As a new concept having emerged in last few years,the“deep eutectic solvents”(DESs)effect integrated into the imprinting technology inevitably exposes design limitations of stimuli-responsive molecularly imprinted p...As a new concept having emerged in last few years,the“deep eutectic solvents”(DESs)effect integrated into the imprinting technology inevitably exposes design limitations of stimuli-responsive molecularly imprinted polymers(MIPs),as well as inadequate analysis of the adsorption performance of MIPs.Herein,a simple yet defined N-isopropylacrylamide/(3-acrylamidopropyl)trimethylammonium chloride(NIPAM/APTMAC)binary DESs system was proposed to prepare intelligent MIPs with thermo-sensitivity.Accordingly,magnetic and thermo-responsive MIPs based on functional monomers-derived DESs(TMDESs-MIPs1)were synthesized,revealing DESs effect-regulated affinity/kinetics for the enhanced adsorption capability,eco-friendly thermo-regulated elution for high release efficiency,and simple magnetic separation,along with superior selectivity to rhein(RH)and good regeneration ability.TM-DESs-MIPs1 were utilized to extract RH from Cassiae semen samples coupled with high performance liquid chromatography(HPLC),yielding satisfactory recoveries(79.47%−110.82%)and low limits of detection(LOD)(16.67μg/L).Another two kinds of MIPs adopting the thermo-responsive moiety-derived DESs effect strategy further demonstrated great applicability of such intelligent MIPs for analyses of complicated samples.展开更多
BACKGROUND Drug-eluting stents(DES)are used to treat lower extremity arterial disease.During DES treatment,aneurysmal degeneration occasionally occurs,especially with fluoropolymer-based DES.However,the incidence of p...BACKGROUND Drug-eluting stents(DES)are used to treat lower extremity arterial disease.During DES treatment,aneurysmal degeneration occasionally occurs,especially with fluoropolymer-based DES.However,the incidence of pseudoaneurysms after DES placement is rarely reported in the lower extremity region,although there have been several reports on pseudoaneurysm formation after DES placement in the coronary artery region.CASE SUMMARY We report the case of a 64-year-old man who presented with fever and pain in his left hand after dialysis.Bacteremia was diagnosed by blood culture,and after admission,he developed pain on the medial side of the right thigh.A pseudoaneurysm was observed in the right superficial femoral artery(SFA)at the proximal end of a previously placed DES.The bacteremia was thought to have been caused by a pseudoaneurysm of the left superficial brachial artery,and the pseudoaneurysm of the left superficial brachial artery was removed after antibiotic treatment.The pseudoaneurysm of the right SFA rapidly expanded after admission,but the expansion rate was reduced after infection control.Seven months after the first admission,the pseudoaneurysm of the left SFA was re-moved and in situ revascularization performed using a rifampicin-soaked Dacron graft.CONCLUSION Although pseudoaneurysm after DES placement in the lower extremity region is rare,it must be considered in patients with bacteremia.展开更多
A new method of 2-amino-4-nitrophenol and 2-amino-5-nitrophenol in hair dye determined by liquid chromatography-mass spectrometry.Chromatographic separation was carried out on a Atlantis C18 (2.1 mm i.d.×150 mm,5...A new method of 2-amino-4-nitrophenol and 2-amino-5-nitrophenol in hair dye determined by liquid chromatography-mass spectrometry.Chromatographic separation was carried out on a Atlantis C18 (2.1 mm i.d.×150 mm,5 μm)column with gradient elution with methanol-acetonitrile at a flow rate 0.2 mL/min.The mass spectrometry was operated in the positive electrospray ionization mode.Quantity was performed using multiple reaction monitoring of the product ion transitions m/z153.0>m/z106(17eV) for 2-amino-4-nitrophenol and m/z153.0>m/z122(15eV) for 2-amino-5-nitrophenol.Linearity of peak was obtained over a range of concentration is from 0.2 to 100 mg/L.The limit is 0.2 mg/L of the method.The proposed method was accurate and rapid with wide linear range.The repeatability and the reproducibility of the method were excellent.It has been applied to detect the real with satisfactory results.展开更多
