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Wellbore breakouts in heavily fractured rocks:A coupled discrete fracture network-distinct element method analysis 被引量:1
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作者 Yongcun Feng Yaoran Wei +4 位作者 Zhenlai Tan Tianyu Yang Xiaorong Li Jincai Zhang Jingen Deng 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1685-1699,共15页
Wellbore breakout is one of the critical issues in drilling due to the fact that the related problems result in additional costs and impact the drilling scheme severely.However,the majority of such wellbore breakout a... Wellbore breakout is one of the critical issues in drilling due to the fact that the related problems result in additional costs and impact the drilling scheme severely.However,the majority of such wellbore breakout analyses were based on continuum mechanics.In addition to failure in intact rocks,wellbore breakouts can also be initiated along natural discontinuities,e.g.weak planes and fractures.Furthermore,the conventional models in wellbore breakouts with uniform distribution fractures could not reflect the real drilling situation.This paper presents a fully coupled hydro-mechanical model of the SB-X well in the Tarim Basin,China for evaluating wellbore breakouts in heavily fractured rocks under anisotropic stress states using the distinct element method(DEM)and the discrete fracture network(DFN).The developed model was validated against caliper log measurement,and its stability study was carried out by stress and displacement analyses.A parametric study was performed to investigate the effects of the characteristics of fracture distribution(orientation and length)on borehole stability by sensitivity studies.Simulation results demonstrate that the increase of the standard deviation of orientation when the fracture direction aligns parallel or perpendicular to the principal stress direction aggravates borehole instability.Moreover,an elevation in the average fracture length causes the borehole failure to change from the direction of the minimum in-situ horizontal principal stress(i.e.the direction of wellbore breakouts)towards alternative directions,ultimately leading to the whole wellbore failure.These findings provide theoretical insights for predicting wellbore breakouts in heavily fractured rocks. 展开更多
关键词 Wellbore breakout Discrete fracture network(DFN) distinct element method(DEM) Heavily fractured rocks
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A Boundary Element Reconstruction (BER) Model for Moving Morphable Component Topology Optimization
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作者 Zhao Li Hongyu Xu +2 位作者 Shuai Zhang Jintao Cui Xiaofeng Liu 《Computers, Materials & Continua》 2026年第1期2213-2230,共18页
The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is m... The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples. 展开更多
关键词 Topology optimization MMC method boundary element reconstruction surrogate material model local mesh
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Feeling the Fragrance--Blending tradition with modern elements,young entrepreneurs revive tea industry and culture in Songyang
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作者 YANG SHUANGSHUANG 《ChinAfrica》 2026年第1期54-55,共2页
On the stone-paved lanes of Songyang County that date back to ancient times,morning mist lingered as a faint fragrance of tea wafted from a century-old house.Inside,Yang Junjie,a tea maker born in the 1980s,worked def... On the stone-paved lanes of Songyang County that date back to ancient times,morning mist lingered as a faint fragrance of tea wafted from a century-old house.Inside,Yang Junjie,a tea maker born in the 1980s,worked deftly at the stove,his hands moving swiftly over the scorching iron wok as tender green tea leaves dance between his fingers. 展开更多
关键词 TEA scorching iron wok FRAGRANCE tea leaves modern elements TRADITION Songyang tea making
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Production of ^(287,288)Mc isotopes in the ^(48)Ca+^(243)Am reaction at China Accelerator Facility for Superheavy Elements
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作者 X.Y.Huang Z.Y.Zhang +38 位作者 J.G.Wang L.Ma C.L.Yang M.H.Huang X.L.Wu Z.G.Gan H.B.Yang M.M.Zhang Y.L.Tian Y.S.Wang J.Y.Wang Y.H.Qiang G.Xie S.Y.Xu Z.Zhao Z.C.Li L.C.Sun L.Zhu X.Zhang H.Zhou F.Guan Z.H.Li W.X.Huang Z.Qin Y.Wang X.J.Yin Y.F.Cui Z.W.Lu Y.He L.T.Sun Z.Z.Ren S.G.Zhou V.K.Utyonkov A.A.Voinov Yu.S.Tsyganov A.N.Polyakov D.I.Solovyev N.D.Kovrizhnykh M.V.Shumeiko 《Chinese Physics Letters》 2026年第1期9-16,共8页
