To the Editor:Biologics have been used successfully for the treatment of psoriasis;however,some patients develop paradoxical reactions,particularly psoriasiform and eczematoid reactions.Eczematoid paradoxical reaction...To the Editor:Biologics have been used successfully for the treatment of psoriasis;however,some patients develop paradoxical reactions,particularly psoriasiform and eczematoid reactions.Eczematoid paradoxical reactions(EPRs)occur in 1%–6%of cases treated with tumor necrosis factor(TNF)-αinhibitors,2.4%with interleukin(IL)-12/23 inhibitors,3.5%with IL-17 inhibitors,and 0.01%with IL-23 inhibitors.[1]In practice,the incidence of EPRs induced by IL-17A inhibitors varies widely[2–4]and biologicals may have to be discontinued in some severe cases.展开更多
基金supported by a grant from Bethune Charitable Foundation(No.J202301E036).
文摘To the Editor:Biologics have been used successfully for the treatment of psoriasis;however,some patients develop paradoxical reactions,particularly psoriasiform and eczematoid reactions.Eczematoid paradoxical reactions(EPRs)occur in 1%–6%of cases treated with tumor necrosis factor(TNF)-αinhibitors,2.4%with interleukin(IL)-12/23 inhibitors,3.5%with IL-17 inhibitors,and 0.01%with IL-23 inhibitors.[1]In practice,the incidence of EPRs induced by IL-17A inhibitors varies widely[2–4]and biologicals may have to be discontinued in some severe cases.
