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Comparison of Hypolipidemic Effect of Refined Konjac Meal With Several Common Dietary Fibers and Their Mechanisms of Action 被引量:5
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作者 WU JIE AND PENG +1 位作者 SHU-SHENG (Department of Nutrition and Food Hygiene, Nantong Medical College, Nantong City, 226001, Jiangsu, China Department of Nutrition and Food Hygiene, West China University of Medical Sciences,Chengdu, Sichuan, China) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第1期27-37,共11页
The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition... The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition and output of fecal bile acid were observed. All four kinds of dietary fiber were given at a level of 5% of diet to young male rats of Wistar strain fed on a lipid-rich diet contalning 5 % lard, 1% cholesteral and 0. 25 % cholate. All the dietary fibers tested have similar effects on serum lipid composition. In all groups, these substances prevent ed increases in total cholesterol in fasting serum, but the level of triglyceride was tmchangd.The concentrations of totaI cholesterol and triglyceride in the liver were lower in the RKM group than in the control group and the other three groups. Hepatic histopathological exami nation also showed the most significant lipotropic effect in the RKM group. The daily output of fecal bile acids (CDCA+GDCA) was significantly increased in the four experimental groups than in the normal group and the control group. The increase of CDCA was more significant than GDCA, suggesting that the increase of fecal bile acids, especially CDCA, may be one of the mechanisms by which RKM and the other three dietary fibers exerts a hypocholesterolemic effect 展开更多
关键词 acid Am Br comparison of Hypolipidemic effect of Refined Konjac Meal With Several Common Dietary Fibers and Their Mechanisms of Action CDCA
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COMPARISON OF ASSISTANT EFFECTS AMONG ASSISTANT MOLECULES ON T CELL ACTIVATION BY SUPERANTIGEN TSST-1
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作者 胡伟钢 朱锡华 +1 位作者 吴玉章 贾正才 《免疫学杂志》 CAS CSCD 北大核心 1997年第2期71-78,共8页
对抗CD28抗体、佛波酯(PMA)和IL-2三种辅助分子在体外缺乏抗原提呈细胞(APC)的情况下辅助超抗原活化T细胞的作用进行比较。结果发现:抗CD28抗体、PMA和IL-2辅助超抗原活化T细胞的最适浓度分别为10μ... 对抗CD28抗体、佛波酯(PMA)和IL-2三种辅助分子在体外缺乏抗原提呈细胞(APC)的情况下辅助超抗原活化T细胞的作用进行比较。结果发现:抗CD28抗体、PMA和IL-2辅助超抗原活化T细胞的最适浓度分别为10μg/ml、10ng/ml和1000u/ml;其中,抗CD28抗体辅助超抗原活化T细胞的作用最强,PMA次之,IL-2最弱。另外,对三种辅助分子辅助超抗原活化T细胞的机制进行了探讨。本研究为今后选择合适的辅助分子与合成肽技术共同组建一种有效的探找超抗原T细胞表位的方法奠定了基础。 展开更多
关键词 超抗原 辅助分子 辅助作用 抗原 抗CD28抗体 PMA
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Comparison of the Thermomagnetic and Thermal Effects duringNanocrystallization of Amorphous Fe_(76.5-x)Cu_1Nb_xSi_(13.5)B_9 Alloys 被引量:1
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作者 B.Varga and Tak■cs(Dept. of Mechanical Engineering Technology Technical University of Budapest, H-1111 Budapest Bertalan L. utca 2., Hungary) A.Lovas and P.Kamasa(Research Institute for Solid State Physics, Hungarian Academy of Sciences, H-1525 Budapest, 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 1998年第4期323-326,共4页
