The China Basic Medical Insurance Program was created in 1999 with three objectives:equal accessibility,affordability,and quality.Today,it has become the biggest medical insurance program in the world,covering 95%of C...The China Basic Medical Insurance Program was created in 1999 with three objectives:equal accessibility,affordability,and quality.Today,it has become the biggest medical insurance program in the world,covering 95%of China's population.Since 2015,China's healthcare ecosystem has been reshaped by increasing innovation,which has in turn been driven by regulatory reform,enhancement of research and development capability,and capital market development.There has also been improved regulatory efficiency to reduce lags in launching drugs.In 2022,nearly 20%of novel active substances launched globally were from China.China has also risen to become the second biggest contributor to innovation in terms of pipelines.Using a“fast-follow”strategy,many locally developed innovative drugs can compete with products from multinational companies in their quality and pricing.However,China's pharmaceutical and biotechnology industry will continue to face challenges in pricing and reimbursement,as well as a shortened product lifecycle with rapid price erosion.The government has already accelerated the timeline for updating the drug reimbursement list and is willing to create a high-quality medical insurance program.However,some obstacles are hard to overcome,including reimbursement for advanced therapies,limited funding and an increasing burden of disease due to an aging population.This article reviews the trajectory of medical innovation in China,including the challenges.Looking forward,balancing affordability and innovation will be critical for China to continue the trajectory of growth.The article also offers some suggestions for future policy reform,including optimizing reimbursement efficiency with a focus on highquality solutions,enhancing the value assessment framework,payer repositioning from“value buyer”to“strategic buyer”,and developing alternative market access pathways for innovative drugs.展开更多
The Shandong Xiajin Yellow River Ancient Mulberry Trees System is a model of desertification control in the floor area in the Luxibei Plain,and of sustainable development.The current study about ancient mulberry trees...The Shandong Xiajin Yellow River Ancient Mulberry Trees System is a model of desertification control in the floor area in the Luxibei Plain,and of sustainable development.The current study about ancient mulberry trees in Xiajin county is mainly qualitative representation,lack of quantitative research.In addition,the relevant important ecological functional assessment should not only confine to quantitative assessment which illustrate the current condition,but also analyze the eco-service changes,derived from ecosystem structure develop,from the time dimension.Based on quantitative eco-service assessment of the ancient mulberry tree group,this paper intend to conduct a comprehensive analysis of ecological functions of ancient mulberry group focuses on the perspective of system structure and function evolution.Quantitative evaluation results show that the system has significant eco-efficiency in water conservation,reducing sediment loss,adjust atmosphere,etc.On timescale,thanks to mulberry cultivation,ecosystem structure and services have also undergone a corresponding change.In ecosystem structure：Planting pioneer trees such as mulberries and other species which can tolerate hostile site conditions,improves the micro-environment.This makes it possible for other crops to grow.The mixed forests and the combination of forestry and agriculture protect biodiversity.What＇s more,they make the structure of the ecosystems more robust,giving full play to their functions.In terms of ecosystem services：ecosystem services of Xiajin Yellow River Ancient Mulberry Trees have shown diversified development.And its main function has transferred from supply products to leisure and entertainment functions.展开更多
A comprehensive understanding of the spatial-temporal evolution and driving forces on ecosystem services(ES)is essential for the agro-pastoral ecotone’s ecological security in northern China.However,the land-use patt...A comprehensive understanding of the spatial-temporal evolution and driving forces on ecosystem services(ES)is essential for the agro-pastoral ecotone’s ecological security in northern China.However,the land-use pattern(LULC)agglomeration with spatial differentiation in the pastoral and agricultural areas has been rarely concerned.Taking distinct LULC(1980-2018)in Chifeng as an example,we compared four crucial categories of ESs with InVEST.Using SEM,we further contrasted the effects of several variables on regional ES variations in pastoral-dominated(North)and agriculture-dominated(South)regions,respectively.Results revealed the conversion between forest and grassland oriented the LULC transformation in the North.In contrast,human-activitiy-oriented land tended to occupy environmentally sensitive places in the South.Similar ES variations were supplied with the North outperforming the South when soil conservation was omitted.As for the impacts of regional ES variations,the natural and LULC policies both showed positive effects,whereas the anthropogenic factors showed positive in the North,which was negative in the South.Therefore,the ecologicallymaintained-dominant and ecologically-restored-dominant strategies should be separately adopted in the North and South.Our study provided appropriate regional ecological management suggestions for balancing the LULC-driven conflicts between ecological protection and regional development.展开更多
