In a recent study published in Cell,Liu et al.1 introduced EchoBack-CAR,a sonogenetic chimeric antigen receptor T cell platform that enables remote,spatiotemporal activation of CAR expression using focused ultrasound(...In a recent study published in Cell,Liu et al.1 introduced EchoBack-CAR,a sonogenetic chimeric antigen receptor T cell platform that enables remote,spatiotemporal activation of CAR expression using focused ultrasound(FUS).By combining an evolved heatinducible promoter with a synthetic positive feedback loop,EchoBack-CAR achieves potent antitumor effects while minimizing off-tumor toxicity.This system offers a promising solution for treating solid tumors,which have remained a significant challenge for conventional CAR-T therapies(Fig.1a,b).展开更多
基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(RS-2023-00279771 and RS-2024-00400827).
文摘In a recent study published in Cell,Liu et al.1 introduced EchoBack-CAR,a sonogenetic chimeric antigen receptor T cell platform that enables remote,spatiotemporal activation of CAR expression using focused ultrasound(FUS).By combining an evolved heatinducible promoter with a synthetic positive feedback loop,EchoBack-CAR achieves potent antitumor effects while minimizing off-tumor toxicity.This system offers a promising solution for treating solid tumors,which have remained a significant challenge for conventional CAR-T therapies(Fig.1a,b).
