Metal-organic framework(MOF)-derived carbon composites have been considered as the promising materials for energy storage.However,the construction of MOF-based composites with highly controllable mode via the liquid-l...Metal-organic framework(MOF)-derived carbon composites have been considered as the promising materials for energy storage.However,the construction of MOF-based composites with highly controllable mode via the liquid-liquid synthesis method has a great challenge because of the simultaneous heterogeneous nucleation on substrates and the self-nucleation of individual MOF nanocrystals in the liquid phase.Herein,we report a bidirectional electrostatic generated self-assembly strategy to achieve the precisely controlled coatings of single-layer nanoscale MOFs on a range of substrates,including carbon nanotubes(CNTs),graphene oxide(GO),MXene,layered double hydroxides(LDHs),MOFs,and SiO_(2).The obtained MOF-based nanostructured carbon composite exhibits the hierarchical porosity(V_(meso)/V_(micro)∶2.4),ultrahigh N content of 12.4 at.%and"dual electrical conductive networks."The assembled aqueous zinc-ion hybrid capacitor(ZIC)with the prepared nanocarbon composite as a cathode shows a high specific capacitance of 236 F g^(-1)at 0.5 A g^(-1),great rate performance of 98 F g^(-1)at 100 A g^(-1),and especially,an ultralong cycling stability up to 230000 cycles with the capacitance retention of 90.1%.This work develops a repeatable and general method for the controlled construction of MOF coatings on various functional substrates and further fabricates carbon composites for ZICs with ultrastability.展开更多
Inertial characteristics of non-cooperative targets are crucial for space capture and sub-sequent on-orbit servicing.Previous methods for identifying inertial parameters involve proximity operations,which are associat...Inertial characteristics of non-cooperative targets are crucial for space capture and sub-sequent on-orbit servicing.Previous methods for identifying inertial parameters involve proximity operations,which are associated with the risk of collision with non-cooperative targets.This paper introduces a long-range,contactless method for identifying the inertial parameters of a non-cooperative target during the pre-capture phase.Specifically,electrostatic interaction is used as an external excitation to alter the target's motion.A force estimation algorithm that uses measure-ments from visual and potential sensors is proposed to estimate the electrostatic interaction and eliminate the need for force sensors.Furthermore,a recursive estimation-identification framework is presented to concurrently estimate the coupled motion state,weak electrostatic interaction,and inertial parameters of the target.The simulation results show that the proposed method extends the identification distance to 170 times that of the previous method while maintaining high identifica-tion precision forall parameters.展开更多
The low drug bioavailability of eye drops challenges the therapy of ocular disorders with high efficacy.One of solutions is to extend the corneal retention and enhance the penetration of drug into cornea.Here we synth...The low drug bioavailability of eye drops challenges the therapy of ocular disorders with high efficacy.One of solutions is to extend the corneal retention and enhance the penetration of drug into cornea.Here we synthesize two fluorophore-conjugated peptide based analogs rich in positive charges(i.e.,NBDFFKK)and with a specific ligand(i.e.,NBD-FFRGD),respectively,to visualize their performances in vitro and in vivo.The peptides both can self-assemble into supramolecular hydrogels with the microstructure of nanofibers.The in vitro experiments exhibit that two peptides are both uniformly distributed in cytoplasm,and the intracellular amount of peptide rich in positive charges is significantly larger than that of peptide with a specific ligand.The living corneal fluorescence shows that two peptides enter the corneal stroma within 15 min,and the peptide rich in positive charges is accumulated more extensively throughout the entire cornea,revealing that the supramolecular hydrogel eye drops penetrate the cornea more efficiently via electrostatic interaction than that via ligand-receptor interaction.This work,as a comparative study of supramolecular hydrogel eye drops on penetrating efficiency,indicates a possible direction for the design of eye drops with efficient corneal penetration.展开更多
Through tailoring interfacial chemistry,electrolyte engineering is a facile yet effective strategy for highperformance lithium(Li)metal batteries,where the solvation structure is critical for interfacial chemistry.Her...Through tailoring interfacial chemistry,electrolyte engineering is a facile yet effective strategy for highperformance lithium(Li)metal batteries,where the solvation structure is critical for interfacial chemistry.Herein,the effect of electrostatic interaction on regulating an anion-rich solvation is firstly proposed.The moderate electrostatic interaction between anion and solvent promotes anion to enter the solvation sheath,inducing stable solid electrolyte interphase with fast Li+transport kinetics on the anode.This asdesigned electrolyte exhibits excellent compatibility with Li metal anode(a Li deposition/stripping Coulombic efficiency of 99.3%)and high-voltage LiCoO_(2) cathode.Consequently,the 50μm-thin Li||high-loading LiCoO_(2) cells achieve significantly improved cycling performance under stringent conditions of high voltage over 4.5 V,lean electrolyte,and wide temperature range(-20 to 60℃).This work inspires a groundbreaking strategy to manipulate the solvation structure through regulating the interactions of solvent and anion for highperformance Li metal batteries.展开更多
In this work,a new type of hydrophobic stationary phase that provide electrostatic interactions with analytes was developed by bondingβ-phenylethylamine as a functional ligand to silica.This stationary phase can sepa...In this work,a new type of hydrophobic stationary phase that provide electrostatic interactions with analytes was developed by bondingβ-phenylethylamine as a functional ligand to silica.This stationary phase can separate proteins with similar hydrophobicity that traditional hydrophobic resins cannot.Hen egg white was separated to examine the selectivity.The results show that the introduced electrostatic interactions are an important factor for the resolution enhancement and the new resin could have important applications in separation and purification of biological macromolecules.展开更多
