The cooperative principle is an important theory of pragmatics,concerning how to maximally achieve communicative goal.While translation serves as a communicative medium,it should also observe the conversational rules...The cooperative principle is an important theory of pragmatics,concerning how to maximally achieve communicative goal.While translation serves as a communicative medium,it should also observe the conversational rules—cooperative principle to achieve the equivalent effect.This paper tries to explore the issue from the perspective of cooperative principle.展开更多
Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical cancer.Methods:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and...Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical cancer.Methods:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups Ⅰ,Ⅱ,Ⅲ and Ⅳ,with 20 rats in each.For Group Ⅰ,the control group,injection of normal saline was given around the tumors.For Group Ⅱ,injection of 2 mg/kg cisplatin was given around the tumors.For Group Ⅲ,injection of 75 mg/kg matrine was given around the tumors while the combined injection of matrine and cisplatin was given for Group Ⅳ with the same doses as Groups Ⅱand Ⅲ.The animals were sacrificed 10 d after the injection and tumors were taken out for the comparisons of tumor weights after injection and calculation of anti-tumor rates,while thymus and spleen were taken for thymus index and spleen index.Blood in eyeball was collected for determination of changes in serum creatinine and urea nitrogen levels.Sections of tumor issue were prepared and morphological changes in tumor tissue cells were observed by using immunohistochemistry technique.Results:After injection,the thymus index and spleen index in Groups Ⅲ and Ⅳ were significantly higher than those in Groups Ⅰ and Ⅱ(P<0.05)while the two indexes in Group Ⅱ were significantly lower than Group Ⅰ(P<0.05).The tumor weights in Groups Ⅱ and Ⅳ were significantly smaller than those in Groups Ⅰ and Ⅲ(P<0.05) with significantly higher anti-tumor rates than Groups Ⅰ and Ⅲ(P<0.05).The serum creatinine and urea nitrogen levels in Groups Ⅲ and Ⅳ were significantly lower than Group Ⅱ(P<0.05) and the two indicators in Group Ⅲ were significantly lower than those in Group Ⅳ(P<0.05).The observation under the histological microscope showed densely arranged tumor cells in Group Ⅰ,growing as a crumby structure and diffuse appearance,with hyperchromatic and large nuclei,and abundant cytoplasm.In the case of Group Ⅱ,it showed less tumor cells,with extensive degenerative necrosis,sparse arrangement and karyopyknosis as well as karyoclasis.For Group Ⅲ,necrosis of tumor cells in different sizes and heterogeneous color in nuclei were observed.For Group Ⅳ,the number of tumor cells was significantly smaller than Groups Ⅰ and Ⅲ and the tumor cells presented an appearance of crumby structure as cancer nests,with more proliferation of connective tissue.Conclusions:The treatment of matrine combined with cisplatin can significantly improve the anti-tumor effect on U14 rats with cervical cancer,which can be a new option for the treatment for cervical cancer.展开更多
The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that ...The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy.展开更多
Stress-rupture properties of a Ni-base Re-containing single-crystal superalloy with three orientations have been tested under 900℃/445 MPa.An obvious anisotropy of stress-rupture property is attributed to orientation...Stress-rupture properties of a Ni-base Re-containing single-crystal superalloy with three orientations have been tested under 900℃/445 MPa.An obvious anisotropy of stress-rupture property is attributed to orientation reliant deformation microstructure.The good strength in[001]orientation is attributed to the rapid multiplication of dislocations active in horizontal channels and laterγ'cutting via dislocations pair coupled with anti-phase boundary.The microtwin formation largely limits the strength and plasticity as a result of the continuous shearing acrossγ/γ'microstructure by{111}112 slip activated in[011]orientation.The property in[111]orientation results mainly from the lateral cross-slip movements of the screw dislocations within connected matrix channels as well as the precipitate shearing by coplanar dislocations.Microcracks all initially originate from the interdendritic micropores in three orientations.The critical temperature of stress-rupture anisotropy could be increased by a high level of refractory solutes especially Re.展开更多
