Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admit...Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admitted to the hospital from April 2022 to April 2024 were randomly assigned to the intervention group(n=35)and the control group(n=34).The control group received routine community hypertension health management,while the intervention group underwent comprehensive geriatric assessment for comprehensive screening of elderly health issues based on routine management,and implemented targeted nursing interventions based on the characteristics of the chronic disease trajectory.After three months of intervention,the blood pressure,medication compliance,self-efficacy,and quality of life of the two groups were evaluated and analyzed.Results:After the intervention,the intervention group showed significant improvement in blood pressure control,medication compliance,self-management efficacy scores,and quality of life scores compared to the control group(P<0.05).Conclusion:Combining comprehensive geriatric assessment with the concept of chronic disease trajectory nursing in the management of community elderly hypertension can effectively optimize the effect of chronic disease management,which has important practical value.展开更多
Publications of Soufan et al and Kristjánsson et al in the World Journal of Orthopedics on mesenchymal stem cell(MSC)therapy for osteoarthritis(OA)represent a significant exploration of regenerative medicine’s p...Publications of Soufan et al and Kristjánsson et al in the World Journal of Orthopedics on mesenchymal stem cell(MSC)therapy for osteoarthritis(OA)represent a significant exploration of regenerative medicine’s potential in OA treatment.In their research,it is highlighted that MSCs can alleviate OA symptoms and even regenerate cartilage,potentially reversing the disease.They also compared the efficacy of three MSC subtypes,emphasizing the therapeutic advantages of adipose-derived MSCs.MSC injections,a novel and less invasive alternative to traditional treatments such as chondrocyte transplantation or arthroplasty,have a low cost,low risks,and favorable outcomes,presenting a promising approach for OA patients.Additionally,we stressed that the efficacy evaluation criteria,heterogeneity,safety,and other factors must be carefully considered to further advance the clinical translation of MSC therapy for OA.展开更多
BACKGROUND Scientifically sound and reasonable care strategies in surgical nursing play a crucial role in facilitating postoperative recovery and preventing complications.This study focused on the application of quant...BACKGROUND Scientifically sound and reasonable care strategies in surgical nursing play a crucial role in facilitating postoperative recovery and preventing complications.This study focused on the application of quantitative assessment strategies to postoperative care.By quantitatively analyzing the effects of nursing interventions,we explored their feasibility and effectiveness at improving postoperative recovery quality and reducing the incidence of complications.This study provides a scientific basis for nursing practice and offers new insights into nursing management with significant clinical value.AIM To analyze the efficacy of postoperative quantitative assessment strategy-based nursing care for patients with colorectal cancer(CRC).METHODS This randomized controlled trial evaluated the ability of nursing interventions using a quantitative assessment strategy to prevent postoperative complications and enhance patient recovery.Patients with CRC were randomly divided into routine nursing(RN)and quantitative assessment strategy nursing(QASN)groups.The RN group received standard care,while the QASN group also underwent screenings for visual analog scale for pain,Barthel Index for functional recovery,and self-rating anxiety scale and self-rating depression scale for psychological status.Follow-ups were conducted on postoperative days 1,7,14,28,and 56.RESULTS The participants’baseline characteristics did not significantly differ between study groups,thereby ensuring the reliability of the results.The QASN vs RN group showed significant improvements in pain management(visual analog scale scores)and psychological status(self-rating anxiety scale and self-rating depression scale scores)and a reduced incidence of postoperative complications(P<0.05).The follow-up evaluations at specified intervals confirmed these findings,indicating that quantitative assessment strategies significantly enhanced patients’postoperative pain management and psychological well-being.CONCLUSION Nursing interventions using structured quantitative assessments demonstrated significantly improved postoperative recovery and quality of life in patients with CRC,supporting their integration into standard postoperative care protocols.展开更多
