Peripheral nerve injury results in sensory and motor dysfunction,which is an enormous economic burden for patients and society.Complete recovery of peripheral nerve function after injury is complicated.Utilizing the e...Peripheral nerve injury results in sensory and motor dysfunction,which is an enormous economic burden for patients and society.Complete recovery of peripheral nerve function after injury is complicated.Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest.Electroactive biomaterials induce an active state of electrical stimulation(ES)at the site of peripheral nerve injury when incorporated into nerve guidance channels.Numerous studies have demonstrated that combining ES with electroactive biomaterials can enhance peripheral nerve repair.This review summarizes the regulation of signal pathways by ES and the functions of various electroactive biomaterials,including metals,carbon-based materials,conductive polymers,and piezoelectric materials.Recent advances and research of ES combined with electroactive biomaterials in peripheral nerve repair are reviewed,which may help to come up with more effective strategies to restore neural function after PNI.展开更多
The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing capability.Endogenous bioelectrical ...The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing capability.Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration.Inspired by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone regeneration.With ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue.In this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue.Next,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering.Finally,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.展开更多
Electrical stimulation could effectively promote the repair of peripheral nerve injuries.However,traditional electrical stimulation requires external devices and connections,inevitably causing unnecessary discomfort a...Electrical stimulation could effectively promote the repair of peripheral nerve injuries.However,traditional electrical stimulation requires external devices and connections,inevitably causing unnecessary discomfort and infection risks for patients.Thus,to ensure clinical safety and support neural regeneration,a dual-functional cellulose-based peripheral nerve conduit with both piezoelectric and conductive properties is developed by incorporating barium titanate(BTO)and poly(3,4-ethylenedioxythiophene)(PEDOT)onto the surface of expanded bacterial cellulose.The electroactive conduit not only provides suitable mechanical support and stability to ensure structural integrity in vivo,but also encourages macrophage polarization into the anti-inflammatory M2 phenotype after 2 weeks of post-implantation.Furthermore,the piezoelectric properties provided by BTO convert mechanical energy into electrical energy,which,in synergy with the conductive PEDOT,enables the conduit to stimulate nerve regeneration by mimicking bioelectric signals with an output voltage of 8.22 mV and output current of 2.05μA at compression distances of 1.0 mm.After implantation into a sciatic nerve defect model,this conduit significantly reduces atrophy of the gastrocnemius muscle and accelerates the regeneration of sciatic nerve by facilitating the transmission of neural electrical signals.In summary,this artificial peripheral nerve conduit possesses excellent repair capacity for nerve defects,hence holding attractive prospects for clinical application.展开更多
基金supported by Science and Technology Commission of Shanghai Municipality,China(20DZ2254900)National Key Research and Development Program of China(2021FYC2400800)+4 种基金Sino German Science Foundation Research Exchange Center,China(M-0263)China Education Association for International Exchange(2022181)the Fundamental Research Funds for the Central Universities(24D311703)Project supported by the Songjiang District Committee of Science and Technology,Shanghai,China(Grant No.2023SJKWGG040)the Deputyship for Research and Innovation,"Ministry of Education"in Saudi Arabia for funding this research(IFKSU-HCRA-5-1).
文摘Peripheral nerve injury results in sensory and motor dysfunction,which is an enormous economic burden for patients and society.Complete recovery of peripheral nerve function after injury is complicated.Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest.Electroactive biomaterials induce an active state of electrical stimulation(ES)at the site of peripheral nerve injury when incorporated into nerve guidance channels.Numerous studies have demonstrated that combining ES with electroactive biomaterials can enhance peripheral nerve repair.This review summarizes the regulation of signal pathways by ES and the functions of various electroactive biomaterials,including metals,carbon-based materials,conductive polymers,and piezoelectric materials.Recent advances and research of ES combined with electroactive biomaterials in peripheral nerve repair are reviewed,which may help to come up with more effective strategies to restore neural function after PNI.
基金support of the National Natural Science Foundation of China(Grant No.52205593)Shaanxi Natural Science Foundation Project(2024JC-YBMS-711).
文摘The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing capability.Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration.Inspired by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone regeneration.With ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue.In this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue.Next,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering.Finally,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.
基金Beijing Natural Science Foundation(L244003)the National Natural Science Foundation of China(grant numbers 52273119,51973018)+2 种基金Key Research and Development Projects of People's Liberation Army(BWS17J036)the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(grant number FRF-IDRY-23-019)Beijing Natural Science Foundation(grant number L222035).
文摘Electrical stimulation could effectively promote the repair of peripheral nerve injuries.However,traditional electrical stimulation requires external devices and connections,inevitably causing unnecessary discomfort and infection risks for patients.Thus,to ensure clinical safety and support neural regeneration,a dual-functional cellulose-based peripheral nerve conduit with both piezoelectric and conductive properties is developed by incorporating barium titanate(BTO)and poly(3,4-ethylenedioxythiophene)(PEDOT)onto the surface of expanded bacterial cellulose.The electroactive conduit not only provides suitable mechanical support and stability to ensure structural integrity in vivo,but also encourages macrophage polarization into the anti-inflammatory M2 phenotype after 2 weeks of post-implantation.Furthermore,the piezoelectric properties provided by BTO convert mechanical energy into electrical energy,which,in synergy with the conductive PEDOT,enables the conduit to stimulate nerve regeneration by mimicking bioelectric signals with an output voltage of 8.22 mV and output current of 2.05μA at compression distances of 1.0 mm.After implantation into a sciatic nerve defect model,this conduit significantly reduces atrophy of the gastrocnemius muscle and accelerates the regeneration of sciatic nerve by facilitating the transmission of neural electrical signals.In summary,this artificial peripheral nerve conduit possesses excellent repair capacity for nerve defects,hence holding attractive prospects for clinical application.
