups after treatment, whereas the CD8^(+) level decreased (P <0.05). Pairwise comparison showed that CD3^(+), CD4^(+), and CD4^(+)/CD8^(+) levels were more elevated in Group C than those in Groups A and B (P <0.05).Conclusion: Fuzheng Jiedu formula notably improves the efficacy of HPV persistent infection and HPV conversion rate in patients with infertility, and its efficacy is better than that of TCM and Western medicine alone. The mechanism is mainly related to the fact that TCM improves the symptom score of syndromes of spleen asthenia and dampness encumbrance and increases CD3^(+), CD4^(+), CD4^(+)/CD8^(+) levels. The effect of combined therapy on improving immunity is more advantageous than that of TCM or Western medicine alone.展开更多
基金the National Natural Science Foundation of China(grant no.:52027817)Shenzhen Science and Technology Innovation Commission(grant no.:GJHZ20210705143204013)+1 种基金Research Grant Council of Hong Kong(grant no.:CityU 11312722)lShenzhen Science and Technology Innovation Commission(grant no.:JCYJ20200109144614514)China Postdoctoral Science Foundation(grant no:2024M761639).
文摘Blue phosphorescent OLEDs(Ph-OLEDs)have long faced critical challenges in efficiency,stability and brightness,which are crucial for advanced display.Herein,we introduce two novel Ir(III)emitters featuring a 3,6-di(tert-butyl)-9Hcarbazolyl(tBuCz)substituted tridentate carbene pincer ligand,significantly improving efficiency and stability.The tBuCz-m-CF3 and tBuCz-p-CF3 complexes are designed to enhance steric encumbrance and minimize exciton accumulation.These innovations lead to exceptional photoluminescence quantum yields(PLQY)of 98%and an impressive decay rate constant of 7.97×10^(5)s^(−1)in doped thin films.The Ph-OLEDs emit blue light with a peak wavelength of 485 nm and CIE coordinates of(0.175,0.446),exhibiting a peak external quantum efficiencies(EQE)of 31.62%and brightness up to 214,255 cdm^(−2).Notably,they shown minimal efficiency roll-off,retaining an EQE of 27.76%at 10,000 cdm^(−2),and 20.58%at 100,000 cdm^(−2).These consistent performances across various brightness levels represent a significant milestone for blue Ph-OLED technology.The devices also exhibit impressive stability,with an operational lifetime(LT50,the time taken for luminance to decrease by 50%)reaching 1237 h at 1000 cdm^(−2),setting new benchmarks for blue Ph-OLEDs.To enhance the color purity,hyper-OLEDs were developed with a full width at half maximum(FWHM)of 20 nm and the CIEy of 0.233,achieving an EQEm of 29.78%and LT50 of 318 h at 1000 cdm^(−2).We also fabricated the active-matrix(AM)blue Hyper-OLEDs with 400 pixels per inch to demonstrate their application in AM displays.
基金General Project of Changning District Science and Technology Committee, Shanghai(CNKW2020Y29)Key Project of Changning District Science and Technology Committee, Shanghai(CNKW2020Z04)+4 种基金Innovative Talent Base for Medical Doctors in Changning District, Shanghai(RCJD2021B09)Shanghai Natural Science Foundation(22ZR1458200)Natural Science Foundation of Shanghai, China(22ZR1458200)medical PhD Innovative Talent Base Project of Changing District, Shanghai, China(RCJD2021B09)Key Specialty of Changning District, Shanghai, China(20231004)。
文摘Objective: To investigate the clinical efficacy of Fuzheng Jiedu formula combined with interferon in the treatment of human papillomavirus (HPV) infection in patients with infertility.Methods: A total of 750 infertile patients with persistent HPV infection were randomly divided into Group A (n = 240, interferon), Group B (n = 260, Fuzheng Jiedu formula), and Group C (n = 250, interferon + Fuzheng Jiedu formula). The traditional Chinese medicine (TCM) symptoms, efficacy, immune function, and HPV conversion were compared among the three groups, and statistical analysis was conducted on the data before and after treatment among the three groups, including TCM symptom score, total efficacy, CD3^(+), CD4^(+), CD8^(+), CD4^(+)/CD8^(+) levels, and HPV-DNA conversion rate.Results: The total efficacies of Group A, Group B, and Group C were 89.58%, 62.50%, and 98.00%, respectively;the conversion rates of HPV-DNA in Group A, Group B, and Group C were 62.50%, 67.31%, and 90.00%, respectively. The TCM symptom score of the three groups was most significantly reduced in Group C, followed by Group B, and there was a statistical difference between the groups (P <0.05). The efficacy of the three groups was highest in Group C, followed by Group A, and Group B, with statistical differences (P <0.05). A pairwise comparison of the HPV conversion rates of the three groups showed that Group C had the highest HPV conversion rate (P <0.05);HPV16 and HPV18 subtypes displayed high conversion rates among the different HPV subtypes (P <0.05), whereas the comparisons between the remaining subtypes showed no statistically significant differences (P >0.05). CD3^(+), CD4^(+), and CD4^(+)/CD8^(+) levels showed an increasing trend in the three groups after treatment, whereas the CD8^(+) level decreased (P <0.05). Pairwise comparison showed that CD3^(+), CD4^(+), and CD4^(+)/CD8^(+) levels were more elevated in Group C than those in Groups A and B (P <0.05).Conclusion: Fuzheng Jiedu formula notably improves the efficacy of HPV persistent infection and HPV conversion rate in patients with infertility, and its efficacy is better than that of TCM and Western medicine alone. The mechanism is mainly related to the fact that TCM improves the symptom score of syndromes of spleen asthenia and dampness encumbrance and increases CD3^(+), CD4^(+), CD4^(+)/CD8^(+) levels. The effect of combined therapy on improving immunity is more advantageous than that of TCM or Western medicine alone.