One way to improve practicability of automatic program repair（APR） techniques is to build prediction models which can predict whether an application of a APR technique on a bug is effective or not. Existing predicti...One way to improve practicability of automatic program repair（APR） techniques is to build prediction models which can predict whether an application of a APR technique on a bug is effective or not. Existing prediction models have some limitations. First, the prediction models are built with hand crafted features which usually fail to capture the semantic characteristics of program repair task. Second, the performance of the prediction models is only evaluated on Genprog, a genetic-programming based APR technique. This paper develops prediction models, i.e., random forest prediction models for SPR, another kind of generate-and-validate APR technique, which can distinguish ineffective repair instances from effective repair instances. Rather than handcrafted features, we use features automatically learned by deep belief network（DBN） to train the prediction models. The empirical results show that compared to the baseline models, that is, all effective models, our proposed models can at least improve the F1 by 9% and AUC（area under the receiver operating characteristics curve） by 19%. At the same time, the prediction model using learned features at least outperforms the one using hand-crafted features in terms of F1 by 11%.展开更多
The fabrication of LPFG in single mode fiber （SMF） was fabricated using amplitude mask writing techniques. The birefringence effect of LPFG for sensing the transverse strain was discussed in detail. The experimented...The fabrication of LPFG in single mode fiber （SMF） was fabricated using amplitude mask writing techniques. The birefringence effect of LPFG for sensing the transverse strain was discussed in detail. The experimented results shou that it exhibits a very high sensitivity and a good linearity to transverse strain, with a sensitivity some hundred times greater than what has been achieved using FBG sensor.展开更多
A basic glucoprotein named α-momorcharin(Mr:29000) that was isolated andpurified from the seeds of MomordicaCharantia was proved to have an obviousinhibitory effect on early pregnacy of
在高二英语课本中相继出现了 affect 和 effect。这两个词虽说都有“影响”之意,但词性不同,而且用法也各异。此外,由于它们发音相似而易于混淆。现辨异如下:一、affect 只用怍动词。使用时常有以下几个意义。1.表示“影响”,“对……有...在高二英语课本中相继出现了 affect 和 effect。这两个词虽说都有“影响”之意,但词性不同,而且用法也各异。此外,由于它们发音相似而易于混淆。现辨异如下:一、affect 只用怍动词。使用时常有以下几个意义。1.表示“影响”,“对……有(产生)影响”。例如;Smoking affects health.吸烟影响健康。The war and the sufferinu that it caused affected him greatly.(SB Ⅱ p.105)这场战争及其所造成的苦难对他影响很大。展开更多
Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindful...Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.展开更多
Radioactivity is a natural phenomenon present in the universe. So, because of human life solidarity with a habitat, we are permanently in contact, especially through building materials. The objective of this work is t...Radioactivity is a natural phenomenon present in the universe. So, because of human life solidarity with a habitat, we are permanently in contact, especially through building materials. The objective of this work is the determination of the used cement radioactivity level in the buildings in Cote d'Ivoire. Thus, samples of grey and white cement currently used on Ivorian territory were taken. In order to determine the radioactivity level of this cement, samples were analyzed by using gamma spectrometry chain which contains a NaI (Tl) scintillation detector designed by the German manufacturer LD-DIDACTIC, coupled to a multichannel analyzer (AMC) using a Cassy Lab software. Thus, the specific activity of the primordial radionuclides 226Ra, 232Th and 40K, was able to be determined. The average values obtained are 29.66 Bq/kg, 34.88 Bq/kg and 178.424 Bq/kg respectively for 226Ra, 232Th and 40K. All average values are below the limit values recommended by UNSCEAR. However, we evaluated the radiological parameters such as the equivalent radium activity and the annual effective dose in order to translate the specific activity in terms of harmfulness. Values obtained for these parameters are below those recommended by ICRP and UNSCEAR. These results show that the risk incurred by the use of these different brands of cement is low.展开更多
