Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which ...Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which may progress to malignancy through atypical hyperplasia.However,there are currently no fully targeted drugs for the treatment of UC.In this review,we discuss several cellular processes,such as autophagy,endoplasmic reticulum stress,mitochondrial dysfunction,macrophage polarization,ferroptosis and the Th/Treg cell balance,which are associated with the occurrence and development of UC.Many molecular targets and signaling pathways,such as nuclear factor kappa-B(NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT),Wnt/β-catenin,adenosine 5’-monophosphate-activated protein kinase(AMPK),toll-like receptor(TLR),Janus kinase/signal transducer and activator of transcription(JAK/STAT),long noncoding RNAs(lncRNAs),and microRNAs(miRNAs),play crucial roles in the progression of UC.We also summarize the common treatment strategies for UC,including lifestyle interventions,aminosalicylic acid preparations,corticosteroid drugs,biologics,fecal microbiota transplantation,and other drugs for symptomatic treatment.This review provides a detailed theoretical basis for the pathology and treatment of UC.Future research could focus on optimizing the treatment plan and achieving more precise and personalized treatment with multiple targets in multiple aspects.展开更多
基金supported by the National Natural Science Foundation of China(82073313 to D.L.)the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province(GZY-KJS-SD-2023-094)+1 种基金the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital(2023ZYZX02)the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project(to D.L.).
文摘Ulcerative colitis(UC)is the most common chronic inflammatory disease of the intestinal tract in clinical practice,and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa,which may progress to malignancy through atypical hyperplasia.However,there are currently no fully targeted drugs for the treatment of UC.In this review,we discuss several cellular processes,such as autophagy,endoplasmic reticulum stress,mitochondrial dysfunction,macrophage polarization,ferroptosis and the Th/Treg cell balance,which are associated with the occurrence and development of UC.Many molecular targets and signaling pathways,such as nuclear factor kappa-B(NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT),Wnt/β-catenin,adenosine 5’-monophosphate-activated protein kinase(AMPK),toll-like receptor(TLR),Janus kinase/signal transducer and activator of transcription(JAK/STAT),long noncoding RNAs(lncRNAs),and microRNAs(miRNAs),play crucial roles in the progression of UC.We also summarize the common treatment strategies for UC,including lifestyle interventions,aminosalicylic acid preparations,corticosteroid drugs,biologics,fecal microbiota transplantation,and other drugs for symptomatic treatment.This review provides a detailed theoretical basis for the pathology and treatment of UC.Future research could focus on optimizing the treatment plan and achieving more precise and personalized treatment with multiple targets in multiple aspects.
