Super-fine electrohydrodynamic inkjet(SIJ)printing of perovskite nanocrystal(PNC)colloid ink exhibits significant potential in the fabrication of high-resolution color conversion microstructures arrays for fullcolor m...Super-fine electrohydrodynamic inkjet(SIJ)printing of perovskite nanocrystal(PNC)colloid ink exhibits significant potential in the fabrication of high-resolution color conversion microstructures arrays for fullcolor micro-LED displays.However,the impact of solvent on both the printing process and the morphology of SIJ-printed PNC color conversion microstructures remains underexplored.In this study,we prepared samples of CsPbBr3PNC colloid inks in various solvents and investigated the solvent's impact on SIJ printed PNC microstructures.Our findings reveal that the boiling point of the solvent is crucial to the SIJ printing process of PNC colloid inks.Only does the boiling point of the solvent fall in the optimal range,the regular positioned,micron-scaled,conical PNC microstructures can be successfully printed.Below this optimal range,the ink is unable to be ejected from the nozzle;while above this range,irregular positioned microstructures with nanoscale height and coffee-ring-like morphology are produced.Based on these observations,high-resolution color conversion PNC microstructures were effectively prepared using SIJ printing of PNC colloid ink dispersed in dimethylbenzene solvent.展开更多
Electrohydrodynamic(EHD)jet printing represents a novel micro/nano-scale additive manufacturing process that utilises a high-voltage induced electric field between the nozzle and the substrate to print micro/nanoscale...Electrohydrodynamic(EHD)jet printing represents a novel micro/nano-scale additive manufacturing process that utilises a high-voltage induced electric field between the nozzle and the substrate to print micro/nanoscale structures.EHD printing is particularly advantageous for the fabrication on flexible or non-flat substrates and of large aspect ratio micro/nanostructures and composite multi-material structures.Despite this,EHD printing has yet to be fully industrialised due to its low throughput,which is primarily caused by the limitations of serial additive printing technology.The parallel multi-nozzle array-based process has become the most promising option for EHD printing to achieve large-scale printing by increasing the number of nozzles to realise multichannel parallel printing.This paper reviews the recent development of multi-nozzle EHD printing technology,analyses jet motion with multi-nozzle,explains the origins of the electric field crosstalk effect under multi-nozzle and discusses several widely used methods for overcoming it.This work also summarises the impact of different process parameters on multi-nozzle EHD printing and describes the current manufacturing process using multi-nozzle as well as the method by which they can be realised independently.In addition,it presents an additional significant utilisation of multi-nozzle printing aside from enhancing single-nozzle production efficiency,which is the production of composite phase change materials through multi-nozzle.Finally,the future direction of multi-nozzle EHD printing development is discussed and envisioned.展开更多
The electrospray thruster supplied by ionic liquid is a promising micro-propulsion thruster with small size and precise thrust, which can emit both cations and anions to achieve self-neutralization. In order to furthe...The electrospray thruster supplied by ionic liquid is a promising micro-propulsion thruster with small size and precise thrust, which can emit both cations and anions to achieve self-neutralization. In order to further investigate the effect of ion solvation energy on the evaporation of cations and anions from ionic liquid under the action of a uniform electric field, this paper establishes a transient Electrohydrodynamic (EHD) model for free ionic liquid droplets undergoing ion evaporation. The dynamic processes of droplet deformation and ion evaporation are simulated. And the study further focuses on the influence of different ion solvation energies for cations on the droplet morphology and the ion evaporation characteristics at the positively charged end and negatively charged end of the droplet. The results indicate that, when the ion solvation energy for cations is higher than that of anions, it will cause the ion evaporation at the positively charged end of the droplet to lag behind the ion evaporation at the negatively charged end. And the higher the ion solvation energy for the cations, the longer the evaporation lag time at the positively charged end of the droplet, which will lead to a higher peak of surface charge density that can be reached, resulting in a larger evaporation current and sharper droplet stretching deformation. Additionally, the peak surface charge density of the positively charged end of the droplet is linearly related to the ion solvation energy for cations, while the peak surface charge density of the negatively charged end remains almost unchanged and is not significantly affected by the ion solvation energy for cations.展开更多
