We revisit the issue of whether the effective potential for the conformal factor of the metric,which is generated by quantized matter fields,possesses a non-vanishing vacuum expectation value(VEV)or not.We prove that ...We revisit the issue of whether the effective potential for the conformal factor of the metric,which is generated by quantized matter fields,possesses a non-vanishing vacuum expectation value(VEV)or not.We prove that the effective potential has a vanishing vacuum expectation value on the basis of a global GL(4)symmetry.We also account for why there seems to be two different effective potentials for the conformal factor in a theory,one of which gives rise to a vanishing VEV for the conformal factor,whereas the other has a non-vanishing VEV.展开更多
Multi-component polymer systems exhibit exceptional versatility and structural diversity,making them indispensable in the polymer industry as well as in advanced and high performance applications.However,constructing ...Multi-component polymer systems exhibit exceptional versatility and structural diversity,making them indispensable in the polymer industry as well as in advanced and high performance applications.However,constructing accurate phase diagrams for these systems remains challenging due to inhomogeneous structures arising from the introduction of block copolymer components.Here,we present a unified and model-agnostic framework for computing phase equilibria in multi-component polymeric systems based on the concept of“effective chemical potential”.This approach directly connects key thermodynamic variables in the canonical ensemble to other ensembles,unifying phase coexistence determination without requiring the reformulation of self-consistent field theory(SCFT)calculations across different ensembles.By decoupling phase equilibrium determination from specific ensemble formulations,our approach enables the reuse of existing SCFT solvers.Moreover,it provides a useful framework to develop highly efficient phase equilibrium solvers for multi-component polymer systems.展开更多
Based on the Skyrme energy density functional and reaction Q-value,this study proposed an effective nucleus-nucleus poten-tial for describing the capture barrier in heavy-ion fusion processes.The 443 extracted barrier...Based on the Skyrme energy density functional and reaction Q-value,this study proposed an effective nucleus-nucleus poten-tial for describing the capture barrier in heavy-ion fusion processes.The 443 extracted barrier heights were well reproduced with a root-mean-square(RMS)error of 1.53 MeV,and the RMS deviations with respect to 144 time-dependent Hartree-Fock capture barrier heights were only 1.05 MeV.Coupled with the Siwek-Wilczyński formula,wherein three parameters were determined by the proposed effective potentials,the measured capture cross sections at energies around the barriers were reasonably well reproduced for several fusion reactions induced by nearly spherical nuclei as well as by nuclei with large deformations,such as^(154)Sm and^(238)U.The shallow capture pockets and small values of the average barrier radii resulted in the reduction of the capture cross sections for 52,54Cr-and 64 Ni-induced reactions,which were related to the synthesis of new super-heavy nuclei.展开更多
Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China ...Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.展开更多
To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmiss...To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmission paths of PM_(2.5) and O_(3) were studied.Based on the MeteoInfo software,the potential source areas and concentration contributions via the weighted potential source contribution function(WPSCF)and the weighted concentration weighted trajectory(WCWT)were analyzed.Besides,trajectory distribution at different starting heights were compared.The results of the backward trajectory(500 m)showed that the PM_(2.5) and O_(3) clustering trajectories were mainly derived from the northwest and passed through Yining/Ili and Tacheng.The air flow proportion of PM_(2.5) pollution was 44.83%in winter.With the highest pollution concentration(119.2μg/m^(3)),the pollution airflow proportion of O_(3) was 30.52%in summer.According to an analysis of the pressure profile,the atmospheric pressure was below 850 hPa in winter,indicating that the near-surface air mass had a substantial impact on PM_(2.5) concentrations,whereas in summer the pressure for O_(3) rose above 750 hP1,leading to higher pollutant concentrations.The WPSCF/WCWT results of PM_(2.5) demonstrated that the largest potential areas were identified in winter and were mainly distributed in Bozhou,Kuitun,and Shihezi(west of Urumqi,cultivated land/grassland),while the largest potential areas of O_(3) were distributed in Changji(east of Urumqi,barren land)and Turpan(southeast of Urumqi,grassland)in summer.The study indicates that the government should implement stricter measures to control regional transmission and air pollution.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Re...The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.595–603.展开更多
Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenv...Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.展开更多
