Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working...Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.展开更多
1.Introduction.This perspective highlights the need for a specialized publication dedicated to neuropsychiatric disorders,collectively termed“dysconnectivity syndromes.”These conditions,including dementia-Alzheimer...1.Introduction.This perspective highlights the need for a specialized publication dedicated to neuropsychiatric disorders,collectively termed“dysconnectivity syndromes.”These conditions,including dementia-Alzheimer’s disease(AD),schizophrenia,and autism spectrum disorders,result from failures in interconnected physiological systems and neural circuits rather than isolated lesions.The proposed Brain Network Disorders(BND)journal aims to promote innovative paradigms for understanding these complex brain disorders by applying general systems theory and complexity sciences.The aim is to broaden the traditional conceptualization of these diseases by stressing the multifactorial roots of these disorders where the focus is on the dynamic interactions among several influences and the failure of multiple overlapping nets that drive clinical manifestations。展开更多
文摘Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.
基金CLARA project is jointly funded by the European Union and Czech Republic under EU’s Horizon Europe Framework Program(grant agreement No.Editorial Brain Network Disorders 1(2025)3-65101136607).
文摘1.Introduction.This perspective highlights the need for a specialized publication dedicated to neuropsychiatric disorders,collectively termed“dysconnectivity syndromes.”These conditions,including dementia-Alzheimer’s disease(AD),schizophrenia,and autism spectrum disorders,result from failures in interconnected physiological systems and neural circuits rather than isolated lesions.The proposed Brain Network Disorders(BND)journal aims to promote innovative paradigms for understanding these complex brain disorders by applying general systems theory and complexity sciences.The aim is to broaden the traditional conceptualization of these diseases by stressing the multifactorial roots of these disorders where the focus is on the dynamic interactions among several influences and the failure of multiple overlapping nets that drive clinical manifestations。