The results of thermomagnetic (TM) and calorimetric (DSC) measurements have been compared in order to clarify some details of the mechanism of nanophase-formation from Finemet-type precursors with different Nb content... The results of thermomagnetic (TM) and calorimetric (DSC) measurements have been compared in order to clarify some details of the mechanism of nanophase-formation from Finemet-type precursors with different Nb contents. It was found that the main features of the DSC thermograms (shape, relative separation and amplitude of the exothermic peaks characteristic for the precipitation of the Fe-(Si) solid solution and the transition metal borides) depend mainly on the composition of the precursor glass, and are only slightly affected by the heating rate between 20 and 80 K/min. The amplitude of the uprise of the magnetization in the TM curves (attributed to the precipitation of bcc-Fe(Si) and borides) decreases with increasing Nb-content. The Curietemperature of the precursor glasses. Tc(am1), the remainder amorphous phases, Tc(am2) and the bcc nanophase, Tc(n-Fe) are determined from the thermomagnetic curves. The shape of the TM curves is interpreted on the basis of the reactions describing the crystalIization of the hypo-eutectic Fe-B glasses. 展开更多
关键词 comparison of the Thermomagnetic and Thermal effects duringNanocrystallization of Amorphous Fe B9 Alloys CU x)Cu1NbxSi
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COMPARISON OF THE EFFECTIVENESS BETWEEN ANTERIOR CAPSULOTOMY WITH Nd:YAG LASER AND WITH BENT NEEDLE IN PATIENTS WITH CONGENITAL CATARACT
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作者 Zhende Lin Shaozhen Li Eye Hospital, Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060,China 《眼科学报》 1991年第3期125-127,124,共4页
The effectiveness of capsulotomy with Nd:YAG laser and with bent needle were compared in 50 patients(66 eyes) with congenital cataract. There were 24 patients(32 eyes) in the laser group and 26 patients(34 eyes) in th... The effectiveness of capsulotomy with Nd:YAG laser and with bent needle were compared in 50 patients(66 eyes) with congenital cataract. There were 24 patients(32 eyes) in the laser group and 26 patients(34 eyes) in the needle group. There were not significant differences in sex, age, pre-operative visual acuity and intraocular pressures, and classification of cataract between the two groups. The results show that patients in the laser group have better post-operative visual acuity. The reason is YAG las... 展开更多
关键词 YAG comparison OF THE effectIVENESS BETWEEN ANTERIOR CAPSULOTOMY WITH Nd ND
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Comparison of the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin
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作者 沈宏亮 《外科研究与新技术》 2003年第2期70-70,共1页
Objective To compare the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin (EPO). Methods Thirty patients aged 8-21 yr, undergoing surgical correction of kyphosc... Objective To compare the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin (EPO). Methods Thirty patients aged 8-21 yr, undergoing surgical correction of kyphoscoliosis were randomly divided into two groups of fifteen:group A and group B. In group A patients received homologous transfusion during operation, while in group B shed blood was collected from operative field and after filtration RBCs were separated by a differential centrifugation and washed in normal saline and reinfused. Anesthesia was induced with fentanyl 2 μg· kg-1 ,propofol 1 mg·kg-1 and vecuronium 0.1 mg·kg-1 and maintained with inhalation of isoflurane and 50 % N2O in oxygen and intermittent iv boluses of vecuronium and fentanyl. Blood routine, blood gases, electrolytes, plasma osmotic pressure and activated clotting time (ACT) were measured before operation, 2 h after skin incision and at the end of surgery. Blood EPO concentration was measured before operation,at the end 展开更多