Cupressus sempervirens is a relevant species in the Mediterranean for its cultural,economic and landscape value.This species is threatened by Seiridium cardinale,the causal agent of the cypress canker disease(CCD).The...Cupressus sempervirens is a relevant species in the Mediterranean for its cultural,economic and landscape value.This species is threatened by Seiridium cardinale,the causal agent of the cypress canker disease(CCD).The effects of biotic stressors on O_(3)risk assessment are unknown and a comprehensive O_(3)risk assessment in C.sempervirens is missing.To fill these gaps,two clones of C.sempervirens,one resistant(Clone R)and one susceptible to CCD(Clone S),were subjected to three levels of O_(3)(Ambient Air-AA;1.5×AA;2.0×AA)for two consecutive years in an O_(3)-free-air controlled exposure facility and artificially inoculated with S.cardinale.Both the exposure-(AOT40)and flux-based(PODy)indices were tested.We found that PODy performed better than AOT40 to assess O_(3)effects on biomass and the critical level for a 4%biomass loss was 2.51 mmol/m^(2)POD2.However,significant O_(3)dose-response relationships were not found for the inoculated cypresses because the combination of middle level O_(3)(1.5×AA)and inoculation stimulated a biomass growth in Clone S as hormetic response.Moreover,we found a different inter-clonal response to both stressors with a statistically significant reduction of total and belowground biomass following O_(3),and lower root biomass in Clone S than in Clone R following pathogen infection.In summary,Clone R was more resistant to O_(3),and inoculation altered O_(3)risk via an hormetic effect on biomass.These results warrant further studies on how biotic stressors affect O_(3)responses and risk assessment.展开更多
Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads,this study investigates typ...Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads,this study investigates typical composite beam-slab structures through integrated blast shock tube experiments and multiscale numerical simulations using Voronoi-coupled Finite-Discrete Element Method(VoroFDEM).The research systematically reveals the dynamic response mechanisms and damage evolution patterns of composite beam-slab structures subjected to prolonged blast loading.An environmenttemperature-coupled P-I curve damage assessment system is established,and a rapid evaluation method based on image crack characteristics is proposed,achieving innovative transition from traditional mechanical indicators to intelligent recognition paradigms.Results demonstrate that composite beam-slab structures exhibit three-phase failure modes:elastic vibration,plastic hinge formation,and global collapse.Numerical simulations identify the brittle-to-ductile transition temperature threshold at-10℃,and establish a temperature-dependent piecewise function-based P-I curve prediction model,whose overpressure asymptote displays nonlinear temperature sensitivity within-50-30℃.A novel dual-mode evaluation methodology integrating Voro-FDEM numerical simulations with image-based damage feature recognition is developed,enabling quantitative mapping between crack area and destruction levels.These findings provide theoretical foundations and technical pathways for rapid blast damage assessment and protective engineering design.展开更多
The development of modern engineering components and equipment features large size,intricate shape and long service life,which places greater demands on valid methods for fatigue performance analysis.Achieving a smoot...The development of modern engineering components and equipment features large size,intricate shape and long service life,which places greater demands on valid methods for fatigue performance analysis.Achieving a smooth transformation between small-scale laboratory specimens’fatigue properties and full-scale engineering components’fatigue strength has been a long-term challenge.In this work,two dominant factors impeding the smooth transformation—notch and size effect were experimentally studied,in which fatigue tests on Al 7075-T6511(a very high-strength aviation alloy)notched specimens of different scales were carried out.Fractography analyses identified the evidence of the size effect on notch fatigue damage evolution.Accordingly,the Energy Field Intensity(EFI)initially developed for multiaxial notch fatigue analysis was improved by utilizing the volume ratio of the Effective Damage Zones(EDZs)for size effect correction.In particular,it was extended to a probabilistic model considering the inherent variability of the fatigue phenomenon.The experimental data of Al 7075-T6511 notched specimens and the model-predicted results were compared,indicating the high potential of the proposed approach in fatigue evaluation under combined notch and size effects.展开更多
Floating offshore wind turbine platforms typically use stiffened tubular joints at the connections between columns and braces.These joints are prone to fatigue due to complex weld geometries and the additional stress ...Floating offshore wind turbine platforms typically use stiffened tubular joints at the connections between columns and braces.These joints are prone to fatigue due to complex weld geometries and the additional stress concentrations caused by the stiffeners.Existing hot-spot stress approaches may be inadequate for analysing these joints because they do not simultaneously address weld-toe and weld-root failures.To address these limitations,this study evaluates the fatigue strength of stiffened tubular joints using the effective notch strain approach and the structural strain approach.Both