The near crack line analysis method was used to investigate a crack loaded by a pair of point shear forces in an infinite plate in an elastic-perfectly plastic solid. The analytical solution was obtained, that is the ...The near crack line analysis method was used to investigate a crack loaded by a pair of point shear forces in an infinite plate in an elastic-perfectly plastic solid. The analytical solution was obtained, that is the elastic-plastic fields near crack line and law that the length of the plastic zone along the crack line is varied with external loads. The results are sufficiently precise near the crack line and are not confined by small scale yielding conditions.展开更多
Short-leg shear wall structures are a new form of building structure that combine the merits of both frame and shear wall structures. Its architectural features, structure bearing and engineering cost are reasonable. ...Short-leg shear wall structures are a new form of building structure that combine the merits of both frame and shear wall structures. Its architectural features, structure bearing and engineering cost are reasonable. To analyze the elastic-plastic response of a short-leg shear wall structure during an earthquake, this study modified the multiple-vertical-rod element model of the shear wall, considered the shear lag effect and proposed a multiple-vertical-rod element coupling beam model with a new local stiffness domain. Based on the principle of minimum potential energy and the variational principle, the stiffness matrixes of a short-leg shear wall and a coupling beam are derived in this study. Furthermore, the bending shear correlation for the analysis of different parameters to describe the structure, such as the beam height to span ratio, short-leg shear wall height to thickness ratio, and steel ratio are introduced. The results show that the height to span ratio directly affects the structural integrity; and the short-leg shear wall height to thickness ratio should be limited to a range of approximately 6.0 to 7.0. The design of short-leg shear walls should be in accordance with the ＂strong wall and weak beam＂ principle.展开更多
A new algorithm for the solution of quadratic programming problemsis put forward in terms of the mixed energy theory and is furtherused for the incremental solution of elastic-plastic trussstructures. The method propo...A new algorithm for the solution of quadratic programming problemsis put forward in terms of the mixed energy theory and is furtherused for the incremental solution of elastic-plastic trussstructures. The method proposed is different from the traditionalone, for which the unknown variables are selected just in one classsuch as displacements or stresses. The present method selects thevariables in the mixed form with both displacement and stress. As themethod is established in the hybrid space, the information found inthe previous incremental step can be used for the solution of thepresent step, making the algorithm highly effi- cient in thenumerical solution process of quadratic programming problems. Theresults obtained in the exm- ples of the elastic-plastic solution ofthe truss structures verify what has been predicted in thetheoretical anal- ysis.展开更多
In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly p...In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly plastic solid. And the analytical solutions are obtained, that is elastic-plastic stress fields near the crack line and the law that the length of the plastic zone along the crack line is varied with an external loads tr,ld the bearing capacity of a finite plate with a center crack. The results of this paper are sufficiently precise near the crack line, because the assumptions of the small scale yielding theory have not been used and no other assumptions have been taken.展开更多
By using numerical analysis methods to simulate the deep excavation,a lot of analyses are established on the basis of two-dimensional plane strain,ignoring the fact that foundation pit possesses three dimensions. For ...By using numerical analysis methods to simulate the deep excavation,a lot of analyses are established on the basis of two-dimensional plane strain,ignoring the fact that foundation pit possesses three dimensions. For soil constitutive relation,people always take linear and nonlinear model,without considering the plastic behavior of soil. Using plastic-elastic hardening model to simulate constitutive relation of soil characteristics,the authors carried out mechanical analysis for pit excavation and support. The results show that the analysis for the stress state of pile anchor system is an effective way which provides theoretical basis for calculation of soil displacement.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analy...AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analysis.METHODS:The causal effects of several behavioral factors,including screen time,education time,time spent outdoors,and physical activity,on the risk of HM using univariable Mendelian randomization(MR)and MVMR analyses were first assessed.Genome-wide association study summary statistics of serum metabolites were also used in mediation analysis to determine the extent to which serum metabolites mediate the effects of behavioral factors on HM.RESULTS:MR analyses indicated that both increased time spent outdoors and a higher frequency of moderate physical activity significantly reduced the risk of HM.Further MVMR analysis confirmed that moderate physical activity independently contributed to a lower risk of HM.Additionally,MR analyses identified 13 serum metabolites significantly associated with HM,of which 12 were lipids and one was an amino acid derivative.Mediation analysis revealed that six lipid metabolites mediated the protective effects of moderate physical activity on HM,with the highest mediation proportion observed for 1-(1-enyl-palmitoyl)-GPC(p-16:0;30.83%).CONCLUSION:This study suggests that in addition to outdoor time,moderate physical activity habits may have an independent protective effect against HM and pointed to lipid metabolites as priority targets for the prevention due to low physical activity.These results emphasize the importance of physical activity and metabolic health in HM and underscore the need for further study of these complex associations.展开更多
AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 ...AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.展开更多
Quayside container crane is a kind of huge dimension steel structure,which is the major equipment used for handling container at modern ports.With the aim to validate the safety and reliability of the crane under seis...Quayside container crane is a kind of huge dimension steel structure,which is the major equipment used for handling container at modern ports.With the aim to validate the safety and reliability of the crane under seismic loads,besides conventional analysis,elastic-plastic time history analysis under rare seismic intensity is carried out.An ideal finite element（FEM） elastic-plastic mechanical model of the quayside container crane is presented by using ANSYS codes.Furthermore,according to elastic-plastic time history analysis theory,deformation,stress and damage pattern of the structure under rare seismic intensity are investigated.Based on the above analysis,the established reliability model according to the reliability theory,together with seismic reliability analysis based on Monte-Carlo simulation is applied to practical analysis.The results show that the overall structure of the quayside container crane is generally unstable under rare seismic intensity,and the structure needs to be reinforced.展开更多
Using the finite element code ANSYS/LS-DYNA, a dynamic finite element modelwith an elastic-linear-kinematic-hardening plastic material is established to analyzeelastic-plastic stresses in the railhead in the impact pr...Using the finite element code ANSYS/LS-DYNA, a dynamic finite element modelwith an elastic-linear-kinematic-hardening plastic material is established to analyzeelastic-plastic stresses in the railhead in the impact process of wheel and rail occurring at thegap of rail joint. The model is based on the discrete elastic support condition of the rails, whichis suitable for the actual situation of wheel/track rolling contact. In the analysis the influencesof axle load, yield stress and tangent modulus of rail material on the stresses and strains areinvestigated in detail. The distribution of stresses and strains in the jointed railhead are given.It is found that the axle load, yield stress and tangent modulus of rail material greatly affect thestresses and strains in the railhead during impacting. The study provides a reliable method anduseful datum for the further research on fatigue and wear of railhead and improving the rail jointmode.展开更多
The reverse analysis provides a convenient method to determine four elastic-plastic parameters through an indentation curve such as Young s modulus E, hardness H, yield strength σy and strain hardening exponent n. In...The reverse analysis provides a convenient method to determine four elastic-plastic parameters through an indentation curve such as Young s modulus E, hardness H, yield strength σy and strain hardening exponent n. In this paper, mathematical analysis on a reverse algorithm from Dao model （Dao et al., Acta Mater., 2001, 49, 3899） was carried out, which thought that only when 20 ≤E＊/σ0.033≤ 26 and 0.3n≤ 0.5, the reverse algorithm would yield two solutions of n by dimensionless function Π2. It is shown that, however, there are also two solutions of n when 20≤E＊/σ0.033≤ 26 and 0≤n0.1. A unique n can be obtained by dimensionless function Π3 instead of Π2 in these two ranges. E and H can be uniquely determined by a full indentation curve, and σy can be determined if n is unique. Furthermore, sensitivity analysis on obtaining n from dimensionless function Π3 or Π2 has been made.展开更多
The elastic-plastic indentation properties of materials with varying ratio of hardness to Young’s modulus(H/E) were analyzed with the finite element method. And the indentation stress fields of materials with varying...The elastic-plastic indentation properties of materials with varying ratio of hardness to Young’s modulus(H/E) were analyzed with the finite element method. And the indentation stress fields of materials with varying ratio H/E on the surface were studied by the experiment. The results show that the penetration depth, contact radius, plastic pile-up and the degree of elastic recovery depend strongly on the ratio H/E. Moreover, graphs were established to describe the relationship between the elastic-plastic indentation parameters and H/E. The established graphs can be used to predict the H/E of materials when compared with experimental data.展开更多
The elastic-plastic behavior and failure of pipe-on-pipe impact(p-o-p-i)problem is studied through analytical model and numerical simulation in this paper.The impact of a whipping pipe with one end hinged and the othe...The elastic-plastic behavior and failure of pipe-on-pipe impact(p-o-p-i)problem is studied through analytical model and numerical simulation in this paper.The impact of a whipping pipe with one end hinged and the other end free on a simply-supported target pipe at its midpoint is considered.The analytical model based on tubular beam theory is proposed in the study of the deformation and plastic collapse behavior of pipes impacted on different positions and therefore to obtain the various failure modes depending on the material and structural parameters of the pipes.Numerical simulations using the finite element code MSC-Marc are performed and the results are coincident with the theoretical predictions.展开更多