关键词 of comparison of the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin
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Comparison of Water and Soil Conservation Effect of Trees,Shrubs and Grasses in the Red Soil Area of Southern China
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作者 Shaoyun PENG Zhujun GU Ping XIU 《Asian Agricultural Research》 2013年第10期106-110,116,共6页
Assessing the effects of vegetation on water and soil conversation is the key basis for research and management of ecological restoration on water-eroded areas.In this study,the runoff depth,soil loss and correspondin... Assessing the effects of vegetation on water and soil conversation is the key basis for research and management of ecological restoration on water-eroded areas.In this study,the runoff depth,soil loss and corresponding precipitation of five plots planted respectively with Pueraria lobata,Lespedeza bicolor Turcz,Manglietia yuyuanensis Law,Paspalum natatu Fliigge,Paspalum wettsteinii Hackel and one control plot were observed monthly from 2003 to 2010 in Hetian Town of Changting County,Fujian Province,a typical water-eroded area in southern China.Then the effects of different vegetation on water/soil conversation(RE/SE)were determined using the ratios of runoff depth/soil loss between vegetated plots to the control plot.Meanwhile,the effect of precipitation on the water and soil loss was also analyzed.The results showed that,both the water and soil conservation effects of Pueraria lobata and Manglietia yuyuanensis Law are better than Lespedeza bicolor Turcz and Paspalum natatu,while Paspalum wettsteinii Hackel are the worst.The differences of effects of water conservation are more significantly than those of soil conversation between five kinds of vegetations.The runoff depth is mainly affected by precipitation,the determination coefficients(R2)of linear regression models between precipitation and runoff depth of all planted plots are all greater than 0.9,whereas the determination coefficients of the linear regression models between precipitation and soil loss vary form 0.3 to 0.8 for different vegetated plots.These results provide a reference for vegetation reconstruction in the current and similar areas. 展开更多
关键词 effect VEGETATION type RUNOFF Soil erosion Multipl
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A comparison of the short-term effects of fixed platform versus rotating high-fiexion prosthesis for the patients with osteoarthrities of knee
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作者 杨赞礼 《外科研究与新技术》 2011年第2期119-120,共2页
Objective To compare the preliminary clinical outcome between fixed platform and rotating high-flexion prosthesis following total knee replacement(TKR).Methods Form January 2007 to December 2009,68 patients with osteo... Objective To compare the preliminary clinical outcome between fixed platform and rotating high-flexion prosthesis following total knee replacement(TKR).Methods Form January 2007 to December 2009,68 patients with osteoarthritis of 展开更多