The conventional protein chromatography technique was adopted to purify the antifreeze proteins (AFPs) from the leaves of Ammopiptanthus mongolicus (Maxim.) Cheng f. Two bands on native PAGE gel showed thermal hys...The conventional protein chromatography technique was adopted to purify the antifreeze proteins (AFPs) from the leaves of Ammopiptanthus mongolicus (Maxim.) Cheng f. Two bands on native PAGE gel showed thermal hysteresis activity, one was band B1, whose thermal hysteresis was 0.46 ℃ at 8 g/L, which showed two bands (67 kD, 21 kD) on SDS_PAGE gel; the other was B3, whose thermal hysteresis was 0.45 ℃ at 10 g/L, and it contained only a single protein (39.8 kD). Both B1 and B3 are not glycoproteins, because neither do they interact with Shiff_reagent, nor show ultraviolet characteristics of a typical glycoprotein.展开更多
Objective:To evaluate the effect of diabetes on outcome of sirolimus-eluting stent.Methods:From December 2002 to May 2005,262 diabetes and 262 non-diabetics treated with sirolimus-eluting stents were studied.The follo...Objective:To evaluate the effect of diabetes on outcome of sirolimus-eluting stent.Methods:From December 2002 to May 2005,262 diabetes and 262 non-diabetics treated with sirolimus-eluting stents were studied.The follow-up angiography was performed in 8-month.Major adverse cardiac events(MACE)defined as death,myocardial infarction,or target lesion revascularization and follow-up angiography were analyzed.Results:Successful rate of stent implantation was 100%.There was no death during the procedure,hospitalization,and follow-up period.Acute myocardial infarction occurred in 1 diabetic at 2 days after PCI,and in 2 non-diabetics at follow-up period.Angiographic follow up at 8 months showed that absolute late lumen loss was 0.06 vs 0.04mm(P>0.05),relative late lumen loss was 2.32% vs 1.63%,and TLR rate was 12.60% vs 9.92% in diabetic group and non-diabetic group respectively.Logistic regression analysis showed that reference vessel lumen and relative late lumen loss were significantly associated with restenosis.Conclusion:Cypher stent implantation in diabetes is safe and effective,while relative late lumen loss may be related to restenosis.In a word,diabetes with small vessel may be considered to be risk factor for restenosis after Cypher stents implantation.展开更多
Objective:To evaluate the safety and effectiveness of rotational atherectomy followed by drug eluting stent(DES)implantation in patients with complex coronary lesions.Methods:From August 2006 to August 2012,253 consec...Objective:To evaluate the safety and effectiveness of rotational atherectomy followed by drug eluting stent(DES)implantation in patients with complex coronary lesions.Methods:From August 2006 to August 2012,253 consecutive patients with 289 lesions and who underwent rotational atherectomy in our center were enrolled in this study.Results:The overall procedure success rate was 98%with the cost of two(0.8%)coronary perforations,three(1.2%)dissections,five(2.0%)slow flows or no flows,three(1.2%)peri-procedure myocardial infarctions,and two(0.8%)in hospital deaths.During follow-up(mean three years),one(0.4%)patient died,two(0.8%)patients had acute myocardial infarction,14(5.5%)had restenosis,and target lesion revascularization occurred in eight patients(3.2%).Conclusions:Rotational atherectomy followed by DES implantation is a safe and effective technique for patients with complex coronary lesions,especially calcified and non-dilatable lesions.展开更多
An effective cation-exchange chromatographic method for lysozyme isolation from chicken egg white is presented, using supermacroporous cryogel grafted with sulfo functional groups. The chromatographic processes were c...An effective cation-exchange chromatographic method for lysozyme isolation from chicken egg white is presented, using supermacroporous cryogel grafted with sulfo functional groups. The chromatographic processes were carried out by one-step and sequential elution, respectively. Sodium phosphate buffer （pH 7.8） containing different concentrations of NaC1 is used as elution agent. The corresponding breakthrough characteristics and elution behaviors in the cryogel bed were investigated and analyzed. Purity of lysozyme in the elution effluent was assayed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE）. The maximum purity of the obtained lysozyme was about 96%, and the cryogel is demonstrated as a potential separation medium for purification of high-purit lysozyme from chicken egg white.展开更多