The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities o...The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities of the reconstructed enthesis tissues.Herein,a tri-layered core–shell microfibrous scaffold with layer-specific growth factors(GFs)release is developed using coaxial electrohydrodynamic(EHD)printing for in situ cell recruitment and differentiation to facilitate gradient enthesis tissue repair.Stromal cell-derived factor-1(SDF-1)is loaded in the shell,while basic fibroblast GF,transforming GF-beta,and bone morphogenetic protein-2 are loaded in the core of the EHD-printed microfibrous scaffolds in a layer-specific manner.Correspondingly,the tri-layered microfibrous scaffolds have a core–shell fiber size of(25.7±5.1)μm,with a pore size sequentially increasing from(81.5±4.6)μm to(173.3±6.9)μm,and to(388.9±6.9μm)for the tenogenic,chondrogenic,and osteogenic instructive layers.A rapid release of embedded GFs is observed within the first 2 d,followed by a faster release of SDF-1 and a slightly slower release of differentiation GFs for approximately four weeks.The coaxial EHD-printed microfibrous scaffolds significantly promote stem cell recruitment and direct their differentiation toward tenocyte,chondrocyte,and osteocyte phenotypes in vitro.When implanted in vivo,the tri-layered core–shell microfibrous scaffolds rapidly restored the biomechanical functions and promoted enthesis tissue regeneration with native-like bone-to-tendon gradients.Our findings suggest that the microfibrous scaffolds with layer-specific GFs release may offer a promising clinical solution for enthesis regeneration.展开更多
Piezoceramic is ubiquitously used in high-performance sensors and actuators.Three-dimensional(3D)printing of lead zirconate titanate(PZT)is attractive and highly desired for such device applications,but most of the ex...Piezoceramic is ubiquitously used in high-performance sensors and actuators.Three-dimensional(3D)printing of lead zirconate titanate(PZT)is attractive and highly desired for such device applications,but most of the existing methods are inherently limited to micron resolution,which makes them untenable for fabricating complex 3D architectures with high-definition features.Here,an electrohydrodynamic jet(E-Jet)nanoprinting strategy has been proposed to fabricate PZT 3D structures with the characteristics of flexibility and scalability.Different kinds of 3D PZT true nanostructures(resolution∼40 nm,aspect ratio∼400)were directly fabricated using a 100μm-sized nozzle.And the PZT nanostructures exhibited well-developed perovskite crystal morphology,large elastic strain(elongation≈13%),and high piezoelectric property(d_(31)≈(236.5×10^(−12))C·N^(-1)).A bionic PZT air-flow sensor was printed to monitor air-flow detection,demonstrating well sensitivity with ultra-slow air-flow of 0.02 m·s^(-1).The discovery reveals an efficient pathway to 3D-printing PZT nanostructures for next-generation high-performance piezoelectric devices.展开更多
Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resol...Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based printing.Recently,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell spreading.This study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell spreading.The printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous environment.By utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.展开更多
基金supported by the National Natural Science Foundation of China(No.62374142)Fundamental Research Funds for the Central Universities(Nos.20720220085 and 20720240064)+2 种基金External Cooperation Program of Fujian(No.2022I0004)Major Science and Technology Project of Xiamen in China(No.3502Z20191015)Xiamen Natural Science Foundation Youth Project(No.3502Z202471002)。
文摘Super-fine electrohydrodynamic inkjet(SIJ)printing of perovskite nanocrystal(PNC)colloid ink exhibits significant potential in the fabrication of high-resolution color conversion microstructures arrays for fullcolor micro-LED displays.However,the impact of solvent on both the printing process and the morphology of SIJ-printed PNC color conversion microstructures remains underexplored.In this study,we prepared samples of CsPbBr3PNC colloid inks in various solvents and investigated the solvent's impact on SIJ printed PNC microstructures.Our findings reveal that the boiling point of the solvent is crucial to the SIJ printing process of PNC colloid inks.Only does the boiling point of the solvent fall in the optimal range,the regular positioned,micron-scaled,conical PNC microstructures can be successfully printed.Below this optimal range,the ink is unable to be ejected from the nozzle;while above this range,irregular positioned microstructures with nanoscale height and coffee-ring-like morphology are produced.Based on these observations,high-resolution color conversion PNC microstructures were effectively prepared using SIJ printing of PNC colloid ink dispersed in dimethylbenzene solvent.
