Organic fi eld-eff ect transistors(OFETs)are fabricated using organic semiconductors(OSCs)as the active layer in the form of thin fi lms.Due to its advantages of high sensitivity,low cost,compact integration,fl exibil...Organic fi eld-eff ect transistors(OFETs)are fabricated using organic semiconductors(OSCs)as the active layer in the form of thin fi lms.Due to its advantages of high sensitivity,low cost,compact integration,fl exibility,and printability,OFETs have been used extensively in the sensing area.For analysis platforms,the construction of sensing layers is a key element for their effi cient detection capability.The strategy used to immobilize biomolecules in these devices is especially important for ensuring that the sensing functions of the OFET are eff ective.Generally,analysis platforms are developed by modifying the gate/electrolyte or OSC/electrolyte interface using biomolecules,such as enzymes,antibodies,or deoxyribonucleic acid(DNA)to ensure high selectivity.To provide better or more convenient biological immobilization methods for researchers in this fi eld and thereby improve detection sensitivity,this review summarizes recent developments in the immobilization strategies used for biological macromolecules in OFETs,including cross-linking,physical adsorption,embedding,and chemical covalent binding.The infl uences of biomolecules on device performance are also discussed.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21922409,21976131,21575100)Tianjin Research Program of Application Foundation and Advanced Technology(Nos.18JCZDJC37500,17JCYBJC20500).
文摘Organic fi eld-eff ect transistors(OFETs)are fabricated using organic semiconductors(OSCs)as the active layer in the form of thin fi lms.Due to its advantages of high sensitivity,low cost,compact integration,fl exibility,and printability,OFETs have been used extensively in the sensing area.For analysis platforms,the construction of sensing layers is a key element for their effi cient detection capability.The strategy used to immobilize biomolecules in these devices is especially important for ensuring that the sensing functions of the OFET are eff ective.Generally,analysis platforms are developed by modifying the gate/electrolyte or OSC/electrolyte interface using biomolecules,such as enzymes,antibodies,or deoxyribonucleic acid(DNA)to ensure high selectivity.To provide better or more convenient biological immobilization methods for researchers in this fi eld and thereby improve detection sensitivity,this review summarizes recent developments in the immobilization strategies used for biological macromolecules in OFETs,including cross-linking,physical adsorption,embedding,and chemical covalent binding.The infl uences of biomolecules on device performance are also discussed.