文摘The China Basic Medical Insurance Program was created in 1999 with three objectives:equal accessibility,affordability,and quality.Today,it has become the biggest medical insurance program in the world,covering 95%of China's population.Since 2015,China's healthcare ecosystem has been reshaped by increasing innovation,which has in turn been driven by regulatory reform,enhancement of research and development capability,and capital market development.There has also been improved regulatory efficiency to reduce lags in launching drugs.In 2022,nearly 20%of novel active substances launched globally were from China.China has also risen to become the second biggest contributor to innovation in terms of pipelines.Using a“fast-follow”strategy,many locally developed innovative drugs can compete with products from multinational companies in their quality and pricing.However,China's pharmaceutical and biotechnology industry will continue to face challenges in pricing and reimbursement,as well as a shortened product lifecycle with rapid price erosion.The government has already accelerated the timeline for updating the drug reimbursement list and is willing to create a high-quality medical insurance program.However,some obstacles are hard to overcome,including reimbursement for advanced therapies,limited funding and an increasing burden of disease due to an aging population.This article reviews the trajectory of medical innovation in China,including the challenges.Looking forward,balancing affordability and innovation will be critical for China to continue the trajectory of growth.The article also offers some suggestions for future policy reform,including optimizing reimbursement efficiency with a focus on highquality solutions,enhancing the value assessment framework,payer repositioning from“value buyer”to“strategic buyer”,and developing alternative market access pathways for innovative drugs.
基金The International Exchange and Cooperation Project of Ministry of Agriculture“Conservation of Globally Important Agricultural Heritage Systems(GIAHS)in China in 2016”The Youth Talent Supporting Project of China Association for Science and Technology(2016010103)
文摘The Shandong Xiajin Yellow River Ancient Mulberry Trees System is a model of desertification control in the floor area in the Luxibei Plain,and of sustainable development.The current study about ancient mulberry trees in Xiajin county is mainly qualitative representation,lack of quantitative research.In addition,the relevant important ecological functional assessment should not only confine to quantitative assessment which illustrate the current condition,but also analyze the eco-service changes,derived from ecosystem structure develop,from the time dimension.Based on quantitative eco-service assessment of the ancient mulberry tree group,this paper intend to conduct a comprehensive analysis of ecological functions of ancient mulberry group focuses on the perspective of system structure and function evolution.Quantitative evaluation results show that the system has significant eco-efficiency in water conservation,reducing sediment loss,adjust atmosphere,etc.On timescale,thanks to mulberry cultivation,ecosystem structure and services have also undergone a corresponding change.In ecosystem structure：Planting pioneer trees such as mulberries and other species which can tolerate hostile site conditions,improves the micro-environment.This makes it possible for other crops to grow.The mixed forests and the combination of forestry and agriculture protect biodiversity.What＇s more,they make the structure of the ecosystems more robust,giving full play to their functions.In terms of ecosystem services：ecosystem services of Xiajin Yellow River Ancient Mulberry Trees have shown diversified development.And its main function has transferred from supply products to leisure and entertainment functions.
基金This study was funded by The National Key Research and Development Program of China(No.2016YFC0503603)The Science and Technology Plan Project of Inner Mongolia(No.2022YFDZ0073)。
文摘A comprehensive understanding of the spatial-temporal evolution and driving forces on ecosystem services(ES)is essential for the agro-pastoral ecotone’s ecological security in northern China.However,the land-use pattern(LULC)agglomeration with spatial differentiation in the pastoral and agricultural areas has been rarely concerned.Taking distinct LULC(1980-2018)in Chifeng as an example,we compared four crucial categories of ESs with InVEST.Using SEM,we further contrasted the effects of several variables on regional ES variations in pastoral-dominated(North)and agriculture-dominated(South)regions,respectively.Results revealed the conversion between forest and grassland oriented the LULC transformation in the North.In contrast,human-activitiy-oriented land tended to occupy environmentally sensitive places in the South.Similar ES variations were supplied with the North outperforming the South when soil conservation was omitted.As for the impacts of regional ES variations,the natural and LULC policies both showed positive effects,whereas the anthropogenic factors showed positive in the North,which was negative in the South.Therefore,the ecologicallymaintained-dominant and ecologically-restored-dominant strategies should be separately adopted in the North and South.Our study provided appropriate regional ecological management suggestions for balancing the LULC-driven conflicts between ecological protection and regional development.
