巨噬细胞样细胞(macrophage-like cells, MLC)指起源、功能与巨噬细胞类似的免疫细胞,包括小胶质细胞、玻璃体细胞及巨噬细胞。将en face OCT显示层面设置在视网膜表明即可观测到视网膜表明的MLC(epiretinal MLC, eMLC),随后利用Image ...巨噬细胞样细胞(macrophage-like cells, MLC)指起源、功能与巨噬细胞类似的免疫细胞,包括小胶质细胞、玻璃体细胞及巨噬细胞。将en face OCT显示层面设置在视网膜表明即可观测到视网膜表明的MLC(epiretinal MLC, eMLC),随后利用Image J软件即可对细胞进行提取和量化。研究表明,eMLC在炎症情况下均可出现细胞募集及活化现象,但在不同眼底病中各具特点。在糖尿病视网膜病变、视网膜静脉阻塞等视网膜缺血缺氧性疾病中,eMLC密度越高,黄斑水肿可能越严重。此外,eMLC密度更高的视网膜静脉阻塞患者抗VEGF疗效更差,视力预后不佳,提示基于en face OCT的eMLC不仅可用于评估视网膜炎症情况,而且还能充当提示疾病疗效及预后的标志物。在葡萄膜炎等免疫炎症性疾病中,en face OCT亦可观测到eMLC密度、形态等改变。白塞病葡萄膜炎患者视网膜血管渗漏程度与eMLC密度相关性强,故eMLC密度可充当无创评估视网膜血管渗漏程度的新指标。然而,目前提取和量化eMLC的方法及标准不统一,降低了各研究间的可比性。因此,亟需制定统一的操作规范和评估标准。此外eMLC所代表的具体细胞类型及功能仍需进一步探究。未来,研究者可以利用en face OCT对眼底炎症地进行无创评估。基于en face OCT的eMLC还能作为基础研究与临床研究之间的桥梁,为揭示疾病的致病机制提供重要参考。展开更多
In this paper, the dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands is performed by the time-sequential piled-up en-face optical coherence tomography (OCT) images with the f...In this paper, the dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands is performed by the time-sequential piled-up en-face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en-face OCT images. Strong non-uniformity is observed in mental sweating where the amount of sweat in response to sound stimulus is different for each sweat gland. Furthermore, the amount of sweat is significantly increased in proportion to the strength of the stimulus.展开更多
Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. OCT has been mainly used for medical applications such as for ophthal...Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. OCT has been mainly used for medical applications such as for ophthalmology and dermatology. In this study we demonstrate its capability in providing much more reliable biometry identification of fingerprints than conventional methods. We prove that OCT can serve secure control of genuine fingerprints as it can detect if extra layers are placed above the finger. This can prevent with a high probability, intruders to a secure area trying to foul standard systems based on imaging the finger surface. En-Face OCT method is employed and recommended for its capability of providing not only the axial succession of layers in depth, but the en-face image that allows the traditional pattern identification. Another reason for using such OCT technology is that it is compatible with dynamic focus and therefore can provide enhanced transversal resolution and sensitivity. Two En-Face OCT systems are used to evaluate the need for high resolution and conclusions are drawn in terms of the most potential commercial route to ex- ploitation.展开更多
We developed high-speed time-domain (TD) en face optical coherence tomography (OCT) system using KTN optical beam deflector. The KTN optical beam deflector operates at a high repetition rate of 200 kHz with a fairly l...We developed high-speed time-domain (TD) en face optical coherence tomography (OCT) system using KTN optical beam deflector. The KTN optical beam deflector operates at a high repetition rate of 200 kHz with a fairly large beam deflection angle. We proposed a high-speed en face OCT system that used a KTN optical deflector as the sample beam scanning. In the experiment, we obtained en face OCT images of human fingerprint with a frame rate of 800 fps, which is the fastest speed obtained by a TD-OCT imaging. Furthermore, a 3D-OCT image was also obtained at 0.2 s (=5 volumes/s) by our imaging system.展开更多
文摘巨噬细胞样细胞(macrophage-like cells, MLC)指起源、功能与巨噬细胞类似的免疫细胞,包括小胶质细胞、玻璃体细胞及巨噬细胞。将en face OCT显示层面设置在视网膜表明即可观测到视网膜表明的MLC(epiretinal MLC, eMLC),随后利用Image J软件即可对细胞进行提取和量化。研究表明,eMLC在炎症情况下均可出现细胞募集及活化现象,但在不同眼底病中各具特点。在糖尿病视网膜病变、视网膜静脉阻塞等视网膜缺血缺氧性疾病中,eMLC密度越高,黄斑水肿可能越严重。此外,eMLC密度更高的视网膜静脉阻塞患者抗VEGF疗效更差,视力预后不佳,提示基于en face OCT的eMLC不仅可用于评估视网膜炎症情况,而且还能充当提示疾病疗效及预后的标志物。在葡萄膜炎等免疫炎症性疾病中,en face OCT亦可观测到eMLC密度、形态等改变。白塞病葡萄膜炎患者视网膜血管渗漏程度与eMLC密度相关性强,故eMLC密度可充当无创评估视网膜血管渗漏程度的新指标。然而,目前提取和量化eMLC的方法及标准不统一,降低了各研究间的可比性。因此,亟需制定统一的操作规范和评估标准。此外eMLC所代表的具体细胞类型及功能仍需进一步探究。未来,研究者可以利用en face OCT对眼底炎症地进行无创评估。基于en face OCT的eMLC还能作为基础研究与临床研究之间的桥梁,为揭示疾病的致病机制提供重要参考。
文摘In this paper, the dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands is performed by the time-sequential piled-up en-face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en-face OCT images. Strong non-uniformity is observed in mental sweating where the amount of sweat in response to sound stimulus is different for each sweat gland. Furthermore, the amount of sweat is significantly increased in proportion to the strength of the stimulus.
文摘Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. OCT has been mainly used for medical applications such as for ophthalmology and dermatology. In this study we demonstrate its capability in providing much more reliable biometry identification of fingerprints than conventional methods. We prove that OCT can serve secure control of genuine fingerprints as it can detect if extra layers are placed above the finger. This can prevent with a high probability, intruders to a secure area trying to foul standard systems based on imaging the finger surface. En-Face OCT method is employed and recommended for its capability of providing not only the axial succession of layers in depth, but the en-face image that allows the traditional pattern identification. Another reason for using such OCT technology is that it is compatible with dynamic focus and therefore can provide enhanced transversal resolution and sensitivity. Two En-Face OCT systems are used to evaluate the need for high resolution and conclusions are drawn in terms of the most potential commercial route to ex- ploitation.
文摘We developed high-speed time-domain (TD) en face optical coherence tomography (OCT) system using KTN optical beam deflector. The KTN optical beam deflector operates at a high repetition rate of 200 kHz with a fairly large beam deflection angle. We proposed a high-speed en face OCT system that used a KTN optical deflector as the sample beam scanning. In the experiment, we obtained en face OCT images of human fingerprint with a frame rate of 800 fps, which is the fastest speed obtained by a TD-OCT imaging. Furthermore, a 3D-OCT image was also obtained at 0.2 s (=5 volumes/s) by our imaging system.