We report the results of the experiment on synthesizing ^(287,288)Mc isotopes (Z=115) using the fusionevaporation reaction ^(243)Am(^(48)Ca,4n,3n)^(287,288)Mc at the Spectrometer for Heavy Atoms and Nuclear Structure-... We report the results of the experiment on synthesizing ^(287,288)Mc isotopes (Z=115) using the fusionevaporation reaction ^(243)Am(^(48)Ca,4n,3n)^(287,288)Mc at the Spectrometer for Heavy Atoms and Nuclear Structure-2(SHANS2),a gas-filled recoil separator located at the China Accelerator Facility for Superheavy Elements(CAFE2).In total,20 decay chains are attributed to ^(288)Mc and 1 decay chain is assigned to ^(287)Mc.The measured oa-decay properties of ^(287,288)Mc as well as its descendants are consistent with the known data.No additional decay chains originating from the 2n or 5n reaction channels were detected.The excitation function of the ^(243)Am(^(48)Ca,3n)^(288)Mc reaction was measured at the cross-section level of picobarn,which indicates the promising capability for the study of heavy and superheavy nuclei at the facility. 展开更多
关键词 spectrometer heavy atoms fusionevaporation reaction China Accelerator Facility Superheavy elements PRODUCTION decay chains ISOTOPES ca am reaction mc
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Three-dimensional distinct element modeling of fault reactivation and induced seismicity due to hydraulic fracturing injection and backflow 被引量:10
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作者 Zirui Yin Hongwei Huang +2 位作者 Fengshou Zhang Lianyang Zhang Shawn Maxwell 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2020年第4期752-767,共16页
This paper presents a three-dimensional fully hydro-mechanical coupled distinct element study on fault reactivation and induced seismicity due to hydraulic fracturing injection and subsequent backflow process,based on... This paper presents a three-dimensional fully hydro-mechanical coupled distinct element study on fault reactivation and induced seismicity due to hydraulic fracturing injection and subsequent backflow process,based on the geological data in Horn River Basin,Northeast British Columbia,Canada.The modeling results indicate that the maximum magnitude of seismic events appears at the fracturing stage.The increment of fluid volume in the fault determines the cumulative moment and maximum fault slippage,both of which are essentially proportional to the fluid volume.After backflow starts,the fluid near the joint intersection keeps flowing into the critically stressed fault,rather than backflows to the wellbore.Although fault slippage is affected by the changes of both pore pressure and ambient rock stress,their contributions are different at fracturing and backflow stages.At fracturing stage,pore pressure change shows a dominant effect on induced fault slippage.While at backflow stage,because the fault plane is under a critical stress state,any minor disturbance would trigger a fault slippage.The energy analysis indicates that aseismic deformation takes up a majority of the total deformation energy during hydraulic fracturing.A common regularity is found in both fracturing-and backflow-induced seismicity that the cumulative moment and maximum fault slippage are nearly proportional to the injected fluid volume.This study shows some novel insights into interpreting fracturing-and backflowinduced seismicity,and provides useful information for controlling and mitigating seismic hazards due to hydraulic fracturing. 展开更多
关键词 Induced seismicity Fault reactivation Hydraulic fracturing BACKFLOW Geomechanical modeling distinct element method
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Distinct Element Modelling of Unreinforced Masonry Wall Under Seismic Loads with and without Cable Retrofitting 被引量:1
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作者 ZHUGE Yan 《Transactions of Tianjin University》 EI CAS 2008年第B10期471-475,共5页
To retrofit and strengthen existing unreinforced masonry (URM) structures to resist the potential earthquake damages has become an important issue in Australia. In order to secure the performance of URM under seismic ... To retrofit and strengthen existing unreinforced masonry (URM) structures to resist the potential earthquake damages has become an important issue in Australia. In order to secure the performance of URM under seismic loading in the future, a research project was carried out aimed at developing a simple and high strength seismic retrofitting technique for masonry structures. A series of experimental testing on URM walls retrofitted with an innovative technique by cable system have been conducted. The results indicated that both the strength and ductility of the tested speci-mens were significantly enhanced with the technique. An analytical model which is based on Dis-tinct Element Method (DEM) has also been developed to simulate the behaviour of URM walls be-fore and after retrofitting. The model is then further developed by applying a seismic wave to the wall to simulate the wall behavior under earthquake loads before and after retrofitting. 展开更多