Objective: to study the effect of continuous quality improvement measures on nosocomial infection control in operating room. Methods: in a comparative study, patients and medical staff who underwent surgery in our hos...Objective: to study the effect of continuous quality improvement measures on nosocomial infection control in operating room. Methods: in a comparative study, patients and medical staff who underwent surgery in our hospital between 2018 and 2020 were included in this experimental study, including 100 patients and medical staff who underwent continuous quality improvement measures between 2019 and 2020. The qualification and compliance of hand hygiene of medical staff before and after implementation were analyzed, the incidence of medical disputes and nursing adverse events were compared between the two groups, and the nursing feelings of patients in the operating room were specifically scored. Results: after implementation, the qualified rate of hand hygiene was significantly improved, and the score of patients' nursing feelings in the operating room was significantly improved, and the incidence of medical disputes and adverse events was reduced. Conclusion: carrying out continuous quality improvement measures in the operating room of the hospital can improve the prevention and treatment effect of infection. It is a good measure for patients and medical staff, and reduces the incidence of medical accidents. It is of great significance for the development of the hospital.展开更多
Objective: the experiment will apply Liuweidihuang decoction to patients with chronic glomerulonephritis. At the same time, we will also compare the patient's condition management results under the treatment of we...Objective: the experiment will apply Liuweidihuang decoction to patients with chronic glomerulonephritis. At the same time, we will also compare the patient's condition management results under the treatment of western medicine, and further analyze the therapeutic efficacy of patients under the two schemes of traditional Chinese and western medicine. Methods: 40 cases of patients with chronic glomerulonephritis treated in our hospital from January 2018 to February 2020 were selected as the objects of this study. The control group was treated with western medicine, while the observation group was treated with Liuweidihuang decoction. The efficacy was compared. Results: in terms of treatment, Scr and BUN levels in the observation group were (117.65±28.13) g/L and (6.55±2.04) umol/L, respectively, which were better than those in the control group, with statistical significance (P < 0.05). At the same time, the therapeutic effect was compared, and the observation group was better. The two groups were 95.0% and 80.0% respectively. The difference was statistically significant. Finally, the TCM symptoms of the patients were compared, which mainly included fatigue, psoas acid softness and edema. The scores were all better in the observation group. Conclusion: Liuweidihuang decoction in the treatment of chronic glomerulonephritis can improve the levels of Scr and BUN, enhance the therapeutic effect, which can alleviate the development of the disease, properly control and solve the clinical symptoms, and it is recommended to promote its application.展开更多
Objective: to observe the clinical effect of intravenous thrombolysis with alteplase combined with Shuxuening injection on ischemic stroke. Methods: selected subjects: 90 patients with acute ischemic stroke in the eme...Objective: to observe the clinical effect of intravenous thrombolysis with alteplase combined with Shuxuening injection on ischemic stroke. Methods: selected subjects: 90 patients with acute ischemic stroke in the emergency department of our hospital were selected from March 2021 to August 2022. They were grouped according to the computer parity distribution method, the control group database (45 patients data), and the observation group database (43 patients data), and Shuxuening injection combined with alteplase therapy. To observe the effects of different therapies on the clinical effect, neurological function score, inflammatory value, neurotransmitter and coagulation value of patients. Results: compared with the parameter difference between groups, there was no significant difference in data before treatment (P > 0.05). After treatment, the results of data comparison were significant, the clinical treatment effect of the patients in the observation group was significantly improved, the inflammatory values and neurological function scores were significantly decreased, and the neurotransmitters and coagulation values were significantly improved, P<0.05. Conclusion: the combined therapy of intravenous thrombolysis with alteplase and Shuxuening injection for patients with acute ischemic stroke has a significant clinical effect, which can effectively change the patients condition and improve the inflammatory response and neurological function.展开更多