methods account for fatigue at the weld toe and weld root and can be applied to both low-cycle fatigue(LCF)and high-cycle fatigue(HCF)regimes.Reanalyzes of a series of fatigue-tested specimens confirm the effectiveness of both approaches.The stiffener-shell fillet weld root is identified as the most critical fatigue location,which is consistent with fractographic observations.Although the brace-to-shell weld root exhibits lower stress levels in finite element(FE)models,weld quality was determined to be a crucial factor in fatigue failure.Furthermore,the results emphasise the importance of material plasticity in the LCF regime and demonstrate that full weld penetration significantly enhances fatigue strength.These findings provide valuable insights for the fatigue design of stiffened tubular joints in floating offshore wind turbine platforms.展开更多
The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins o...The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins of periodic signals in GPS observations makes it difficult to isolate the millimeter-levelMTE displacement from other signals and noises.In this study,to assess the diurnal and semidiurnalsignals induced by MTE,we processed 12 very short GPS baselines(VSGB)with length<150 m.Themonument pairs for each baseline differ in their heights,horizontal structure,or base foundations.Meanwhile,two zero-baselines were also processed as the control group.Results showed that the sea-sonal signals observed in VSGB time series in the horizontal and vertical directions,were mainly inducedby seasonal MTE.Time-varying diurnal and semidiurnal signals with amplitude up to 4 mm wereobserved in the vertical direction for baselines with monument height difference(MHD)larger than10 m.Horizontal diurnal signal with an amplitude of about 2 mm was also detected for baselines withnon-axisymmetric monument structure.The orientation of the detected horizontal displacement wascoherent with the direction of daily temperature variation(DTV)driven by direct solar radiation,whichindicates that the diurnal and semidiurnal signals are likely induced by MTE.The observed high-frequency MTE displacements,if not well modeled and removed,may propagate into spurious long-term signals and bias the velocity estimation in the daily GPS time series.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in a...Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in alpine mountains with climate change.Hence,94 samples of river water were collected from 2018 to 2020 in the headwaters of the Shule River Basin to assess the nutrients spatiotemporal distribution and combined ap-proach of water quality index to assess water quality and potential sources.The findings depict that high nutrient concentrations were found to coincide with snowmelt and glacial meltwater and rainfall recharge periods,while total flux peaked from June to September due to increased runoff.Notably,total nitrogen(TN)concentrations were significantly higher near the town,primarily attributed to the replenishment of nitrate(NO_(3)^(‒)-N)from live-stock manure.The high total P(TP)was near the glacier,which was attributed to the transportation of glacial sediments into the river,and pH was another critical factor.N was the primary nutrient limiting factor for the growth of phytoplankton in river water.Although the migration and transport of nutrients have altered with climate change,river water quality is good in alpine mountains based on an overall evaluation.These findings contribute to enriching nutrient datasets and highlight the importance of water resource management and water quality assessment in sensitive and fragile alpine mountains.展开更多
Excessive levels of Fluoride(F−)and Cadmium(Cd)in drinking groundwater may pose health risks.This study assessed the health risks associated with F−and Cd contamination in rural drinking groundwater sources in Wutai C...Excessive levels of Fluoride(F−)and Cadmium(Cd)in drinking groundwater may pose health risks.This study assessed the health risks associated with F−and Cd contamination in rural drinking groundwater sources in Wutai County,Shanxi Province,China,to support population health protection,water resource management,and environmental decision-making.Groundwater samples were collected and analyzed,and a Human Health Risk Model(HHRA)was applied to evaluate groundwater quality.The results showed that both contents of F−and Cd in groundwater exceeded the Class III limits of China's national groundwater quality standard(GB/T 14848—2024).Fluoride levels met the Class V threshold,with enrichment area mainly located in the east part of the study area.Cadmium levels reached Class IV,with elevated concentrations primarily observed in the western and northwestern regions.Correlation analysis revealed that F−showed weak or no correlation with other measured substances,indicating independent sources.Health risk assessment results indicated that F−poses potential health risks to rural residents,while cadmium,due to its relatively low concentrations,does not currently present a significant health risk.Among different demographic groups,the health risk levels of F−exposure followed the order:Infants>children>adult females>adult males.The findings highlight that fluoride is the primary contributor to health risks associated with groundwater consumption in the study area.Strengthened monitoring and prevention of F−contamination are urgently needed.This research provides a scientific basis for the prevention and control of fluoride pollution in groundwater and offers practical guidance for safeguarding drinking water safety in rural China.展开更多
