Hydrogen sulfide （H2S） is the third gaseous signaling molecule discovered in recent years, and plays an important physiological role in the cardivascular system. To explore the effects of different doses of exogenou...Hydrogen sulfide （H2S） is the third gaseous signaling molecule discovered in recent years, and plays an important physiological role in the cardivascular system. To explore the effects of different doses of exogenous H2S on the electrocardiogram （ECG） of rats generally anesthetized by zoletil, different doses of NariS solution were used for the intervention of intraperitoneal injection 20 rain before the zoletil anesthesia. The ECGs of rats from each treatment group during the time range of 10^th-50^th min were determined under general anesthesia, and then were compared with those from the control group. The results showed that exogenous H2S could significantly reduce the Q-T interval time limit, thus played a role in slowing tachycardia or arrhythmia and other anomalies, thereby protecting the heart. S-T segment and T segment evaluation values were significantly reduced, which might be associated with bradycardia.展开更多
Left anterior fascicular block（LAFB） is a heart disease identifiable from an abnormal electrocardiogram（ECG）. It has been reported that LAFB is associated with an increased risk of heart failure. Non-specific intr...Left anterior fascicular block（LAFB） is a heart disease identifiable from an abnormal electrocardiogram（ECG）. It has been reported that LAFB is associated with an increased risk of heart failure. Non-specific intraventricular conduction delay due to the lesions of the conduction bundles and slow cell to cell conduction has also been considered as another cause of heart failure. Since the location and mechanism of conduction delay have notable variability between individual patients, we hypothesized that the impaired conduction in the ventricular myocardium may lead to abnormal ECGs similar to LAFB ECG patterns. To test this hypothesis, based on a computer model with a three dimensional whole-heart anatomical structure, we simulated the cardiac exciting sequence map and 12-lead ECG caused by the block in the left anterior fascicle and by the slowed conduction velocity in the ventricular myocardium. The simulation results showed that the typical LAFB ECG patterns can also be observed from cases with slowed conduction velocity in the ventricular myocardium. The main differences were the duration of QRS and wave amplitude. In conclusion, our simulations provide a promising starting point to further investigate the underlying mechanism of heart failure with LAFB, which would provide a potential reference for LAFB diagnosis.展开更多
Electrocardiogram(ECG)is a low-cost,simple,fast,and non-invasive test.It can reflect the heart’s electrical activity and provide valuable diagnostic clues about the health of the entire body.Therefore,ECG has been wi...Electrocardiogram(ECG)is a low-cost,simple,fast,and non-invasive test.It can reflect the heart’s electrical activity and provide valuable diagnostic clues about the health of the entire body.Therefore,ECG has been widely used in various biomedical applications such as arrhythmia detection,disease-specific detection,mortality prediction,and biometric recognition.In recent years,ECG-related studies have been carried out using a variety of publicly available datasets,with many differences in the datasets used,data preprocessing methods,targeted challenges,and modeling and analysis techniques.Here we systematically summarize and analyze the ECGbased automatic analysis methods and applications.Specifically,we first reviewed 22 commonly used ECG public datasets and provided an overview of data preprocessing processes.Then we described some of the most widely used applications of ECG signals and analyzed the advanced methods involved in these applications.Finally,we elucidated some of the challenges in ECG analysis and provided suggestions for further research.展开更多
