Despite the individual merits of photodynamic or photothermal therapy(PTT)for clinical cancer treatment,the inherent shortcomings of single-modal therapy significantly hinder therapeutic outcomes in tumors.Therefore,i...Despite the individual merits of photodynamic or photothermal therapy(PTT)for clinical cancer treatment,the inherent shortcomings of single-modal therapy significantly hinder therapeutic outcomes in tumors.Therefore,integrating multimodal therapeutic functions into a smart dye can address the drawbacks of single-modal therapy,albeit with significant challenges.By employing an electron-acceptor engineering strategy to regulate the excitation dynamics processes of dyes,we designed a series of near-infrared(NIR)dyes(Hcy-OO,Hcy-ON,and Hcy-NN).Among these dyes,Hcy-ON demonstrated the best photodynamic/mild-photothermal performances by optimizing the energy release pathway of the excited state of dyes,which is attributed to the synergistic effects of the lowest difference in gap between S1 and T_(1) energy levels of 0.678 eV,a large spin-orbit coupling matrix element value of 0.725 cm^(−1),a high root mean squared displacement value of 1.662Å,and a Huang-Rhys factor of>70.Importantly,upon irradiation at 760 nm,through mild-photothermal therapy(MPTT)in synergy with the photodynamic therapy,Hcy-ON successfully ablated tumors in the mouse model with a single treatment under a safe light dose of 300 mW/cm_(2).Overall,we hope that this work will provide practical guidance to enhance the phototherapeutic performance of NIR dyes for clinical multimodal treatment of tumors.展开更多
基金supported by the National Key Research and Development Program of China(grant no.2023YFB3810300)the National Natural Science Foundation of China(grant nos.22078050,22278061,22378050,22378051,and 22090011)+4 种基金the Science and Technology Plan Project of Liaoning Province(grant no.2023JH2/101700296)the Fundamental Research Funds for the Central Universities(grant nos.DUT24ZD117 and DUT24LAB105)the Open Research Fund from the State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University(grant no.20240604)the Nano&Material Technology Development Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(grant no.RS-2024-00407093)the NRF for the grant funded by the Korean government(MSIT)(grant no.2022R1A2C3005420).
文摘Despite the individual merits of photodynamic or photothermal therapy(PTT)for clinical cancer treatment,the inherent shortcomings of single-modal therapy significantly hinder therapeutic outcomes in tumors.Therefore,integrating multimodal therapeutic functions into a smart dye can address the drawbacks of single-modal therapy,albeit with significant challenges.By employing an electron-acceptor engineering strategy to regulate the excitation dynamics processes of dyes,we designed a series of near-infrared(NIR)dyes(Hcy-OO,Hcy-ON,and Hcy-NN).Among these dyes,Hcy-ON demonstrated the best photodynamic/mild-photothermal performances by optimizing the energy release pathway of the excited state of dyes,which is attributed to the synergistic effects of the lowest difference in gap between S1 and T_(1) energy levels of 0.678 eV,a large spin-orbit coupling matrix element value of 0.725 cm^(−1),a high root mean squared displacement value of 1.662Å,and a Huang-Rhys factor of>70.Importantly,upon irradiation at 760 nm,through mild-photothermal therapy(MPTT)in synergy with the photodynamic therapy,Hcy-ON successfully ablated tumors in the mouse model with a single treatment under a safe light dose of 300 mW/cm_(2).Overall,we hope that this work will provide practical guidance to enhance the phototherapeutic performance of NIR dyes for clinical multimodal treatment of tumors.