Objective: to analyze the diagnostic value of two-dimensional ultrasound imaging in peripheral vascular atherosclerosis. Methods: in this study, 100 patients with peripheral vascular atherosclerosis who were treated i...Objective: to analyze the diagnostic value of two-dimensional ultrasound imaging in peripheral vascular atherosclerosis. Methods: in this study, 100 patients with peripheral vascular atherosclerosis who were treated in our hospital from February 2020 to May 2021 were enrolled in the study. All patients were diagnosed by two-dimensional ultrasound imaging technology, and the plaque formation site, imaging manifestations, plaque types and basic diseases were analyzed. Results: for the 100 patients enrolled in this group, the ultrasonic manifestations of the patients mainly included 87 cases of rough intima, 35 cases of thickening, 12 cases of carotid intima thickening and 42 cases of rough intima. 21 plaque formation sites, 62 on the left and 59 on the right;There are 16 origins of internal carotid artery and 13 origins of common carotid artery at 22 bifurcation points and 70 bulbous points of common carotid artery. There were 49 soft spots, 45 hard spots, 4 mixed spots and 2 flat spots. Among the enrolled patients, cerebral infarction and coronary heart disease account for a large proportion, with 43 cases of cerebral infarction, accounting for 43.00%, and 39 cases of coronary heart disease, accounting for 39.00%. Conclusion: two-dimensional ultrasound imaging technology can effectively detect plaque and realize the exact diagnosis of peripheral vascular atherosclerosis.展开更多
Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differen...Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability.The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques.These methods can influence the cellular microenvironment,activate disparate signaling pathways,and induce different biological effects.“Epigenetic regulation”refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences,such as histone methylation.Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages.The most important sites of histone methylation in tooth organization were found to be H3K4,H3K9,and H3K27.Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites,generating distinct chromatin structures associated with specific downstream transcriptional states.Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications.A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation.Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4,H3K9,and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments.This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.展开更多
目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组...目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组的基础上,结合泻青丸及清心平肝法针刺治疗,两组数据观察:治疗前后耶鲁综合抽动严重程度量表(Yale global tie severityb scale,YGTSS)评分变化、临床疗效、不良反应、中医证候积分变化、血清多巴胺(Dopamine,DA)以及5-羟色胺(5-Hydroxytryptophan,5-HT)、γ-氨基丁酸(γ-Aminobutyric acid,GABA)水平变化、Achenbach儿童行为量表(Child behavior check list,CBCL)及生活质量量表(Short form 36 questionnaire,SF-36)评分变化。结果观察组患儿总有效率(96.23%,51/53)比对照组患儿(84.91%,45/53)更高,差异有统计学意义(P<0.05);两组患儿治疗前YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分比较,差异无统计学意义(P>0.05),治疗后两组患儿YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标均改善,观察组患儿治疗后YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标优于对照组,差异有统计学意义(P<0.05);观察组患儿不良反应率(3.77%,2/53)比对照组患儿(16.98%,9/53)更低,差异有统计学意义(P<0.05)。结论泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果显著,且患儿症状改善,恢复较好,患儿行为改善,生活质量提升,不良反应率降低,较为安全可靠。展开更多
文摘The cooperative principle is an important theory of pragmatics,concerning how to maximally achieve communicative goal.While translation serves as a communicative medium,it should also observe the conversational rules—cooperative principle to achieve the equivalent effect.This paper tries to explore the issue from the perspective of cooperative principle.
基金Supported by special program of molecular genetics medicine for women and children's health,National Center for Women and Children's Health.China Centers for Disease Control with Grant No.FY-ZX-ZD-0059
文摘Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical cancer.Methods:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups Ⅰ,Ⅱ,Ⅲ and Ⅳ,with 20 rats in each.For Group Ⅰ,the control group,injection of normal saline was given around the tumors.For Group Ⅱ,injection of 2 mg/kg cisplatin was given around the tumors.For Group Ⅲ,injection of 75 mg/kg matrine was given around the tumors while the combined injection of matrine and cisplatin was given for Group Ⅳ with the same doses as Groups Ⅱand Ⅲ.The animals were sacrificed 10 d after the injection and tumors were taken out for the comparisons of tumor weights after injection and calculation of anti-tumor rates,while thymus and spleen were taken for thymus index and spleen index.Blood in eyeball was collected for determination of changes in serum creatinine and urea nitrogen levels.Sections of tumor issue were prepared and morphological changes in tumor tissue cells were observed by using immunohistochemistry technique.Results:After injection,the thymus index and spleen index in Groups Ⅲ and Ⅳ were significantly higher than those in Groups Ⅰ and Ⅱ(P<0.05)while the two indexes in