In this work grand canonical Monte Carlo simulations were performed to study gas separation in three pairs of isoreticular metal-organic frameworks (IRMOFs) with and without catenation at room temperature.Mixture comp...In this work grand canonical Monte Carlo simulations were performed to study gas separation in three pairs of isoreticular metal-organic frameworks (IRMOFs) with and without catenation at room temperature.Mixture composed of CO2 and H2 was selected as the model system to separate.The results show that CO2 selectivity in catenated MOFs with multi-porous frameworks is much higher than their non-catenated counterparts.The simulations also show that the electrostatic interactions are very important for the selectivity,and the contributions of different electrostatic interactions are different,depending on pore size,pressure and mixture composition.In fact,changing the electrostatic interactions can even qualitatively change the adsorption behavior.A general conclusion is that the electrostatic interactions between adsorbate molecules and the framework atoms play a dominant role at low pressures,and these interactions in catenated MOFs have much more pronounced effects than those in their non-catenated counterparts,while the electrostatic interactions between adsorbate molecules become evident with increasing pressure,and eventually dominant.展开更多
The light weight,good bending resistance and low production cost make flexible perovskite solar cells(PSCs)good candidates in wearable electronics,portable charger,remote power,and flying objects.High power conversion...The light weight,good bending resistance and low production cost make flexible perovskite solar cells(PSCs)good candidates in wearable electronics,portable charger,remote power,and flying objects.High power conversion efficiency(PCE)plays a crucial role on obtaining the high mass specific power of flexible devices.However,the performance for flexible PSCs is still having a large room to be improved.Here,we added the 2-amino-5-cyanopyridine(ACP)molecule with a polar electron density distribution in the perovskite precursor solution to improve the performance of flexible PSCs.The cyano groups with electron-withdrawing ability are expected to passivate positively charged point defects,while amines with electron donating ability are expected to passivate negatively charged point defects in perovskite films.Thanks to the effective passivation of defects at the grain boundary and surface of perovskite films,the PCE of flexible PSCs is obviously increased from 16.9%to 18.0%.These results provide a universal approach to improve performance of flexible PSCs by healing the defects in perovskite films through electrostatic interactions.展开更多
Until now, nerve conduction has been described on the basis of equivalent circuit model and cable theory, both of which supposed closed electric circuits spreading inside and outside the axoplasm. With these conventio...Until now, nerve conduction has been described on the basis of equivalent circuit model and cable theory, both of which supposed closed electric circuits spreading inside and outside the axoplasm. With these conventional models, we can simulate the propagating pattern of action potential along the axonal membrane based on Ohm＇s law and Kirchhoff＇s law. However, we could not fully explain the different conductive patterns in unmyelinated and myelinated nerves with these theories. Also, whether we can really suppose closed electrical circuits in the actual site of the nerves or not has not been fully discussed yet. In this report, a recently introduced new theoretical model of nerve conduction based on electrostatic molecular interactions within the axoplasm will be reviewed. With this new approach, we can explain the different conductive patterns in unmyelinated and myelinated nerves. This new mathematical conductive model based on electrostatic compressional wave in the intracellular fluid may also be able to explain the signal integration in the neuronal cell body and the back-propagation mechanism from the axons to the dendrites. With this new mathematical nerve conduction model based on electrostatic molecular interactions within the intracellular fluid, we may be able to achieve an integrated explanation for the physiological phenomena taking place in the nervous system.展开更多
Au/CdTe nanocomposites were prepared by electrostatic interaction between oppositely-charged gold （Au） and cadmium telluride （CdTe） nanoparticles. Au and CdTe nanoparticles were stabilized by 4-（dimethylamino）py...Au/CdTe nanocomposites were prepared by electrostatic interaction between oppositely-charged gold （Au） and cadmium telluride （CdTe） nanoparticles. Au and CdTe nanoparticles were stabilized by 4-（dimethylamino）pyridine （DMAP） and 3-mercaptopropionic acid to develop positive and negative charges on their surfaces in aqueous solutions, respectively. The red shifts of the surface plasmon absorptions with the increase of Au content indicate that the sizes of the nanocomposites expanded due to the complex formation. Mixing ratio of Au and CdTe nanoparticles controls the structure of the resulting composites effectively. Moreover, the sizes and shapes of the mixed nanoparticles are important parameters for the formation of metal/semiconductor nanocomposites. The Au/CdTe nanocomposites were characterized by small angle X-ray scattering technique （SAXS）, transmission electron microscopy （TEM）, cyclic voltammetry （CV） and X-ray photoelectron spectroscopy （XPS）.展开更多
Piezoresponse force microscopy(PFM)has emerged as one of the most powerful techniques to probe ferroelectric materials at the nanoscale,yet it has been increasingly recognized that piezoresponse measured by PFM is oft...Piezoresponse force microscopy(PFM)has emerged as one of the most powerful techniques to probe ferroelectric materials at the nanoscale,yet it has been increasingly recognized that piezoresponse measured by PFM is often influenced by electrostatic interactions.In this letter,we report a capacitive excitation PFM(ce-PFM)to minimize the electrostatic interactions.The effectiveness of ce-PFM in minimizing electrostatic interactions is demonstrated by comparing the piezoresponse and the effective piezoelectric coefficient measured by ce-PFM and conventional PFM.The effectiveness is further confirmed through the ferroelectric domain pattern imaged via ce-PFM and conventional PFM in vertical modes,with the corresponding domain contrast obtained by ce-PFM is sharper than conventional PFM.These results demonstrate ce-PFM as an effective tool to minimize the interference from electrostatic interactions and to image ferroelectric domain pattern,and it can be easily implemented in conventional atomic force microscope(AFM)setup to probe true piezoelectricity at the nanoscale.展开更多
A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction betwe...A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction between polyelectrolyte and charged fluorophore. As for the system, the excimer-monomer conversion, thermosensitive behavior and thermo-responsive reversibility were investigated experimentally. Temperature variation and temperature-distribution induced fluorescence changes can be observed directly by naked eyes. Thus, this polymer system holds promise for serving as a fluorescent thermometer.展开更多