A new model based on dyadic differential wavelet was developed for detecting the R peak in Holter ECG signal according to the design of data mining. The Mallat recursive filter algorithm was introduced to calculate wa...A new model based on dyadic differential wavelet was developed for detecting the R peak in Holter ECG signal according to the design of data mining. The Mallat recursive filter algorithm was introduced to calculate wavelet and optimize the detection algorithm which is based on the equivalent filter technique. The detection algorithm has been verified by MIT arrhythmia database with a high efficiency of 99%. After optimization, the algorithm was put into clinical experiment and tested in the Air Force Hospital in Tianjin for about two months. After about 108 hearts beating test of more than 100 patients, the total efficient detection rate has reached 97%. Now this algorithm module has been applied in business software and shows perfect performance under the complex conditions such as the inversion of heart beating, the falling off of the electrodes, the excursion of base line and so on.展开更多
-An efficient ECG (Electrocardiogram) data compression algorithm called KPDEC (key point detection and error compensation) is presented in this pa-Per. With tkis KPDEC method only the key points (KPs) of ECG signals a...-An efficient ECG (Electrocardiogram) data compression algorithm called KPDEC (key point detection and error compensation) is presented in this pa-Per. With tkis KPDEC method only the key points (KPs) of ECG signals are con-sidered to be saved to make the compression more efficient. These KPs can be ex-tracted from ECG samples by calculating the second-ordered central difrerences.Then an error pre-correcting technique is used to let the saved sample having a rea-sonable compensation berore it is stored. This technique is able to reduce the PRD (Percentage Root Mean Square Difference) obviously. In the paper we describe an optimal cording sckeme for getting higer compression rate. Furthermore, an adap-tive filtering tecknique is designed for reconstructed ECG signals to get better fi-delity waves. The algorithm is able to compress ECG data to 168 bits per second with PRD less than 3%.展开更多
Computer analysis of electrocardiograms(ECGs)was introduced more than 50 years ago,with the aim to improve efficiency and clinical workflow.[1,2]However,inaccuracies have been documented in the literature.[3,4]Researc...Computer analysis of electrocardiograms(ECGs)was introduced more than 50 years ago,with the aim to improve efficiency and clinical workflow.[1,2]However,inaccuracies have been documented in the literature.[3,4]Research indicates that emergency department(ED)clinician interruptions occur every 4-10 min,which is significantly more common than in other specialties.[5]This increases the cognitive load and error rates and impacts patient care and clinical effi ciency.[1,2,5]De-prioritization protocols have been introduced in certain centers in the United Kingdom(UK),removing the need for clinician ECG interpretation where ECGs have been interpreted as normal by the machine.展开更多
Background:The accurate identification of cardiac abnormalities is essential for proper diagnosis and effective treatment of cardiovascular diseases.Method:This work introduces an advanced methodology for detecting ca...Background:The accurate identification of cardiac abnormalities is essential for proper diagnosis and effective treatment of cardiovascular diseases.Method:This work introduces an advanced methodology for detecting cardiac abnormalities and estimating electrocardiographic age(ECG Age)using sophisticated signal processing and deep learning techniques.This study looks at six main heart conditions found in 12-lead electrocardiogram(ECG)data.It addresses important issues like class imbalances,missing lead scenarios,and model generalizations.A modified residual neural network(ResNet)architecture was developed to enhance the detection of cardiac abnormalities.Results:The proposed ResNet demonst rated superior performance when compared with two linear models and an alternative ResNet architectures,achieving an overall classification accuracy of 91.25%and an F1 score of 93.9%,surpassing baseline models.A comprehensive lead loss analysis was conducted,evaluating model performance across 4096 combinations of missing leads.The results revealed that pulse rate-based factors remained robust with up to 75%lead loss,while block-based factors experienced significant performance declines beyond the loss of four leads.Conclusion:This analysis highlighted the importance of addressing lead loss impacts to maintain a robust model.To optimize performance,targeted training approaches were developed for different conditions.Based on these insights,a grouping strategy was implemented to train specialized models for pulse rate-based and block-based conditions.This approach resulted in notable improvements,achieving an overall classification accuracy of 95.12%and an F1 score of 95.79%.展开更多