关键词 unreinforced masonry distinct element method earthquake loads in-plane shear retrofitting
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Distinct Element Modelling of Mahabaleshwar Road Cut Hill Slope 被引量:1
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作者 Ashutosh Kainthola P. K. Singh +1 位作者 A. B. Wasnik T. N. Singh 《Geomaterials》 2012年第4期105-113,共9页
Reliable estimates of slope stability are essential for safe design and planning of road cut hill slopes which accommo-date a number of tourist destinations around the world. The failure of cut slopes along these hill... Reliable estimates of slope stability are essential for safe design and planning of road cut hill slopes which accommo-date a number of tourist destinations around the world. The failure of cut slopes along these hills puts human life in grave danger and it is also disastrous for the economy. In the present study, a section of 100 m high jointed basalt hill slope has been analyzed numerically in a distinct element code, which is apt for simulating the behavior for jointed rock. The analysis was carried out for both the dry and saturated conditions. The distinct element analysis of the hill slope demonstrates it to be marginally stable under dry condition, while for the saturated condition, the hill slope fails along well defined joint planes. 展开更多
关键词 distinct element Method UDEC SLOPE Stability Mahabaleshwar
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AN ESTIMATION OF FUZZY RELIABILITY OF DISTINCT ELEMENT METHOD IN PREDICTION OF SURFACE SUBSIDENCE DUE TO COAL MINING 被引量:1
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作者 张玉卓 《Journal of Coal Science & Engineering(China)》 1998年第2期7-12,共6页
The quantitative evaluation of errors involved in a particular numerical modelling is of prime importance for the effectiveness and reliability of the method. Errors in Distinct Element Modelling are generated mainly ... The quantitative evaluation of errors involved in a particular numerical modelling is of prime importance for the effectiveness and reliability of the method. Errors in Distinct Element Modelling are generated mainly through three resources as simplification of physical model, determination of parameters and boundary conditions. A measure of errors which represent the degree of numerical solution 'close to true value' is proposed through fuzzy probability in this paper. The main objective of this paper is to estimate the reliability of Distinct Element Method in rock engineering practice by varying the parameters and boundary conditions. The accumulation laws of standard errors induced by improper determination of parameters and boundary conditions are discussed in delails. Furthermore, numerical experiments are given to illustrate the estimation of fuzzy reliability. Example shows that fuzzy reliability falls between 75%-98% when the relative standard errors of input data is under 10 %. 展开更多
关键词 RELIABILITY fuzzy sets ERRORS distinct element Method BALL
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Distinct element modelling of fracture plan control in continuum and jointed rock mass in presplitting method of surface mining 被引量:4
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作者 Sharafisafa Mansour Aliabadian Zeinab +1 位作者 Alizadeh Rezvan Mortazavi Ali 《International Journal of Mining Science and Technology》 SCIE EI 2014年第6期871-881,共11页
Controlled blasting techniques are used to control overbreak and to aid in the stability of the remaining rock formation. Presplitting is one of the most common methods which is used in many open pit mining and surfac... Controlled blasting techniques are used to control overbreak and to aid in the stability of the remaining rock formation. Presplitting is one of the most common methods which is used in many open pit mining and surface blast design. The purpose of presplitting is to form a fracture plane across which the radial cracks from the production blast cannot travel. The purpose of this study is to investigate of effect of presplitting on the generation of a smooth wall in continuum and jointed rock mass. The 2D distinct element code was used to simulate the presplitting in a rock slope. The blast load history as a function of time was applied to the inner wall of each blasthole. Important parameters that were considered in the analysis were stress tensor and fracturing pattern. The blast loading magnitude and blasthole spacing and jointing pattern were found to be very significant in the final results. 展开更多
关键词 Controlled blasting Presplitting method Continuum and jointed rock mass distinct element modelling
