Crop varieties with broad-spectrum resistance(BSR)are highly beneficial,as they provide resistance against the majority of races within the same species of pathogen or even across multiple pathogen species(Li et al.,2...Crop varieties with broad-spectrum resistance(BSR)are highly beneficial,as they provide resistance against the majority of races within the same species of pathogen or even across multiple pathogen species(Li et al.,2020).Plant breeders usually introduce dominant resistance(R)genes in their breeding programs.However,these genes often recognize cognate avirulence effectors,resulting in race-specific resistance against a single or few pathogen strains(Li et al.,2019,2020).Recent studies have suggested that disabling some susceptibility(S)genes in elite cultivars could significantly enhance quantitative resistance,but the level of resistance is much less than qualitative resistance(van Schie and Takken,2014;Tao et al.,2021;Gao et al.,2024).Therefore,combining R gene stacks with S genes editing may represent an excellent strategy for achieving BSR and durable resistance(Deng et al.,2020;Jones et al.,2024).展开更多
基金supported by the National Key Research and Development Program of China(2022YFD1401400)National Natural Science Foundation of China(32272505 and 32161143009)+2 种基金Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSCB-202301)to Y.Nthe National Natural Science Foundation of China(U24A20388)to A.Lthe China Postdoctoral Science Foundation(2023M733827)to H.T.
文摘Crop varieties with broad-spectrum resistance(BSR)are highly beneficial,as they provide resistance against the majority of races within the same species of pathogen or even across multiple pathogen species(Li et al.,2020).Plant breeders usually introduce dominant resistance(R)genes in their breeding programs.However,these genes often recognize cognate avirulence effectors,resulting in race-specific resistance against a single or few pathogen strains(Li et al.,2019,2020).Recent studies have suggested that disabling some susceptibility(S)genes in elite cultivars could significantly enhance quantitative resistance,but the level of resistance is much less than qualitative resistance(van Schie and Takken,2014;Tao et al.,2021;Gao et al.,2024).Therefore,combining R gene stacks with S genes editing may represent an excellent strategy for achieving BSR and durable resistance(Deng et al.,2020;Jones et al.,2024).