Two highly water-soluble amino acids, which derived from β-CDs, i.e., glutamic acid-β-cyclodextrin （GluCD） and ethylene-diamine- β-cyclodextrin （EDCD）, were synthesized and were examined for their effect on sol...Two highly water-soluble amino acids, which derived from β-CDs, i.e., glutamic acid-β-cyclodextrin （GluCD） and ethylene-diamine- β-cyclodextrin （EDCD）, were synthesized and were examined for their effect on solubilization of anthracene （ANT）, complexation of cadmium （Cd^2＋）, and elution removal of ANT and Cd^2＋ in soil. The results showed that GluCD and EDCD were powerful complexant for ANT and Cd^2＋. In the presence of 10 g/L GIuCD and EDCD, the solubilization of ANT increased by 47.04 and 23.85 times compared to the control, respectively. GluCD resulted in approximately 90% complexation of Cd^2＋ while 70% complexation was observed for EDCD. Simultaneously, GluCD and EDCD could greatly enhance the elution removal of ANT and Cd^2＋ from soil. GluCD resulted in the highest elution efficiency of ANT and Cd^2＋. With the addition of 10 g/L GluCD, 53.5% of ANT and 85.6% of Cd^2＋ were eluted, respectively. The ANT had a negligible effect on the Cd^2＋ removal due to different complexing sites of ANT and Cd^2＋, while Cd^2＋ enhanced the ANT removal under the addition of GluCD because Cd^2＋ neutralized the -COOH group of GIuCD. Adversely, the removal of ANT was decreased with Cd^2＋ under the addition of EDCD, this was due to the fact that Cd^2＋ enhanced the polarity of EDCD molecule and inhibited the complexation between ANT and EDCD. The study suggested that GluCD could be preferred and be successfully applied to remediation of heavy metals or organic compounds in contaminated soil.展开更多
Coronary angioplasty with drug-eluting stent(DES)implantation is currently the most common stent procedure worldwide.Since the introduction of DES,coronary restenosis as well as the incidence of target vessel and targ...Coronary angioplasty with drug-eluting stent(DES)implantation is currently the most common stent procedure worldwide.Since the introduction of DES,coronary restenosis as well as the incidence of target vessel and target lesion revascularization have been significantly reduced.However,the incidence of very late stent thrombosis beyond the first year after stent deployment has more commonly been linked to DES than to baremetal stent(BMS)implantation.Several factors have been associated with very late stent thrombosis after DES implantation,such as delayed healing,inflammation,stent mal-apposition and endothelial dysfunction. Some of these adverse events were associated with the presence of durable polymers,which were essential to allow the elution of the immunosuppressive drug in the first DES designs.The introduction of erodable polymers in DES technology has provided the potential to complete the degradation of the polymer simultaneously or immediately after the release of the immunosuppressive drug,after which a BMS remains in place.Several DES designs with biodegradable(BIO)polymers have been introduced in preclinical and clinical studies, including randomized trials.In this review,we analyze the clinical results from 6 observational and randomized studies with BIO polymers and discuss advantages and disadvantages of this new technology.展开更多
A new approach was proposed for grouping separation of 14 lanthanide rare-earth ions from their coexisting mixed aqueous solutions, by performing liquid-column elution using the aqueous solution containing 14 lanthani...A new approach was proposed for grouping separation of 14 lanthanide rare-earth ions from their coexisting mixed aqueous solutions, by performing liquid-column elution using the aqueous solution containing 14 lanthanide rare-earth ions as the stationary phase and the dispersed organic oil droplets containing P507 extractant as the mobile phase. It was revealed that 14 lanthanide rare-earth ions could be separated into four groups, according to the lanthanide tetrad effect, respectively eluting out from the liquid column at different time in a certain order. Various effects including the saponification degree of P507, the concentration of P507 in organic phase, the length and inner diameter of the extraction column on the performance of grouping separation of rare-earth ions were discussed. The changes of the mass transfer coefficients were also investigated. The separation efficiency of the four groups of rareearth elements(REEs) was evaluated based on the elution resolution, Rs, of the elution peaks of La(Ⅲ),Gd(Ⅲ), Ho(Ⅲ) and Lu(Ⅲ), the four representative elements respectively from each of the four groups of REEs. Experimental results demonstrated that the separation of REEs by liquid-column elution mainly depended on the competitive adsorption of different rare-earth groups onto the surface of ascending P507 oil droplets. The affinity of different rare-earth groups with P507 extractant and a limited adsorption capacity of P507 molecules at the surface of the oil droplets ascending in liquid column play the important role. The present work highlights a promising technique for grouping separation of multiple lanthanide elements co-existing complex systems.展开更多