Based on the Huybrechts' linear-combination operator,effects of thermal lattice vibration on the effective potential of weak-coupling bipolaron in semiconductor quantum dots are studied by using the LLP variationa...Based on the Huybrechts' linear-combination operator,effects of thermal lattice vibration on the effective potential of weak-coupling bipolaron in semiconductor quantum dots are studied by using the LLP variational method and quantum statistical theory.The results show that the absolute value of the induced potential of the bipolaron increases with increasing the electron-phonon coupling strength,but decreases with increasing the temperature and the distance of electrons,respectively;the absolute value of the effective potential increases with increasing the radius of the quantum dot,electron-phonon coupling strength and the distance of electrons,respectively,but decreases with increasing the temperature;the temperature and electron-phonon interaction have the important influence on the formation and state properties of the bipolaron:the bipolarons in the bound state are closer and more stable when the electron-phonon coupling strength is larger or the temperature is lower;the confinement potential and coulomb repulsive potential between electrons are unfavorable to the formation of bipolarons in the bound state.展开更多
It is arguable that the development of reinforcing roof bolting systems has largely stagnated in recent times, primarily due to the prevailing industry view that few, if any, further improvements can be made to what c...It is arguable that the development of reinforcing roof bolting systems has largely stagnated in recent times, primarily due to the prevailing industry view that few, if any, further improvements can be made to what currently exists.However, this paper contends that reinforcing roof bolting systems can be further refined by considering both the specific manner by which horizontally bedded roof strata loses its natural self-supporting ability and the specific means by which reinforcing roof bolts act to promote or retain this natural self-supporting ability.The Australian coal industry has insisted on minimising bolt-hole diameter to maximise load transfer and on targeting full-encapsulation by any means necessary for many years.This has led to a significant, albeit unintended, consequence in terms of overall roof bolting effectiveness, namely increased resin pressures during bolt installation and the associated potential for opening bedding planes that may have, otherwise, remained closed during the bolt installation process.Given that the natural self-supporting ability of roof strata is strongly linked to whether bedding planes are open or closed, logically, minimising resin pressures should be a significant benefit.This paper focuses primarily on three key issues that relate directly to the function of the roof bolting system itself:(1) the importance of proper resin mixing in the context of maximising load transfer strength and stiffness,(2) the importance of minimising resin pressures developed during bolt installation, and(3) the importance of maximising the effectiveness of the available bolt pre-tension.All mine operators should be invested in improving the individual effectiveness of each installed roof bolt, even by relatively small incremental amounts, so this is an important topic for discussion within the mining community.展开更多
We complete the derivation of the Cornwall-Jackiw-Tomboulis effective potentiM for quark propagator at finite temperature and finite quark chemical potential in the real-time formalism of thermal field theory and in L...We complete the derivation of the Cornwall-Jackiw-Tomboulis effective potentiM for quark propagator at finite temperature and finite quark chemical potential in the real-time formalism of thermal field theory and in Landau gauge. In the approximation that the function A（p^2） in inverse quark propagator is replaced by unity, by means of the running gauge coupling and the quark mass function invariant under the renormalization group in zero temperature Quantum Chromadynamics （QCD）, we obtain a calculable expression for the thermal effective potential, which will be a useful means to research chiral phase transition in QCD in the real-time formalism.展开更多
We have proven the general relations between the gap equations obeyed by dynamical fermion mass and thecorresponding effective potentials at finite temperature and chemical potential in D-dimensional four-fermion inte...We have proven the general relations between the gap equations obeyed by dynamical fermion mass and thecorresponding effective potentials at finite temperature and chemical potential in D-dimensional four-fermion interactionmodels. This gives an easy approach to get effective potentials directly from the gap equations. We find out explicitexpressions for the effective potentials at zero temperature in the cases of D = 2,3, and 4 for practical use.展开更多
We calculate for the first time the static properties of the deuteron, within the framework of supersymmetric quantum mechanics, analytically. A new effective potential and its partner are derived from a superpotentia...We calculate for the first time the static properties of the deuteron, within the framework of supersymmetric quantum mechanics, analytically. A new effective potential and its partner are derived from a superpotential so that all parameters are fitted by the experimental data. An analytical expression is obtained for the deuteron wave function and contributions of the orthogonal ^(13)S_(1) and ^(13)D_(1) states are determined, explicitly. Compared to one pion exchange, the superpotential produces an electrostatic as well as two pion exchange terms for the potential. The saddle point radius of the potential and the maximum of the wave function are linearly proportional. In comparison with other methods, the approach presented in this paper is a new and extensible symmetry-based approach that, despite its straightforward calculations and explicit analytical expressions, provides a good explanation for two-body effective interactions such as two-nucleon systems and diatomic molecules.展开更多
