Aims:To compare the efficacy and safety of vonoprazan-based bismuth-containing quadruple therapy(VBCQ)versus proton pump inhibitor(PPI)-based bismuth-containing quadruple Therapy(PBCQ)for Helicobacter pylorieradicatio...Aims:To compare the efficacy and safety of vonoprazan-based bismuth-containing quadruple therapy(VBCQ)versus proton pump inhibitor(PPI)-based bismuth-containing quadruple Therapy(PBCQ)for Helicobacter pylorieradication.Methods:We performed a systematic search in PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang databases for relevant randomized controlled trials up to March 2024.Meta-analysis by RevMan 5.4 software.Results:Ten randomized controlled trials were evaluated in this meta-analysis.In intention-to-treat(ITT)analysis and per-protocol(PP)analysis,the eradication rate of VBCQ was signifi cantly higher than PBCQ[ITT overall eradication rate:86.7%vs 82.8%,RR:1.05,95%CI(1.05,1.09),P<0.05;PP overall eradication rate:92.0%vs 88.0%;RR=1.05,95%CI(1.05,1.08),P<0.05].The incidence of adverse events in VBCQ was higher than PBCQ(36.7%vs 36.5%),there was no signifi cant diff erence(P>0.05).Conclusions:VBCQ has a higher eradication rate and comparable safety.展开更多
Given Türkiye's high seismic risk,earthquake preparedness is vital.This study explored factors aff ecting earthquake preparedness behaviors among residents in high-risk areas.The factors aff ecting earthquake...Given Türkiye's high seismic risk,earthquake preparedness is vital.This study explored factors aff ecting earthquake preparedness behaviors among residents in high-risk areas.The factors aff ecting earthquake preparedness behaviors Scale based on protection motivation theory was developed,and its validity was tested.Scale development consists of a pilot and main application process.The pilot application was carried out with 50 participants,and the main application was carried out with 804 participants.The sample consisted of 804 participants who were divided into two groups for exploratory and confirmatory factor analysis.The sample was selected from 11 neighborhoods using the cluster sampling method.IBM SPSS 25 was used for exploratory factor analysis,while AMOS 24.0 was employed for confirmatory factor analysis.The final version of the scale consists of 24 items across four dimensions,with a Cronbach's alpha of 0.883,exceeding the acceptable threshold of 0.7 for each dimension.The Kaiser–Meyer–Olkin value is 0.898,and Bartlett's test of sphericity is significant,with the total variance explained being 51%.Confirmatory factor analysis results indicate a good fit for both the measurement and structural models(χ2/df=1.779;RMSEA=0.44;CFI=0.96;NFI=0.91;TLI=0.95;p<0.001).Structural equation modeling showed that,among the constructs of protection motivation theory,perceived e fficacy(β=0.690)is the most important factor aff ecting earthquake preparedness behaviors.The results show that the scale is a valid and reliable tool to determine the factors aff ecting earthquake preparedness behaviors in Turkish society.展开更多
文摘Aims:To compare the efficacy and safety of vonoprazan-based bismuth-containing quadruple therapy(VBCQ)versus proton pump inhibitor(PPI)-based bismuth-containing quadruple Therapy(PBCQ)for Helicobacter pylorieradication.Methods:We performed a systematic search in PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang databases for relevant randomized controlled trials up to March 2024.Meta-analysis by RevMan 5.4 software.Results:Ten randomized controlled trials were evaluated in this meta-analysis.In intention-to-treat(ITT)analysis and per-protocol(PP)analysis,the eradication rate of VBCQ was signifi cantly higher than PBCQ[ITT overall eradication rate:86.7%vs 82.8%,RR:1.05,95%CI(1.05,1.09),P<0.05;PP overall eradication rate:92.0%vs 88.0%;RR=1.05,95%CI(1.05,1.08),P<0.05].The incidence of adverse events in VBCQ was higher than PBCQ(36.7%vs 36.5%),there was no signifi cant diff erence(P>0.05).Conclusions:VBCQ has a higher eradication rate and comparable safety.
文摘Given Türkiye's high seismic risk,earthquake preparedness is vital.This study explored factors aff ecting earthquake preparedness behaviors among residents in high-risk areas.The factors aff ecting earthquake preparedness behaviors Scale based on protection motivation theory was developed,and its validity was tested.Scale development consists of a pilot and main application process.The pilot application was carried out with 50 participants,and the main application was carried out with 804 participants.The sample consisted of 804 participants who were divided into two groups for exploratory and confirmatory factor analysis.The sample was selected from 11 neighborhoods using the cluster sampling method.IBM SPSS 25 was used for exploratory factor analysis,while AMOS 24.0 was employed for confirmatory factor analysis.The final version of the scale consists of 24 items across four dimensions,with a Cronbach's alpha of 0.883,exceeding the acceptable threshold of 0.7 for each dimension.The Kaiser–Meyer–Olkin value is 0.898,and Bartlett's test of sphericity is significant,with the total variance explained being 51%.Confirmatory factor analysis results indicate a good fit for both the measurement and structural models(χ2/df=1.779;RMSEA=0.44;CFI=0.96;NFI=0.91;TLI=0.95;p<0.001).Structural equation modeling showed that,among the constructs of protection motivation theory,perceived e fficacy(β=0.690)is the most important factor aff ecting earthquake preparedness behaviors.The results show that the scale is a valid and reliable tool to determine the factors aff ecting earthquake preparedness behaviors in Turkish society.