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Distinct element method investigation on mechanical behavior within shear bands in granulates under the Earth and the Moon conditions
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作者 Mingjing Jiang Wangcheng Zhang 《Theoretical & Applied Mechanics Letters》 CAS 2013年第2期25-29,共5页
This letter mainly aims to investigate the mechanical behavior within shear bands in regolith both under the Earth and the Moon conditions via the distinct element method, in which a novel contact model considering in... This letter mainly aims to investigate the mechanical behavior within shear bands in regolith both under the Earth and the Moon conditions via the distinct element method, in which a novel contact model considering interparticle van der Waals forces and rolling resistance is employed. The results show that for regolith under both conditions the stress paths are almost identical inside and outside the shear bands but void ratio, average pure rotation rate, and strain paths are rather distinct with dilation, particle rotation and the second invariant of strain tensor mainly occurring within the bands. However, the regolith under the Moon condition has higher peak strength and more significant strain localization than those under the Earth condition. 展开更多
关键词 lunar regolith shear band van der Waals forces MICROMECHANICS distinct element method
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Investigating Earth Reaction to Pull-Out Process of Frictional Rock Bolts Using Distinct Element Method
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作者 Mohammad Sadegh Ayyoobi Arash Refahi 《Open Journal of Geology》 2020年第8期851-862,共12页
The reaction of earth to pull-out process of frictional rock bolts was here modeled by the distinct element method (DEM). Ten frictional bolts were prepared;the expanding shells of five bolts included convex edges and... The reaction of earth to pull-out process of frictional rock bolts was here modeled by the distinct element method (DEM). Ten frictional bolts were prepared;the expanding shells of five bolts included convex edges and the others had the shells with concave bits. The strength of bolts was measured by applying a standard pull-out test;the results confirmed that the strength of shells with convex edges was remarkably more than the strength of other shells. Furthermore, a two-dimensional DEM model of the test was developed by a particle flow code;the obtained results showed that the reaction of rock particles to the contacts occurring between the convex edges and earth was considerably more than those of the concave bits. In the other words, the convex edges transferred the pull-out force into a large area of the surrounded rock, causing these bolts to have the highest resistance against earth movements. 展开更多
关键词 Frictional Rock Bolt Pull-Out Test distinct element Method Particle Flow Code
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Object-Based Classification of Urban Distinct Sub-Elements Using High Spatial Resolution Orthoimages and DSM Layers
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作者 Ali Nouh Mabdeh A'kif Al-Fugara Mu’men Al jarah 《Journal of Geographic Information System》 2018年第4期323-343,共21页
This paper aims to assess the ways in which multi-resolution object-based classification methods can be used to group urban environments made up of a mixture of buildings, sub-elements such as car parks, roads, shades... This paper aims to assess the ways in which multi-resolution object-based classification methods can be used to group urban environments made up of a mixture of buildings, sub-elements such as car parks, roads, shades and pavements and foliage such as grass and trees. This involves using both unmanned aerial vehicles (UAVs) which provide high-resolution mosaic Orthoimages and generate a Digital Surface Model (DSM). For the study area chosen for this paper, 400 Orthoimages with a spatial resolution of 7 cm each were used to build the Orthoimages and DSM, which were georeferenced using well distributed network of ground control points (GCPs) of 12 reference points (RMSE = 8 cm). As these were combined with onboard RTK-GNSS-enabled 2-frequency receivers, they were able to provide absolute block orientation which had a similar accuracy range if the data had been collected by traditional indirect sensor orientation. Traditional indirect sensor orientation involves the GNSS receiver in the UAV receiving a differential signal from the base station through a communication link. This allows for the precise position of the UAV to be established, as the RTK uses correction, allowing position, velocity, altitude and heading to tracked, as well as the measurement of raw sensor data. By assessing the results of the confusion matrices, it can be seen that the overall accuracy of the object-oriented classification was 84.37%. This has an overall Kappa of 0.74 and the data that had poor classification accuracy included shade, parking lots and concrete pavements. These had a producer accuracy (precision) of 81%, 74% and 74% respectively, while lakes and solar panels each scored 100% in comparison, meaning that they had good classification accuracy. 展开更多