We study force generation and motion of molecular motors using a simple two-state model in the paper.Asymmetric and periodic potential is adopted to describe the interaction between motor proteins and filaments that a...We study force generation and motion of molecular motors using a simple two-state model in the paper.Asymmetric and periodic potential is adopted to describe the interaction between motor proteins and filaments that are periodic and polar. The current and the slope of the effective potential as functions of the temperature and transition rates are calculated in the two-state model. The ratio of the slope of the effective potential to the current is also calculated. It is shown that the directed motion of motor proteins is relevant to the effective potential. The slope of the effective potential corresponds to an average force. The non-vanishing force therefore implies that detailed balance is broken in the process of transition between different states.展开更多
In the framework of the functional integral formalism, we calculate the effective potential of the double sine-Gordon (DsG) model up to the second order with an optimized expansion and the Coleman's normal-orderin...In the framework of the functional integral formalism, we calculate the effective potential of the double sine-Gordon (DsG) model up to the second order with an optimized expansion and the Coleman's normal-ordering prescription. Within the range of convergence, we make a comparison among the classicaland the effective potential of the first and second order. The numerical analysis shows that the DsG post-Gaussian EP possesses some fine global properties and makes a substantial and a concordant quantum correction to the features of the classical potential.展开更多
Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer.However,the specific effective components and the potential mechanism of Poria remain largely unknown.To identify the ef...Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer.However,the specific effective components and the potential mechanism of Poria remain largely unknown.To identify the effective components and the mechanism of Poria water extract(PWE)to treat dampness stagnancy due to spleen deficiency syndrome(DSSD),a rat model of DSSD was established through weight-loaded forced swimming,intragastric ice-water stimulation,humid living environment,and alternate-day fasting for 21 days.After 14 days of treatment with PWE,the results indicated that PWE increased fecal moisture percentage,urine output,D-xylose level and weight;amylase,albumin,and total protein levels;and the swimming time of rats with DSSD to different extents.Eleven highly related components were screened out using the spectrum-effect relationship and LC-MS.Mechanistic studies revealed that PWE significantly increased the expression of serum motilin(MTL),gastrin(GAS),ADCY5/6,p-PKAα/β/γcat,and phosphorylated cAMP-response element binding protein in the stomach,and AQP3 expression in the colon.Moreover,it decreased the levels of serum ADH,the expression of AQP3 and AQP4 in the stomach,AQP1 and AQP3 in the duodenum,and AQP4 in the colon.PWE induced diuresis to drain dampness in rats with DSSD.Eleven main effective components were identified in PWE.They exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach,MTL and GAS levels in the serum,AQP1 and AQP3 expression in the duodenum,and AQP3 and AQP4 expression in the colon.展开更多
Summary： The effect of acute ischemia on the electrophysiological characteristics of the three layers myocardium of canine in vivo was investigated. Twelve canines were divided into two groups randomly： acute ischem...Summary： The effect of acute ischemia on the electrophysiological characteristics of the three layers myocardium of canine in vivo was investigated. Twelve canines were divided into two groups randomly： acute ischemia （AI） group and sham operation （SO） group. By using the monophasic action potential （MAP） technique, MAP and effective refractory period （ERP） of the three layers myocardium were measured by specially designed plunge needle electrodes and the transmural dispersion of repolarization （TDR） and transmural dispersion of ERP （TDE） were analyzed. The results showed that in the AI group, MAP duration （MAPD） was shortened from 201.67±21.42 ms to 169.50±13.81 ms （P〈0.05）, but ERP prolonged to varying degrees and TDE increased during ischemia. In the SO group, MAPD and ERP did not change almost. Among of the three layers myocardium of canine, MAPD was coincident in two groups. It was concluded that during acute ischemia, MAPD was shortened sharply, but there was no significant difference among of the three layers myocardium. The prolonged ERP was concomitant with increased TDE during acute ischemia, which may play an important role in the occurrence of arrhythmias induced by acute ischemia. These findings may have important implications in arrhythmogenesis.展开更多
