Aims: To review one year of ultrasound impulse elastometry in a hospital in Ouagadougou. Patients and Method: This is a retrospective descriptive study of data from one year’s use of impulse ultrasound elastometry. U...Aims: To review one year of ultrasound impulse elastometry in a hospital in Ouagadougou. Patients and Method: This is a retrospective descriptive study of data from one year’s use of impulse ultrasound elastometry. Ultrasound impulse elastometry was performed using the FibroScan® COMPACT 530. Fibrosis was considered significant when E (hepatic elasticity) ≥ 7.2 kPa (F2 fibrosis). The test was considered valid when the IQR/Median ratio ≤ 30% and there were at least 10 valid measurements. Results: A total of 1911 patients underwent FibroScan®. There were 1079 men, giving a sex ratio of 1.3. The mean age of the patients was 37.9 ± 12.2 years. The indication for FibroScan® was hepatitis B virus infection in 89% of cases. The validation criteria for FibroScan® were met in all patients. The mean value for elasticity was 7.9 kPa and for steatosis 212 dB/m. Fibrosis was non-significant in 75.5% of cases. More than half of our patients (56.7%) didn’t have steatosis, 24.8% had mild steatosis, 12.4% had moderate steatosis and 6.1% had severe steatosis. Conclusion: Ultrasound pulse elastometry plays an important role in monitoring chronic liver disease. It allows non-invasive diagnosis of hepatic fibrosis and steatosis. In our context, however, access to the test is limited by its availability only in large urban centers, and by its cost.展开更多
AIM To investigate the relationships among diverse metalloproteases(MMPs)and their tissue inhibitors(TIMPs)and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleot...AIM To investigate the relationships among diverse metalloproteases(MMPs)and their tissue inhibitors(TIMPs)and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs)in MMPs,TNF-αand CCR5 genes,and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV)coinfection.A total of 158 patients were included,57 of whom were HCVcoinfected.All patients drank<50 g ethanol/day.Diverse SNPs(MMP-1-16071G/2G,MMP-8-799C/T,MMP-9-1562 C/T,MMP-13-77A/G,TNF-α-308 G/A,CCR5-?32),and serum levels of MMPs(2,3,8,9 and 10)and TIMPs(1,2 and 4)were assessed.Liver fibrosis was determined by transient elastometry,although other non-invasive markers of fibrosis were also considered.Significant liver fibrosis(F≥2)was defined by a transient elastometry value≥7.1 kP a.RESULTS A total of 34 patients(21.5%)had liver fibrosis≥F2.MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis≥F2(P=0.02 and P=0.03,respectively)and correlated positively with transient elastometry values(P=0.02 and P=0.0009,respectively),whereas MMP-9 values were negatively correlated with transient elastometry measurements(P=0.01).Multivariate analyses showed that high levels of MMP-2(OR=2.397;95%CI:1.191-4.827,P=0.014)were independently associated with liver fibrosis≥F2 in the patients as a whole.MMP-2(OR=7.179;95%CI:1.210-42.581,P=0.03)and male gender(OR=10.040;95%CI:1.621-62.11,P=0.013)were also independent predictors of fibrosis≥F2 in the HCV-infected subgroup.Likewise,MMP-2,TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis.None of the six SNPs evaluated had any significant association with liver fibrosis≥F2.CONCLUSION Certain MMPs and TIMPs,particularly MMP-2,seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection.展开更多
文摘Aims: To review one year of ultrasound impulse elastometry in a hospital in Ouagadougou. Patients and Method: This is a retrospective descriptive study of data from one year’s use of impulse ultrasound elastometry. Ultrasound impulse elastometry was performed using the FibroScan® COMPACT 530. Fibrosis was considered significant when E (hepatic elasticity) ≥ 7.2 kPa (F2 fibrosis). The test was considered valid when the IQR/Median ratio ≤ 30% and there were at least 10 valid measurements. Results: A total of 1911 patients underwent FibroScan®. There were 1079 men, giving a sex ratio of 1.3. The mean age of the patients was 37.9 ± 12.2 years. The indication for FibroScan® was hepatitis B virus infection in 89% of cases. The validation criteria for FibroScan® were met in all patients. The mean value for elasticity was 7.9 kPa and for steatosis 212 dB/m. Fibrosis was non-significant in 75.5% of cases. More than half of our patients (56.7%) didn’t have steatosis, 24.8% had mild steatosis, 12.4% had moderate steatosis and 6.1% had severe steatosis. Conclusion: Ultrasound pulse elastometry plays an important role in monitoring chronic liver disease. It allows non-invasive diagnosis of hepatic fibrosis and steatosis. In our context, however, access to the test is limited by its availability only in large urban centers, and by its cost.
基金Supported by the Oviedo University research grants,Nos.UNIOV-12-MA-03 and SV-PA-13-ECOEMP-57
文摘AIM To investigate the relationships among diverse metalloproteases(MMPs)and their tissue inhibitors(TIMPs)and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs)in MMPs,TNF-αand CCR5 genes,and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV)coinfection.A total of 158 patients were included,57 of whom were HCVcoinfected.All patients drank<50 g ethanol/day.Diverse SNPs(MMP-1-16071G/2G,MMP-8-799C/T,MMP-9-1562 C/T,MMP-13-77A/G,TNF-α-308 G/A,CCR5-?32),and serum levels of MMPs(2,3,8,9 and 10)and TIMPs(1,2 and 4)were assessed.Liver fibrosis was determined by transient elastometry,although other non-invasive markers of fibrosis were also considered.Significant liver fibrosis(F≥2)was defined by a transient elastometry value≥7.1 kP a.RESULTS A total of 34 patients(21.5%)had liver fibrosis≥F2.MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis≥F2(P=0.02 and P=0.03,respectively)and correlated positively with transient elastometry values(P=0.02 and P=0.0009,respectively),whereas MMP-9 values were negatively correlated with transient elastometry measurements(P=0.01).Multivariate analyses showed that high levels of MMP-2(OR=2.397;95%CI:1.191-4.827,P=0.014)were independently associated with liver fibrosis≥F2 in the patients as a whole.MMP-2(OR=7.179;95%CI:1.210-42.581,P=0.03)and male gender(OR=10.040;95%CI:1.621-62.11,P=0.013)were also independent predictors of fibrosis≥F2 in the HCV-infected subgroup.Likewise,MMP-2,TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis.None of the six SNPs evaluated had any significant association with liver fibrosis≥F2.CONCLUSION Certain MMPs and TIMPs,particularly MMP-2,seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection.