基金National Natural Science Foundation of China(Grant Nos.52275345,52175331)the Support plan for Outstanding Youth Innovation Team in Universities of Shandong Province,China(2021KJ044)Natural Science Foundation of Shandong Province,China(Granted No.ZR2020ZD04)。
文摘Electrohydrodynamic(EHD)jet printing represents a novel micro/nano-scale additive manufacturing process that utilises a high-voltage induced electric field between the nozzle and the substrate to print micro/nanoscale structures.EHD printing is particularly advantageous for the fabrication on flexible or non-flat substrates and of large aspect ratio micro/nanostructures and composite multi-material structures.Despite this,EHD printing has yet to be fully industrialised due to its low throughput,which is primarily caused by the limitations of serial additive printing technology.The parallel multi-nozzle array-based process has become the most promising option for EHD printing to achieve large-scale printing by increasing the number of nozzles to realise multichannel parallel printing.This paper reviews the recent development of multi-nozzle EHD printing technology,analyses jet motion with multi-nozzle,explains the origins of the electric field crosstalk effect under multi-nozzle and discusses several widely used methods for overcoming it.This work also summarises the impact of different process parameters on multi-nozzle EHD printing and describes the current manufacturing process using multi-nozzle as well as the method by which they can be realised independently.In addition,it presents an additional significant utilisation of multi-nozzle printing aside from enhancing single-nozzle production efficiency,which is the production of composite phase change materials through multi-nozzle.Finally,the future direction of multi-nozzle EHD printing development is discussed and envisioned.
基金supported by the National Key R&D Program of China(No.2020YFC2201100)the National Natural Science Foundation of China(Nos.12175032,12102082,12275044,12402327,12405290 and 12211530449)+4 种基金the Joint Program of the Science and Technology Program of Liaoning,China(No.2023JH2/101700285)the Fundamental Research Funds for the Central Universities of China(Nos.DUT22RC(3)078,DUT23RC(3)040 and DUT24ZD106)the S&T Program of Hebei,China(No.246Z2301G)the S&T Innovation Program of Hebei,China(Nos.SJMYF2022X18 and SJMYF2022X06)the Beijing Engineering Research Center of Efficient and Green Aerospace Propulsion Technology and Advanced Space Propulsion Laboratory of BICE,China(No.LabASP-2023-07).
文摘The electrospray thruster supplied by ionic liquid is a promising micro-propulsion thruster with small size and precise thrust, which can emit both cations and anions to achieve self-neutralization. In order to further investigate the effect of ion solvation energy on the evaporation of cations and anions from ionic liquid under the action of a uniform electric field, this paper establishes a transient Electrohydrodynamic (EHD) model for free ionic liquid droplets undergoing ion evaporation. The dynamic processes of droplet deformation and ion evaporation are simulated. And the study further focuses on the influence of different ion solvation energies for cations on the droplet morphology and the ion evaporation characteristics at the positively charged end and negatively charged end of the droplet. The results indicate that, when the ion solvation energy for cations is higher than that of anions, it will cause the ion evaporation at the positively charged end of the droplet to lag behind the ion evaporation at the negatively charged end. And the higher the ion solvation energy for the cations, the longer the evaporation lag time at the positively charged end of the droplet, which will lead to a higher peak of surface charge density that can be reached, resulting in a larger evaporation current and sharper droplet stretching deformation. Additionally, the peak surface charge density of the positively charged end of the droplet is linearly related to the ion solvation energy for cations, while the peak surface charge density of the negatively charged end remains almost unchanged and is not significantly affected by the ion solvation energy for cations.