关键词 OBJECT-ORIENTED Classification Real Time KINEMATICS DSM UAV Orthoimages MOSAIC URBAN distinct Sub-elements
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Modelling of URM Walls Retrofitted with Cable: A Comparison Between a Basic Mechanical Model and Distinct Element Method
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作者 ZHUGE Yan CHUANG Shihwei 《Transactions of Tianjin University》 EI CAS 2006年第B09期171-176,共6页
The Australian love of 'heritage' buildings (most of them are unreinforced masonry (URM)) means that greater attention is required to secure their performance under seismic or impact loading in the future. A r... The Australian love of 'heritage' buildings (most of them are unreinforced masonry (URM)) means that greater attention is required to secure their performance under seismic or impact loading in the future. A research project has been carried out to develop a new, economic and high strength retrofitting technique for masonry structures. A series of experimental testing on URM walls retrofitted with an innovative technique by cable system have been conducted. In this paper, an analytical model which is based on distinct element method (DEM) is developed to simulate the behaviour of retrofitted walls. In DEM, a solid is represented as an assembly of discrete blocks. Joints are modelled as interface between distinct bodies. It is a dynamic process and specially designed to model the behaviour of discontinuities. In order to assist the practising engineers to design this new retrofitted wall system, a simple mechanical model was also developed to predict the strength of the retrofitted walls. The results obtained from this simple mechanical model are compared with those from both experiments and distinct element model. 展开更多
关键词 unreinforced masonry walls retrofitting CABLE distinct element method
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Modeling and Simulation of Particle-Packing Structures and Their Stability Using the Distinct Element Method
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作者 Takuya Uehara 《Open Journal of Modelling and Simulation》 2018年第4期59-70,共12页
A numerical method for simulating the stability of particle-packing structures is presented. The packing structures were modeled on the basis of face-centered cubic (fcc) and body-centered cubic (bcc) structures, and ... A numerical method for simulating the stability of particle-packing structures is presented. The packing structures were modeled on the basis of face-centered cubic (fcc) and body-centered cubic (bcc) structures, and the stability of these structures was investigated using the distinct element method. The interaction between the particles was simplified by considering repulsive, adhesive, and damping forces, and the stability against the gravitational force was simulated. The results under a certain set of parameters showed characteristic deformation when the particles were arranged in an fcc array. Focusing on the local structure, the resulting model was divided into several domains: The bottom base, four top corners, and intermediate domains. The bottom base notably became a body-centered tetragonal (bct) structure, which corresponds to a uniaxially compressed bcc structure. Conversely, the models based on the bcc arrangement were structurally stable, as no specific deformation was observed, and a monotonously compressed bct structure was obtained. Consequently, the bcc arrangement is concluded to be more stable against uniaxial compression, such as the gravitational force, in a particle-packing system. 展开更多
关键词 distinct element Method PARTICLE PACKING Structural STABILITY GEOMETRICAL SYMMETRY Computer Simulation
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Distinct element method simulation of mechanical properties of material layer of pellet belt roasting machine
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作者 Yin-hua Tang Xing-wang Li +3 位作者 Xu Gao Tao Yang Hong-ming Long Jie Lei 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2024年第11期2633-2644,共12页
