The use of redox-active organic electrode materials in energy storage is restricted due to their inferior solvent resistance,abysmal conductivity,and the resultant low practical capacity.To address these issues,a clas...The use of redox-active organic electrode materials in energy storage is restricted due to their inferior solvent resistance,abysmal conductivity,and the resultant low practical capacity.To address these issues,a class of bipolar p-phenylenediimidazole-based small-molecule compounds are designed and fabricated.Theπ-conjugated backbone of these small molecules allows for electron delocalization on a big conjugation plane,endowing them with good conductivity and reaction reversibility.Furthermore,when the para-positions of phenylene are occupied by hydroxyl groups,as-formed intramolecular hydrogen bonds(N-H...O)between phenolic hydroxyl groups and the–NH groups of imidazole rings further enhance the structural planarity,resulting in higherπ-conjugation degree and better conductivity,and thus higher utilization of active sites and electrode capacity,proved by both experimental results and theoretical calculations.The optimized composite electrode DBNQ@rGO-45 shows a high specific capacity(∼308 mA h g^(−1)at 100 mA g^(−1))and a long cycling stability(112.9 mA h g^(−1)after 6000 cycles at 2000 mA g^(−1)).The significantly better electrochemical properties for hydroxyl group-containing compounds than those without hydroxyl groups attributed to intramolecular hydrogen bond-induced conjugation enhancement will inspire the structure design of organic electrodes for better energy storage.展开更多
We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to prec...We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to precisely control their movement mode.MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles(7.02±0.18 nm).Doxorubicin(12%±2%[w/w])was encapsulated in MDNs by an imide bond.MDNs could imitate the movement mode of a school of wild herrings(e.g.,re-dispersion/arrangement/vortex/directional movement)to adapt to the changing and complex physiological environment through the 3D MMP system.MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to in vivo imaging(magnetic resonance imaging and fluorescence)and histopathology.The performance of fabricated MDNs was verified through cells and tumor-bearing mouse models.The MDNs showed high efficiency of drug delivery and targeting at the tumor site(>10-fold),lower toxicity than free doxorubicin(5 mg/kg body weight),activated immune response in the tumor site,and significantly lengthened survival for mice.The synergistic interaction between MDNs and the 3D MMP system underscores the immense potential of this drug delivery system,indicating a potential revolution in the field of tumor chemotherapy.展开更多
基金the financial support by the National Natural Science Foundation of China (22371010, 21771017, and 51702009)the "Hundred Talents Program" of the Chinese Academy of Sciences, the Fundamental Research Funds for the Central Universities+1 种基金the Shenzhen Science and Technology Program (JCYJ20210324115412035, JCYJ2021-0324123202008, JCYJ20210 324122803009 and ZDSYS20210813095534001)the Guangdong Basic and Applied Basic Research Foundation (2021A1515110880)
文摘The use of redox-active organic electrode materials in energy storage is restricted due to their inferior solvent resistance,abysmal conductivity,and the resultant low practical capacity.To address these issues,a class of bipolar p-phenylenediimidazole-based small-molecule compounds are designed and fabricated.Theπ-conjugated backbone of these small molecules allows for electron delocalization on a big conjugation plane,endowing them with good conductivity and reaction reversibility.Furthermore,when the para-positions of phenylene are occupied by hydroxyl groups,as-formed intramolecular hydrogen bonds(N-H...O)between phenolic hydroxyl groups and the–NH groups of imidazole rings further enhance the structural planarity,resulting in higherπ-conjugation degree and better conductivity,and thus higher utilization of active sites and electrode capacity,proved by both experimental results and theoretical calculations.The optimized composite electrode DBNQ@rGO-45 shows a high specific capacity(∼308 mA h g^(−1)at 100 mA g^(−1))and a long cycling stability(112.9 mA h g^(−1)after 6000 cycles at 2000 mA g^(−1)).The significantly better electrochemical properties for hydroxyl group-containing compounds than those without hydroxyl groups attributed to intramolecular hydrogen bond-induced conjugation enhancement will inspire the structure design of organic electrodes for better energy storage.
基金supported by the National Key R&D Program of China(2022YFA1207300,2021YFA1201204,and 2022YFF1502000)the directional institutional-ized scientific research platform relying on the Beijing Synchrotron Radiation Facility(BSRF)of the Chinese Academy of Sclences,the Science and Technology Plan Program of Beijing(Z221100007122006)the Beijing Municipal Fund for Distinguished Young Scholars(grant JQ22022).
文摘We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to precisely control their movement mode.MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles(7.02±0.18 nm).Doxorubicin(12%±2%[w/w])was encapsulated in MDNs by an imide bond.MDNs could imitate the movement mode of a school of wild herrings(e.g.,re-dispersion/arrangement/vortex/directional movement)to adapt to the changing and complex physiological environment through the 3D MMP system.MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to in vivo imaging(magnetic resonance imaging and fluorescence)and histopathology.The performance of fabricated MDNs was verified through cells and tumor-bearing mouse models.The MDNs showed high efficiency of drug delivery and targeting at the tumor site(>10-fold),lower toxicity than free doxorubicin(5 mg/kg body weight),activated immune response in the tumor site,and significantly lengthened survival for mice.The synergistic interaction between MDNs and the 3D MMP system underscores the immense potential of this drug delivery system,indicating a potential revolution in the field of tumor chemotherapy.