Cardiovascular diseases are the world’s leading cause of death;therefore cardiac health of the human heart has been a fascinating topic for decades.The electrocardiogram(ECG)signal is a comprehensive non-invasive met...Cardiovascular diseases are the world’s leading cause of death;therefore cardiac health of the human heart has been a fascinating topic for decades.The electrocardiogram(ECG)signal is a comprehensive non-invasive method for determining cardiac health.Various health practitioners use the ECG signal to ascertain critical information about the human heart.In this article,swarm intelligence approaches are used in the biomedical signal processing sector to enhance adaptive hybrid filters and empirical wavelet transforms(EWTs).At first,the white Gaussian noise is added to the input ECG signal and then applied to the EWT.The ECG signals are denoised by the proposed adaptive hybrid filter.The honey badge optimization(HBO)algorithm is utilized to optimize the EWT window function and adaptive hybrid filter weight parameters.The proposed approach is simulated by MATLAB 2018a using the MIT-BIH dataset with white Gaussian,electromyogram and electrode motion artifact noises.A comparison of the HBO approach with recursive least square-based adaptive filter,multichannel least means square,and discrete wavelet transform methods has been done in order to show the efficiency of the proposed adaptive hybrid filter.The experimental results show that the HBO approach supported by EWT and adaptive hybrid filter can be employed efficiently for cardiovascular signal denoising.展开更多
The integration of IoT and Deep Learning(DL)has significantly advanced real-time health monitoring and predictive maintenance in prognostic and health management(PHM).Electrocardiograms(ECGs)are widely used for cardio...The integration of IoT and Deep Learning(DL)has significantly advanced real-time health monitoring and predictive maintenance in prognostic and health management(PHM).Electrocardiograms(ECGs)are widely used for cardiovascular disease(CVD)diagnosis,but fluctuating signal patterns make classification challenging.Computer-assisted automated diagnostic tools that enhance ECG signal categorization using sophisticated algorithms and machine learning are helping healthcare practitioners manage greater patient populations.With this motivation,the study proposes a DL framework leveraging the PTB-XL ECG dataset to improve CVD diagnosis.Deep Transfer Learning(DTL)techniques extract features,followed by feature fusion to eliminate redundancy and retain the most informative features.Utilizing the African Vulture Optimization Algorithm(AVOA)for feature selection is more effective than the standard methods,as it offers an ideal balance between exploration and exploitation that results in an optimal set of features,improving classification performance while reducing redundancy.Various machine learning classifiers,including Support Vector Machine(SVM),eXtreme Gradient Boosting(XGBoost),Adaptive Boosting(AdaBoost),and Extreme Learning Machine(ELM),are used for further classification.Additionally,an ensemble model is developed to further improve accuracy.Experimental results demonstrate that the proposed model achieves the highest accuracy of 96.31%,highlighting its effectiveness in enhancing CVD diagnosis.展开更多
文摘Hydrogen sulfide （H2S） is the third gaseous signaling molecule discovered in recent years, and plays an important physiological role in the cardivascular system. To explore the effects of different doses of exogenous H2S on the electrocardiogram （ECG） of rats generally anesthetized by zoletil, different doses of NariS solution were used for the intervention of intraperitoneal injection 20 rain before the zoletil anesthesia. The ECGs of rats from each treatment group during the time range of 10^th-50^th min were determined under general anesthesia, and then were compared with those from the control group. The results showed that exogenous H2S could significantly reduce the Q-T interval time limit, thus played a role in slowing tachycardia or arrhythmia and other anomalies, thereby protecting the heart. S-T segment and T segment evaluation values were significantly reduced, which might be associated with bradycardia.