A stability-indicating RP-HPLC method was developed and validated lbr the determination of Rufinamide in tablet dosage forms using C 18 column （250 mm x 4.6 mm, 5 μm） wilh mobile phase consisting of water acetonitr...A stability-indicating RP-HPLC method was developed and validated lbr the determination of Rufinamide in tablet dosage forms using C 18 column （250 mm x 4.6 mm, 5 μm） wilh mobile phase consisting of water acetonitrile （40：60, v/v） with a [low rate of 0.8 mL/min （UV detection 215 nm）. Linearity was observed over the concentration range 1.0 200 μg/mL （R2=0.9997） with regression equation y-113190 x＋63053. Rufinamide was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation. Rufinaraide is more sensitive towards acidic degradation. The method was validated as per ICH guidelines.展开更多
A new nanometer material, nanometer AlO（OH） loaded on the fiberglass with activated carbon fibers felt（ACF） as the carrier, was prepared by hydrolytic reaction for the removal of Cd（II） from aqueous solution usi...A new nanometer material, nanometer AlO（OH） loaded on the fiberglass with activated carbon fibers felt（ACF） as the carrier, was prepared by hydrolytic reaction for the removal of Cd（II） from aqueous solution using column adsorption experiment. As was confirmed by XRD determination, the hydrolysis production loaded on fiberglass was similar to the orthorhombic phase AlO（OH）. SEM images showed that AlO（OH） particles were in the form of small aggregated clusters. The Thomas model was applied for estimating the kinetic parameters and the saturated adsorption ability of Cd（II） adsorption on the new adsorbent. The results showed that the maximum adsorption capacity of Cd（II） was 128.50 mg·g^-1 and 117.86 mg·g^-1 for the adsorbent mass of 0.3289 g and the adsorbent mass of 0.2867 g, respectively. The elution experiment result indicated that the adsorbed Cd ions was easily desorbed from the material with 0.1 mol·L^-1 HCl solution. Adsorption-desorption cycles showed the feasibility of repealed uses of the composited material. The adsorption capacities were influenced by pH and the initial Cd（II） concentration. The amount adsorbed was greatest at pH 6.5 and the initial Cd（II） concentration of 0.07 mg·L^-1, respectively. Nanometer AlO（OH） played a major role in the adsorption process, whereas the fiberglass and ACF were assistants in the process of removing Cd（II）. In addition, the adsorption capacities for Cd（II） were obviously reduced from 128.50 mg·L^-1 to 64.28 mg·L^-1 when Pb ions were present because Pb ions took up more adsorption sites.展开更多
基金National Key Research and Development Project(No.2019YFC1604904)National Natural Science Foundation of China(No.32101212)+1 种基金Natural Science Foundation of Jiangxi(No.20224ACB215009)Research Program of State Key Laboratory of Food Science and Technology in Nanchang University(No.SKLF-ZZB-202127).
文摘As a new concept having emerged in last few years,the“deep eutectic solvents”(DESs)effect integrated into the imprinting technology inevitably exposes design limitations of stimuli-responsive molecularly imprinted polymers(MIPs),as well as inadequate analysis of the adsorption performance of MIPs.Herein,a simple yet defined N-isopropylacrylamide/(3-acrylamidopropyl)trimethylammonium chloride(NIPAM/APTMAC)binary DESs system was proposed to prepare intelligent MIPs with thermo-sensitivity.Accordingly,magnetic and thermo-responsive MIPs based on functional monomers-derived DESs(TMDESs-MIPs1)were synthesized,revealing DESs effect-regulated affinity/kinetics for the enhanced adsorption capability,eco-friendly thermo-regulated elution for high release efficiency,and simple magnetic separation,along with superior selectivity to rhein(RH)and good regeneration ability.TM-DESs-MIPs1 were utilized to extract RH from Cassiae semen samples coupled with high performance liquid chromatography(HPLC),yielding satisfactory recoveries(79.47%−110.82%)and low limits of detection(LOD)(16.67μg/L).Another two kinds of MIPs adopting the thermo-responsive moiety-derived DESs effect strategy further demonstrated great applicability of such intelligent MIPs for analyses of complicated samples.