This study compares the environmental sustainability of five alternatives for the remediation of marine sediments of one of the most polluted coastal sites in Europe(Bagnoli-Coroglio bay,Mediterranean Sea),using the L...This study compares the environmental sustainability of five alternatives for the remediation of marine sediments of one of the most polluted coastal sites in Europe(Bagnoli-Coroglio bay,Mediterranean Sea),using the Life Cycle Assessment(LCA)methodology.The treatments are either in-situ or exsitu,the latter requiring an initial dredging to transport the contaminated sediments to the management site.More in detail,four ex-situ remediation technologies based on landfilling,bioremediation,electrokinetic technique and soil washing were identified.These technologies are compared to an in-situ strategy currently under validation for enhancing bioremediation of the polluted sediments of the Bagnoli-Coroglio site.Our results indicate that the disposal in landfilling site is the worst option in most categories(e.g.,650 kg CO_(2) eq./t of treated sediment,considering the nearest landfilling site),followed by the bioremediation,mainly due to the high energy demand.Electrokinetic remediation,soil washing,and innovative in-situ technology represent the most sustainable options.In particular,the new in-situ technology appears to be the least impacting in all categories(e.g.,54 kg CO_(2) eq./t of treated sediment),although it is expected to require longer treatment time(estimated up to 12 months based on its potential efficiency).It can reduce the impact on climate change more than 12 times compared to the disposal and 7 times compared to bioremediation in addition to the possibility to avoid/reduce the dredging operations and the consequent dispersion of pollutants.The results open relevant perspectives towards more eco-sustainable and costly effective actions for the reclamation of contaminated marine sediments.展开更多
Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure f...Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative patho...Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forc...Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.展开更多
The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) underg...The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) undergoes an antiferromagnetic(AFM)transition at T_(N)∼5 K.Under high pressures within 8.9 GPa,we find that Kondo scattering contributes differently to the high-temperature resistance,R(T),depending on the applied current direction,demonstrating a significantly anisotropic Kondo effect.The complete P–T phase diagram has been constructed,in which the pressure dependence of T_(N) exhibits a dome-like shape.The AFM order remains robust under pressure,even when the coherence temperature T^(*) far exceeds 300 K.We attribute the observed anisotropic Kondo effect and the robust AFM to the underlying anisotropy in electronic hybridization under high pressure.展开更多
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a...In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.展开更多
Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenv...Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.展开更多
基金Nanjing Medical University 2023 Education Research Project(Project No.:2023LX103):Design and Practice of a Primary Care Chronic Disease Management Course Based on the BOPPPS Model-A Case Study of Taizhou RegionTaizhou People’s Hospital Nursing Research Special Project(Project No.:HLYB202411):The Impact of 5A Model-Based Exercise Rehabilitation Guidance on Exercise Adherence in Young and Middle-Aged Hypertensive Patients.
文摘Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admitted to the hospital from April 2022 to April 2024 were randomly assigned to the intervention group(n=35)and the control group(n=34).The control group received routine community hypertension health management,while the intervention group underwent comprehensive geriatric assessment for comprehensive screening of elderly health issues based on routine management,and implemented targeted nursing interventions based on the characteristics of the chronic disease trajectory.After three months of intervention,the blood pressure,medication compliance,self-efficacy,and quality of life of the two groups were evaluated and analyzed.Results:After the intervention,the intervention group showed significant improvement in blood pressure control,medication compliance,self-management efficacy scores,and quality of life scores compared to the control group(P<0.05).Conclusion:Combining comprehensive geriatric assessment with the concept of chronic disease trajectory nursing in the management of community elderly hypertension can effectively optimize the effect of chronic disease management,which has important practical value.