Group Ⅱ were significantly lower than Group Ⅰ(P<0.05).The tumor weights in Groups Ⅱ and Ⅳ were significantly smaller than those in Groups Ⅰ and Ⅲ(P<0.05) with significantly higher anti-tumor rates than Groups Ⅰ and Ⅲ(P<0.05).The serum creatinine and urea nitrogen levels in Groups Ⅲ and Ⅳ were significantly lower than Group Ⅱ(P<0.05) and the two indicators in Group Ⅲ were significantly lower than those in Group Ⅳ(P<0.05).The observation under the histological microscope showed densely arranged tumor cells in Group Ⅰ,growing as a crumby structure and diffuse appearance,with hyperchromatic and large nuclei,and abundant cytoplasm.In the case of Group Ⅱ,it showed less tumor cells,with extensive degenerative necrosis,sparse arrangement and karyopyknosis as well as karyoclasis.For Group Ⅲ,necrosis of tumor cells in different sizes and heterogeneous color in nuclei were observed.For Group Ⅳ,the number of tumor cells was significantly smaller than Groups Ⅰ and Ⅲ and the tumor cells presented an appearance of crumby structure as cancer nests,with more proliferation of connective tissue.Conclusions:The treatment of matrine combined with cisplatin can significantly improve the anti-tumor effect on U14 rats with cervical cancer,which can be a new option for the treatment for cervical cancer.
基金financially supported by the National Natural Science Foundation of China(Nos.51601192,51671188,51671189and 11332010)the High Technology Research and Development Program of China(No.2014AA041701)
文摘The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy.
基金financially supported by the National Key R&D Program of China(No.2017YFA0700704)the National Natural Science Foundation of China(No.51871221)the National Science and Technology Major Project(No.2017-VI-0002-0072)。
文摘Stress-rupture properties of a Ni-base Re-containing single-crystal superalloy with three orientations have been tested under 900℃/445 MPa.An obvious anisotropy of stress-rupture property is attributed to orientation reliant deformation microstructure.The good strength in[001]orientation is attributed to the rapid multiplication of dislocations active in horizontal channels and laterγ'cutting via dislocations pair coupled with anti-phase boundary.The microtwin formation largely limits the strength and plasticity as a result of the continuous shearing acrossγ/γ'microstructure by{111}112 slip activated in[011]orientation.The property in[111]orientation results mainly from the lateral cross-slip movements of the screw dislocations within connected matrix channels as well as the precipitate shearing by coplanar dislocations.Microcracks all initially originate from the interdendritic micropores in three orientations.The critical temperature of stress-rupture anisotropy could be increased by a high level of refractory solutes especially Re.
基金Supported by the National Natural Science Foundation of China(61603242)Opening Project of Collaborative Innovation Center for Economics Crime Investigation and Prevention Technology(JXJZXTCX-030)+1 种基金the Scientific Research Fund of Zhaoqing Univeristy(201734)Innovative Guidance Fund of Zhaoqing City(201704030409)
文摘One way to improve practicability of automatic program repair（APR） techniques is to build prediction models which can predict whether an application of a APR technique on a bug is effective or not. Existing prediction models have some limitations. First, the prediction models are built with hand crafted features which usually fail to capture the semantic characteristics of program repair task. Second, the performance of the prediction models is only evaluated on Genprog, a genetic-programming based APR technique. This paper develops prediction models, i.e., random forest prediction models for SPR, another kind of generate-and-validate APR technique, which can distinguish ineffective repair instances from effective repair instances. Rather than handcrafted features, we use features automatically learned by deep belief network（DBN） to train the prediction models. The empirical results show that compared to the baseline models, that is, all effective models, our proposed models can at least improve the F1 by 9% and AUC（area under the receiver operating characteristics curve） by 19%. At the same time, the prediction model using learned features at least outperforms the one using hand-crafted features in terms of F1 by 11%.
文摘The fabrication of LPFG in single mode fiber （SMF） was fabricated using amplitude mask writing techniques. The birefringence effect of LPFG for sensing the transverse strain was discussed in detail. The experimented results shou that it exhibits a very high sensitivity and a good linearity to transverse strain, with a sensitivity some hundred times greater than what has been achieved using FBG sensor.