文摘BACKGROUND Drug-eluting stents(DES)are used to treat lower extremity arterial disease.During DES treatment,aneurysmal degeneration occasionally occurs,especially with fluoropolymer-based DES.However,the incidence of pseudoaneurysms after DES placement is rarely reported in the lower extremity region,although there have been several reports on pseudoaneurysm formation after DES placement in the coronary artery region.CASE SUMMARY We report the case of a 64-year-old man who presented with fever and pain in his left hand after dialysis.Bacteremia was diagnosed by blood culture,and after admission,he developed pain on the medial side of the right thigh.A pseudoaneurysm was observed in the right superficial femoral artery(SFA)at the proximal end of a previously placed DES.The bacteremia was thought to have been caused by a pseudoaneurysm of the left superficial brachial artery,and the pseudoaneurysm of the left superficial brachial artery was removed after antibiotic treatment.The pseudoaneurysm of the right SFA rapidly expanded after admission,but the expansion rate was reduced after infection control.Seven months after the first admission,the pseudoaneurysm of the left SFA was re-moved and in situ revascularization performed using a rifampicin-soaked Dacron graft.CONCLUSION Although pseudoaneurysm after DES placement in the lower extremity region is rare,it must be considered in patients with bacteremia.
文摘A new method of 2-amino-4-nitrophenol and 2-amino-5-nitrophenol in hair dye determined by liquid chromatography-mass spectrometry.Chromatographic separation was carried out on a Atlantis C18 (2.1 mm i.d.×150 mm,5 μm)column with gradient elution with methanol-acetonitrile at a flow rate 0.2 mL/min.The mass spectrometry was operated in the positive electrospray ionization mode.Quantity was performed using multiple reaction monitoring of the product ion transitions m/z153.0>m/z106(17eV) for 2-amino-4-nitrophenol and m/z153.0>m/z122(15eV) for 2-amino-5-nitrophenol.Linearity of peak was obtained over a range of concentration is from 0.2 to 100 mg/L.The limit is 0.2 mg/L of the method.The proposed method was accurate and rapid with wide linear range.The repeatability and the reproducibility of the method were excellent.It has been applied to detect the real with satisfactory results.
文摘The conventional protein chromatography technique was adopted to purify the antifreeze proteins (AFPs) from the leaves of Ammopiptanthus mongolicus (Maxim.) Cheng f. Two bands on native PAGE gel showed thermal hysteresis activity, one was band B1, whose thermal hysteresis was 0.46 ℃ at 8 g/L, which showed two bands (67 kD, 21 kD) on SDS_PAGE gel; the other was B3, whose thermal hysteresis was 0.45 ℃ at 10 g/L, and it contained only a single protein (39.8 kD). Both B1 and B3 are not glycoproteins, because neither do they interact with Shiff_reagent, nor show ultraviolet characteristics of a typical glycoprotein.
文摘Objective:To evaluate the effect of diabetes on outcome of sirolimus-eluting stent.Methods:From December 2002 to May 2005,262 diabetes and 262 non-diabetics treated with sirolimus-eluting stents were studied.The follow-up angiography was performed in 8-month.Major adverse cardiac events(MACE)defined as death,myocardial infarction,or target lesion revascularization and follow-up angiography were analyzed.Results:Successful rate of stent implantation was 100%.There was no death during the procedure,hospitalization,and follow-up period.Acute myocardial infarction occurred in 1 diabetic at 2 days after PCI,and in 2 non-diabetics at follow-up period.Angiographic follow up at 8 months showed that absolute late lumen loss was 0.06 vs 0.04mm(P>0.05),relative late lumen loss was 2.32% vs 1.63%,and TLR rate was 12.60% vs 9.92% in diabetic group and non-diabetic group respectively.Logistic regression analysis showed that reference vessel lumen and relative late lumen loss were significantly associated with restenosis.Conclusion:Cypher stent implantation in diabetes is safe and effective,while relative late lumen loss may be related to restenosis.In a word,diabetes with small vessel may be considered to be risk factor for restenosis after Cypher stents implantation.