基金Supported by Capital Fund Project for Clinical Diagnosis and Treatment Technology Research and Translational Application,No.Z201100005520091.
文摘Publications of Soufan et al and Kristjánsson et al in the World Journal of Orthopedics on mesenchymal stem cell(MSC)therapy for osteoarthritis(OA)represent a significant exploration of regenerative medicine’s potential in OA treatment.In their research,it is highlighted that MSCs can alleviate OA symptoms and even regenerate cartilage,potentially reversing the disease.They also compared the efficacy of three MSC subtypes,emphasizing the therapeutic advantages of adipose-derived MSCs.MSC injections,a novel and less invasive alternative to traditional treatments such as chondrocyte transplantation or arthroplasty,have a low cost,low risks,and favorable outcomes,presenting a promising approach for OA patients.Additionally,we stressed that the efficacy evaluation criteria,heterogeneity,safety,and other factors must be carefully considered to further advance the clinical translation of MSC therapy for OA.
文摘BACKGROUND Scientifically sound and reasonable care strategies in surgical nursing play a crucial role in facilitating postoperative recovery and preventing complications.This study focused on the application of quantitative assessment strategies to postoperative care.By quantitatively analyzing the effects of nursing interventions,we explored their feasibility and effectiveness at improving postoperative recovery quality and reducing the incidence of complications.This study provides a scientific basis for nursing practice and offers new insights into nursing management with significant clinical value.AIM To analyze the efficacy of postoperative quantitative assessment strategy-based nursing care for patients with colorectal cancer(CRC).METHODS This randomized controlled trial evaluated the ability of nursing interventions using a quantitative assessment strategy to prevent postoperative complications and enhance patient recovery.Patients with CRC were randomly divided into routine nursing(RN)and quantitative assessment strategy nursing(QASN)groups.The RN group received standard care,while the QASN group also underwent screenings for visual analog scale for pain,Barthel Index for functional recovery,and self-rating anxiety scale and self-rating depression scale for psychological status.Follow-ups were conducted on postoperative days 1,7,14,28,and 56.RESULTS The participants’baseline characteristics did not significantly differ between study groups,thereby ensuring the reliability of the results.The QASN vs RN group showed significant improvements in pain management(visual analog scale scores)and psychological status(self-rating anxiety scale and self-rating depression scale scores)and a reduced incidence of postoperative complications(P<0.05).The follow-up evaluations at specified intervals confirmed these findings,indicating that quantitative assessment strategies significantly enhanced patients’postoperative pain management and psychological well-being.CONCLUSION Nursing interventions using structured quantitative assessments demonstrated significantly improved postoperative recovery and quality of life in patients with CRC,supporting their integration into standard postoperative care protocols.
基金supported by the Italian Integrated Environmental Research Infrastructures Systems(ITINERIS)(Nos.IR0000032 and CUP B53C22002150006).
文摘Cupressus sempervirens is a relevant species in the Mediterranean for its cultural,economic and landscape value.This species is threatened by Seiridium cardinale,the causal agent of the cypress canker disease(CCD).The effects of biotic stressors on O_(3)risk assessment are unknown and a comprehensive O_(3)risk assessment in C.sempervirens is missing.To fill these gaps,two clones of C.sempervirens,one resistant(Clone R)and one susceptible to CCD(Clone S),were subjected to three levels of O_(3)(Ambient Air-AA;1.5×AA;2.0×AA)for two consecutive years in an O_(3)-free-air controlled exposure facility and artificially inoculated with S.cardinale.Both the exposure-(AOT40)and flux-based(PODy)indices were tested.We found that PODy performed better than AOT40 to assess O_(3)effects on biomass and the critical level for a 4%biomass loss was 2.51 mmol/m^(2)POD2.However,significant O_(3)dose-response relationships were not found for the inoculated cypresses because the combination of middle level O_(3)(1.5×AA)and inoculation stimulated a biomass growth in Clone S as hormetic response.Moreover,we found a different inter-clonal response to both stressors with a statistically significant reduction of total and belowground biomass following O_(3),and lower root biomass in Clone S than in Clone R following pathogen infection.In summary,Clone R was more resistant to O_(3),and inoculation altered O_(3)risk via an hormetic effect on biomass.These results warrant further studies on how biotic stressors affect O_(3)responses and risk assessment.