We investigate the many-body wave function of a quantum system with time-dependent effective mass, confined by a harmonic potential with time-dependent frequency, and perturbed by a time-dependent spatially homogeneou...We investigate the many-body wave function of a quantum system with time-dependent effective mass, confined by a harmonic potential with time-dependent frequency, and perturbed by a time-dependent spatially homogeneous electric field. It is found that the wave function is comprised of a phase factor times the solution to the unperturbed time-dependent Schr6dinger equation with the latter being translated by a time-dependent value that satisfies the classical driven equation of motion. The wave function reduces to that of the harmonic potential theorem wave function when both the effective mass and frequency are static. An example of application is also given.展开更多
Using experimental values of the structure factor of liquid Se1-xTex(x =0. 0, 0. 6, 0. 7, 0. 8, 1. 0. ) alloys measured by Takeda et al., the potential functions at different compositions are derived from Rao-Joarder&...Using experimental values of the structure factor of liquid Se1-xTex(x =0. 0, 0. 6, 0. 7, 0. 8, 1. 0. ) alloys measured by Takeda et al., the potential functions at different compositions are derived from Rao-Joarder'S equation. From the change of the shape of the potential function at different compositions, we can infer that when x is between 0. 7 and 0. 8 the nonmetal-metal transition occurs in this system. This is the first time to use the calculation of the potential function to find the NM-M transition Furthermore we give the longitudinal and transverse phonon frequencies by using Bhatia-Singh'S model. Then the elastic constants are computed. Using the potential function, the characteristic frequency is obtained and compared with the average frequency, Debye frequency, and the maximum longitudinal frequency compute4 by other methods. Finally, we compare the sound velocities calculated from the elastic constants in the long-wave limit with corresponding experimental values.展开更多
We study the stochastic motion of a Brownian particle driven by a constant force over a static periodic potential. We show that both the effective diffusion and the effective drag coefficient are mathematically well-d...We study the stochastic motion of a Brownian particle driven by a constant force over a static periodic potential. We show that both the effective diffusion and the effective drag coefficient are mathematically well-defined and we derive analytic expressions for these two quantities. We then investigate the asymptotic behaviors of the effective diffusion and the effective drag coefficient, respectively, for small driving force and for large driving force. In the case of small driving force, the effective diffusion is reduced from its Brownian value by a factor that increases exponentially with the amplitude of the potential. The effective drag coefficient is increased by approximately the same factor. As a result, the Einstein relation between the diffusion coefficient and the drag coefficient is approximately valid when the driving force is small. For moderately large driving force, both the effective diffusion and the effective drag coefficient are increased from their Brownian values, and the Einstein relation breaks down. In the limit of very large driving force, both the effective diffusion and the effective drag coefficient converge to their Brownian values and the Einstein relation is once again valid.展开更多
基金supported in part by the JSPS Kakenhi under Grant No.21K03539。
文摘We revisit the issue of whether the effective potential for the conformal factor of the metric,which is generated by quantized matter fields,possesses a non-vanishing vacuum expectation value(VEV)or not.We prove that the effective potential has a vanishing vacuum expectation value on the basis of a global GL(4)symmetry.We also account for why there seems to be two different effective potentials for the conformal factor in a theory,one of which gives rise to a vanishing VEV for the conformal factor,whereas the other has a non-vanishing VEV.
基金supported by the National Natural Science Foundation of China(No.21873021).
文摘Multi-component polymer systems exhibit exceptional versatility and structural diversity,making them indispensable in the polymer industry as well as in advanced and high performance applications.However,constructing accurate phase diagrams for these systems remains challenging due to inhomogeneous structures arising from the introduction of block copolymer components.Here,we present a unified and model-agnostic framework for computing phase equilibria in multi-component polymeric systems based on the concept of“effective chemical potential”.This approach directly connects key thermodynamic variables in the canonical ensemble to other ensembles,unifying phase coexistence determination without requiring the reformulation of self-consistent field theory(SCFT)calculations across different ensembles.By decoupling phase equilibrium determination from specific ensemble formulations,our approach enables the reuse of existing SCFT solvers.Moreover,it provides a useful framework to develop highly efficient phase equilibrium solvers for multi-component polymer systems.
基金supported by the National Natural Science Foundation of China(Nos.12265006,12375129,U1867212)the Innovation Project of Guangxi Graduate Education(No.YCSWYCSW2022176)the Guangxi Natural Science Foundation(2017GXNSFGA198001).