Based on the Plastica theory (see ref. [12]), the large deflection of an elastic-perfectly plastic cantilever subjected to an inclined concentrated force at its tip, before the unloading in the plastic region occurs, ...Based on the Plastica theory (see ref. [12]), the large deflection of an elastic-perfectly plastic cantilever subjected to an inclined concentrated force at its tip, before the unloading in the plastic region occurs, is analyzed in this paper. The emphasis of the analysis is put on the effects of the angle of inclination of the concentrated force upon the deformed shape, the load-deflection relationship and the length of the plastic region. Both analytical and computed results are given.展开更多
The layered approach was adopted to study the numerical procedure of the large deflection of art elastic-plastic Timoshenko' s beam, and the nonlinear equilibrium equation was derived by TL Formula. The solution w...The layered approach was adopted to study the numerical procedure of the large deflection of art elastic-plastic Timoshenko' s beam, and the nonlinear equilibrium equation was derived by TL Formula. The solution was conducted by means of mNR method. The tangential stiffness matrix of the beam,vas introduced, and the solving procedures were presented in detail. The solution of the problem is satisfactory.展开更多
The triangular zone cracks in 2101 duplex stainless steel produced by the vertical continuous caster have troubled company A for a long time. To simulate the temperature and thermal stress distributions in the solidif...The triangular zone cracks in 2101 duplex stainless steel produced by the vertical continuous caster have troubled company A for a long time. To simulate the temperature and thermal stress distributions in the solidification process of 2101 duplex stainless steel produced by the vertical continuous caster, a two-dimensional viscoelastic-plastic thermomechanically coupled finite element model was established by the secondary development of the commercial nonlinear finite element analysis software MSC Marc. The results show that the thermal stress on the surface reaches a maximum at the exit of the mould, and the highest thermal stresses at the centre of the wide face and the narrow face are 75 and 115 MPa, respectively. Meanwhile, the internal temperature of slab is still higher than the solidus temperature, resulting in no thermal stress. The slab shows different high-temperature strengths and suffers from different stresses at different positions; thus, the risk of cracking also varies. At a location of 6-8 m from the meniscus, the temperature of the triangular zone is 1270-1360℃ and the corresponding permissible high-temperature strength is about 10-30 MPa, while the thermal stress at this time is 60 MPa, which is higher than the high-temperature strength. As a result, triangular zone cracks form easily.展开更多
基金National Natural Science Foundation ofChina( No.5 98790 12 )
文摘The near crack line analysis method was used to investigate a crack loaded by a pair of point shear forces in an infinite plate in an elastic-perfectly plastic solid. The analytical solution was obtained, that is the elastic-plastic fields near crack line and law that the length of the plastic zone along the crack line is varied with external loads. The results are sufficiently precise near the crack line and are not confined by small scale yielding conditions.
文摘Short-leg shear wall structures are a new form of building structure that combine the merits of both frame and shear wall structures. Its architectural features, structure bearing and engineering cost are reasonable. To analyze the elastic-plastic response of a short-leg shear wall structure during an earthquake, this study modified the multiple-vertical-rod element model of the shear wall, considered the shear lag effect and proposed a multiple-vertical-rod element coupling beam model with a new local stiffness domain. Based on the principle of minimum potential energy and the variational principle, the stiffness matrixes of a short-leg shear wall and a coupling beam are derived in this study. Furthermore, the bending shear correlation for the analysis of different parameters to describe the structure, such as the beam height to span ratio, short-leg shear wall height to thickness ratio, and steel ratio are introduced. The results show that the height to span ratio directly affects the structural integrity; and the short-leg shear wall height to thickness ratio should be limited to a range of approximately 6.0 to 7.0. The design of short-leg shear walls should be in accordance with the ＂strong wall and weak beam＂ principle.
基金the National Natural Science Foundation of China(No.50178916,No.19732020 and No.19872016)the National Key Basic lteseareh Special Foundation(No.G1999032805)+1 种基金the Special Funds for Major State Basic Researeh Projectsthe Foundation for University Key Teachers by the Ministry of Education of China
文摘A new algorithm for the solution of quadratic programming problemsis put forward in terms of the mixed energy theory and is furtherused for the incremental solution of elastic-plastic trussstructures. The method proposed is different from the traditionalone, for which the unknown variables are selected just in one classsuch as displacements or stresses. The present method selects thevariables in the mixed form with both displacement and stress. As themethod is established in the hybrid space, the information found inthe previous incremental step can be used for the solution of thepresent step, making the algorithm highly effi- cient in thenumerical solution process of quadratic programming problems. Theresults obtained in the exm- ples of the elastic-plastic solution ofthe truss structures verify what has been predicted in thetheoretical anal- ysis.