基金supported by Open Research Fund of State Key Laboratory of Target Vulnerability Assessment,Defense Engineering Institute,AMS,PLA(Grant No.YSX2024KFPG002)。
文摘Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads,this study investigates typical composite beam-slab structures through integrated blast shock tube experiments and multiscale numerical simulations using Voronoi-coupled Finite-Discrete Element Method(VoroFDEM).The research systematically reveals the dynamic response mechanisms and damage evolution patterns of composite beam-slab structures subjected to prolonged blast loading.An environmenttemperature-coupled P-I curve damage assessment system is established,and a rapid evaluation method based on image crack characteristics is proposed,achieving innovative transition from traditional mechanical indicators to intelligent recognition paradigms.Results demonstrate that composite beam-slab structures exhibit three-phase failure modes:elastic vibration,plastic hinge formation,and global collapse.Numerical simulations identify the brittle-to-ductile transition temperature threshold at-10℃,and establish a temperature-dependent piecewise function-based P-I curve prediction model,whose overpressure asymptote displays nonlinear temperature sensitivity within-50-30℃.A novel dual-mode evaluation methodology integrating Voro-FDEM numerical simulations with image-based damage feature recognition is developed,enabling quantitative mapping between crack area and destruction levels.These findings provide theoretical foundations and technical pathways for rapid blast damage assessment and protective engineering design.
基金support from the Key Program of the National Natural Science Foundation of China(No.12232004)the Training Program of the Sichuan Province Science and the Technology Innovation Seedling Project(No.MZGC20230012)are acknowledged.
文摘The development of modern engineering components and equipment features large size,intricate shape and long service life,which places greater demands on valid methods for fatigue performance analysis.Achieving a smooth transformation between small-scale laboratory specimens’fatigue properties and full-scale engineering components’fatigue strength has been a long-term challenge.In this work,two dominant factors impeding the smooth transformation—notch and size effect were experimentally studied,in which fatigue tests on Al 7075-T6511(a very high-strength aviation alloy)notched specimens of different scales were carried out.Fractography analyses identified the evidence of the size effect on notch fatigue damage evolution.Accordingly,the Energy Field Intensity(EFI)initially developed for multiaxial notch fatigue analysis was improved by utilizing the volume ratio of the Effective Damage Zones(EDZs)for size effect correction.In particular,it was extended to a probabilistic model considering the inherent variability of the fatigue phenomenon.The experimental data of Al 7075-T6511 notched specimens and the model-predicted results were compared,indicating the high potential of the proposed approach in fatigue evaluation under combined notch and size effects.
基金supported by the National Natural Science Foundation of China(Grant No.52101350).
文摘Floating offshore wind turbine platforms typically use stiffened tubular joints at the connections between columns and braces.These joints are prone to fatigue due to complex weld geometries and the additional stress concentrations caused by the stiffeners.Existing hot-spot stress approaches may be inadequate for analysing these joints because they do not simultaneously address weld-toe and weld-root failures.To address these limitations,this study evaluates the fatigue strength of stiffened tubular joints using the effective notch strain approach and the structural strain approach.Both methods account for fatigue at the weld toe and weld root and can be applied to both low-cycle fatigue(LCF)and high-cycle fatigue(HCF)regimes.Reanalyzes of a series of fatigue-tested specimens confirm the effectiveness of both approaches.The stiffener-shell fillet weld root is identified as the most critical fatigue location,which is consistent with fractographic observations.Although the brace-to-shell weld root exhibits lower stress levels in finite element(FE)models,weld quality was determined to be a crucial factor in fatigue failure.Furthermore,the results emphasise the importance of material plasticity in the LCF regime and demonstrate that full weld penetration significantly enhances fatigue strength.These findings provide valuable insights for the fatigue design of stiffened tubular joints in floating offshore wind turbine platforms.