The electrostatic interaction of a charged spherical particle in the vicinity of an orifice plane has been investigated in this paper. The particle can creep along the axis of the orifice and is immersed in a bulk ele...The electrostatic interaction of a charged spherical particle in the vicinity of an orifice plane has been investigated in this paper. The particle can creep along the axis of the orifice and is immersed in a bulk electrolyte. By solving the Poisson-Boltzmann problem, we have obtained the effective electrostatic interaction for several values of reduced orifice radius h, including the cases of h ~ 1, h = i and h 〈 1. Two kinds of boundary conditions of the orifice plane are considered. One is the constant potential model corresponding to a conducting plane, the other is the constant charge model. In the constant potential model, there is an electrostatic attraction between the particle and the orifice plane when they get close to each other, while there is a pure electrostatic repulsion in the constant charge model. The interactions in both boundary models are sensitive to the parameters of the reduced orifice radius, the reduced particle-rifice distance, surface charge densities of the particle and orifice plane, and the reduced Debye screen constant corresponding to the salt-ion concentration and ion valence.展开更多
Electrostatic interaction conductive hybrids were prepared in water/ethanol solution by the sol-gel process from inorganic sol containing carboxyl group and water-borne conductive polyaniline （cPANI）. The electrosta...Electrostatic interaction conductive hybrids were prepared in water/ethanol solution by the sol-gel process from inorganic sol containing carboxyl group and water-borne conductive polyaniline （cPANI）. The electrostatic interaction hybrids film displayed 1-2 orders of magnitude higher electrical conductivity in comparison with common hybrids film, showing remarkable conductivity stability against water soaking. Most strikingly, it displayed ideal electrochemical activity even in a solution with pH = 14, which enlarged the conducting polyaniline application window to strong alkaline media.展开更多
We present the solutions of the interaction energy for a colloid system with a charged rod-like macromolecule immersed in a bulk electrolyte and moving along the axis of a circular orifice or disk （orifice/disk）. Th...We present the solutions of the interaction energy for a colloid system with a charged rod-like macromolecule immersed in a bulk electrolyte and moving along the axis of a circular orifice or disk （orifice/disk）. The calculation requires a numerical computation of the surface charge profiles, which result from a constant surface potential on the macromolecule and the orifice/disk. In the calculation, remarkable divergences of the surface charge emerge on the edges of the macromolecule and the orifice/disk, which are well-known edge effects. The anisotropic distribution of the surface charge （effective dipole） results in an attraction between these two charged objects. This attraction is enhanced with the increase of the screening length of the system for both the orifice and the disk systems. However, the sizes of the orifice and the disk reduce to different effects on the interaction energy.展开更多
Nanoparticles self-assembly plays a pivotal role in designing new functional structural materials.The manipulation of interactions among nanoparticle building blocks is crucial for achieving assemblies with desired st...Nanoparticles self-assembly plays a pivotal role in designing new functional structural materials.The manipulation of interactions among nanoparticle building blocks is crucial for achieving assemblies with desired structures and properties.In this work,we assemble binary inorganic nanoparticles into alternating copolymer-like nanostructures by independently regulating hydrogen bonding and electrostatic interactions.The block copolymers grafted on nanoparticles feature oppositely charged groups,where electrostatic attraction drives the linear assembly of nanoparticles into alternate chain configurations.The hydrogen bonding interaction originates from the direct introduction of polyethylene glycol into the systems,serving as hydrogen bond acceptors with the grafted polymer and facilitating the side-by-side assembly of the chain structures.These two forces were observed to compete with each other during the assembly process,and could be precisely controlled by adjusting the quantities of acetic acid and polyethylene glycol,thus regulating the nanoparticle assembly behavior.This work provides a practical framework for the design of muti-force interactions in hierarchical colloid nanomaterials.展开更多
Taking stearic acid as the raw material,N-(2-(dimethylamino)ethyl)stearamide(C18N2N)was synthesized.A new surfactant was prepared by mixing C18N2N and cinnamic acid(TA)with fixed ratio.This surfactant was formed by no...Taking stearic acid as the raw material,N-(2-(dimethylamino)ethyl)stearamide(C18N2N)was synthesized.A new surfactant was prepared by mixing C18N2N and cinnamic acid(TA)with fixed ratio.This surfactant was formed by noncovalent electrostatic interactions,which avoided complicated synthetic procedures.The surface activity and rheological properties of the surfactant were investigated with a surface tensiometer and a rheometer.The critical micelle concentration(cmc)and the surface tension at cmc(γ_(cmc))of the surfactant were 0.11 mmol/L and 32.4 mN/m,indicative of strong aggregation and adsorption ability.The maximum amount adsorbed(Γ_(max))and the minimum molecular area occupied(A_(min))were 2.77μmol/m^(2)and 0.6 nm^(2).Wormlike micelles were formed at the concentration of 25 mmol/L.When the concentration was over 100 mmol/L,the zero-shear viscosity(η_(0))abruptly increased and then reached the maximum value for the surfactant of C18N2N/TA containing 150 mmol/L TA.The solution viscosity was as high as 1761.38 Pa·s.The effects of temperature on the rheological behavior were also considered.With the increase of temperature,the viscosity gradually increased.And when the temperature reached 40℃,η_(0)of the solution with the concentration of 100 mmol/L achieved the maximum value of 1370.386 Pa·s.When the temperature continued to rise,η_(0)began to decrease with further increasing temperature.A remarkable viscosity of 305.55 Pa·s was still remained at 50℃.The viscoelastic solutions showed good temperature resistance and shear resistance.The surfactant solutions applied as the fracturing fluid were also investigated.This surfactant also showed excellent sand-carrying performance,and the settling rate of the sand was merely 0.26 cm/min.This surfactant could be simply prepared and showed excellent performance,which expanded the preparation and application field of novel surfactants.展开更多