关键词 HSS high TKR A comparison of the short-term effects of fixed platform versus rotating high-fiexion prosthesis for the patients with osteoarthrities of knee
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Protective Effects of Common Masks against PM2.5 被引量:1
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作者 Zhang Xianbao Qiu Jian Chen Cheng 《Meteorological and Environmental Research》 CAS 2016年第2期24-26,共3页
By using two PM2.5 automatic monitors,the protective effects of five common masks against PM2.5 were synchronously tested under actual ambient air conditions for a whole day. The results showed that not all masks had ... By using two PM2.5 automatic monitors,the protective effects of five common masks against PM2.5 were synchronously tested under actual ambient air conditions for a whole day. The results showed that not all masks had protective effects on PM2.5,and the protective effects of masks N95 and N90,which were designed specially for dust-proof,were superior among the five tested masks. 展开更多
关键词 Masks PM2.5 Protective effect comparison Simulation China
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Effect of Teacher Feedback, Peer Review and the Combination on EFL Writing Study Proposal
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作者 姚静 邢伟华 《海外英语》 2015年第8期96-97,共2页
Since the result of effect comparison is important for teacher's decision making,roles teacher feedback and peer review play respectively and collaboratively in tertiary-level EFL writing context should be address... Since the result of effect comparison is important for teacher's decision making,roles teacher feedback and peer review play respectively and collaboratively in tertiary-level EFL writing context should be addressed via quantitative study as this paper proposed.Quantitative data should be collected from students'first drafts,second drafts and written comments from teachers and peers.Gains for overall scores between the first and second drafts and correlation between suggestions and gains should be examined. 展开更多
关键词 TEACHER feedback PEER review EFL writing quantitative STUDY effect comparison
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Comparison of Transperineum and Transrectal Prostate Puncture Biopsy Guided by Rectal Ultrasound
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作者 ZHANGXiaolei 《外文科技期刊数据库(文摘版)医药卫生》 2022年第3期094-097,共4页
Objective: to compare the effect of transperineum and transrectal prostate puncture biopsy guided by rectal ultrasound. Methods: 117 patients who underwent perineal and transrectal prostate puncture biopsy from 2019 t... Objective: to compare the effect of transperineum and transrectal prostate puncture biopsy guided by rectal ultrasound. Methods: 117 patients who underwent perineal and transrectal prostate puncture biopsy from 2019 to 2021, including 58 patients and 59 patients from transrectal prostate puncture biopsy group, were selected to compare the final effect of patients with different puncture biopsies. Results: the effect of perineal biopsy was better than transrectal prostate biopsy, and patients were significantly lower than transrectal prostate biopsy. Conclusion: on the whole, the two rectal biopsy methods differ the actual biopsy results, which can check the disease well, but the related complications of perineal puncture biopsy will be relatively low. 展开更多