文摘Based on the Skyrme energy density functional and reaction Q-value,this study proposed an effective nucleus-nucleus poten-tial for describing the capture barrier in heavy-ion fusion processes.The 443 extracted barrier heights were well reproduced with a root-mean-square(RMS)error of 1.53 MeV,and the RMS deviations with respect to 144 time-dependent Hartree-Fock capture barrier heights were only 1.05 MeV.Coupled with the Siwek-Wilczyński formula,wherein three parameters were determined by the proposed effective potentials,the measured capture cross sections at energies around the barriers were reasonably well reproduced for several fusion reactions induced by nearly spherical nuclei as well as by nuclei with large deformations,such as^(154)Sm and^(238)U.The shallow capture pockets and small values of the average barrier radii resulted in the reduction of the capture cross sections for 52,54Cr-and 64 Ni-induced reactions,which were related to the synthesis of new super-heavy nuclei.
基金supported by the National Natural Science Foundation of China(No.41975156)and the Fundamental Research Funds for the Central Universities.
文摘Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.
基金supported by the Central Guiding Local Science and Technology Development Fund Projects(No.236Z4203G)the Science Research Project of Hebei Education Department(No.BJK2024008)+2 种基金Hebei Provincial Graduate Demonstration Course Project and Construction Project(No.KCJSX2022085)Tangshan Municipal Science and Technology Plan-Key Research and Development Plan project(No.22150231J)the Opening Project of Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3)(No.FDLAP20005).
文摘To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmission paths of PM_(2.5) and O_(3) were studied.Based on the MeteoInfo software,the potential source areas and concentration contributions via the weighted potential source contribution function(WPSCF)and the weighted concentration weighted trajectory(WCWT)were analyzed.Besides,trajectory distribution at different starting heights were compared.The results of the backward trajectory(500 m)showed that the PM_(2.5) and O_(3) clustering trajectories were mainly derived from the northwest and passed through Yining/Ili and Tacheng.The air flow proportion of PM_(2.5) pollution was 44.83%in winter.With the highest pollution concentration(119.2μg/m^(3)),the pollution airflow proportion of O_(3) was 30.52%in summer.According to an analysis of the pressure profile,the atmospheric pressure was below 850 hPa in winter,indicating that the near-surface air mass had a substantial impact on PM_(2.5) concentrations,whereas in summer the pressure for O_(3) rose above 750 hP1,leading to higher pollutant concentrations.The WPSCF/WCWT results of PM_(2.5) demonstrated that the largest potential areas were identified in winter and were mainly distributed in Bozhou,Kuitun,and Shihezi(west of Urumqi,cultivated land/grassland),while the largest potential areas of O_(3) were distributed in Changji(east of Urumqi,barren land)and Turpan(southeast of Urumqi,grassland)in summer.The study indicates that the government should implement stricter measures to control regional transmission and air pollution.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
文摘AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
文摘The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.595–603.
文摘Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.
基金Supported by the Items of Institution of Higher Education Scientific Research of Inner Mongolia under Grant No. NJ101116
文摘Based on the Huybrechts' linear-combination operator,effects of thermal lattice vibration on the effective potential of weak-coupling bipolaron in semiconductor quantum dots are studied by using the LLP variational method and quantum statistical theory.The results show that the absolute value of the induced potential of the bipolaron increases with increasing the electron-phonon coupling strength,but decreases with increasing the temperature and the distance of electrons,respectively;the absolute value of the effective potential increases with increasing the radius of the quantum dot,electron-phonon coupling strength and the distance of electrons,respectively,but decreases with increasing the temperature;the temperature and electron-phonon interaction have the important influence on the formation and state properties of the bipolaron:the bipolarons in the bound state are closer and more stable when the electron-phonon coupling strength is larger or the temperature is lower;the confinement potential and coulomb repulsive potential between electrons are unfavorable to the formation of bipolarons in the bound state.