The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aq...The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aqueous binder for iodine-loading cathode to enable stable and efficient Zn-I_(2) batteries.The positively charged region in gelatin presents electrostatic attraction to the iodine species,while the electron-rich regions could donate electrons to form physical or even covalent bonds with iodine species,thus inhibiting polyiodides shuttle effect and boosting redox reaction.A high reversible capacity of 138 mAh g^(-1) after 3000 cycles at 2C and an ultra-long cycling stability of 30000 cycles at 25C with 107 mAh g^(-1) capacity was achieved.Gelatin binder also can accommodate high iodine-loading(~10 mg)cathode,punch cells,and severe temperature conditions(-10℃ and 60℃).In-situ UV-vis absorption spectroscopy,in-situ Raman spectra and theoretical calculation revealed the critical role of gelatin binder in suppressing polyiodide shuttling and accelerating reaction kinetics.This work uncovers the potential of natural low-cost binder material in advanced Zn-I_(2) batteries and drives future study of designing functional binders.展开更多
Organelle-targeted imaging can provide information on cellular functions and intracellular interactions,being significant for disease diagnosis.The use of room-temperature phosphorescence(RTP)in organelle-targeted ima...Organelle-targeted imaging can provide information on cellular functions and intracellular interactions,being significant for disease diagnosis.The use of room-temperature phosphorescence(RTP)in organelle-targeted imaging can fully utilize its unique characteristics of long wavelength and deep penetration.However,this technology has long been plagued by insufficient probe targeting and limited luminous intensity.In this work,we prepared a series of complexes composed of multicationic persulfurated arenes and biomacromolecules via electrostatic interactions in 1:1 stoichiometry for high-contrast mitochondrial-targeted RTP imaging.Such an electrostatic interaction design effectively prevented the self-aggregation of the probes,which is not conducive to mitochondrial targeting.Simultaneously,it suppressed the non-radiative decay to the maximum extent,enabling the probes to exhibit strong RTP signals both in aqueous solution and at the cellular level.Furthermore,the biomacromolecules can serve as carriers for an electrostatic interaction transfer of the persulfurated arenes to mitochondria.This leads to high mitochondrial targeting Pearson's correlation coefficients of the probes and high-contrast RTP imaging effects,as well as the independence of the co-incubated probe concentration.These results provide new insights for the development of targeted imaging technologies.展开更多
The insulin-degrading enzyme(IDE)plays a significant role in the degradation of the amyloid beta(Aβ),a peptide found in the brain regions of the patients with early Alzheimer’s disease.Adenosine triphosphate(ATP)all...The insulin-degrading enzyme(IDE)plays a significant role in the degradation of the amyloid beta(Aβ),a peptide found in the brain regions of the patients with early Alzheimer’s disease.Adenosine triphosphate(ATP)allosterically regulates the Aβ-degrading activity of IDE.The present study investigates the electrostatic interactions between ATP-IDE at the allosteric site of IDE,including thermostabilities/flexibilities of IDE residues,which have not yet been explored systematically.This study applies the quantum mechanics/molecular mechanics(QM/MM)to the proposed computational model for exploring electrostatic interactions between ATP and IDE.Molecular dynamic(MD)simulations are performed at different temperatures for identifying flexible and thermostable residues of IDE.The proposed computational model predicts QM/MM energy-minimised structures providing the IDE residues(Lys530 and Asp385)with high binding affinities.Considering root mean square fluctuation values during the MD simulations at 300.00 K including heat-shock temperatures(321.15 K and 315.15 K)indicates that Lys530 and Asp385 are also the thermostable residues of IDE,whereas Ser576 and Lys858 have high flexibilities with compromised thermostabilities.The present study sheds light on the phenomenon of biological recognition and interactions at the ATP-binding domain,which may have important implications for pharmacological drug design.The proposed computational model may facilitate the development of allosteric IDE activators/inhibitors,which mimic ATP interactions.展开更多
Nuclear magnetic resonance(NMR)serves as a powerful tool for studying both the structure and dynamics of proteins.The NOE method,alongside residual dipolar;coupling,paramagnetic effects,J-coupling,and other related te...Nuclear magnetic resonance(NMR)serves as a powerful tool for studying both the structure and dynamics of proteins.The NOE method,alongside residual dipolar;coupling,paramagnetic effects,J-coupling,and other related techniques,has reached a level of maturity that allows for the determination of protein structures.Furthermore,NMR relaxation methods prove to be highly effective in characterizing protein dynamics across various timescales.The properties of protein systems are dictated by intra-and intermo-lecular interactions among atoms,which involve covalent bonds,hydrogen bonds(H-bonds),electrostatic interactions,and van der Waals forces.Multiple NMR approaches have been developed to measure noncovalent interactions,and this paper offers a concise overview of noncovalent interaction measurements using NMR,with a specific emphasis on the advancements accomplished in our laboratory.展开更多
基金financial support from Project funded by National Natural Science Foundation of China(52172038,22179017)funding from Dalian University of Technology Open Fund for Large Scale Instrument Equipment
文摘Metal-organic framework(MOF)-derived carbon composites have been considered as the promising materials for energy storage.However,the construction of MOF-based composites with highly controllable mode via the liquid-liquid synthesis method has a great challenge because of the simultaneous heterogeneous nucleation on substrates and the self-nucleation of individual MOF nanocrystals in the liquid phase.Herein,we report a bidirectional electrostatic generated self-assembly strategy to achieve the precisely controlled coatings of single-layer nanoscale MOFs on a range of substrates,including carbon nanotubes(CNTs),graphene oxide(GO),MXene,layered double hydroxides(LDHs),MOFs,and SiO_(2).The obtained MOF-based nanostructured carbon composite exhibits the hierarchical porosity(V_(meso)/V_(micro)∶2.4),ultrahigh N content of 12.4 at.%and"dual electrical conductive networks."The assembled aqueous zinc-ion hybrid capacitor(ZIC)with the prepared nanocarbon composite as a cathode shows a high specific capacitance of 236 F g^(-1)at 0.5 A g^(-1),great rate performance of 98 F g^(-1)at 100 A g^(-1),and especially,an ultralong cycling stability up to 230000 cycles with the capacitance retention of 90.1%.This work develops a repeatable and general method for the controlled construction of MOF coatings on various functional substrates and further fabricates carbon composites for ZICs with ultrastability.
