OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao...OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets.展开更多
Calorie restriction (CR) is as close to a real fountain of youth as any known technique is. Caloric restriction known to extend the human lifespan by up to five years has quietly become accepted among leading research...Calorie restriction (CR) is as close to a real fountain of youth as any known technique is. Caloric restriction known to extend the human lifespan by up to five years has quietly become accepted among leading researchers. Even scientists who are cautious about anti-aging hype say it works. The formula is simple: Eat less. It could add years to your life. In the context of health and longevity, I analyzed data documenting proofs which suggest that the caloric restriction extends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast as well as improve biomarkers of aging in humans. Research has shown that not only does it result in a longer lifespan, but it also lowers blood pressure, oxidative damage, cardiovascular disease, modifies insulin sensitivity, reduces loss of central nervous system cells, strengthens the immune system, lowers cholesterol, diminishes the rate of heart disease, reduces muscle oxygen loss, improves muscle function, reduces free radical damage to body tissue and helps stabilize blood sugar in adult-onset diabetes. Caloric restriction the most widely recognized life span-extending intervention has shown that it does indeed have age-slowing effects in humans like it has been shown to work in animals and Dr. Fontana has already made medical history in studying anti aging effects of caloric restriction.展开更多
With the continuous improvement of the national economy and people's quality of life, people's attention to human health and health is increasing. Taking exercise and reasonable diet and good living habits to ...With the continuous improvement of the national economy and people's quality of life, people's attention to human health and health is increasing. Taking exercise and reasonable diet and good living habits to adjust the body's meridian operation and promote the continuous optimization of human body function is an important way to achieve healthy development and optimize people's lifestyle. This paper describes the formation and development of Longevity Internal Elixir form Yue School in East Sichuan and its positive effects on human health. It analyzes the implementation methods and steps of Longevity Internal Elixir and points out the precautions and safeguards for the implementation of Longevity Internal Elixir. Through the analysis of this paper, it is clear that Longevity Internal Elixir plays an important role in the health of the people, exerts its role in promoting bodily functions. The implementation methods and safeguard measures of Longevity Internal Elixir are also clarified in this paper.展开更多
A buttress on the need for welfare program in Nigeria and the important obligation to consider the Economics’and CIA’s contextual position for the dependency ratios,both total and elderly dependency ratio alongside ...A buttress on the need for welfare program in Nigeria and the important obligation to consider the Economics’and CIA’s contextual position for the dependency ratios,both total and elderly dependency ratio alongside the consideration of the age structure and demography statistics of Nigeria relatively to other economies,particularly as an elixir for the declining older population in Nigeria and the aged male contraction in the nation.Although,older female population is higher in every country as obtainable globally,the Nigerian case is that of drastic contraction in both aged male and older population generally.Therefore,the submission is that the government has to consider the total dependency ratio to the elderly dependency ratio,which is all-encompassing in order to cater for the declining older population and to appropriate the requisite welfare cum benefits programs in the nation.展开更多
基金Supported by the National Natural Science Foundation of China(No.20100714200121000071220002+2 种基金20100721200202010072220008 and 20180072020005)the Classical Prescription Basic Research Team of Beijing University of Chinese Medicine。
文摘OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets.
文摘Calorie restriction (CR) is as close to a real fountain of youth as any known technique is. Caloric restriction known to extend the human lifespan by up to five years has quietly become accepted among leading researchers. Even scientists who are cautious about anti-aging hype say it works. The formula is simple: Eat less. It could add years to your life. In the context of health and longevity, I analyzed data documenting proofs which suggest that the caloric restriction extends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast as well as improve biomarkers of aging in humans. Research has shown that not only does it result in a longer lifespan, but it also lowers blood pressure, oxidative damage, cardiovascular disease, modifies insulin sensitivity, reduces loss of central nervous system cells, strengthens the immune system, lowers cholesterol, diminishes the rate of heart disease, reduces muscle oxygen loss, improves muscle function, reduces free radical damage to body tissue and helps stabilize blood sugar in adult-onset diabetes. Caloric restriction the most widely recognized life span-extending intervention has shown that it does indeed have age-slowing effects in humans like it has been shown to work in animals and Dr. Fontana has already made medical history in studying anti aging effects of caloric restriction.
文摘With the continuous improvement of the national economy and people's quality of life, people's attention to human health and health is increasing. Taking exercise and reasonable diet and good living habits to adjust the body's meridian operation and promote the continuous optimization of human body function is an important way to achieve healthy development and optimize people's lifestyle. This paper describes the formation and development of Longevity Internal Elixir form Yue School in East Sichuan and its positive effects on human health. It analyzes the implementation methods and steps of Longevity Internal Elixir and points out the precautions and safeguards for the implementation of Longevity Internal Elixir. Through the analysis of this paper, it is clear that Longevity Internal Elixir plays an important role in the health of the people, exerts its role in promoting bodily functions. The implementation methods and safeguard measures of Longevity Internal Elixir are also clarified in this paper.
文摘A buttress on the need for welfare program in Nigeria and the important obligation to consider the Economics’and CIA’s contextual position for the dependency ratios,both total and elderly dependency ratio alongside the consideration of the age structure and demography statistics of Nigeria relatively to other economies,particularly as an elixir for the declining older population in Nigeria and the aged male contraction in the nation.Although,older female population is higher in every country as obtainable globally,the Nigerian case is that of drastic contraction in both aged male and older population generally.Therefore,the submission is that the government has to consider the total dependency ratio to the elderly dependency ratio,which is all-encompassing in order to cater for the declining older population and to appropriate the requisite welfare cum benefits programs in the nation.