文摘In this paper, the improved near crack line analysis method proposed in Refs. [1] and [2] is used to investigate a center crack loaded by two pairs of antiplane point forces in a finite plate in an elastic-perfectly plastic solid. And the analytical solutions are obtained, that is elastic-plastic stress fields near the crack line and the law that the length of the plastic zone along the crack line is varied with an external loads tr,ld the bearing capacity of a finite plate with a center crack. The results of this paper are sufficiently precise near the crack line, because the assumptions of the small scale yielding theory have not been used and no other assumptions have been taken.
文摘By using numerical analysis methods to simulate the deep excavation,a lot of analyses are established on the basis of two-dimensional plane strain,ignoring the fact that foundation pit possesses three dimensions. For soil constitutive relation,people always take linear and nonlinear model,without considering the plastic behavior of soil. Using plastic-elastic hardening model to simulate constitutive relation of soil characteristics,the authors carried out mechanical analysis for pit excavation and support. The results show that the analysis for the stress state of pile anchor system is an effective way which provides theoretical basis for calculation of soil displacement.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金Supported by the Central High Level Hospital Clinical Research Funding(No.BJ-2024-089).
文摘AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analysis.METHODS:The causal effects of several behavioral factors,including screen time,education time,time spent outdoors,and physical activity,on the risk of HM using univariable Mendelian randomization(MR)and MVMR analyses were first assessed.Genome-wide association study summary statistics of serum metabolites were also used in mediation analysis to determine the extent to which serum metabolites mediate the effects of behavioral factors on HM.RESULTS:MR analyses indicated that both increased time spent outdoors and a higher frequency of moderate physical activity significantly reduced the risk of HM.Further MVMR analysis confirmed that moderate physical activity independently contributed to a lower risk of HM.Additionally,MR analyses identified 13 serum metabolites significantly associated with HM,of which 12 were lipids and one was an amino acid derivative.Mediation analysis revealed that six lipid metabolites mediated the protective effects of moderate physical activity on HM,with the highest mediation proportion observed for 1-(1-enyl-palmitoyl)-GPC(p-16:0;30.83%).CONCLUSION:This study suggests that in addition to outdoor time,moderate physical activity habits may have an independent protective effect against HM and pointed to lipid metabolites as priority targets for the prevention due to low physical activity.These results emphasize the importance of physical activity and metabolic health in HM and underscore the need for further study of these complex associations.
基金Supported by National Natural Science Foundation of China(No.82020108006,No.81730025).
文摘AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.
基金supported by National High Technology Research and Development Program 863 Plan (No. 2009AA043000)
文摘Quayside container crane is a kind of huge dimension steel structure,which is the major equipment used for handling container at modern ports.With the aim to validate the safety and reliability of the crane under seismic loads,besides conventional analysis,elastic-plastic time history analysis under rare seismic intensity is carried out.An ideal finite element（FEM） elastic-plastic mechanical model of the quayside container crane is presented by using ANSYS codes.Furthermore,according to elastic-plastic time history analysis theory,deformation,stress and damage pattern of the structure under rare seismic intensity are investigated.Based on the above analysis,the established reliability model according to the reliability theory,together with seismic reliability analysis based on Monte-Carlo simulation is applied to practical analysis.The results show that the overall structure of the quayside container crane is generally unstable under rare seismic intensity,and the structure needs to be reinforced.
基金National Natural Science Foundation of China(No.599355100)Foundation for Excellent PhD Thesis of University of Ministry of Education of China (No.200048)
文摘Using the finite element code ANSYS/LS-DYNA, a dynamic finite element modelwith an elastic-linear-kinematic-hardening plastic material is established to analyzeelastic-plastic stresses in the railhead in the impact process of wheel and rail occurring at thegap of rail joint. The model is based on the discrete elastic support condition of the rails, whichis suitable for the actual situation of wheel/track rolling contact. In the analysis the influencesof axle load, yield stress and tangent modulus of rail material on the stresses and strains areinvestigated in detail. The distribution of stresses and strains in the jointed railhead are given.It is found that the axle load, yield stress and tangent modulus of rail material greatly affect thestresses and strains in the railhead during impacting. The study provides a reliable method anduseful datum for the further research on fatigue and wear of railhead and improving the rail jointmode.