基金supported by the National Natural Science Foundation of China(No.6200326).
文摘Inertial characteristics of non-cooperative targets are crucial for space capture and sub-sequent on-orbit servicing.Previous methods for identifying inertial parameters involve proximity operations,which are associated with the risk of collision with non-cooperative targets.This paper introduces a long-range,contactless method for identifying the inertial parameters of a non-cooperative target during the pre-capture phase.Specifically,electrostatic interaction is used as an external excitation to alter the target's motion.A force estimation algorithm that uses measure-ments from visual and potential sensors is proposed to estimate the electrostatic interaction and eliminate the need for force sensors.Furthermore,a recursive estimation-identification framework is presented to concurrently estimate the coupled motion state,weak electrostatic interaction,and inertial parameters of the target.The simulation results show that the proposed method extends the identification distance to 170 times that of the previous method while maintaining high identifica-tion precision forall parameters.
基金supported by National Natural Science Foundation of China(Nos.82102215 and 82372129)Wenzhou Medical University Scientific Research Fund(No.KYQD20210602)。
文摘The low drug bioavailability of eye drops challenges the therapy of ocular disorders with high efficacy.One of solutions is to extend the corneal retention and enhance the penetration of drug into cornea.Here we synthesize two fluorophore-conjugated peptide based analogs rich in positive charges(i.e.,NBDFFKK)and with a specific ligand(i.e.,NBD-FFRGD),respectively,to visualize their performances in vitro and in vivo.The peptides both can self-assemble into supramolecular hydrogels with the microstructure of nanofibers.The in vitro experiments exhibit that two peptides are both uniformly distributed in cytoplasm,and the intracellular amount of peptide rich in positive charges is significantly larger than that of peptide with a specific ligand.The living corneal fluorescence shows that two peptides enter the corneal stroma within 15 min,and the peptide rich in positive charges is accumulated more extensively throughout the entire cornea,revealing that the supramolecular hydrogel eye drops penetrate the cornea more efficiently via electrostatic interaction than that via ligand-receptor interaction.This work,as a comparative study of supramolecular hydrogel eye drops on penetrating efficiency,indicates a possible direction for the design of eye drops with efficient corneal penetration.
基金supported by National Nature Science Foundation of China(No.51872157 and No.52072208)National Key R&D Program of China 2021YFA1202802Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01N111)。
文摘Through tailoring interfacial chemistry,electrolyte engineering is a facile yet effective strategy for highperformance lithium(Li)metal batteries,where the solvation structure is critical for interfacial chemistry.Herein,the effect of electrostatic interaction on regulating an anion-rich solvation is firstly proposed.The moderate electrostatic interaction between anion and solvent promotes anion to enter the solvation sheath,inducing stable solid electrolyte interphase with fast Li+transport kinetics on the anode.This asdesigned electrolyte exhibits excellent compatibility with Li metal anode(a Li deposition/stripping Coulombic efficiency of 99.3%)and high-voltage LiCoO_(2) cathode.Consequently,the 50μm-thin Li||high-loading LiCoO_(2) cells achieve significantly improved cycling performance under stringent conditions of high voltage over 4.5 V,lean electrolyte,and wide temperature range(-20 to 60℃).This work inspires a groundbreaking strategy to manipulate the solvation structure through regulating the interactions of solvent and anion for highperformance Li metal batteries.
基金supported by the National Natural Science Foundation in China(No.21006077)the Foundation of Northwest University(No.09NW14)
文摘In this work,a new type of hydrophobic stationary phase that provide electrostatic interactions with analytes was developed by bondingβ-phenylethylamine as a functional ligand to silica.This stationary phase can separate proteins with similar hydrophobicity that traditional hydrophobic resins cannot.Hen egg white was separated to examine the selectivity.The results show that the introduced electrostatic interactions are an important factor for the resolution enhancement and the new resin could have important applications in separation and purification of biological macromolecules.
基金Supported by the National Natural Science Foundation of China （20725622, 20706002, and 20876006）, Beijing Nova Program （2008B15） and the Dutch STW/CW Separation Technology Program （700.56.655-DPC.6243）.
