Since the debut of the Warburg effect,our understanding of lactate in cancer has evolved from a metabolic waste of"low-efficient"glucose metabolism,an acidification factor reshaping tumor microenvironments,t...Since the debut of the Warburg effect,our understanding of lactate in cancer has evolved from a metabolic waste of"low-efficient"glucose metabolism,an acidification factor reshaping tumor microenvironments,to key molecular signals modulating signaling pathways,thereby influencing cell fates.Recently,Zhang’s work introduced a novel post-translational modification(PTM),lactylation,revealing a previously unidentified identity of lactate.Further findings in Plantae and Bacteria have projected lactylation as a common PTM among biological kingdoms.展开更多
基金supported by the National Natural Science Foundation of China(NSFC)(T2225006,T2488301,and 82272948 to M.L.)the Beijing Municipal Natural Science Foundation(Key Program Z220011 to M.L.).
文摘Since the debut of the Warburg effect,our understanding of lactate in cancer has evolved from a metabolic waste of"low-efficient"glucose metabolism,an acidification factor reshaping tumor microenvironments,to key molecular signals modulating signaling pathways,thereby influencing cell fates.Recently,Zhang’s work introduced a novel post-translational modification(PTM),lactylation,revealing a previously unidentified identity of lactate.Further findings in Plantae and Bacteria have projected lactylation as a common PTM among biological kingdoms.