基金Project(Nos.2009C33123 and 2007C13058)supported by the Science and Technology Project of Zhejiang Province,China
文摘Objective:To evaluate the safety and effectiveness of rotational atherectomy followed by drug eluting stent(DES)implantation in patients with complex coronary lesions.Methods:From August 2006 to August 2012,253 consecutive patients with 289 lesions and who underwent rotational atherectomy in our center were enrolled in this study.Results:The overall procedure success rate was 98%with the cost of two(0.8%)coronary perforations,three(1.2%)dissections,five(2.0%)slow flows or no flows,three(1.2%)peri-procedure myocardial infarctions,and two(0.8%)in hospital deaths.During follow-up(mean three years),one(0.4%)patient died,two(0.8%)patients had acute myocardial infarction,14(5.5%)had restenosis,and target lesion revascularization occurred in eight patients(3.2%).Conclusions:Rotational atherectomy followed by DES implantation is a safe and effective technique for patients with complex coronary lesions,especially calcified and non-dilatable lesions.
基金Supported by the National lqatural Science Foundation of China （21036005, 20876145）, the Science and Technology Cooperation Project between China-Europe Country＇s Governments from the Ministry of Science and Technology of China （1017） and the Natural Science Foundation of Zhejiang Provincial （Y4080326）.
文摘An effective cation-exchange chromatographic method for lysozyme isolation from chicken egg white is presented, using supermacroporous cryogel grafted with sulfo functional groups. The chromatographic processes were carried out by one-step and sequential elution, respectively. Sodium phosphate buffer （pH 7.8） containing different concentrations of NaC1 is used as elution agent. The corresponding breakthrough characteristics and elution behaviors in the cryogel bed were investigated and analyzed. Purity of lysozyme in the elution effluent was assayed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE）. The maximum purity of the obtained lysozyme was about 96%, and the cryogel is demonstrated as a potential separation medium for purification of high-purit lysozyme from chicken egg white.
基金supported by the Public Foundation of National Environmental Protection Department(No.201009047)Xi’an Science and Technology Plan Projects(No. CXY09025(3))
文摘Two highly water-soluble amino acids, which derived from β-CDs, i.e., glutamic acid-β-cyclodextrin （GluCD） and ethylene-diamine- β-cyclodextrin （EDCD）, were synthesized and were examined for their effect on solubilization of anthracene （ANT）, complexation of cadmium （Cd^2＋）, and elution removal of ANT and Cd^2＋ in soil. The results showed that GluCD and EDCD were powerful complexant for ANT and Cd^2＋. In the presence of 10 g/L GIuCD and EDCD, the solubilization of ANT increased by 47.04 and 23.85 times compared to the control, respectively. GluCD resulted in approximately 90% complexation of Cd^2＋ while 70% complexation was observed for EDCD. Simultaneously, GluCD and EDCD could greatly enhance the elution removal of ANT and Cd^2＋ from soil. GluCD resulted in the highest elution efficiency of ANT and Cd^2＋. With the addition of 10 g/L GluCD, 53.5% of ANT and 85.6% of Cd^2＋ were eluted, respectively. The ANT had a negligible effect on the Cd^2＋ removal due to different complexing sites of ANT and Cd^2＋, while Cd^2＋ enhanced the ANT removal under the addition of GluCD because Cd^2＋ neutralized the -COOH group of GIuCD. Adversely, the removal of ANT was decreased with Cd^2＋ under the addition of EDCD, this was due to the fact that Cd^2＋ enhanced the polarity of EDCD molecule and inhibited the complexation between ANT and EDCD. The study suggested that GluCD could be preferred and be successfully applied to remediation of heavy metals or organic compounds in contaminated soil.
