Objective:To determine whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can rapidly distinguish among lung cancer,tuberculosis and sarcodosis,and to explore its sensitivity and spec...Objective:To determine whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can rapidly distinguish among lung cancer,tuberculosis and sarcodosis,and to explore its sensitivity and specificity.Methods:Clinical data of patients with enlarged mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA at our hospital between September 1,2012 and June 30,2015 for were retrospectively analyzed.The sensitivity,specificity,positive predictive value,and negative predicted value [including 95% confidence interval (CI)] were calculated..Results:A total of 299 lymph nodes from 201 patients underwent EBUS-TBNA were selected and no serious complications occurred.EBUS-TBNA showed a sensitivity of 87.9% (124/141) (95% CI:81%-92%),a specificity of 100.0% (124/124) (95% CI:97%-100%),and a negative predicted value of 41.3% (95% CI:23%-61%) in the detection of lung cancer.The sensitivity and specificity of diagnosis of mediastinal tuberculosis lymphadenitis were 72.4% (21/29) (95% CI:53%-87%) and 100.0% (95% CI:82%-100%);while sensitivity and specificity of diagnosis of sarcoidosis were 71.4% (5/7) (95% CI:29%-96%) and 100.0% (95% CI:91%-100%).Conclusions:The sensitivity and specificity of EBUS-TBNA do not significantly differ for a diagnosis of lung cancer versus tuberculosis or sarcodosis.展开更多
基金grants from the National Science Foundation of China(NSFC)(No.81260010,81460006).
文摘Objective:To determine whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can rapidly distinguish among lung cancer,tuberculosis and sarcodosis,and to explore its sensitivity and specificity.Methods:Clinical data of patients with enlarged mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA at our hospital between September 1,2012 and June 30,2015 for were retrospectively analyzed.The sensitivity,specificity,positive predictive value,and negative predicted value [including 95% confidence interval (CI)] were calculated..Results:A total of 299 lymph nodes from 201 patients underwent EBUS-TBNA were selected and no serious complications occurred.EBUS-TBNA showed a sensitivity of 87.9% (124/141) (95% CI:81%-92%),a specificity of 100.0% (124/124) (95% CI:97%-100%),and a negative predicted value of 41.3% (95% CI:23%-61%) in the detection of lung cancer.The sensitivity and specificity of diagnosis of mediastinal tuberculosis lymphadenitis were 72.4% (21/29) (95% CI:53%-87%) and 100.0% (95% CI:82%-100%);while sensitivity and specificity of diagnosis of sarcoidosis were 71.4% (5/7) (95% CI:29%-96%) and 100.0% (95% CI:91%-100%).Conclusions:The sensitivity and specificity of EBUS-TBNA do not significantly differ for a diagnosis of lung cancer versus tuberculosis or sarcodosis.