基金Project supported by the National Natural Science Foundation of China(Nos.61527811 and 61701435)
文摘Left anterior fascicular block（LAFB） is a heart disease identifiable from an abnormal electrocardiogram（ECG）. It has been reported that LAFB is associated with an increased risk of heart failure. Non-specific intraventricular conduction delay due to the lesions of the conduction bundles and slow cell to cell conduction has also been considered as another cause of heart failure. Since the location and mechanism of conduction delay have notable variability between individual patients, we hypothesized that the impaired conduction in the ventricular myocardium may lead to abnormal ECGs similar to LAFB ECG patterns. To test this hypothesis, based on a computer model with a three dimensional whole-heart anatomical structure, we simulated the cardiac exciting sequence map and 12-lead ECG caused by the block in the left anterior fascicle and by the slowed conduction velocity in the ventricular myocardium. The simulation results showed that the typical LAFB ECG patterns can also be observed from cases with slowed conduction velocity in the ventricular myocardium. The main differences were the duration of QRS and wave amplitude. In conclusion, our simulations provide a promising starting point to further investigate the underlying mechanism of heart failure with LAFB, which would provide a potential reference for LAFB diagnosis.
基金Supported by the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(U1909208)the Science and Technology Major Project of Changsha(kh2202004)the Changsha Municipal Natural Science Foundation(kq2202106).
文摘Electrocardiogram(ECG)is a low-cost,simple,fast,and non-invasive test.It can reflect the heart’s electrical activity and provide valuable diagnostic clues about the health of the entire body.Therefore,ECG has been widely used in various biomedical applications such as arrhythmia detection,disease-specific detection,mortality prediction,and biometric recognition.In recent years,ECG-related studies have been carried out using a variety of publicly available datasets,with many differences in the datasets used,data preprocessing methods,targeted challenges,and modeling and analysis techniques.Here we systematically summarize and analyze the ECGbased automatic analysis methods and applications.Specifically,we first reviewed 22 commonly used ECG public datasets and provided an overview of data preprocessing processes.Then we described some of the most widely used applications of ECG signals and analyzed the advanced methods involved in these applications.Finally,we elucidated some of the challenges in ECG analysis and provided suggestions for further research.
文摘A new model based on dyadic differential wavelet was developed for detecting the R peak in Holter ECG signal according to the design of data mining. The Mallat recursive filter algorithm was introduced to calculate wavelet and optimize the detection algorithm which is based on the equivalent filter technique. The detection algorithm has been verified by MIT arrhythmia database with a high efficiency of 99%. After optimization, the algorithm was put into clinical experiment and tested in the Air Force Hospital in Tianjin for about two months. After about 108 hearts beating test of more than 100 patients, the total efficient detection rate has reached 97%. Now this algorithm module has been applied in business software and shows perfect performance under the complex conditions such as the inversion of heart beating, the falling off of the electrodes, the excursion of base line and so on.
文摘-An efficient ECG (Electrocardiogram) data compression algorithm called KPDEC (key point detection and error compensation) is presented in this pa-Per. With tkis KPDEC method only the key points (KPs) of ECG signals are con-sidered to be saved to make the compression more efficient. These KPs can be ex-tracted from ECG samples by calculating the second-ordered central difrerences.Then an error pre-correcting technique is used to let the saved sample having a rea-sonable compensation berore it is stored. This technique is able to reduce the PRD (Percentage Root Mean Square Difference) obviously. In the paper we describe an optimal cording sckeme for getting higer compression rate. Furthermore, an adap-tive filtering tecknique is designed for reconstructed ECG signals to get better fi-delity waves. The algorithm is able to compress ECG data to 168 bits per second with PRD less than 3%.
文摘Computer analysis of electrocardiograms(ECGs)was introduced more than 50 years ago,with the aim to improve efficiency and clinical workflow.[1,2]However,inaccuracies have been documented in the literature.[3,4]Research indicates that emergency department(ED)clinician interruptions occur every 4-10 min,which is significantly more common than in other specialties.[5]This increases the cognitive load and error rates and impacts patient care and clinical effi ciency.[1,2,5]De-prioritization protocols have been introduced in certain centers in the United Kingdom(UK),removing the need for clinician ECG interpretation where ECGs have been interpreted as normal by the machine.