文摘It is arguable that the development of reinforcing roof bolting systems has largely stagnated in recent times, primarily due to the prevailing industry view that few, if any, further improvements can be made to what currently exists.However, this paper contends that reinforcing roof bolting systems can be further refined by considering both the specific manner by which horizontally bedded roof strata loses its natural self-supporting ability and the specific means by which reinforcing roof bolts act to promote or retain this natural self-supporting ability.The Australian coal industry has insisted on minimising bolt-hole diameter to maximise load transfer and on targeting full-encapsulation by any means necessary for many years.This has led to a significant, albeit unintended, consequence in terms of overall roof bolting effectiveness, namely increased resin pressures during bolt installation and the associated potential for opening bedding planes that may have, otherwise, remained closed during the bolt installation process.Given that the natural self-supporting ability of roof strata is strongly linked to whether bedding planes are open or closed, logically, minimising resin pressures should be a significant benefit.This paper focuses primarily on three key issues that relate directly to the function of the roof bolting system itself:(1) the importance of proper resin mixing in the context of maximising load transfer strength and stiffness,(2) the importance of minimising resin pressures developed during bolt installation, and(3) the importance of maximising the effectiveness of the available bolt pre-tension.All mine operators should be invested in improving the individual effectiveness of each installed roof bolt, even by relatively small incremental amounts, so this is an important topic for discussion within the mining community.
文摘We complete the derivation of the Cornwall-Jackiw-Tomboulis effective potentiM for quark propagator at finite temperature and finite quark chemical potential in the real-time formalism of thermal field theory and in Landau gauge. In the approximation that the function A（p^2） in inverse quark propagator is replaced by unity, by means of the running gauge coupling and the quark mass function invariant under the renormalization group in zero temperature Quantum Chromadynamics （QCD）, we obtain a calculable expression for the thermal effective potential, which will be a useful means to research chiral phase transition in QCD in the real-time formalism.
文摘We have proven the general relations between the gap equations obeyed by dynamical fermion mass and thecorresponding effective potentials at finite temperature and chemical potential in D-dimensional four-fermion interactionmodels. This gives an easy approach to get effective potentials directly from the gap equations. We find out explicitexpressions for the effective potentials at zero temperature in the cases of D = 2,3, and 4 for practical use.
基金the financial support from Golestan University and Istanbul University。
文摘We calculate for the first time the static properties of the deuteron, within the framework of supersymmetric quantum mechanics, analytically. A new effective potential and its partner are derived from a superpotential so that all parameters are fitted by the experimental data. An analytical expression is obtained for the deuteron wave function and contributions of the orthogonal ^(13)S_(1) and ^(13)D_(1) states are determined, explicitly. Compared to one pion exchange, the superpotential produces an electrostatic as well as two pion exchange terms for the potential. The saddle point radius of the potential and the maximum of the wave function are linearly proportional. In comparison with other methods, the approach presented in this paper is a new and extensible symmetry-based approach that, despite its straightforward calculations and explicit analytical expressions, provides a good explanation for two-body effective interactions such as two-nucleon systems and diatomic molecules.
文摘We study force generation and motion of molecular motors using a simple two-state model in the paper.Asymmetric and periodic potential is adopted to describe the interaction between motor proteins and filaments that are periodic and polar. The current and the slope of the effective potential as functions of the temperature and transition rates are calculated in the two-state model. The ratio of the slope of the effective potential to the current is also calculated. It is shown that the directed motion of motor proteins is relevant to the effective potential. The slope of the effective potential corresponds to an average force. The non-vanishing force therefore implies that detailed balance is broken in the process of transition between different states.
文摘In the framework of the functional integral formalism, we calculate the effective potential of the double sine-Gordon (DsG) model up to the second order with an optimized expansion and the Coleman's normal-ordering prescription. Within the range of convergence, we make a comparison among the classicaland the effective potential of the first and second order. The numerical analysis shows that the DsG post-Gaussian EP possesses some fine global properties and makes a substantial and a concordant quantum correction to the features of the classical potential.
基金supported by the Key Technologies Research and Development Program(No.2017YFC1703004)Hubei Technological Innovation Special Fund(No.2019ACA121).