文摘In this work grand canonical Monte Carlo simulations were performed to study gas separation in three pairs of isoreticular metal-organic frameworks (IRMOFs) with and without catenation at room temperature.Mixture composed of CO2 and H2 was selected as the model system to separate.The results show that CO2 selectivity in catenated MOFs with multi-porous frameworks is much higher than their non-catenated counterparts.The simulations also show that the electrostatic interactions are very important for the selectivity,and the contributions of different electrostatic interactions are different,depending on pore size,pressure and mixture composition.In fact,changing the electrostatic interactions can even qualitatively change the adsorption behavior.A general conclusion is that the electrostatic interactions between adsorbate molecules and the framework atoms play a dominant role at low pressures,and these interactions in catenated MOFs have much more pronounced effects than those in their non-catenated counterparts,while the electrostatic interactions between adsorbate molecules become evident with increasing pressure,and eventually dominant.
基金financial support from the National Natural Science Foundation of China(No.NSFC21773218)。
文摘The light weight,good bending resistance and low production cost make flexible perovskite solar cells(PSCs)good candidates in wearable electronics,portable charger,remote power,and flying objects.High power conversion efficiency(PCE)plays a crucial role on obtaining the high mass specific power of flexible devices.However,the performance for flexible PSCs is still having a large room to be improved.Here,we added the 2-amino-5-cyanopyridine(ACP)molecule with a polar electron density distribution in the perovskite precursor solution to improve the performance of flexible PSCs.The cyano groups with electron-withdrawing ability are expected to passivate positively charged point defects,while amines with electron donating ability are expected to passivate negatively charged point defects in perovskite films.Thanks to the effective passivation of defects at the grain boundary and surface of perovskite films,the PCE of flexible PSCs is obviously increased from 16.9%to 18.0%.These results provide a universal approach to improve performance of flexible PSCs by healing the defects in perovskite films through electrostatic interactions.
文摘Until now, nerve conduction has been described on the basis of equivalent circuit model and cable theory, both of which supposed closed electric circuits spreading inside and outside the axoplasm. With these conventional models, we can simulate the propagating pattern of action potential along the axonal membrane based on Ohm＇s law and Kirchhoff＇s law. However, we could not fully explain the different conductive patterns in unmyelinated and myelinated nerves with these theories. Also, whether we can really suppose closed electrical circuits in the actual site of the nerves or not has not been fully discussed yet. In this report, a recently introduced new theoretical model of nerve conduction based on electrostatic molecular interactions within the axoplasm will be reviewed. With this new approach, we can explain the different conductive patterns in unmyelinated and myelinated nerves. This new mathematical conductive model based on electrostatic compressional wave in the intracellular fluid may also be able to explain the signal integration in the neuronal cell body and the back-propagation mechanism from the axons to the dendrites. With this new mathematical nerve conduction model based on electrostatic molecular interactions within the intracellular fluid, we may be able to achieve an integrated explanation for the physiological phenomena taking place in the nervous system.
基金Project (2010-0021425) supported by Basic Science Research Program through a National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology, Koreathe support from LG Yonam Foundation
文摘Au/CdTe nanocomposites were prepared by electrostatic interaction between oppositely-charged gold （Au） and cadmium telluride （CdTe） nanoparticles. Au and CdTe nanoparticles were stabilized by 4-（dimethylamino）pyridine （DMAP） and 3-mercaptopropionic acid to develop positive and negative charges on their surfaces in aqueous solutions, respectively. The red shifts of the surface plasmon absorptions with the increase of Au content indicate that the sizes of the nanocomposites expanded due to the complex formation. Mixing ratio of Au and CdTe nanoparticles controls the structure of the resulting composites effectively. Moreover, the sizes and shapes of the mixed nanoparticles are important parameters for the formation of metal/semiconductor nanocomposites. The Au/CdTe nanocomposites were characterized by small angle X-ray scattering technique （SAXS）, transmission electron microscopy （TEM）, cyclic voltammetry （CV） and X-ray photoelectron spectroscopy （XPS）.
基金We acknowledge the National Key Research and Development Program of China(Grant 2016YFA0201001)the National Natural Science Foundation of China(Grants 11372268,11627801,and 1472236)+2 种基金Unite State National Science Foundation(Grant CBET-1435968)the Leading Talents Program of Guangdong Province(Grant 2016LJ06C372)Shenzhen Science and Technology Innovation Committee(Grant KQJSCX20170331162214306).
文摘Piezoresponse force microscopy(PFM)has emerged as one of the most powerful techniques to probe ferroelectric materials at the nanoscale,yet it has been increasingly recognized that piezoresponse measured by PFM is often influenced by electrostatic interactions.In this letter,we report a capacitive excitation PFM(ce-PFM)to minimize the electrostatic interactions.The effectiveness of ce-PFM in minimizing electrostatic interactions is demonstrated by comparing the piezoresponse and the effective piezoelectric coefficient measured by ce-PFM and conventional PFM.The effectiveness is further confirmed through the ferroelectric domain pattern imaged via ce-PFM and conventional PFM in vertical modes,with the corresponding domain contrast obtained by ce-PFM is sharper than conventional PFM.These results demonstrate ce-PFM as an effective tool to minimize the interference from electrostatic interactions and to image ferroelectric domain pattern,and it can be easily implemented in conventional atomic force microscope(AFM)setup to probe true piezoelectricity at the nanoscale.