基金funded by the Independent Innovation Project of Changjiang Institute of Survey,Planning,Design and Research Corporation (CX2020Z32)supported by the National Natural Science Foundation of China (Grant Numbers42204006 and 42104028)the Open Fund of Hubei Luojia Laboratory (Grant Numbers 230100020 and 230100019)
文摘The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins of periodic signals in GPS observations makes it difficult to isolate the millimeter-levelMTE displacement from other signals and noises.In this study,to assess the diurnal and semidiurnalsignals induced by MTE,we processed 12 very short GPS baselines(VSGB)with length<150 m.Themonument pairs for each baseline differ in their heights,horizontal structure,or base foundations.Meanwhile,two zero-baselines were also processed as the control group.Results showed that the sea-sonal signals observed in VSGB time series in the horizontal and vertical directions,were mainly inducedby seasonal MTE.Time-varying diurnal and semidiurnal signals with amplitude up to 4 mm wereobserved in the vertical direction for baselines with monument height difference(MHD)larger than10 m.Horizontal diurnal signal with an amplitude of about 2 mm was also detected for baselines withnon-axisymmetric monument structure.The orientation of the detected horizontal displacement wascoherent with the direction of daily temperature variation(DTV)driven by direct solar radiation,whichindicates that the diurnal and semidiurnal signals are likely induced by MTE.The observed high-frequency MTE displacements,if not well modeled and removed,may propagate into spurious long-term signals and bias the velocity estimation in the daily GPS time series.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(No.2019QZKK0208)the National Natural Science Foundation of China(Nos.42171148 and 42330512)the Key R&D Project from the Science and Technology Department of Tibet(No.XZ202501ZY0030).
文摘Nitrogen(N)and phosphorus(P)are essential nutrients and can significantly impact primary productivity of the ecosystem causing water environmental problems.However,their cycling mechanisms are not well understood in alpine mountains with climate change.Hence,94 samples of river water were collected from 2018 to 2020 in the headwaters of the Shule River Basin to assess the nutrients spatiotemporal distribution and combined ap-proach of water quality index to assess water quality and potential sources.The findings depict that high nutrient concentrations were found to coincide with snowmelt and glacial meltwater and rainfall recharge periods,while total flux peaked from June to September due to increased runoff.Notably,total nitrogen(TN)concentrations were significantly higher near the town,primarily attributed to the replenishment of nitrate(NO_(3)^(‒)-N)from live-stock manure.The high total P(TP)was near the glacier,which was attributed to the transportation of glacial sediments into the river,and pH was another critical factor.N was the primary nutrient limiting factor for the growth of phytoplankton in river water.Although the migration and transport of nutrients have altered with climate change,river water quality is good in alpine mountains based on an overall evaluation.These findings contribute to enriching nutrient datasets and highlight the importance of water resource management and water quality assessment in sensitive and fragile alpine mountains.
基金supported by the Northeast Geological Science and Technology Innovation Center of China Geological Survey(Grant NO.QCJJ2022-43)the Natural Resources Comprehensive Survey Project(Grant Nos.DD20230470,DD20230508)the National Groundwater Monitoring Network Operation and Maintenance Program(Grant No.DD20251300109).
文摘Excessive levels of Fluoride(F−)and Cadmium(Cd)in drinking groundwater may pose health risks.This study assessed the health risks associated with F−and Cd contamination in rural drinking groundwater sources in Wutai County,Shanxi Province,China,to support population health protection,water resource management,and environmental decision-making.Groundwater samples were collected and analyzed,and a Human Health Risk Model(HHRA)was applied to evaluate groundwater quality.The results showed that both contents of F−and Cd in groundwater exceeded the Class III limits of China's national groundwater quality standard(GB/T 14848—2024).Fluoride levels met the Class V threshold,with enrichment area mainly located in the east part of the study area.Cadmium levels reached Class IV,with elevated concentrations primarily observed in the western and northwestern regions.Correlation analysis revealed that F−showed weak or no correlation with other measured substances,indicating independent sources.Health risk assessment results indicated that F−poses potential health risks to rural residents,while cadmium,due to its relatively low concentrations,does not currently present a significant health risk.Among different demographic groups,the health risk levels of F−exposure followed the order:Infants>children>adult females>adult males.The findings highlight that fluoride is the primary contributor to health risks associated with groundwater consumption in the study area.Strengthened monitoring and prevention of F−contamination are urgently needed.This research provides a scientific basis for the prevention and control of fluoride pollution in groundwater and offers practical guidance for safeguarding drinking water safety in rural China.