文摘Background:The accurate identification of cardiac abnormalities is essential for proper diagnosis and effective treatment of cardiovascular diseases.Method:This work introduces an advanced methodology for detecting cardiac abnormalities and estimating electrocardiographic age(ECG Age)using sophisticated signal processing and deep learning techniques.This study looks at six main heart conditions found in 12-lead electrocardiogram(ECG)data.It addresses important issues like class imbalances,missing lead scenarios,and model generalizations.A modified residual neural network(ResNet)architecture was developed to enhance the detection of cardiac abnormalities.Results:The proposed ResNet demonst rated superior performance when compared with two linear models and an alternative ResNet architectures,achieving an overall classification accuracy of 91.25%and an F1 score of 93.9%,surpassing baseline models.A comprehensive lead loss analysis was conducted,evaluating model performance across 4096 combinations of missing leads.The results revealed that pulse rate-based factors remained robust with up to 75%lead loss,while block-based factors experienced significant performance declines beyond the loss of four leads.Conclusion:This analysis highlighted the importance of addressing lead loss impacts to maintain a robust model.To optimize performance,targeted training approaches were developed for different conditions.Based on these insights,a grouping strategy was implemented to train specialized models for pulse rate-based and block-based conditions.This approach resulted in notable improvements,achieving an overall classification accuracy of 95.12%and an F1 score of 95.79%.
文摘Cardiovascular diseases are the world’s leading cause of death;therefore cardiac health of the human heart has been a fascinating topic for decades.The electrocardiogram(ECG)signal is a comprehensive non-invasive method for determining cardiac health.Various health practitioners use the ECG signal to ascertain critical information about the human heart.In this article,swarm intelligence approaches are used in the biomedical signal processing sector to enhance adaptive hybrid filters and empirical wavelet transforms(EWTs).At first,the white Gaussian noise is added to the input ECG signal and then applied to the EWT.The ECG signals are denoised by the proposed adaptive hybrid filter.The honey badge optimization(HBO)algorithm is utilized to optimize the EWT window function and adaptive hybrid filter weight parameters.The proposed approach is simulated by MATLAB 2018a using the MIT-BIH dataset with white Gaussian,electromyogram and electrode motion artifact noises.A comparison of the HBO approach with recursive least square-based adaptive filter,multichannel least means square,and discrete wavelet transform methods has been done in order to show the efficiency of the proposed adaptive hybrid filter.The experimental results show that the HBO approach supported by EWT and adaptive hybrid filter can be employed efficiently for cardiovascular signal denoising.
基金funded by Researchers Supporting ProjectNumber(RSPD2025R947),King Saud University,Riyadh,Saudi Arabia.
文摘The integration of IoT and Deep Learning(DL)has significantly advanced real-time health monitoring and predictive maintenance in prognostic and health management(PHM).Electrocardiograms(ECGs)are widely used for cardiovascular disease(CVD)diagnosis,but fluctuating signal patterns make classification challenging.Computer-assisted automated diagnostic tools that enhance ECG signal categorization using sophisticated algorithms and machine learning are helping healthcare practitioners manage greater patient populations.With this motivation,the study proposes a DL framework leveraging the PTB-XL ECG dataset to improve CVD diagnosis.Deep Transfer Learning(DTL)techniques extract features,followed by feature fusion to eliminate redundancy and retain the most informative features.Utilizing the African Vulture Optimization Algorithm(AVOA)for feature selection is more effective than the standard methods,as it offers an ideal balance between exploration and exploitation that results in an optimal set of features,improving classification performance while reducing redundancy.Various machine learning classifiers,including Support Vector Machine(SVM),eXtreme Gradient Boosting(XGBoost),Adaptive Boosting(AdaBoost),and Extreme Learning Machine(ELM),are used for further classification.Additionally,an ensemble model is developed to further improve accuracy.Experimental results demonstrate that the proposed model achieves the highest accuracy of 96.31%,highlighting its effectiveness in enhancing CVD diagnosis.