The thick layer and graded feeding technology of a belt roasting machine is an effective method for improving the production efficiency and quality index of pellet production,and a reasonable design of the mechanical ... The thick layer and graded feeding technology of a belt roasting machine is an effective method for improving the production efficiency and quality index of pellet production,and a reasonable design of the mechanical structure of the layer is the basis for optimizing the heat and mass transfer performance of the layer.Janssen effect and von Mises yield criterion were used to establish a simplified mathematical model describing the elastic and plastic deformation of the green pellet under the action of an external force.The mechanical characteristics of extrusion,contact,and elastic-plastic deformation between green pellet particles in the material layer of the belt roasting machine were modeled using EDEM software.For a green pellet size of 12 mm,as the layer height increases from 300 to 1000 mm,the maximum vertical pressure on the pellets increases from 11.64 to 24.01 N,and the porosity decreases from 27.04%to 22.01%.As the layer height increases,the contact between the green pellets becomes more intense,and the force chain structure of the layer becomes more stable;the Janssen effect is observed when the layer reaches 700 mm.The compressive strength of the green pellets is linearly related to the particle size,and the compressive strength increases with an increase in particle size.At a layer height of 600 mm,as the particle size of the green pellets increases from 8 to 20 mm,the maximum vertical pressure increases from 7.54 to 44.16 N,and the porosity increases from 23.20%to 31.47%,while the yield per unit of the layer decreased by 12.1%.Small particles have a more stable force chain structure,larger comparative area,and higher production efficiency;however,their compressive strength is lower.Large particles have higher compressive strength and good permeability in the layer,but the production efficiency is relatively low.In actual production,a variety of factors should be integrated to optimize the feeding,and a multi-granularity graded feeding is the most ideal feeding. 展开更多
关键词 Belt roasting machine distinct element method Green pellet Thick material layer Mechanical property
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Study of the Transport Behavior of Multispherical Proppant in Intersecting Fracture Based on Discrete Element Method 被引量:1
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作者 Chengyong Peng JianshuWu +2 位作者 Mao Jiang Biao Yin Yishan Lou 《Energy Engineering》 EI 2025年第1期185-201,共17页
To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fract... To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fractures,this study considered the combined impact of geological-engineering factors on conductivity.Using reservoir production parameters and the discrete elementmethod,multispherical proppants were constructed.Additionally,a 3D fracture model,based on the specified conditions of the L block,employed coupled(Computational Fluid Dynamics)CFD-DEM(Discrete ElementMethod)for joint simulations to quantitatively analyze the transport and placement patterns of multispherical proppants in intersecting fractures.Results indicate that turbulent kinetic energy is an intrinsic factor affecting proppant transport.Moreover,the efficiency of placement and migration distance of low-sphericity quartz sand constructed by the DEM in the main fracture are significantly reduced compared to spherical ceramic proppants,with a 27.7%decrease in the volume fraction of the fracture surface,subsequently affecting the placement concentration and damaging fracture conductivity.Compared to small-angle fractures,controlling artificial and natural fractures to expand at angles of 45°to 60°increases the effective support length by approximately 20.6%.During hydraulic fracturing of gas wells,ensuring the fracture support area and post-closure conductivity can be achieved by controlling the sphericity of proppants and adjusting the perforation direction to control the direction of artificial fractures. 展开更多
关键词 Hydraulic fracturing discrete element method PROPPANT SPHERICITY CFD-DEM
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Toward understanding the role of genomic repeat elements in neurodegenerative diseases 被引量:1
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作者 Zhengyu An Aidi Jiang Jingqi Chen 《Neural Regeneration Research》 SCIE CAS 2025年第3期646-659,共14页
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se... Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements. 展开更多
关键词 Alzheimer's disease ATAXIA deep learning long-read sequencing NEURODEGENERATION neurodegenerative diseases Parkinson's disease repeat element structural variant
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Element Transfer Reaction theory:Scientific connotation and its applications in chemical industry 被引量:1
