Typhoons can cause large-area blackouts or partial outages of distribution networks.We define a partial outage state in the distribution network as a gray state and propose a gray-start strategy and two-stage distribu...Typhoons can cause large-area blackouts or partial outages of distribution networks.We define a partial outage state in the distribution network as a gray state and propose a gray-start strategy and two-stage distribution network emergency recovery framework.A phase-space reconstruction and stacked integrated model for predicting wind and photovoltaic generation during typhoon disasters is proposed in the first stage.This provides guidance for second-stage post-disaster emergency recovery scheduling.The emergency recovery scheduling model is established in the second stage,and this model is supported by a thermal power-generating unit,mobile emergency generators,and distributed generators.Distributed generation includes wind power generation,photovoltaics,fuel cells,etc.Simultaneously,we con-sider the gray-start based on the pumped storage unit to be an important first step in the emergency recovery strategy.This model is val-idated on the improved IEEE 33 node system,which utilizes data from the 2022 super typhoon“Muifa”in Zhoushan,Zhejiang,China.Simulations indicate the superiority of a gray start with a pumped storage unit and the proposed emergency recovery strategy.展开更多
The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring lin...The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring line tensions,module motions,connector loads and wave power production)of the HMFS system under typical sea con-ditions are comparatively investigated.The results indicate that the mooring tension distribution,certain module motions(surge,sway and yaw)and connector loads(Mz)are significantly influenced by mooring line fractures.The adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines,and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions,module motions and connector loads.There-fore,one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line fractures.In addition,connector failures substantially affect certain module motions(heave and pitch),certain connector loads(Fz and My)and wave power production.The present work can be helpful and instructive for studies on malfunction conditions of modular floating structure(MFS)systems.展开更多
In 2018,an intergovernmental climate-change panel concluded that,to maintain a global temperature increases of<1.5℃,net-zero greenhouse-gas emissions would be required by 2050.Since then,>110 countries have ple...In 2018,an intergovernmental climate-change panel concluded that,to maintain a global temperature increases of<1.5℃,net-zero greenhouse-gas emissions would be required by 2050.Since then,>110 countries have pledged net-zero carbon ambitions by 2050 and hydrogen has been identified at national levels as key to achieving this.Governments have pledged>US$70 billion to further advance hydrogen infrastructure and technology,with an additional investigation on>200 proposed hydrogen-based projects expecting completion before 2030,totalling a value of US$300 billion.Reaching these aggressive targets will require a disciplined cohesion of collaborative strategies to develop an integrated macro infrastructure system.This article discusses the current infancy of the hydrogen market,introduces and defines a new‘collaborative emergent strategy’based on the emergent strategy concept by Mintzberg and Waters,and links its developmental viability through a staged micro-meso-macro architecture.Successful strategic business case studies and current market opportunities across multiple industries are reviewed as they all vie for a strategic early market position.展开更多
Acute pancreatitis(AP)is a heterogeneous inflammatory condition.Although emerging therapeutic strategies targeting pathways such as calcium signaling,TNF-α,the NLRP3 inflammasome,and HMGB1 have shown promise,their ef...Acute pancreatitis(AP)is a heterogeneous inflammatory condition.Although emerging therapeutic strategies targeting pathways such as calcium signaling,TNF-α,the NLRP3 inflammasome,and HMGB1 have shown promise,their efficacy may be limited by the underlying biological heterogeneity of the disease.In this multinational retrospective cohort study across three large ICU databases(ICU-HAI,MIMIC-IV,and eICU-CRD),we used group-based trajectory modeling of early vital signs to identify four distinct AP subphenotypes:hyperinflammatory,hypertensive,hypotensive,and hypoinflammatory.These subtypes differed markedly in 30-day mortality,inflammatory burden,and hemodynamic stability.Compared to the hypertensive phenotype,hyperinflammatory and hypotensive patients had significantly higher 30-day mortality risks(HR=3.38 and HR=1.87,respectively),while the hypoinflammatory phenotype carried no excess risk.Fluid resuscitation responses were phenotype-specific:hyperinflammatory patients benefited from higher fluid volumes,whereas hypoinflammatory patients were at risk of fluid overload.Notably,distinct subphenotypes displayed unique responses to fluid intake over the first two ICU days.For hyperinflammatory phenotype,the algorithm-estimated lowest-risk fluid range was 4100-4300 mL on day 1 and 3400-3600 mL on day 2;for phenotype hypoinflammatory phenotype,the optimal ranges were 2800-3800 mL and 1400-2600 mL,respectively.Early use of lactated Ringer’s solution,which inhibited NLRP3,was associated with reduced mortality in hypotensive phenotype.These findings underscore the clinical relevance of early physiological trajectories and support precision fluid resuscitation based on subtype.This study establishes the largest early-trajectory-based classification of AP to date,offering new insights into immune and vascular mechanisms that drive heterogeneity and therapeutic responsiveness.展开更多
基金supported in part by the National Nat-ural Science Foundation of China(52177110)Key Pro-gram of the National Natural Science Foundation of China(U22B20106,U2142206)+2 种基金Shenzhen Science and Technology Program(JCYJ20210324131409026)the Science and Technology Project of the State Grid Corpo-ration of China(5200-202319382A-2-3-XG)State Grid Zhejiang Elctric Power Co.,Ltd.Science and Tech-nology Project(B311DS24001A).
