The present manuscript describes a facile and versatile method for preparing uniform wrinkled silica microspheres with diameters of tens of microns.The method comprises a one-pot emulsion/sol-gel method using silica p...The present manuscript describes a facile and versatile method for preparing uniform wrinkled silica microspheres with diameters of tens of microns.The method comprises a one-pot emulsion/sol-gel method using silica precursors of organosilane and tetraethoxysilane.By controlling the sol-to-gel transition of the silica precursors,a series of silica microspheres based on uniform emulsion droplets was synthesized by membrane emulsification.The silica microspheres had a variety of surface morphologies ranging from smooth,maze-like wrinkles to polygon-like ravines.It was possible to alter the surface morphologies of the microspheres by controlling the amount of organosilane in the dispersed phase and the amount of ammonia catalyst in the continuous phase of the emulsion.The grooves on the wrinkled microspheres were able to trap polymer nanoparticles of matching size,thereby demonstrating the potential usefulness of the microspheres in separation science and drug delivery.展开更多
[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behn...[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment,and the drug release in vitro was carried out.[Results]The average diameter of the nanoparticles was(119.60±2.29)nm and the polydispersity index was(0.12±0.02),the size was uniform.The encapsulation efficiency and drug loading of protopanaxadiol were(87.99±1.29)%and(14.86±0.25)%,respectively.[Conclusions]The 20(S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method,and the 20(S)-PPD-PLGA-NPs had good stability,to lay a foundation for the study of 20(S)-PPD-PLGA-NPs in vitro and in vivo.展开更多
n-Type ZnO-based semiconducting materials are increasingly studied for thermoelectrics(TE)in the past due to their inexpensive and non-toxic nature coupled with their high Seebeck coefficient and stability at elevated...n-Type ZnO-based semiconducting materials are increasingly studied for thermoelectrics(TE)in the past due to their inexpensive and non-toxic nature coupled with their high Seebeck coefficient and stability at elevated temperatures.However,their high thermal conductivity limits their prospect for TE application.In this work,a novel,simpler and faster bottom-up approach to produce thermoelectric Al-doped ZnO ceramics from nanopowders produced by an interfacial reaction(double emulsion method)followed by consolidation by spark plasma sintering(SPS)is explored.This alternative interfacial reaction yielded porous aggregates composed of nanoparticles,which exhibited distinctly enhanced TE performance after densification by SPS at low pressure,due to the notable improvement in the power factor and pro-nounced suppression of the lattice thermal conductivity caused by the nano/micro-structure engineered by this bottom-up synthesis technique.This encompasses grain size reduction,inclusion of Al-rich nano-precipitates,and nanoporosity,thus enabling scattering of phonons of different mean free paths.A maximum figure of merit ZT∼0.13 at 750 K was obtained for Zn_(0.97)Al_(0.03)O ceramics,a substantial enhancement to the previously reported values for the same composition synthesized by the traditional synthesis methods.展开更多
Oleogels have been extensively employed for the encapsulation and protection of lipophilic nutrient.This study was investigated the effect of low ionic strength(0-100 mM)on the delivery system properties of oleogels p...Oleogels have been extensively employed for the encapsulation and protection of lipophilic nutrient.This study was investigated the effect of low ionic strength(0-100 mM)on the delivery system properties of oleogels prepared by emulsion template method using Soy protein isolate-Xanthan gum nanoparticles(SXNPs)as stabilizers.With the increase of ionic strength(0-100 mM),the particle size of SXNPs showed a trend of decreasing and then increasing.At ionic strength of 50 mM,SXNPs had the best interfacial adsorption properties(82.71±0.19%),which was attributed to the salt ions improved the surface hydrophobicity of SXNPs.Under this condition,the emulsion stabilized by SXNPs exhibited the smallest particle size(2.23μm)and the best rheological properties.Microscopic images showed that the oleogel had the densest network structure at ionic strength of 50 mM,which enhanced the retention ofβ-carotene in storage environments at 4,25 and 55℃ and oil binding capacity of oleogel(10.20%).In vitro digestion showed up to 55.17%free fatty acid release from the oleogels compared to bulk oil,highlighting their potential for controlled nutrient delivery.展开更多
基金supported by the project of National Natural Science Foundation of China(No.21676275 and No.22078334).