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作者 Hongen Cao Xinrui Xiao +2 位作者 Xu Zhang Yiyang Zhang Lei Yu 《Chinese Chemical Letters》 2025年第9期4-7,共4页
Element Transfer Reaction(ETR)theory is a new fundamental theory guiding the design of synthetic routes.It analyses problems from a brand-new perspective of element circulation,decomposing the factors affecting synthe... Element Transfer Reaction(ETR)theory is a new fundamental theory guiding the design of synthetic routes.It analyses problems from a brand-new perspective of element circulation,decomposing the factors affecting synthetic efficiency into three elements:element sources,driving force,and output.Different from the retrosynthetic analysis method and the atom economy theory,the ETR theory places more emphasis on examining the problem as a whole and comprehensively considering various factors involved in industrial applications.This perspective intends to elaborate on the scientific connotation of the ETR theory and explore its characteristics by discussing the practical application cases. 展开更多
关键词 element Transfer Reaction theory element source Driving force OUTPUT Energy conservation Atom economy
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High-efficiency RGB achromatic liquid crystal diffractive optical elements 被引量:1
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作者 Yuqiang Ding Xiaojin Huang +2 位作者 Yongziyan Ma Yan Li Shin-Tson Wu 《Opto-Electronic Advances》 2025年第3期4-15,共12页
Liquid crystal Pacharatnam-Berry phase optical elements(PBOEs)have found promising applications in augmented reality and virtual reality because of their slim formfactor,lightweight,and high optical efficiency.However... Liquid crystal Pacharatnam-Berry phase optical elements(PBOEs)have found promising applications in augmented reality and virtual reality because of their slim formfactor,lightweight,and high optical efficiency.However,chromatic aberration remains a serious longstanding problem for diffractive optics,hindering their broader adoption.To overcome the chromatic aberrations for red,green and blue(RGB)light sources,in this paper,we propose a counterintuitive multi-twist structure to achieve narrowband PBOEs without crosstalk,which plays a vital role to eliminate the chromatic aberration.The performance of our designed and fabricated narrowband Pacharatnam-Berry lenses(PBLs)aligns well with our simulation results.Furthermore,in a feasibility demonstration experiment using a laser projector,our proposed PBL system indeed exhibits a diminished chromatic aberration as compared to a broadband PBL.Additionally,polarization raytracing is implemented to demonstrate the versatility of the multi-twist structure for designing any RGB wavelengths with high contrast ratios.This analysis explores the feasibility of using RGB laser lines and quantum dot light-emitting diodes.Overall,our approach enables high optical efficiency,low fabrication complexity,and high degree of design freedom to accommodate any liquid crystal material and RGB light sources,holding immense potential for widespread applications of achromatic PBOEs. 展开更多
关键词 achromatic diffractive optical elements Pacharatnam-Berry phase optical elements liquid crystal planar optics near-eye displays
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Data Elements Accumulation Enabling the“Threeizations”Upgrading of Manufacturing:Theoretical Mechanism 被引量:1
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作者 Hao Xie 《Proceedings of Business and Economic Studies》 2025年第2期298-304,共7页
The data production elements are driving profound transformations in the real economy across production objects,methods,and tools,generating significant economic effects such as industrial structure upgrading.This pap... The data production elements are driving profound transformations in the real economy across production objects,methods,and tools,generating significant economic effects such as industrial structure upgrading.This paper aims to reveal the impact mechanism of the data elements on the“three transformations”(high-end,intelligent,and green)in the manufacturing sector,theoretically elucidating the intrinsic mechanisms by which the data elements influence these transformations.The study finds that the data elements significantly enhance the high-end,intelligent,and green levels of China's manufacturing industry.In terms of the pathways of impact,the data elements primarily influence the development of high-tech industries and overall green technological innovation,thereby affecting the high-end,intelligent,and green transformation of the industry. 展开更多
关键词 Data elements MANUFACTURING HIGH-END INTELLIGENT Green
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