文摘A basic glucoprotein named α-momorcharin(Mr:29000) that was isolated andpurified from the seeds of MomordicaCharantia was proved to have an obviousinhibitory effect on early pregnacy of
文摘在高二英语课本中相继出现了 affect 和 effect。这两个词虽说都有“影响”之意,但词性不同,而且用法也各异。此外,由于它们发音相似而易于混淆。现辨异如下:一、affect 只用怍动词。使用时常有以下几个意义。1.表示“影响”,“对……有(产生)影响”。例如;Smoking affects health.吸烟影响健康。The war and the sufferinu that it caused affected him greatly.(SB Ⅱ p.105)这场战争及其所造成的苦难对他影响很大。
文摘Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.
文摘Radioactivity is a natural phenomenon present in the universe. So, because of human life solidarity with a habitat, we are permanently in contact, especially through building materials. The objective of this work is the determination of the used cement radioactivity level in the buildings in Cote d'Ivoire. Thus, samples of grey and white cement currently used on Ivorian territory were taken. In order to determine the radioactivity level of this cement, samples were analyzed by using gamma spectrometry chain which contains a NaI (Tl) scintillation detector designed by the German manufacturer LD-DIDACTIC, coupled to a multichannel analyzer (AMC) using a Cassy Lab software. Thus, the specific activity of the primordial radionuclides 226Ra, 232Th and 40K, was able to be determined. The average values obtained are 29.66 Bq/kg, 34.88 Bq/kg and 178.424 Bq/kg respectively for 226Ra, 232Th and 40K. All average values are below the limit values recommended by UNSCEAR. However, we evaluated the radiological parameters such as the equivalent radium activity and the annual effective dose in order to translate the specific activity in terms of harmfulness. Values obtained for these parameters are below those recommended by ICRP and UNSCEAR. These results show that the risk incurred by the use of these different brands of cement is low.
文摘Objective: to study the effect of continuous quality improvement measures on nosocomial infection control in operating room. Methods: in a comparative study, patients and medical staff who underwent surgery in our hospital between 2018 and 2020 were included in this experimental study, including 100 patients and medical staff who underwent continuous quality improvement measures between 2019 and 2020. The qualification and compliance of hand hygiene of medical staff before and after implementation were analyzed, the incidence of medical disputes and nursing adverse events were compared between the two groups, and the nursing feelings of patients in the operating room were specifically scored. Results: after implementation, the qualified rate of hand hygiene was significantly improved, and the score of patients' nursing feelings in the operating room was significantly improved, and the incidence of medical disputes and adverse events was reduced. Conclusion: carrying out continuous quality improvement measures in the operating room of the hospital can improve the prevention and treatment effect of infection. It is a good measure for patients and medical staff, and reduces the incidence of medical accidents. It is of great significance for the development of the hospital.
文摘Objective: the experiment will apply Liuweidihuang decoction to patients with chronic glomerulonephritis. At the same time, we will also compare the patient's condition management results under the treatment of western medicine, and further analyze the therapeutic efficacy of patients under the two schemes of traditional Chinese and western medicine. Methods: 40 cases of patients with chronic glomerulonephritis treated in our hospital from January 2018 to February 2020 were selected as the objects of this study. The control group was treated with western medicine, while the observation group was treated with Liuweidihuang decoction. The efficacy was compared. Results: in terms of treatment, Scr and BUN levels in the observation group were (117.65±28.13) g/L and (6.55±2.04) umol/L, respectively, which were better than those in the control group, with statistical significance (P < 0.05). At the same time, the therapeutic effect was compared, and the observation group was better. The two groups were 95.0% and 80.0% respectively. The difference was statistically significant. Finally, the TCM symptoms of the patients were compared, which mainly included fatigue, psoas acid softness and edema. The scores were all better in the observation group. Conclusion: Liuweidihuang decoction in the treatment of chronic glomerulonephritis can improve the levels of Scr and BUN, enhance the therapeutic effect, which can alleviate the development of the disease, properly control and solve the clinical symptoms, and it is recommended to promote its application.