基金financially supported by the Science and Technology Planning Project of Guangdong Province(No.2014A010105009)the National Key Basic Research Program of China(No.2013CB834702)+1 种基金the National Natural Science Foundation of China(Nos.21574044 and 21474031)the Fundamental Research Funds for the Central Universities(No.2015ZY013)
文摘A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction between polyelectrolyte and charged fluorophore. As for the system, the excimer-monomer conversion, thermosensitive behavior and thermo-responsive reversibility were investigated experimentally. Temperature variation and temperature-distribution induced fluorescence changes can be observed directly by naked eyes. Thus, this polymer system holds promise for serving as a fluorescent thermometer.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 10805029 and 10947175)the Education Department of Natural Science Foundation of Zhejiang province of China (Grant No. Y200803420)+1 种基金the Science Foundation of Ningbo University (Grant No. xkl09057)sponsored by K.C.Wong Magna Fund in Ningbo University of China
文摘The electrostatic interaction of a charged spherical particle in the vicinity of an orifice plane has been investigated in this paper. The particle can creep along the axis of the orifice and is immersed in a bulk electrolyte. By solving the Poisson-Boltzmann problem, we have obtained the effective electrostatic interaction for several values of reduced orifice radius h, including the cases of h ~ 1, h = i and h 〈 1. Two kinds of boundary conditions of the orifice plane are considered. One is the constant potential model corresponding to a conducting plane, the other is the constant charge model. In the constant potential model, there is an electrostatic attraction between the particle and the orifice plane when they get close to each other, while there is a pure electrostatic repulsion in the constant charge model. The interactions in both boundary models are sensitive to the parameters of the reduced orifice radius, the reduced particle-rifice distance, surface charge densities of the particle and orifice plane, and the reduced Debye screen constant corresponding to the salt-ion concentration and ion valence.
基金This work was financially supported by the National Science Foundation of China (No. 20225414).
文摘Electrostatic interaction conductive hybrids were prepared in water/ethanol solution by the sol-gel process from inorganic sol containing carboxyl group and water-borne conductive polyaniline （cPANI）. The electrostatic interaction hybrids film displayed 1-2 orders of magnitude higher electrical conductivity in comparison with common hybrids film, showing remarkable conductivity stability against water soaking. Most strikingly, it displayed ideal electrochemical activity even in a solution with pH = 14, which enlarged the conducting polyaniline application window to strong alkaline media.
基金Project supported by the Scientific Research Fund of the Education Department of Zhejiang Province of China (Grant No.Y200803420)the National Natural Science Foundation of China (Grant No.10947175)+1 种基金the Natural Science Foundation of Ningbo,China (Grand No.2010A610089)K.C.Wong Magna Fund in Ningbo University of China
文摘We present the solutions of the interaction energy for a colloid system with a charged rod-like macromolecule immersed in a bulk electrolyte and moving along the axis of a circular orifice or disk （orifice/disk）. The calculation requires a numerical computation of the surface charge profiles, which result from a constant surface potential on the macromolecule and the orifice/disk. In the calculation, remarkable divergences of the surface charge emerge on the edges of the macromolecule and the orifice/disk, which are well-known edge effects. The anisotropic distribution of the surface charge （effective dipole） results in an attraction between these two charged objects. This attraction is enhanced with the increase of the screening length of the system for both the orifice and the disk systems. However, the sizes of the orifice and the disk reduce to different effects on the interaction energy.
基金This work is financially supported by the Innovation Program of Shanghai Municipal Education Commission(No.2021-01-07-0007-E00073)the National Natural Science Foundation of China(Nos.52125308 and 52293473)+3 种基金the Shanghai Municipal Science and Technology Project(No.23JC1400100)the National Key Research&Development Program of China(No.2022YFA1404700)the Shanghai Pujiang Program(No.23PJ1401000)China Postdoctoral Science Foundation(No.2022M720754).
文摘Nanoparticles self-assembly plays a pivotal role in designing new functional structural materials.The manipulation of interactions among nanoparticle building blocks is crucial for achieving assemblies with desired structures and properties.In this work,we assemble binary inorganic nanoparticles into alternating copolymer-like nanostructures by independently regulating hydrogen bonding and electrostatic interactions.The block copolymers grafted on nanoparticles feature oppositely charged groups,where electrostatic attraction drives the linear assembly of nanoparticles into alternate chain configurations.The hydrogen bonding interaction originates from the direct introduction of polyethylene glycol into the systems,serving as hydrogen bond acceptors with the grafted polymer and facilitating the side-by-side assembly of the chain structures.These two forces were observed to compete with each other during the assembly process,and could be precisely controlled by adjusting the quantities of acetic acid and polyethylene glycol,thus regulating the nanoparticle assembly behavior.This work provides a practical framework for the design of muti-force interactions in hierarchical colloid nanomaterials.
文摘Taking stearic acid as the raw material,N-(2-(dimethylamino)ethyl)stearamide(C18N2N)was synthesized.A new surfactant was prepared by mixing C18N2N and cinnamic acid(TA)with fixed ratio.This surfactant was formed by noncovalent electrostatic interactions,which avoided complicated synthetic procedures.The surface activity and rheological properties of the surfactant were investigated with a surface tensiometer and a rheometer.The critical micelle concentration(cmc)and the surface tension at cmc(γ_(cmc))of the surfactant were 0.11 mmol/L and 32.4 mN/m,indicative of strong aggregation and adsorption ability.The maximum amount adsorbed(Γ_(max))and the minimum molecular area occupied(A_(min))were 2.77μmol/m^(2)and 0.6 nm^(2).Wormlike micelles were formed at the concentration of 25 mmol/L.When the concentration was over 100 mmol/L,the zero-shear viscosity(η_(0))abruptly increased and then reached the maximum value for the surfactant of C18N2N/TA containing 150 mmol/L TA.The solution viscosity was as high as 1761.38 Pa·s.The effects of temperature on the rheological behavior were also considered.With the increase of temperature,the viscosity gradually increased.And when the temperature reached 40℃,η_(0)of the solution with the concentration of 100 mmol/L achieved the maximum value of 1370.386 Pa·s.When the temperature continued to rise,η_(0)began to decrease with further increasing temperature.A remarkable viscosity of 305.55 Pa·s was still remained at 50℃.The viscoelastic solutions showed good temperature resistance and shear resistance.The surfactant solutions applied as the fracturing fluid were also investigated.This surfactant also showed excellent sand-carrying performance,and the settling rate of the sand was merely 0.26 cm/min.This surfactant could be simply prepared and showed excellent performance,which expanded the preparation and application field of novel surfactants.