文摘Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer.However,the specific effective components and the potential mechanism of Poria remain largely unknown.To identify the effective components and the mechanism of Poria water extract(PWE)to treat dampness stagnancy due to spleen deficiency syndrome(DSSD),a rat model of DSSD was established through weight-loaded forced swimming,intragastric ice-water stimulation,humid living environment,and alternate-day fasting for 21 days.After 14 days of treatment with PWE,the results indicated that PWE increased fecal moisture percentage,urine output,D-xylose level and weight;amylase,albumin,and total protein levels;and the swimming time of rats with DSSD to different extents.Eleven highly related components were screened out using the spectrum-effect relationship and LC-MS.Mechanistic studies revealed that PWE significantly increased the expression of serum motilin(MTL),gastrin(GAS),ADCY5/6,p-PKAα/β/γcat,and phosphorylated cAMP-response element binding protein in the stomach,and AQP3 expression in the colon.Moreover,it decreased the levels of serum ADH,the expression of AQP3 and AQP4 in the stomach,AQP1 and AQP3 in the duodenum,and AQP4 in the colon.PWE induced diuresis to drain dampness in rats with DSSD.Eleven main effective components were identified in PWE.They exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach,MTL and GAS levels in the serum,AQP1 and AQP3 expression in the duodenum,and AQP3 and AQP4 expression in the colon.
文摘Summary： The effect of acute ischemia on the electrophysiological characteristics of the three layers myocardium of canine in vivo was investigated. Twelve canines were divided into two groups randomly： acute ischemia （AI） group and sham operation （SO） group. By using the monophasic action potential （MAP） technique, MAP and effective refractory period （ERP） of the three layers myocardium were measured by specially designed plunge needle electrodes and the transmural dispersion of repolarization （TDR） and transmural dispersion of ERP （TDE） were analyzed. The results showed that in the AI group, MAP duration （MAPD） was shortened from 201.67±21.42 ms to 169.50±13.81 ms （P〈0.05）, but ERP prolonged to varying degrees and TDE increased during ischemia. In the SO group, MAPD and ERP did not change almost. Among of the three layers myocardium of canine, MAPD was coincident in two groups. It was concluded that during acute ischemia, MAPD was shortened sharply, but there was no significant difference among of the three layers myocardium. The prolonged ERP was concomitant with increased TDE during acute ischemia, which may play an important role in the occurrence of arrhythmias induced by acute ischemia. These findings may have important implications in arrhythmogenesis.
基金Supported by the National Natural Science Foundation of China under Grant No 11275100the K.C.Wong Magna Foundation of Ningbo University
文摘We investigate the many-body wave function of a quantum system with time-dependent effective mass, confined by a harmonic potential with time-dependent frequency, and perturbed by a time-dependent spatially homogeneous electric field. It is found that the wave function is comprised of a phase factor times the solution to the unperturbed time-dependent Schr6dinger equation with the latter being translated by a time-dependent value that satisfies the classical driven equation of motion. The wave function reduces to that of the harmonic potential theorem wave function when both the effective mass and frequency are static. An example of application is also given.
文摘Using experimental values of the structure factor of liquid Se1-xTex(x =0. 0, 0. 6, 0. 7, 0. 8, 1. 0. ) alloys measured by Takeda et al., the potential functions at different compositions are derived from Rao-Joarder'S equation. From the change of the shape of the potential function at different compositions, we can infer that when x is between 0. 7 and 0. 8 the nonmetal-metal transition occurs in this system. This is the first time to use the calculation of the potential function to find the NM-M transition Furthermore we give the longitudinal and transverse phonon frequencies by using Bhatia-Singh'S model. Then the elastic constants are computed. Using the potential function, the characteristic frequency is obtained and compared with the average frequency, Debye frequency, and the maximum longitudinal frequency compute4 by other methods. Finally, we compare the sound velocities calculated from the elastic constants in the long-wave limit with corresponding experimental values.
文摘We study the stochastic motion of a Brownian particle driven by a constant force over a static periodic potential. We show that both the effective diffusion and the effective drag coefficient are mathematically well-defined and we derive analytic expressions for these two quantities. We then investigate the asymptotic behaviors of the effective diffusion and the effective drag coefficient, respectively, for small driving force and for large driving force. In the case of small driving force, the effective diffusion is reduced from its Brownian value by a factor that increases exponentially with the amplitude of the potential. The effective drag coefficient is increased by approximately the same factor. As a result, the Einstein relation between the diffusion coefficient and the drag coefficient is approximately valid when the driving force is small. For moderately large driving force, both the effective diffusion and the effective drag coefficient are increased from their Brownian values, and the Einstein relation breaks down. In the limit of very large driving force, both the effective diffusion and the effective drag coefficient converge to their Brownian values and the Einstein relation is once again valid.