关键词 rectal ultrasound guidance transperineal puncture transrectal prostate puncture effect comparison
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The Biological Promotion Effect of a new Biological Promotive Ceramsite 被引量:2
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作者 邱珊 马放 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2010年第4期604-608,共5页
Tourmaline can promote the growth of microorganisms under the temperature less than 900 ℃ by experiment. However, this promotion effect will vanish at 900 ℃ as a result of denaturation. Through the XRD analysis the ... Tourmaline can promote the growth of microorganisms under the temperature less than 900 ℃ by experiment. However, this promotion effect will vanish at 900 ℃ as a result of denaturation. Through the XRD analysis the crystal form change can explain the vanishment of tourmaline’s biological promotion effect at high temperature. Therefore, tourmaline as a biological promoter was used to prepare a kind of biological promotive ceramsite with the surface area of 7.914 m2/g, pore volume of 0.1002 mg/L, superficial pH value of 7.8, Zeta potential of 25 mV, unit water absorption of 0.1365 g/g, biocompatibility of 0.023 A/g and SICE of 0.8456. The experimental results show that the biomass of biological promotive ceramsite is 3.58 times more than that of ordinary ceramsite, and the treatment effect of the biological promotive ceramsite is better than the ordinary ceramsite. These features of this new biological promotive ceramsite makes it a preferable biovector. 展开更多
关键词 TOURMALINE biological promotion effect DENATURATION comparison
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高比例的收益分配是否激励科技成果转化——来自中美高校的证据 被引量:5
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作者 康旭东 冯晓晨 +1 位作者 林德明 郝涛 《科学学研究》 北大核心 2025年第3期617-629,共13页
自2015年《中华人民共和国促进科技成果转化法》颁布以来,我国各个高校普遍提高了科技成果完成人的转化收益比例,目前已经成为收益分配比例最高的国家之一。为探究高比例的收益分配能否起到预期的激励作用,利用双重差分模型,选取中美两... 自2015年《中华人民共和国促进科技成果转化法》颁布以来,我国各个高校普遍提高了科技成果完成人的转化收益比例,目前已经成为收益分配比例最高的国家之一。为探究高比例的收益分配能否起到预期的激励作用,利用双重差分模型,选取中美两国重点高校科技成果转化的平衡面板数据进行政策效果的评估。结果表明,高比例的收益分配并未对高校科技成果转化呈现出正向、显著的直接促进作用,但是高比例的收益分配起到了信号传递的中介效应,其中介效应影响了资金投入等控制变量,同时此效应对转化水平不同的高校存在异质性的作用。 展开更多
关键词 政策效果评估 双重差分 中美比较 收益分配
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传统清洗筐与新型特制清洗筐清洗效果比较
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作者 程颖 邱素红 《中华医院感染学杂志》 北大核心 2025年第8期1247-1250,共4页
目的比较消毒供应中心传统清洗筐与新型特制清洗筐对器械盘清洗消毒效果的影响。方法根据实际工作需要,结合喷淋清洗机操作流程,设计和改良传统器械清洗筐成为带筛网清洗筐。收集解放军总医院第一医学中心消毒供应中心2024年3月的600件... 目的比较消毒供应中心传统清洗筐与新型特制清洗筐对器械盘清洗消毒效果的影响。方法根据实际工作需要,结合喷淋清洗机操作流程,设计和改良传统器械清洗筐成为带筛网清洗筐。收集解放军总医院第一医学中心消毒供应中心2024年3月的600件污染器械盘。随机分为实验组和对照组,实验组采用带筛网的新型特制清洗筐进行清洗消毒,对照组采用传统清洗筐进行清洗消毒方法。采用目测法、光源放大镜法及ATP生物荧光检测法,对器械盘表面、内角、边缘凹槽处进行对比,检测不同清洗筐对器械盘清洗效果影响。结果ATP生物荧光剂检测结果显示,新型特制清洗筐清洗质量优于传统清洗筐清洗质量(P<0.05)。ATP生物荧光检测法实验组表面清洗合格率(91.33%)、内角清洗合格率(89.00%)、边缘凹槽合格率(86.33%)高于对照组,有统计学差异(P<0.05)。结论相比传统清洗筐清洗效果,新型特制清洗筐能够显著提高器械盘清洗质量,从而显著提高其清洗质量合格率,提高工作效率。 展开更多
关键词 消毒供应中心 清洗筐 清洗效果 新型特制清洗筐 效果对比 清洗工具
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翳风穴水针疗法联合针刺治疗耳鸣伴睡眠障碍的临床研究
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作者 胡蓉 沙一飞 《中国中西医结合耳鼻咽喉科杂志》 2025年第5期331-334,共4页