基金supported by National Natural Science Foundation of China(22309029,52404316)Guangdong Basic and Applied Basic Research Foundation(Nos.2024A1515140011,and 2024A1515110010)+2 种基金Dongguan Social Development Technology Foundation(Nos.20231800907933,and 20221800905122)Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14)Start-up Research Foundation of Hainan University(No.KYQD(ZR)-23069).
文摘The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aqueous binder for iodine-loading cathode to enable stable and efficient Zn-I_(2) batteries.The positively charged region in gelatin presents electrostatic attraction to the iodine species,while the electron-rich regions could donate electrons to form physical or even covalent bonds with iodine species,thus inhibiting polyiodides shuttle effect and boosting redox reaction.A high reversible capacity of 138 mAh g^(-1) after 3000 cycles at 2C and an ultra-long cycling stability of 30000 cycles at 25C with 107 mAh g^(-1) capacity was achieved.Gelatin binder also can accommodate high iodine-loading(~10 mg)cathode,punch cells,and severe temperature conditions(-10℃ and 60℃).In-situ UV-vis absorption spectroscopy,in-situ Raman spectra and theoretical calculation revealed the critical role of gelatin binder in suppressing polyiodide shuttling and accelerating reaction kinetics.This work uncovers the potential of natural low-cost binder material in advanced Zn-I_(2) batteries and drives future study of designing functional binders.
基金supported by the National Natural Science Foundation of China(22275038)partially funded by the Swedish Research Council(2022-06725)+1 种基金the support from the Swedish Research Council(2020-04600)funded by the European Union(ERC,LUMOR,101077649)the support from the Swedish Science Research Council(2022-03405)。
文摘Organelle-targeted imaging can provide information on cellular functions and intracellular interactions,being significant for disease diagnosis.The use of room-temperature phosphorescence(RTP)in organelle-targeted imaging can fully utilize its unique characteristics of long wavelength and deep penetration.However,this technology has long been plagued by insufficient probe targeting and limited luminous intensity.In this work,we prepared a series of complexes composed of multicationic persulfurated arenes and biomacromolecules via electrostatic interactions in 1:1 stoichiometry for high-contrast mitochondrial-targeted RTP imaging.Such an electrostatic interaction design effectively prevented the self-aggregation of the probes,which is not conducive to mitochondrial targeting.Simultaneously,it suppressed the non-radiative decay to the maximum extent,enabling the probes to exhibit strong RTP signals both in aqueous solution and at the cellular level.Furthermore,the biomacromolecules can serve as carriers for an electrostatic interaction transfer of the persulfurated arenes to mitochondria.This leads to high mitochondrial targeting Pearson's correlation coefficients of the probes and high-contrast RTP imaging effects,as well as the independence of the co-incubated probe concentration.These results provide new insights for the development of targeted imaging technologies.
文摘The insulin-degrading enzyme(IDE)plays a significant role in the degradation of the amyloid beta(Aβ),a peptide found in the brain regions of the patients with early Alzheimer’s disease.Adenosine triphosphate(ATP)allosterically regulates the Aβ-degrading activity of IDE.The present study investigates the electrostatic interactions between ATP-IDE at the allosteric site of IDE,including thermostabilities/flexibilities of IDE residues,which have not yet been explored systematically.This study applies the quantum mechanics/molecular mechanics(QM/MM)to the proposed computational model for exploring electrostatic interactions between ATP and IDE.Molecular dynamic(MD)simulations are performed at different temperatures for identifying flexible and thermostable residues of IDE.The proposed computational model predicts QM/MM energy-minimised structures providing the IDE residues(Lys530 and Asp385)with high binding affinities.Considering root mean square fluctuation values during the MD simulations at 300.00 K including heat-shock temperatures(321.15 K and 315.15 K)indicates that Lys530 and Asp385 are also the thermostable residues of IDE,whereas Ser576 and Lys858 have high flexibilities with compromised thermostabilities.The present study sheds light on the phenomenon of biological recognition and interactions at the ATP-binding domain,which may have important implications for pharmacological drug design.The proposed computational model may facilitate the development of allosteric IDE activators/inhibitors,which mimic ATP interactions.
文摘Nuclear magnetic resonance(NMR)serves as a powerful tool for studying both the structure and dynamics of proteins.The NOE method,alongside residual dipolar;coupling,paramagnetic effects,J-coupling,and other related techniques,has reached a level of maturity that allows for the determination of protein structures.Furthermore,NMR relaxation methods prove to be highly effective in characterizing protein dynamics across various timescales.The properties of protein systems are dictated by intra-and intermo-lecular interactions among atoms,which involve covalent bonds,hydrogen bonds(H-bonds),electrostatic interactions,and van der Waals forces.Multiple NMR approaches have been developed to measure noncovalent interactions,and this paper offers a concise overview of noncovalent interaction measurements using NMR,with a specific emphasis on the advancements accomplished in our laboratory.