基金supported by the National Natural Science Foundation of China (Nos. 11002121, 11002122,and 10828205)the Natural Science Foundation of Hu-nan Province for Innovation Group (No. 09JJ7004)+2 种基金the Key Special Program for Science and Technology of Hu-nan Province (No. 2009FJ1002)and the Natural Science Foundation of Xiangtan University (No. 09XZX04)One of the authors (C. Lu) is also grateful to the support from the Australian Research Council (No. DP0985450)
文摘The reverse analysis provides a convenient method to determine four elastic-plastic parameters through an indentation curve such as Young s modulus E, hardness H, yield strength σy and strain hardening exponent n. In this paper, mathematical analysis on a reverse algorithm from Dao model （Dao et al., Acta Mater., 2001, 49, 3899） was carried out, which thought that only when 20 ≤E＊/σ0.033≤ 26 and 0.3n≤ 0.5, the reverse algorithm would yield two solutions of n by dimensionless function Π2. It is shown that, however, there are also two solutions of n when 20≤E＊/σ0.033≤ 26 and 0≤n0.1. A unique n can be obtained by dimensionless function Π3 instead of Π2 in these two ranges. E and H can be uniquely determined by a full indentation curve, and σy can be determined if n is unique. Furthermore, sensitivity analysis on obtaining n from dimensionless function Π3 or Π2 has been made.
基金Science Research Foundation of Shanghai Municipal Education Commission (No.06VZ004)
文摘The elastic-plastic indentation properties of materials with varying ratio of hardness to Young’s modulus(H/E) were analyzed with the finite element method. And the indentation stress fields of materials with varying ratio H/E on the surface were studied by the experiment. The results show that the penetration depth, contact radius, plastic pile-up and the degree of elastic recovery depend strongly on the ratio H/E. Moreover, graphs were established to describe the relationship between the elastic-plastic indentation parameters and H/E. The established graphs can be used to predict the H/E of materials when compared with experimental data.
基金National Natural Science Foundation of China(No.11032001)
文摘The elastic-plastic behavior and failure of pipe-on-pipe impact(p-o-p-i)problem is studied through analytical model and numerical simulation in this paper.The impact of a whipping pipe with one end hinged and the other end free on a simply-supported target pipe at its midpoint is considered.The analytical model based on tubular beam theory is proposed in the study of the deformation and plastic collapse behavior of pipes impacted on different positions and therefore to obtain the various failure modes depending on the material and structural parameters of the pipes.Numerical simulations using the finite element code MSC-Marc are performed and the results are coincident with the theoretical predictions.
文摘Based on the Plastica theory (see ref. [12]), the large deflection of an elastic-perfectly plastic cantilever subjected to an inclined concentrated force at its tip, before the unloading in the plastic region occurs, is analyzed in this paper. The emphasis of the analysis is put on the effects of the angle of inclination of the concentrated force upon the deformed shape, the load-deflection relationship and the length of the plastic region. Both analytical and computed results are given.
文摘The layered approach was adopted to study the numerical procedure of the large deflection of art elastic-plastic Timoshenko' s beam, and the nonlinear equilibrium equation was derived by TL Formula. The solution was conducted by means of mNR method. The tangential stiffness matrix of the beam,vas introduced, and the solving procedures were presented in detail. The solution of the problem is satisfactory.
文摘The triangular zone cracks in 2101 duplex stainless steel produced by the vertical continuous caster have troubled company A for a long time. To simulate the temperature and thermal stress distributions in the solidification process of 2101 duplex stainless steel produced by the vertical continuous caster, a two-dimensional viscoelastic-plastic thermomechanically coupled finite element model was established by the secondary development of the commercial nonlinear finite element analysis software MSC Marc. The results show that the thermal stress on the surface reaches a maximum at the exit of the mould, and the highest thermal stresses at the centre of the wide face and the narrow face are 75 and 115 MPa, respectively. Meanwhile, the internal temperature of slab is still higher than the solidus temperature, resulting in no thermal stress. The slab shows different high-temperature strengths and suffers from different stresses at different positions; thus, the risk of cracking also varies. At a location of 6-8 m from the meniscus, the temperature of the triangular zone is 1270-1360℃ and the corresponding permissible high-temperature strength is about 10-30 MPa, while the thermal stress at this time is 60 MPa, which is higher than the high-temperature strength. As a result, triangular zone cracks form easily.