文摘The present manuscript describes a facile and versatile method for preparing uniform wrinkled silica microspheres with diameters of tens of microns.The method comprises a one-pot emulsion/sol-gel method using silica precursors of organosilane and tetraethoxysilane.By controlling the sol-to-gel transition of the silica precursors,a series of silica microspheres based on uniform emulsion droplets was synthesized by membrane emulsification.The silica microspheres had a variety of surface morphologies ranging from smooth,maze-like wrinkles to polygon-like ravines.It was possible to alter the surface morphologies of the microspheres by controlling the amount of organosilane in the dispersed phase and the amount of ammonia catalyst in the continuous phase of the emulsion.The grooves on the wrinkled microspheres were able to trap polymer nanoparticles of matching size,thereby demonstrating the potential usefulness of the microspheres in separation science and drug delivery.
文摘[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment,and the drug release in vitro was carried out.[Results]The average diameter of the nanoparticles was(119.60±2.29)nm and the polydispersity index was(0.12±0.02),the size was uniform.The encapsulation efficiency and drug loading of protopanaxadiol were(87.99±1.29)%and(14.86±0.25)%,respectively.[Conclusions]The 20(S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method,and the 20(S)-PPD-PLGA-NPs had good stability,to lay a foundation for the study of 20(S)-PPD-PLGA-NPs in vitro and in vivo.
基金supported by JSPS JP19H00833,JP19F19720,JP16H06441,JP17H02749,JST Mirai JPMJMI19A1,CREST JPMJCR19Q4.
文摘n-Type ZnO-based semiconducting materials are increasingly studied for thermoelectrics(TE)in the past due to their inexpensive and non-toxic nature coupled with their high Seebeck coefficient and stability at elevated temperatures.However,their high thermal conductivity limits their prospect for TE application.In this work,a novel,simpler and faster bottom-up approach to produce thermoelectric Al-doped ZnO ceramics from nanopowders produced by an interfacial reaction(double emulsion method)followed by consolidation by spark plasma sintering(SPS)is explored.This alternative interfacial reaction yielded porous aggregates composed of nanoparticles,which exhibited distinctly enhanced TE performance after densification by SPS at low pressure,due to the notable improvement in the power factor and pro-nounced suppression of the lattice thermal conductivity caused by the nano/micro-structure engineered by this bottom-up synthesis technique.This encompasses grain size reduction,inclusion of Al-rich nano-precipitates,and nanoporosity,thus enabling scattering of phonons of different mean free paths.A maximum figure of merit ZT∼0.13 at 750 K was obtained for Zn_(0.97)Al_(0.03)O ceramics,a substantial enhancement to the previously reported values for the same composition synthesized by the traditional synthesis methods.
基金support from the China Postdoctoral Science Foundation(2024M762440)the Project of Tianjin Science and Technology Program(24YDTPJC00960)+1 种基金Shandong Province Base and Talent Program(Postdoctoral Category)(SDCX-ZG-202400127)Project of Quanzhou Science and Technology Program(2024QZC006QR).
文摘Oleogels have been extensively employed for the encapsulation and protection of lipophilic nutrient.This study was investigated the effect of low ionic strength(0-100 mM)on the delivery system properties of oleogels prepared by emulsion template method using Soy protein isolate-Xanthan gum nanoparticles(SXNPs)as stabilizers.With the increase of ionic strength(0-100 mM),the particle size of SXNPs showed a trend of decreasing and then increasing.At ionic strength of 50 mM,SXNPs had the best interfacial adsorption properties(82.71±0.19%),which was attributed to the salt ions improved the surface hydrophobicity of SXNPs.Under this condition,the emulsion stabilized by SXNPs exhibited the smallest particle size(2.23μm)and the best rheological properties.Microscopic images showed that the oleogel had the densest network structure at ionic strength of 50 mM,which enhanced the retention ofβ-carotene in storage environments at 4,25 and 55℃ and oil binding capacity of oleogel(10.20%).In vitro digestion showed up to 55.17%free fatty acid release from the oleogels compared to bulk oil,highlighting their potential for controlled nutrient delivery.