目的观察翳风穴水针联合针刺疗法治疗耳鸣伴睡眠障碍的临床疗效。方法72例耳鸣伴睡眠障碍患者,随机分为对照组和治疗组,每组各36例。对照组予以口服甲钴胺片联合针刺疗法治疗方案,治疗组采用翳风穴水针联合针刺疗法治疗方案。每周治疗2... 目的观察翳风穴水针联合针刺疗法治疗耳鸣伴睡眠障碍的临床疗效。方法72例耳鸣伴睡眠障碍患者,随机分为对照组和治疗组,每组各36例。对照组予以口服甲钴胺片联合针刺疗法治疗方案,治疗组采用翳风穴水针联合针刺疗法治疗方案。每周治疗2次,疗程4周。疗程结束后,比较观察两组患者治疗前后的耳鸣症状改善程度、睡眠质量评分变化以评估临床疗效。结果两组患者治疗前基线资料差异无统计学意义(P>0.05);治疗后,两组患者耳鸣症状分级及睡眠质量评分均较治疗前降低(P<0.05),但治疗组疗效显著优于对照组(P<0.05)。结论翳风穴水针联合针刺疗法治疗耳鸣伴睡眠障碍患者疗效显著,值得临床推广应用。 展开更多
关键词 耳鸣 睡眠障碍 翳风穴水针疗法 针刺疗法 疗效比较
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Comparison, Selection and Progeny Test of Natural Populations of White Birch (Betula platyphylla Suk.) in Northern China
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作者 Shibo LAN 《Agricultural Biotechnology》 CAS 2019年第4期113-118,共6页
[Objectives]This study was conducted to rationally and effectively use natural genetic resources of white birch(Betula platyphylla Suk.),and improve the scientific and technological content of improved varieties.[Meth... [Objectives]This study was conducted to rationally and effectively use natural genetic resources of white birch(Betula platyphylla Suk.),and improve the scientific and technological content of improved varieties.[Methods]With the progeny of the white birch populations naturally distributed in northern China as objects,based on genetic effect analysis and comprehensive evaluation,the genetic variation,heritability and genetic gain of the growth characters in the progeny forest were systematically analyzed,by which populations or individuals with good growth vigor and strong stress resistance and adaptability were finally selected.[Results]There were extremely significant differences in the growth characters between the natural populations of white birch in northern China.The variation was the smallest in tree height,followed by crown width,and largest in DBH,and the average coefficients of variation were 20.56%,32.25%and 33.00%,respectively.The differences in characters between progeny of the same population were also extremely significant.The growth characters of white birch were more controlled by genes,and the genetic gains were larger.The heritability of tree height,DBH and crown width was 0.971,0.816 and 0.576,respectively,and the genetic gains were 15.97%,21.54%and 13.87%,respectively.[Conclusions]With the growth characters as the main evaluation indexes,taking various influencing factors into account,the Shanxi[SX]population,Hebei[HB]population and Liaoning[LN]population were selected to be excellent populations,and LN305,SX516 and HB403 were excellent individuals,which are advised to be widely used in multi-generation genetic improvement breeding. 展开更多
关键词 BETULA platyphylla Suk. Natural population comparison and SELECTION PROGENY test GENETIC effect GENETIC gain
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前处理新技术DMsPE与传统QuEChERS技术在果蔬中烟碱类农残检测应用效果比较
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作者 王丹 管益涛 +2 位作者 孙广雷 史亚萍 李勤 《中国卫生工程学》 2025年第4期444-447,451,共5页
目的比较分散微固相萃取(DMsPE)与分散固相萃取(QuEChERS)技术在烟碱类农药残留检测前处理应用的效果,从而获得更快速、简便、回收率高、最低溶剂耗损的前处理手段。方法通过对潍坊市市售蔬菜水果中3种烟碱类农药(环氧虫啶、噻虫嗪、吡... 目的比较分散微固相萃取(DMsPE)与分散固相萃取(QuEChERS)技术在烟碱类农药残留检测前处理应用的效果,从而获得更快速、简便、回收率高、最低溶剂耗损的前处理手段。方法通过对潍坊市市售蔬菜水果中3种烟碱类农药(环氧虫啶、噻虫嗪、吡虫啉)分析检测,使用DMsPE与QuEChERS前处理技术,对检测结果进行比对分析。结果实验数据显示,传统QuEChERS前处理技术和DMsPE技术在果蔬空白基质中平均加标回收率分别为74.7%~108.0%、89.6%~105.0%,RSD分别为0.29%~14.70%、0.11%~5.26%,QuEChERS技术处理后的LOD值为0.001~0.002 mg/kg,DMsPE技术下的LOD值为0.001 mg/kg。在不同果蔬种类基质中,QuEChERS技术的基质效应为0.97~1.78,DMsPE技术的基质效应为0.96~1.82。结论较传统QuEChERS技术,DMsPE有较好的回收率和重复性表现。对于不同基质,DMsPE的测定数值中基质效应有一定程度的减弱,且DMsPE前处理技术使用提取溶剂量较小,降低实验室环境负荷,方法简便易操作,可以满足精准度的实验需求,针对果蔬中烟碱类农残检测的各项指标也均符合国标要求。 展开更多