文摘Objective: to observe the clinical effect of intravenous thrombolysis with alteplase combined with Shuxuening injection on ischemic stroke. Methods: selected subjects: 90 patients with acute ischemic stroke in the emergency department of our hospital were selected from March 2021 to August 2022. They were grouped according to the computer parity distribution method, the control group database (45 patients data), and the observation group database (43 patients data), and Shuxuening injection combined with alteplase therapy. To observe the effects of different therapies on the clinical effect, neurological function score, inflammatory value, neurotransmitter and coagulation value of patients. Results: compared with the parameter difference between groups, there was no significant difference in data before treatment (P > 0.05). After treatment, the results of data comparison were significant, the clinical treatment effect of the patients in the observation group was significantly improved, the inflammatory values and neurological function scores were significantly decreased, and the neurotransmitters and coagulation values were significantly improved, P<0.05. Conclusion: the combined therapy of intravenous thrombolysis with alteplase and Shuxuening injection for patients with acute ischemic stroke has a significant clinical effect, which can effectively change the patients condition and improve the inflammatory response and neurological function.
文摘Objective: to analyze the diagnostic value of two-dimensional ultrasound imaging in peripheral vascular atherosclerosis. Methods: in this study, 100 patients with peripheral vascular atherosclerosis who were treated in our hospital from February 2020 to May 2021 were enrolled in the study. All patients were diagnosed by two-dimensional ultrasound imaging technology, and the plaque formation site, imaging manifestations, plaque types and basic diseases were analyzed. Results: for the 100 patients enrolled in this group, the ultrasonic manifestations of the patients mainly included 87 cases of rough intima, 35 cases of thickening, 12 cases of carotid intima thickening and 42 cases of rough intima. 21 plaque formation sites, 62 on the left and 59 on the right;There are 16 origins of internal carotid artery and 13 origins of common carotid artery at 22 bifurcation points and 70 bulbous points of common carotid artery. There were 49 soft spots, 45 hard spots, 4 mixed spots and 2 flat spots. Among the enrolled patients, cerebral infarction and coronary heart disease account for a large proportion, with 43 cases of cerebral infarction, accounting for 43.00%, and 39 cases of coronary heart disease, accounting for 39.00%. Conclusion: two-dimensional ultrasound imaging technology can effectively detect plaque and realize the exact diagnosis of peripheral vascular atherosclerosis.
基金supported by grants from the National Key Research and Development Program(2022YFA1104401)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-031 to Z.P.F.)grants from Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(NO.CXTD202204 to Z.P.F.).
文摘Dental mesenchymal stem cells(DMSCs)are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability.The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques.These methods can influence the cellular microenvironment,activate disparate signaling pathways,and induce different biological effects.“Epigenetic regulation”refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences,such as histone methylation.Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages.The most important sites of histone methylation in tooth organization were found to be H3K4,H3K9,and H3K27.Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites,generating distinct chromatin structures associated with specific downstream transcriptional states.Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications.A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation.Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4,H3K9,and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments.This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.
文摘目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组的基础上,结合泻青丸及清心平肝法针刺治疗,两组数据观察:治疗前后耶鲁综合抽动严重程度量表(Yale global tie severityb scale,YGTSS)评分变化、临床疗效、不良反应、中医证候积分变化、血清多巴胺(Dopamine,DA)以及5-羟色胺(5-Hydroxytryptophan,5-HT)、γ-氨基丁酸(γ-Aminobutyric acid,GABA)水平变化、Achenbach儿童行为量表(Child behavior check list,CBCL)及生活质量量表(Short form 36 questionnaire,SF-36)评分变化。结果观察组患儿总有效率(96.23%,51/53)比对照组患儿(84.91%,45/53)更高,差异有统计学意义(P<0.05);两组患儿治疗前YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分比较,差异无统计学意义(P>0.05),治疗后两组患儿YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标均改善,观察组患儿治疗后YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标优于对照组,差异有统计学意义(P<0.05);观察组患儿不良反应率(3.77%,2/53)比对照组患儿(16.98%,9/53)更低,差异有统计学意义(P<0.05)。结论泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果显著,且患儿症状改善,恢复较好,患儿行为改善,生活质量提升,不良反应率降低,较为安全可靠。