文摘Typhoons can cause large-area blackouts or partial outages of distribution networks.We define a partial outage state in the distribution network as a gray state and propose a gray-start strategy and two-stage distribution network emergency recovery framework.A phase-space reconstruction and stacked integrated model for predicting wind and photovoltaic generation during typhoon disasters is proposed in the first stage.This provides guidance for second-stage post-disaster emergency recovery scheduling.The emergency recovery scheduling model is established in the second stage,and this model is supported by a thermal power-generating unit,mobile emergency generators,and distributed generators.Distributed generation includes wind power generation,photovoltaics,fuel cells,etc.Simultaneously,we con-sider the gray-start based on the pumped storage unit to be an important first step in the emergency recovery strategy.This model is val-idated on the improved IEEE 33 node system,which utilizes data from the 2022 super typhoon“Muifa”in Zhoushan,Zhejiang,China.Simulations indicate the superiority of a gray start with a pumped storage unit and the proposed emergency recovery strategy.
基金supported by Shenzhen Science and Technology Program(Grant No.KQTD20210811090112003)the National Natural Science Foundation of China(Grant No.52161041).
文摘The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring line tensions,module motions,connector loads and wave power production)of the HMFS system under typical sea con-ditions are comparatively investigated.The results indicate that the mooring tension distribution,certain module motions(surge,sway and yaw)and connector loads(Mz)are significantly influenced by mooring line fractures.The adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines,and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions,module motions and connector loads.There-fore,one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line fractures.In addition,connector failures substantially affect certain module motions(heave and pitch),certain connector loads(Fz and My)and wave power production.The present work can be helpful and instructive for studies on malfunction conditions of modular floating structure(MFS)systems.
文摘In 2018,an intergovernmental climate-change panel concluded that,to maintain a global temperature increases of<1.5℃,net-zero greenhouse-gas emissions would be required by 2050.Since then,>110 countries have pledged net-zero carbon ambitions by 2050 and hydrogen has been identified at national levels as key to achieving this.Governments have pledged>US$70 billion to further advance hydrogen infrastructure and technology,with an additional investigation on>200 proposed hydrogen-based projects expecting completion before 2030,totalling a value of US$300 billion.Reaching these aggressive targets will require a disciplined cohesion of collaborative strategies to develop an integrated macro infrastructure system.This article discusses the current infancy of the hydrogen market,introduces and defines a new‘collaborative emergent strategy’based on the emergent strategy concept by Mintzberg and Waters,and links its developmental viability through a staged micro-meso-macro architecture.Successful strategic business case studies and current market opportunities across multiple industries are reviewed as they all vie for a strategic early market position.
基金funded by the National Natural Science Foundation of China(Grant Nos.82225049,72104155,and 72304198)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYGD23004).
文摘Acute pancreatitis(AP)is a heterogeneous inflammatory condition.Although emerging therapeutic strategies targeting pathways such as calcium signaling,TNF-α,the NLRP3 inflammasome,and HMGB1 have shown promise,their efficacy may be limited by the underlying biological heterogeneity of the disease.In this multinational retrospective cohort study across three large ICU databases(ICU-HAI,MIMIC-IV,and eICU-CRD),we used group-based trajectory modeling of early vital signs to identify four distinct AP subphenotypes:hyperinflammatory,hypertensive,hypotensive,and hypoinflammatory.These subtypes differed markedly in 30-day mortality,inflammatory burden,and hemodynamic stability.Compared to the hypertensive phenotype,hyperinflammatory and hypotensive patients had significantly higher 30-day mortality risks(HR=3.38 and HR=1.87,respectively),while the hypoinflammatory phenotype carried no excess risk.Fluid resuscitation responses were phenotype-specific:hyperinflammatory patients benefited from higher fluid volumes,whereas hypoinflammatory patients were at risk of fluid overload.Notably,distinct subphenotypes displayed unique responses to fluid intake over the first two ICU days.For hyperinflammatory phenotype,the algorithm-estimated lowest-risk fluid range was 4100-4300 mL on day 1 and 3400-3600 mL on day 2;for phenotype hypoinflammatory phenotype,the optimal ranges were 2800-3800 mL and 1400-2600 mL,respectively.Early use of lactated Ringer’s solution,which inhibited NLRP3,was associated with reduced mortality in hypotensive phenotype.These findings underscore the clinical relevance of early physiological trajectories and support precision fluid resuscitation based on subtype.This study establishes the largest early-trajectory-based classification of AP to date,offering new insights into immune and vascular mechanisms that drive heterogeneity and therapeutic responsiveness.