关键词 分散微固相萃取 分散固相萃取 果蔬 烟碱类 应用效果比较
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基于学习者视角的来华预科中文教材有效性实证研究
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作者 刘涛 乔梦羽 《汉语学习》 北大核心 2025年第3期84-93,共10页
本研究采用问卷调查、实验对比与半结构化访谈相结合的研究方法,对230名接受来华预科教育的学习者进行教材有效性研究。结果显示,使用《学在中国》教材的实验组在短期内语言能力的提升显著优于对照组;教材部分板块内容对学习者学习动机... 本研究采用问卷调查、实验对比与半结构化访谈相结合的研究方法,对230名接受来华预科教育的学习者进行教材有效性研究。结果显示,使用《学在中国》教材的实验组在短期内语言能力的提升显著优于对照组;教材部分板块内容对学习者学习动机与策略有正向调控与促进作用;教材具有内容丰富、结构清晰等特点,能满足短期内提高中文水平的需求。本研究为进一步优化汉语作为第二语言的教材开发与教学设计提供了理论依据和实践参考。 展开更多
关键词 《学在中国》教材 实验对比 来华预科生 有效性
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牛活检胚胎细胞微量扩增体系效果评估
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作者 牛一凡 李崇阳 +8 位作者 张培培 张航 冯肖艺 余洲 曹建华 杜卫华 万鹏程 马友记 赵学明 《畜牧兽医学报》 北大核心 2025年第1期246-258,共13页
旨在通过二代测序技术评估不同单细胞全基因组扩增体系对不同数量胚胎细胞的扩增效率。本研究选择同一饲养管理条件下、体况良好的华西牛母牛为供体,采用FSH法超数排卵后进行人工授收集第7天胚胎,通过活检技术获得含1细胞(cell, 1C)、5C... 旨在通过二代测序技术评估不同单细胞全基因组扩增体系对不同数量胚胎细胞的扩增效率。本研究选择同一饲养管理条件下、体况良好的华西牛母牛为供体,采用FSH法超数排卵后进行人工授收集第7天胚胎,通过活检技术获得含1细胞(cell, 1C)、5C、10C胚胎细胞样本用于全基因组扩增(whole genome amplification),随后通过全基因组重测序(whole genome sequencing)技术评估单细胞基因组扩增体系扩增效率的差异。结果显示,在1C和5C样本中多重置换扩增(multiple displacement amplification, MDA)体系的扩增成功率优于多次退火环状循环扩增(multiple annealing and looping-based amplification cycles, MALBAC)体系(100%vs. 60%,100%vs. 80%,P<0.05),此外MDA体系的扩增产物总量极显著高于MALBAC体系(P<0.01),基于测序分析指标:正确比对率、重复率、分型一致率、等位基因缺失率、假阳性率等,MALBAC体系优于MDA体系;全同胞样品的分型一致率大于半同胞样品的分型一致率,但不同全同胞、半同胞胚胎样本之间的分型一致率有很大差异。综上所述,MDA和MALBAC体系各具特点,结合两者优势可能是改进扩增效率的途径之一,本研究为牛早期胚胎全基因组选择研究和促进牛育种发展提供一定理论基础。 展开更多
关键词 华西牛 活检胚胎 扩增体系 效果比较
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不同介质中自热效应对铂电阻温度计校准的影响分析
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作者 陈平 《气象水文海洋仪器》 2025年第6期89-93,共5页
对Pt100铂电阻温度计在空气介质温度箱和水介质恒温槽中开展试验,重点分析Pt100铂电阻温度计自热及其在温度箱和恒温槽中不同位置对温度测量带来的影响,提出使用空气介质和液体介质开展铂电阻温度计校准的优劣。结果显示,在空气介质中... 对Pt100铂电阻温度计在空气介质温度箱和水介质恒温槽中开展试验,重点分析Pt100铂电阻温度计自热及其在温度箱和恒温槽中不同位置对温度测量带来的影响,提出使用空气介质和液体介质开展铂电阻温度计校准的优劣。结果显示,在空气介质中铂电阻温度计激励电流从0.05 mA增加到8 mA时,温度上升近3℃,激励电流1 mA以下时,可将自热效应产生的误差控制在0.05℃以下,且铂电阻温度计在空气介质中放置越多,带来的误差越小;在液体介质中,铂电阻温度计自热效应和放置位置对测量结果影响较小。本文研究结果将为优化铂电阻温度计校准方法和提高气象温度观测资料的可比性、准确性和一致性提供支撑。 展开更多
关键词 铂电阻温度计 不同介质 校准 对比分析 自热效应
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酶替代疗法在中国法布雷病患者肾脏并发症中的成本效用分析 被引量:1
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作者 陈登云 郑斌 刘茂柏 《中国医院药学杂志》 北大核心 2025年第5期503-509,共7页
目的:比较中国人群中酶替代疗法(enzyme replacement therapy,ERT)与常规对症治疗在法布雷病患者肾脏并发症中的经济性。方法:从中国医疗卫生体系角度,基于中国人群回顾性队列研究的个体患者数据,采用匹配调整间接比较法调整患者基线特... 目的:比较中国人群中酶替代疗法(enzyme replacement therapy,ERT)与常规对症治疗在法布雷病患者肾脏并发症中的经济性。方法:从中国医疗卫生体系角度,基于中国人群回顾性队列研究的个体患者数据,采用匹配调整间接比较法调整患者基线特征,间接比较两种方案的临床疗效。通过构建Markov模型,模拟10年内法布雷病患者的肾病健康状况变化,转移概率数据基于中国人群的个体随访数据,效用值数据来源于文献,成本数据参考相关文献和中国某省省属公立医疗机构收费标准,主要的结果指标是终末期肾损伤,以2023年3倍国内生产总值作为意愿支付(willingness to pay,WTP)阈值进行成本效用分析,同时进行单因素敏感性分析、概率敏感性分析和情境分析来验证结果的稳健性。结果:相比常规对症治疗,ERT组患者获得的质量调整生命年(quality-adjusted life-years,QALYs)为0.7,增量成本为2311405.4元,增量成本效用比为3314875.70元/QALY,显著高于WTP阈值(268074元/QALY)。当阿加糖酶α的药品价格下降至37891.266元时,得到ICER≤WTP,则认为ERT具有经济性。单因素敏感性分析、概率敏感性分析和情境分析验证了结果的稳健性。结论:该研究强调了优化ERT治疗策略和降低治疗成本的重要性,并为医保决策提供参考依据,以制定更合理的医疗保障政策。 展开更多
关键词 法布雷病 酶替代疗法 匹配调整间接比较 成本效用分析
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