文摘Coronary angioplasty with drug-eluting stent(DES)implantation is currently the most common stent procedure worldwide.Since the introduction of DES,coronary restenosis as well as the incidence of target vessel and target lesion revascularization have been significantly reduced.However,the incidence of very late stent thrombosis beyond the first year after stent deployment has more commonly been linked to DES than to baremetal stent(BMS)implantation.Several factors have been associated with very late stent thrombosis after DES implantation,such as delayed healing,inflammation,stent mal-apposition and endothelial dysfunction. Some of these adverse events were associated with the presence of durable polymers,which were essential to allow the elution of the immunosuppressive drug in the first DES designs.The introduction of erodable polymers in DES technology has provided the potential to complete the degradation of the polymer simultaneously or immediately after the release of the immunosuppressive drug,after which a BMS remains in place.Several DES designs with biodegradable(BIO)polymers have been introduced in preclinical and clinical studies, including randomized trials.In this review,we analyze the clinical results from 6 observational and randomized studies with BIO polymers and discuss advantages and disadvantages of this new technology.
基金Supported by the National Natural Science Foundation of China(51574213,51074150)the Key Project of Chinese National Programs for Fundamental Research and Development(2012CBA01203)
文摘A new approach was proposed for grouping separation of 14 lanthanide rare-earth ions from their coexisting mixed aqueous solutions, by performing liquid-column elution using the aqueous solution containing 14 lanthanide rare-earth ions as the stationary phase and the dispersed organic oil droplets containing P507 extractant as the mobile phase. It was revealed that 14 lanthanide rare-earth ions could be separated into four groups, according to the lanthanide tetrad effect, respectively eluting out from the liquid column at different time in a certain order. Various effects including the saponification degree of P507, the concentration of P507 in organic phase, the length and inner diameter of the extraction column on the performance of grouping separation of rare-earth ions were discussed. The changes of the mass transfer coefficients were also investigated. The separation efficiency of the four groups of rareearth elements(REEs) was evaluated based on the elution resolution, Rs, of the elution peaks of La(Ⅲ),Gd(Ⅲ), Ho(Ⅲ) and Lu(Ⅲ), the four representative elements respectively from each of the four groups of REEs. Experimental results demonstrated that the separation of REEs by liquid-column elution mainly depended on the competitive adsorption of different rare-earth groups onto the surface of ascending P507 oil droplets. The affinity of different rare-earth groups with P507 extractant and a limited adsorption capacity of P507 molecules at the surface of the oil droplets ascending in liquid column play the important role. The present work highlights a promising technique for grouping separation of multiple lanthanide elements co-existing complex systems.
文摘A stability-indicating RP-HPLC method was developed and validated lbr the determination of Rufinamide in tablet dosage forms using C 18 column （250 mm x 4.6 mm, 5 μm） wilh mobile phase consisting of water acetonitrile （40：60, v/v） with a [low rate of 0.8 mL/min （UV detection 215 nm）. Linearity was observed over the concentration range 1.0 200 μg/mL （R2=0.9997） with regression equation y-113190 x＋63053. Rufinamide was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation. Rufinaraide is more sensitive towards acidic degradation. The method was validated as per ICH guidelines.
文摘A new nanometer material, nanometer AlO（OH） loaded on the fiberglass with activated carbon fibers felt（ACF） as the carrier, was prepared by hydrolytic reaction for the removal of Cd（II） from aqueous solution using column adsorption experiment. As was confirmed by XRD determination, the hydrolysis production loaded on fiberglass was similar to the orthorhombic phase AlO（OH）. SEM images showed that AlO（OH） particles were in the form of small aggregated clusters. The Thomas model was applied for estimating the kinetic parameters and the saturated adsorption ability of Cd（II） adsorption on the new adsorbent. The results showed that the maximum adsorption capacity of Cd（II） was 128.50 mg·g^-1 and 117.86 mg·g^-1 for the adsorbent mass of 0.3289 g and the adsorbent mass of 0.2867 g, respectively. The elution experiment result indicated that the adsorbed Cd ions was easily desorbed from the material with 0.1 mol·L^-1 HCl solution. Adsorption-desorption cycles showed the feasibility of repealed uses of the composited material. The adsorption capacities were influenced by pH and the initial Cd（II） concentration. The amount adsorbed was greatest at pH 6.5 and the initial Cd（II） concentration of 0.07 mg·L^-1, respectively. Nanometer AlO（OH） played a major role in the adsorption process, whereas the fiberglass and ACF were assistants in the process of removing Cd（II）. In addition, the adsorption capacities for Cd（II） were obviously reduced from 128.50 mg·L^-1 to 64.28 mg·L^-1 when Pb ions were present because Pb ions took up more adsorption sites.