基金financially supported by the National Key Research and Development Program of China(2018YFA0703003)National Natural Science Foundation of China(82072429,52125501,82371590)+6 种基金the Program for Innovation Team of Shaanxi Province(2023-CX-TD-17)the Key Research&Development Program of Shaanxi Province(2024SF-YBXM-355,2020SF-093,2021LLRH-08)the Natural Science Foundation of Henan Province(222300420358)the Postdoctoral Project of Shaanxi Province(2023BSHYDZZ30)the Postdoctoral Fellowship Program of CPSF(GZB20230573)the Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University(2019ZYTS-02)the Fundamental Research Funds for the Central Universities.
文摘The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities of the reconstructed enthesis tissues.Herein,a tri-layered core–shell microfibrous scaffold with layer-specific growth factors(GFs)release is developed using coaxial electrohydrodynamic(EHD)printing for in situ cell recruitment and differentiation to facilitate gradient enthesis tissue repair.Stromal cell-derived factor-1(SDF-1)is loaded in the shell,while basic fibroblast GF,transforming GF-beta,and bone morphogenetic protein-2 are loaded in the core of the EHD-printed microfibrous scaffolds in a layer-specific manner.Correspondingly,the tri-layered microfibrous scaffolds have a core–shell fiber size of(25.7±5.1)μm,with a pore size sequentially increasing from(81.5±4.6)μm to(173.3±6.9)μm,and to(388.9±6.9μm)for the tenogenic,chondrogenic,and osteogenic instructive layers.A rapid release of embedded GFs is observed within the first 2 d,followed by a faster release of SDF-1 and a slightly slower release of differentiation GFs for approximately four weeks.The coaxial EHD-printed microfibrous scaffolds significantly promote stem cell recruitment and direct their differentiation toward tenocyte,chondrocyte,and osteocyte phenotypes in vitro.When implanted in vivo,the tri-layered core–shell microfibrous scaffolds rapidly restored the biomechanical functions and promoted enthesis tissue regeneration with native-like bone-to-tendon gradients.Our findings suggest that the microfibrous scaffolds with layer-specific GFs release may offer a promising clinical solution for enthesis regeneration.
基金supported by National Natural Science Foundation of China(Grant No.52105577)Natural Science Foundation of Zhejiang Province(Grant No.LQ22E050001)+3 种基金Natural Science Foundation of Ningbo(Grant Nos.2024J427 and 2023J376)China Postdoctoral Science Foundation(Grant No.2024M753510)Ningbo Yongjiang Talent Introduction Programme(Grant No.2021A-137-G)Research Grants Council of the Hong Kong Special Administrative Region,China(Grant Nos.11200623 and RFS2021-1S05).
文摘Piezoceramic is ubiquitously used in high-performance sensors and actuators.Three-dimensional(3D)printing of lead zirconate titanate(PZT)is attractive and highly desired for such device applications,but most of the existing methods are inherently limited to micron resolution,which makes them untenable for fabricating complex 3D architectures with high-definition features.Here,an electrohydrodynamic jet(E-Jet)nanoprinting strategy has been proposed to fabricate PZT 3D structures with the characteristics of flexibility and scalability.Different kinds of 3D PZT true nanostructures(resolution∼40 nm,aspect ratio∼400)were directly fabricated using a 100μm-sized nozzle.And the PZT nanostructures exhibited well-developed perovskite crystal morphology,large elastic strain(elongation≈13%),and high piezoelectric property(d_(31)≈(236.5×10^(−12))C·N^(-1)).A bionic PZT air-flow sensor was printed to monitor air-flow detection,demonstrating well sensitivity with ultra-slow air-flow of 0.02 m·s^(-1).The discovery reveals an efficient pathway to 3D-printing PZT nanostructures for next-generation high-performance piezoelectric devices.
基金This work was financially supported by the National Key Research and Development Program of China(No.2018YFA0703003)the National Natural Science Foundation of China(No.52125501)+1 种基金the Key Research Project of Shaanxi Province(Nos.2021LLRH-08,2020GXLH-Y-021,and 2021GXLH-Z-028)the Youth InnovationTeam of Shaanxi Universities and the Fundamental Research Funds for the Central Universities.
文摘Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based printing.Recently,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell spreading.This study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell spreading.The printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous environment.By utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.