基金support in the literature analysis.This study has been carried out in the framework of the project funded by EU entitled“Bioremediation of contaminated sediments in coastal areas of exindustrial sites-LIFE SEDREMED”(No.LIFE20 ENV/IT/000572).
文摘This study compares the environmental sustainability of five alternatives for the remediation of marine sediments of one of the most polluted coastal sites in Europe(Bagnoli-Coroglio bay,Mediterranean Sea),using the Life Cycle Assessment(LCA)methodology.The treatments are either in-situ or exsitu,the latter requiring an initial dredging to transport the contaminated sediments to the management site.More in detail,four ex-situ remediation technologies based on landfilling,bioremediation,electrokinetic technique and soil washing were identified.These technologies are compared to an in-situ strategy currently under validation for enhancing bioremediation of the polluted sediments of the Bagnoli-Coroglio site.Our results indicate that the disposal in landfilling site is the worst option in most categories(e.g.,650 kg CO_(2) eq./t of treated sediment,considering the nearest landfilling site),followed by the bioremediation,mainly due to the high energy demand.Electrokinetic remediation,soil washing,and innovative in-situ technology represent the most sustainable options.In particular,the new in-situ technology appears to be the least impacting in all categories(e.g.,54 kg CO_(2) eq./t of treated sediment),although it is expected to require longer treatment time(estimated up to 12 months based on its potential efficiency).It can reduce the impact on climate change more than 12 times compared to the disposal and 7 times compared to bioremediation in addition to the possibility to avoid/reduce the dredging operations and the consequent dispersion of pollutants.The results open relevant perspectives towards more eco-sustainable and costly effective actions for the reclamation of contaminated marine sediments.
基金supported by the National Key R&D Program of China(Nos.2018YFC1004300 and 2018YFC1004302)the Science&Technology Program of Guizhou Province(Nos.QKHHBZ[2020]3002,QKHPTRC-GCC[2022]039-1 and QKHPTRCCXTD[2022]014)the Scientific Research Program of Guizhou Provincial Department of Education(No.QJJ[2023]019).
文摘Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金supported by the National Natural Science Foundation of China(No.32170121).
文摘Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
文摘AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
文摘Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.
基金supported by the National Key Research and Development Program of Chinathe National Natural Science Foundation of China (Grant Nos.2024YFA1408000,12474097,and2023YFA1406001)+2 种基金the Guangdong Provincial Quantum Science Strategic Initiative (Grant No.GDZX2201001)the Center for Computational Science and Engineering at Southern University of Science and Technology,the Major Science and Technology Infrastructure Project of Material Genome Big-science Facilities Platform supported by Municipal Development and Reform Commission of Shenzhen(for J.L.Z.and Y.L.)the Chinese funding sources applied via HPSTAR。
文摘The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) undergoes an antiferromagnetic(AFM)transition at T_(N)∼5 K.Under high pressures within 8.9 GPa,we find that Kondo scattering contributes differently to the high-temperature resistance,R(T),depending on the applied current direction,demonstrating a significantly anisotropic Kondo effect.The complete P–T phase diagram has been constructed,in which the pressure dependence of T_(N) exhibits a dome-like shape.The AFM order remains robust under pressure,even when the coherence temperature T^(*) far exceeds 300 K.We attribute the observed anisotropic Kondo effect and the robust AFM to the underlying anisotropy in electronic hybridization under high pressure.
基金supported by the CAS Strategic Priority Research Program(No.XDB0760102),the Ministry of Science and Technology of China(No.2022YFF0802501)the Major Science and Technology Infrastructure Maintenance and Transformation Project of the Chinese Academy of Sciences,Shanghai Science and Technology Innovation Action Plan-Phospherus Project(No.23YF1426200)the National Key Research and Development Program of China(No.2024YFE0212200).
文摘In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.
文摘Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.
